54 results match your criteria: "From physiopathology of ocular diseases to clinical development[Affiliation]"
Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in non-human primates.
Transl Res
October 2017
Unit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland. Electronic address:
Several approaches have been developed for gene therapy in RPE65-related Leber congenital amaurosis. To date, strategies that have reached the clinical stages rely on adeno-associated viral vectors and two of them documented limited long-term effect. We have developed a lentiviral-based strategy of RPE65 gene transfer that efficiently restored protein expression and cone function in RPE65-deficient mice.
View Article and Find Full Text PDFMacular Telangiectasia Type 1: Capillary Density and Microvascular Abnormalities Assessed by Optical Coherence Tomography Angiography.
Am J Ophthalmol
July 2016
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital. Fondation Asile des Aveugles, Lausanne, Switzerland; Inserm, U1138, Team 17, From Physiopathology of Ocular Diseases to Clinical Development, Université Paris Descartes Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France. Electronic address:
Purpose: To describe microvascular abnormalities and capillary density in macular telangiectasia type 1 (MT1) using optical coherence tomography angiography (OCTA), and correlate them with fluorescein angiography (FA).
Design: Observational case series.
Methods: Seven patients with MT1 and 12 age-matched controls were included.
Targeting iron-mediated retinal degeneration by local delivery of transferrin.
Free Radic Biol Med
December 2015
INSERM, UMRS 1138, team Behar-Cohen, From physiopathology of ocular diseases to clinical development, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers UMRS 1138, Paris, France; Université René Descartes, Centre de Recherche des Cordeliers UMRS 1138, Paris, France; Jules Gonin Ophthalmic Hospital, Lausanne, Switzerland.
Article Synopsis
- Iron is crucial for eye health but can lead to damage if there's too much, necessitating careful regulation of iron levels in the retina.
- Researchers tested the delivery of transferrin (Tf), a protein that binds iron, in animal models to see if it could help protect against retinal degeneration caused by light exposure.
- Results showed that Tf not only reduced harmful iron levels and oxidative stress but also improved retinal function and structure, indicating its potential as a safe treatment for retinal diseases linked to oxidative damage.
En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells.
Am J Ophthalmol
June 2015
Centro Italiano Macula, Rome, Italy.
Purpose: To characterize perifoveal intraretinal cavities observed around full-thickness macular holes (MH) using en face optical coherence tomography and to establish correlations with histology of human and primate maculae.
Design: Retrospective nonconsecutive observational case series.
Methods: Macular en face scans of 8 patients with MH were analyzed to quantify the areas of hyporeflective spaces, and were compared with macular flat mounts and sections from 1 normal human donor eye and 2 normal primate eyes (Macaca fascicularis).