84 results match your criteria: "From the Harvard Medical School[Affiliation]"

Against Our Instincts: Decriminalization of Buprenorphine.

J Am Board Fam Med

April 2022

From the Harvard Medical School, Boston, MA (JCM, AC, WB); Baylor College of Medicine, Houston, TX (WB).

Article Synopsis
  • The number of overdose deaths has surged in the last 20 years, prompting efforts to make treatments for opioid use disorder, like buprenorphine, more accessible by eliminating certain training requirements.
  • Concerns have arisen about increased diversion rates, where buprenorphine is used improperly or by unauthorized individuals.
  • The authors argue that while diversion is problematic, criminalizing diverted buprenorphine is a misguided and harmful response that undermines the efforts to improve access to this essential medication.
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Background: Surgical patients with limited digital literacy may experience reduced telemedicine access. We investigated racial/ethnic and socioeconomic disparities in telemedicine compared with in-person surgical consultation during the coronavirus disease 2019 (COVID-19) pandemic.

Study Design: Retrospective analysis of new visits within the Division of General & Gastrointestinal Surgery at an academic medical center occurring between March 24 through June 23, 2020 (Phase I, Massachusetts Public Health Emergency) and June 24 through December 31, 2020 (Phase II, relaxation of restrictions on healthcare operations) was performed.

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Objective: To determine trends in internet search volume for elective surgery terms during the first peak of the coronavirus disease 2019 (COVID-19) pandemic using Google Trends data.

Background: Postponement of much-needed elective and urgent oncologic surgeries takes a toll on patients and the health care system. The COVID-19 pandemic has led to a decline in elective surgery volume, partially due to the cancellation of elective surgeries at the start of the pandemic.

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Migraine, Stroke, and Cervical Arterial Dissection: Shared Genetics for a Triad of Brain Disorders With Vascular Involvement.

Neurol Genet

February 2022

From the Harvard Medical School (I.D., D.I.C.), Boston, MA; Division of Preventive Medicine (I.D., R.D., D.I.C.), Brigham and Women's Hospital, Boston, MA; University of Bordeaux (M.S., S.D.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, France; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (M.S.), University of Texas Health, San Antonio; Massachusetts General Hospital (P.G.), Boston; Institute for Stroke and Dementia Research (R.M.), Klinikum der Universität München, Ludwig-Maximilians-University, Germany; LabEx DISTALZ-U1167 (P.A.), RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille; Inserm U1167 (P.A.), Lille; Centre Hospitalier Universitaire Lille (P.A.); Institut Pasteur de Lille (P.A.), France; Department of Neurology (T.M.), Helsinki University Central Hospital, Finland; Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, Brescia University Hospital, Italy; Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (S.D.), CHU de Bordeaux, France.

Background And Objectives: Migraine, stroke, and cervical artery dissection (CeAD) represent a triad of cerebrovascular disorders with pairwise comorbid relationships and vascular involvement. Larger samples and recent advances in methodology invite systematic exploration of their shared genetics.

Methods: Genetic analyses leveraged summary statistics from genome-wide association studies of the largest available samples of each disorder, including subtypes of stroke (ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke) and migraine (with aura and without aura).

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Introduction.

Harv Rev Psychiatry

January 2022

From the Harvard Medical School and Department of Psychiatry, Beth Israel Deaconess Medical Center. Email: The present work is supported, in part, by National Institute of Mental Health grant no. K23 MH122701, National Institute of Health grant no. UL1 TR002541, and a One Mind Bipolar Research Award.

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The Fragility of Statistical Findings in Achilles Tendon Injury Research: A Systematic Review.

J Am Acad Orthop Surg Glob Res Rev

September 2021

From the Harvard Medical School, Boston, MA (Dr. Parisien); the Columbia University Medical Center, New York, NY (Dr. Danford, Dr. Trofa); the Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (Jarin); the Boston University Medical Center, Boston, MA (Dr. Li); and the Jacksonville Orthopaedic Institute, Jacksonville, FL (Dr. Vosseller).

Introduction: Probability analysis with the reporting of P values is often used to determine the statistical significance of study findings in the Achilles literature. The purpose of this study was to determine the utility of applying a fragility analysis to comparative trials evaluating Achilles tendon injuries.

Methods: We identified all dichotomous outcome data for comparative studies of Achilles tendon injuries published in 11 orthopaedic journals from 2000 to 2020.

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Identifying Characteristics Predictive of Lost-to-Follow-Up Status in Amblyopia.

Am J Ophthalmol

October 2021

From the Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Purpose: To identify demographic and disease-related characteristics predictive of Lost-to-Follow-Up (LTFU) status in amblyopia treatment and create a risk model for predicting LTFU status.

Design: Retrospective cohort study METHODS: Setting: Single-center, ophthalmology department at Boston Children's Hospital (BCH).

Patients: 2037 patients treated for amblyopia at BCH between 2010 and 2014.

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Development of Patient Education Materials for Total Joint Replacement During an International Surgical Brigade.

J Am Acad Orthop Surg Glob Res Rev

October 2020

From the Harvard Medical School, Boston, MA (Dr. Stenquist, Dr. Katz); the Harvard Combined Orthopaedic Residency Program, Massachusetts General Hospital, Boston, MA (Dr. Stenquist); the Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA (Dr. Stenquist, Ready, Dr. Ghazinouri, Dr. Katz); the Department of Medicine, Center for Healthcare Delivery Sciences, Brigham and Women's Hospital (Dr. Ghazinouri), Boston, MA; the Departments of Rehabilitation Services, Physical Therapy (Dr. Ghazinouri, Beagan), Brigham and Women's Hospital, Boston, MA; the Department of Orthopedic Surgery (Dr. Ghazinouri, Wisdom, Dr. Katz), Brigham and Women's Hospital, Boston, MA; the Department of Epidemiology, Harvard School of Public Health, Boston, MA (Dr. Katz); and the Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA (Dr. Katz).

Background: Temporary brigade trips to deliver international surgical care are increasingly common. For the purposes of this work, we use the term brigade to describe self-contained short-term medical or surgical mission trips where healthcare professionals are brought in from foreign regions to provide care to an underserved population. Many brigade programs have begun to collect and publish data on outcomes and complications, but few have examined their own patient education practices.

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A proof of concept study was conducted to implement an automated preoperative triage and preparation service with 2 components: (1) triage between preoperative visits and phone screens, and (2) delivery of preoperative instructions to patients. The study enrolled 2604 patients, of whom 75.7% completed the preoperative triage questionnaire and 47.

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Cross-Cultural Comparison of Nonopioid and Multimodal Analgesic Prescribing in Orthopaedic Trauma.

J Am Acad Orthop Surg Glob Res Rev

May 2020

From the Harvard Medical School (Mr. Young, Dr. Bhashyam, Dr. Dyer); the Harvard Combined Orthopaedic Residency Program (Dr. Bhashyam, Dr. Dyer); Boston, MA; the Department of Orthopaedic Surgery (Dr. Parisien), University of Pennsylvania; Philadelphia, PA; the Department of Trauma Surgery (Dr. Van der Vliet), University Medical Center Utrecht; Utrecht, the Netherlands; the Department of Orthopaedics, Nemours (Dr. Qudsi)/A.I. duPont Hospital for Children; Wilmington, DE; and the Department of Orthopaedic Surgery (Dr. Fils, Dr. Dyer), Brigham and Women's Hospital, Boston, MA.

Background: After musculoskeletal injury, US providers prescribe opioids more frequently and at higher dosages than prescribers in the Netherlands and Haiti; however, the extent of variation in nonopioid analgesic prescribing is unknown. The aim of our study was to evaluate how nonopioid prescribing by orthopaedic residents varies by geographic context.

Methods: Orthopaedic residents in three countries in which residents are the primary prescribers of postoperative analgesia in academic medical centers (Haiti, the Netherlands, and the United States) responded to surveys using vignette-based musculoskeletal trauma case scenarios.

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Telehealth Utilization in Response to the COVID-19 Pandemic in Pediatric Orthopaedic Surgery.

J Am Acad Orthop Surg

December 2021

From the Harvard Medical School & Boston Children's Hospital, Boston, MA (Parisien), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (Shin and Prasad), Columbia University Medical Center, New York City, NY (Trofa and Levine), Boston University Medical Center (Li), Boston, MA, and The Children's Hospital of Philadelphia, Philadelphia, PA (Parisien, Flynn, and Ganley).

Introduction: The purpose of this investigation was to assess the utilization of telehealth capabilities by pediatric orthopaedic departments across the United States in response to the COVID-19 pandemic.

Methods: One hundred four pediatric orthopaedic departments were investigated regarding each institution's current telehealth utilization as a direct response to the COVID-19 pandemic.

Results: Of the 104 hospitals contacted across the United States, 100 pediatric orthopaedic departments in 39 states responded for an overall response rate of 96%.

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Plastic Surgical Management of Hidradenitis Suppurativa.

Plast Reconstr Surg

March 2021

From the Harvard Medical School, Division of Plastic Surgery, Brigham & Women's Hospital, and the Department of Dermatology, Beth Israel Deaconess Medical Center.

Learning Objectives: After studying this article, the participant should be able to: 1. Describe the pathogenesis of hidradenitis suppurativa. 2.

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Immediate hypersensitivity to drugs is characterized by symptoms such as hives, swelling, and wheezing. To prevent a negative impact on care, assessment by an allergist is important. Evaluation requires a clear clinical history, but it is often lacking or vague, which makes a diagnosis difficult.

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Association of Academic Physiatrists Women's Task Force Follow-up Report.

Am J Phys Med Rehabil

June 2021

From the Harvard Medical School and Spaulding Rehabilitation Network, Boston, Massachusetts (JKS); Association of Academic Physiatrists Women's Task Force, Owing Mills, Maryland (JKS, SC); JFK Johnson Rehabilitation Institute and Rutgers Robert Wood Johnson Medical School/Hackensack Meridian School of Medicine, Edison, New Jersey (SC, TKF); New York University, Long Island School of Medicine, Mineola, New York (LW); Department of Rehabilitation and Regenerative Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York City, New York (CV); NewYork-Presbyterian Hospital-Columbia and Cornell, New York, New York (CV); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (GS); Burke Rehabilitation Hospital, Albert Einstein College of Medicine, Montefiore Health System, New York City, New York (MO-P); University of California Irvine School of Medicine, Irvine, California (DPK); University of Puerto Rico School of Medicine, San Juan, Puerto Rico (WRF); McGovern Medical School at University of Texas Health Science Center, Shriners Hospital for Children in Houston, TIRR Memorial Hermann Hospital, Houston, Texas (GB); Montefiore Medical Center, Albert Einstein College of Medicine, New York City, New York (AFA); and Association of Academic Physiatrists, Owing Mills, Maryland (TK).

The Association of Academic Physiatrists convened a Women's Task Force in 2016, under the leadership of then Association of Academic Physiatrists President Gerard Francisco, MD, to evaluate data and metrics pertaining to the representation and inclusion of female physiatrists in the society. An initial published report focused on a retrospective analysis of data in categories such as leadership, conference presentations, and recognition awards. The findings, which highlighted areas in which the Association of Academic Physiatrists had been successful in supporting gender equity as well as areas in which female physiatrists were underrepresented, provided a base from which to strategically focus on closing gaps in representation.

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Correlation Between Social Media Posts and Academic Citations of Orthopaedic Research.

J Am Acad Orthop Surg Glob Res Rev

September 2020

From the Harvard Medical School, Boston, MA (Dr. Zhang and Dr. Earp), and the Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA (Dr. Zhang and Dr. Earp).

Introduction: The objectives of this study were to quantify adoption of social media for the dissemination of original research in orthopaedic research and to determine the correlation between academic citations and social medial posts among recent orthopaedic publications.

Methods: An Internet-based study was performed of 835 articles from three orthopaedic journals from 2018 to 2019. The number of academic citations for each article was determined using Google Scholar and Web of Science.

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A Positive Psychology-Motivational Interviewing Intervention to Promote Positive Affect and Physical Activity in Type 2 Diabetes: The BEHOLD-8 Controlled Clinical Trial.

Psychosom Med

September 2020

From the Harvard Medical School (Huffman, Massey, Feig, Chung, Millstein, Brown, Healy, Wexler, Park, Celano); Departments of Psychiatry (Huffman, Golden, Massey, Feig, Chung, Millstein, Brown, Gianangelo, Park, Celano), Neurology (Healy), and Medicine (Endocrinology; Wexler), Massachusetts General Hospital, Boston, Massachusetts.

Objective: Physical activity is associated with superior health outcomes in patients with type 2 diabetes (T2D), but most T2D patients do not follow physical activity recommendations. The objective of this study was to assess the feasibility and impact of a novel combined positive psychology-motivational interviewing (PP-MI) intervention to promote physical activity in T2D.

Methods: This controlled clinical trial compared an 8-week, phone-delivered PP-MI intervention to an attention-matched MI-enhanced behavioral counseling condition among 60 participants with T2D and suboptimal moderate to vigorous physical activity (MVPA; <150 min/wk).

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Familial Alzheimer disease-causing mutations in Presenilin 1 (PSEN1) are generally thought to shift the processing of APP toward longer, more amyloidogenic Aβ fragments. However, certain PSEN1 mutations cause severe reduction in gamma secretase function when expressed in the homozygous state, thus challenging the amyloid hypothesis. We sought to evaluate the effects of one such mutation, PSEN1 L435F, in more physiologic conditions and genetic contexts by using human induced pluripotent stem cell (iPSC)-derived neurons from an individual with familial AD (fAD) linked to the PSEN1 L435F mutation, and compared the biochemical phenotype of the iPS-derived neurons with brain tissue obtained at autopsy from the same patient.

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Alcohol-Related Dermatitis: A Review.

Dermatitis

March 2021

Department of Dermatology, Brigham and Women's Hospital, Boston, MA.

: Wine, beer, liquor, and spirits are widely consumed in many cultures across the globe, and for some individuals, ingestion, cutaneous contact, or other exposure can lead to dermatologic findings. However, there currently exist no comprehensive reviews on alcohol-related dermatitis. Herein, we will provide an overview of alcohol-related dermatitis and contact urticaria, including the epidemiology and clinical manifestations, potential allergens found in alcoholic beverages, testing approaches, and strategies for allergen avoidance.

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With an aging and growing US population, American healthcare faces an impending physician shortage. This is important for the field of physical medicine and rehabilitation, because physiatrists' skills in managing chronic conditions and functional outcomes are especially relevant to an older population. The present study was designed to better understand the future physical medicine and rehabilitation workforce, by recording and analyzing the quantities of Accreditation Council of Graduate Medical Education-accredited physical medicine and rehabilitation graduate medical education programs and positions between 2001-2002 and 2017-2018.

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Cochrane Corners to Enhance Access to Evidence-Based Physiatry.

Am J Phys Med Rehabil

February 2019

From the Harvard Medical School, Department of PM&R, Spaulding Rehabilitation Hospital, Boston, Massachusetts (SP); and Universidad de Puerto Rico, San Juan, Puerto Rico (WRF).

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More Than Just a Game: The Public Health Impact of Sport and Physical Activity for People With Disabilities (The 2017 DeLisa Lecture).

Am J Phys Med Rehabil

January 2019

From the Harvard Medical School, Kelley Adaptive Sports Research Institute, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts.

Although people with disabilities make up a large proportion of our global population and are known to be disproportionately impacted by sedentary lifestyles leading to chronic disease, programs promoting physical activity often fail to address their unique needs. Both environmental and attitudinal factors also act as barriers to full participation. In this context, increasing evidence shows the positive impact of physical activity and sport on outcomes related to physical health, mental health, community participation, and, in some cases, neurorecovery for people with disabilities.

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