1 results match your criteria: "From the Center of Animal Biotechnology and Gene Therapy[Affiliation]"
Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage.
J Biol Chem
July 2015
From the Center of Animal Biotechnology and Gene Therapy, Departments of Biochemistry and Molecular Biology and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, 08036-Barcelona, Spain
The human insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region. Although human genomic studies have demonstrated associations between diabetes and the insulin/IGF2 locus or the IGF2 mRNA-binding protein 2 (IGF2BP2), the role of IGF2 in diabetes pathogenesis is not fully understood. We previously described that transgenic mice overexpressing IGF2 specifically in β-cells (Tg-IGF2) develop a pre-diabetic state.
View Article and Find Full Text PDF