The Posthyaluronidase Syndrome: Dosing Strategies for Hyaluronidase in the Dissolving of Facial Filler and Independent Predictors of Poor Outcomes.

Background: Hyaluronic acid dermal fillers are used extensively in periocular aesthetic medicine, and the incidence of filler-related complications is increasing. This study aimed to investigate the optimal dosing strategy for hyaluronidase and to identify predictors of poor outcomes.

Methods: We performed a retrospective review of 157 orbits of 90 patients treated with hyaluronidase over a 4-year period.

RBP3-Retinopathy-Inherited High Myopia and Retinal Dystrophy: Genetic Characterization, Natural History, and Deep Phenotyping.

Purpose: To examine the genetic and clinical features and the natural history of RBP3-associated retinopathy.

Design: Multi-center international, retrospective, case series of adults and children, with moleculraly confirmed RBP3-asociated retinopathy.

Methods: The genetic, clinical, and retinal imaging findings, including optical coherence tomography (OCT) and fundus autofluorescence (FAF), were investigated both cross-sectionally and longitudinally.

Charles Bonnet syndrome and periodic alternating nystagmus: Moving visual hallucinations.

Objective: To describe and discuss potential mechanisms for modulation of visual hallucinations by nystagmus.

Methods: We present 2 patients with coexistent Charles Bonnet syndrome and periodic alternating nystagmus in the context of acquired visual loss.

Results: The combination has given rise to a rare phenomenon: visual hallucinations that move in a manner governed by the nystagmus, specifically by the direction and velocity of the slow phase.

Methods for assessing forward and backward light scatter in patients with cataract.

Purpose: To compare objective methods for assessing backward and forward light scatter and psychophysical tests in patients with cataracts.

Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.

Design: Prospective case series.

Patient-reported outcome measuring tools in cataract surgery: Clinical comparison at a tertiary hospital.

Purpose: To assess the performance of patient-reported outcome measure questionnaires and determine their appropriateness for routine use in cataract patients.

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Prospective cohort study.

Comparative analysis of optical biometers.

Purpose: To evaluate the level of agreement, repeatability, and correlation of 2 optical biometers, the IOLMaster (based on partial coherence interferometry [PCI]) and Aladdin (based on optical low-coherence interferometry [OLCI]) in terms of axial length (AL), mean keratometry (K), anterior chamber depth (ACD), and corneal diameter.

Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.

Design: Prospective comparative case series.

Predictors of femtosecond laser intrastromal astigmatic keratotomy efficacy for astigmatism management in cataract surgery.

Purpose: To evaluate the factors associated with the efficacy of femtosecond laser intrastromal astigmatic keratotomy (AK).

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Prospective case series.

Nonpenetrating femtosecond laser intrastromal astigmatic keratotomy in eyes having cataract surgery.

Purpose: To describe the effect of femtosecond laser intrastromal astigmatic keratotomy (AK) performed during cataract surgery.

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Prospective case series.

Multiple regression analysis in nomogram development for myopic wavefront laser in situ keratomileusis: Improving astigmatic outcomes.

Purpose: To describe and evaluate a new multiple regression-derived nomogram for myopic wavefront laser in situ keratomileusis (LASIK).

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Prospective comparative case series.

Reshaping procedures for the surgical management of corneal ectasia.

Unlabelled: Corneal ectasia is a progressive, degenerative, and noninflammatory thinning disorder of the cornea. Recently developed corneal reshaping techniques have expanded the treatment armamentarium available to the corneal specialist by offering effective nontransplant options. This review summarizes the current evidence base for corneal collagen crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal ring segment implantation for the treatment of corneal ectasia by analyzing the data published between the years 2000 and 2014.

Efficacy of anterior capsulotomy creation in femtosecond laser-assisted cataract surgery.

Purpose: To report the rate of complete capsulotomies without adhesions and anterior capsule tears using the Catalys femtosecond laser.

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Prospective consecutive case series.

Multifocal toric intraocular lenses versus multifocal intraocular lenses combined with peripheral corneal relaxing incisions to correct moderate astigmatism.

Purpose: To compare the outcomes of multifocal toric intraocular lens (IOL) implantation and standard nontoric multifocal IOL implantation combined with peripheral corneal relaxing incisions (PCRIs) in patients with moderate preexisting corneal astigmatism.

Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.

Design: Prospective randomized controlled trial.

Unsutured phakic implantation of a black intraocular lens in the sulcus to treat leukocoria.

Unlabelled: We describe a 40-year-old woman with von Hippel-Lindau syndrome, secondary chronic exudative retinal detachment, and white cataract with consequent leukocoria. Because the cataract was contracted and calcified, a black Morcher 85F poly(methyl methacrylate) IOL was implanted in the ciliary sulcus anterior to the lens to prevent posterior capsule rupture and potential destabilization of the retinal detachment with a risk for phthisis. Excellent centration of the black IOL was achieved with good cosmetic outcome and without postoperative uveitis or glaucoma.

Phacoemulsification using 8 flexible iris hooks in a patient with a short eye, small pupil, and phacodonesis.

Unlabelled: We describe a technique that uses flexible iris hooks to dilate and stabilize the capsular bag in a patient with a very deep set and small eye, narrow palpebral fissure, shallow anterior chamber, and very small pupil, who was scheduled for routine phacoemulsification for a white cataract. At the time of iris hook placement, the capsular bag was noted to be markedly unstable. The patient was managed successfully with phacoemulsification of the lens using 4 iris hooks to dilate the pupil and 4 iris hooks to stabilize the capsular bag during surgery.

Hydration of the anterior stroma in phacoemulsification cataract surgery.

We describe a simple technique to hydrate the anterior stroma in cataract surgery using a 30-gauge needle. At the end of phacoemulsification, the needle is inserted into the stroma to create a watertight seal of the clear corneal incision.

Comparison of methods to quantify posterior capsule opacification using forward and backward light scattering.

Purpose: To compare forward and backward light scattering measurements to quantify posterior capsule opacification (PCO).

Setting: Vienna Institute for Research in Ocular Surgery, Vienna, Austria.

Design: Prospective single-center study.

Correction of moderate corneal astigmatism during cataract surgery: toric intraocular lens versus peripheral corneal relaxing incisions.

Purpose: To compare the astigmatism-reducing effect of a toric intraocular lens (IOL) and peripheral corneal relaxing incisions (PCRIs).

Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.

Design: Prospective masked bilateral randomized study.

Perineural infiltrates in Pseudomonas keratitis.

We describe 2 cases of contact lens-related microbial keratitis caused by infection with Pseudomonas aeruginosa in which perineural infiltrates were observed at presentation. In both cases, examination by confocal microscopy was negative for Acanthamoeba cysts but bacterial cultures and microscopy of corneal scrapings were positive for P aeruginosa. Both cases responded rapidly to treatment with topical levofloxacin with no significant long-term sequelae.

Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos.

Purpose: To evaluate the outcomes of phacoemulsification and intraocular lens (IOL) implantation in microphthalmos and nanophthalmos.

Setting: Moorfields Eye Hospital, London, United Kingdom.

Design: Retrospective case series.

Use of low-cost video recording device in reflective practice in cataract surgery.

Reflective surgical practice is invaluable for surgeons at all levels of experience. For trainees in particular, every surgical opportunity must be optimized for its learning potential. Recording and reviewing cataract surgery is an invaluable tool.