Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.

LPS triggers inflammatory responses; however, the negative regulation of LPS responses remains poorly understood. CD300f is an inhibitory receptor among the CD300 family of paired activating and inhibitory receptors. We have previously identified ceramide as a ligand for CD300f and shown that the binding of ceramide to CD300f inhibits IgE-mediated mast cell activation and allergic responses in mouse models.