46 results match your criteria: "From McMaster University.[Affiliation]"
2024 Canadian Surgery Forum: Sept. 25-28, 2024.
Can J Surg
November 2024
From St. Michael's Hospital (Naveed, Deshpande, Gomez, Rezende-Neto, Ahmed, Beckett), and the University of Toronto (Naveed).
Extending the Range of Measurement for Minimally Invasive Treatments by Adding New Concepts to FACE-Q Aesthetics Scales.
Plast Reconstr Surg Glob Open
April 2024
Modus Outcomes (a company of Thread), Cheltenham, United Kingdom.
Article Synopsis
- - This study aimed to expand the existing FACE-Q Aesthetics scales by developing new measurement items focused on facial aesthetics and psychological functions after minimally invasive facial treatments.
- - Researchers conducted interviews and refined item concepts with input from patients and experts, ultimately testing 52 appearance and 22 psychological items among a large participant group from the US, Canada, and the UK.
- - Results indicated strong psychometric properties, showing reliability and validity of the new scales, and highlighted how they can effectively evaluate the effects of aesthetic treatments while reducing the burden on respondents.
Objective: The interpretation of magnetic resonance imaging (MRI) reports is crucial for the diagnosis of axial spondyloarthritis, but the subjective nature of narrative reports can lead to varying interpretations. This study presents a validation of a novel MRI reporting system for the sacroiliac joint in clinical practice.
Methods: A historical review was conducted on 130 consecutive patients referred by 2 rheumatologists for initial MRI assessment of possible axial spondyloarthritis.
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity.
N Engl J Med
September 2023
From McMaster University, York University, and Wharton Weight Management Clinic - all in Toronto (S.W.); Texas Diabetes and Endocrinology, Austin (T.B.), and Velocity Clinical Research at Medical City, Dallas (J.R.) - both in Texas; Alliance for Multispecialty Research, Norman, OK (L.C.); and Eli Lilly, Indianapolis (S.R., R.L., X.M., K.J.M., A.H., D.R., E.P., C.K., M.K.).
Background: Obesity is a major risk factor for many leading causes of illness and death worldwide. Data are needed regarding the efficacy and safety of the nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist orforglipron as a once-daily oral therapy for weight reduction in adults with obesity.
Methods: In this phase 2, randomized, double-blind trial, we enrolled adults with obesity, or with overweight plus at least one weight-related coexisting condition, and without diabetes.
High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality.
N Engl J Med
March 2022
From McMaster University (P.J.D., A.L., M.H.M., E.P.B.-C., N.D., D.C., P.A.K., M.J.M., J.S., Y.L.M., R.M., S.F.L., S.I.B., S.H., F.K.B., G.H.G., S.Y., R.P.W.), Hamilton Health Sciences (P.J.D., A.L., E.P.B.-C., N.D., D.C., P.A.K., Y.L.M., F.K.B., G.H.G., S.Y., R.P.W.), and the Population Health Research Institute (P.J.D., A.L., M.H.M., E.P.B.-C., D.C., M.J.M., K.B., J.S., Y.L.M., R.M., S.F.L., S.I.B., F.K.B., S.P., J.V., S.Y., R.P.W.), Hamilton, Queen's University, Kingston (R.V.A., J.L.P.), and Sunnybrook Health Sciences Centre and the University of Toronto, Toronto (S.C., S.F.) - all in Ontario, Canada; the Chinese University of Hong Kong, Hong Kong (M.T.V.C., M.J.U.), and the First Affiliated Hospital of Xinjiang Medical University, Urumqi (H.Z.) - both in China; E. Meshalkin National Medical Research Center (V.V.L., M.A.) and Novosibirsk State University (V.V.L.), Novosibirsk, and the Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (D.S.) - all in Russia; IRCCS San Raffaele Scientific Institute (G.L., E.F., F.M.) and Vita-Salute San Raffaele University (G.L., F.M.), Milan, the University of Foggia, Foggia (D.P.), and Santa Maria Hospital GVM Care and Research, Bari (D.P., V.M.) - all in Italy; the University of Malaya, Kuala Lumpur, Malaysia (C.Y.W.); Hospital de la Santa Creu i Sant Pau (G.U., M.M.) and Institut d'Investigació Biomèdica Sant Pau-CIBERESP (G.U.) - both in Barcelona; Instituto do Coração, Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo (L.A.H.), and Hospital Moinhos de Vento (C.A.P.), Hospital de Clínicas de Porto Alegre (C.A.P.), and Instituto de Cardiologia do Rio Grande do Sul (R.S.), Porto Alegre - all in Brazil; Royal Perth Hospital and the University of Western Australia - both in Perth (G.S.H.); the University of Edinburgh, Edinburgh (N.L.M.), the Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool (J.D.M.), and the Royal Wolverhampton NHS Trust, Wolverhampton (J.S.B.) - all in the United Kingdom; the University of California, Los Angeles, Los Angeles (E.M.); the University of Arizona College of Medicine, Tucson (J.S.A.); and Auckland City Hospital and the University of Auckland - both in Auckland, New Zealand (H.D.W.).
Background: Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations.
Methods: We undertook an international prospective cohort study involving patients 18 years of age or older who underwent cardiac surgery.
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
N Engl J Med
June 2021
From McMaster University (R.P.W., E.P.B.-C., J.S.H., M.S., P.J.D., J.N., K. Balasubramanian, A.L., S.Y., S.J.C.), Hamilton Health Sciences (R.P.W., E.P.B.-C., J.S.H., K. Brady, M.S., P.J.D., J.V., A.L., S.Y., S.J.C.), and the Population Health Research Institute (R.P.W., E.P.B.-C., J.S.H., K. Brady, M.S., P.J.D., J.N., K. Balasubramanian, J.V., A.L., S.Y., S.J.C.), Hamilton, ON, Southlake Regional Health Centre, Newmarket, ON (K.H.T.T.), the University of Toronto and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto (C.D.M.), and Quebec Heart and Lung Institute, Quebec, QC (P.V.) - all in Canada; University of Foggia, Foggia (D.P.), Santa Maria Hospital, Gruppo Villa Maria Care and Research, Bari (D.P.), and the University of Pisa, Pisa (A.C.) - all in Italy; Rhön-Klinikum Campus Bad Neustadt, Bad Neustadt (W.R.), and University Hospital Giessen, Giessen (A.B.) - both in Germany; the Institute for Clinical and Experimental Medicine, Prague (P.B.), and the Center of Cardiovascular Surgery and Transplantation, Brno (P.F.) - both in the Czech Republic; "G. Papanikolaou" Hospital (A.J.B.) and Aristotle University of Thessaloniki (G.I.T.) - both in Thessaloniki, Greece; E. Meshalkin National Medical Research Center, Novosibirsk, Russia (A.B.-P.); the University of Louisville, Louisville, KY (M.S.S.); the University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia (A.G.R.); Auckland City Hospital, Auckland, New Zealand (S.M.); Amphia Ziekenhuis, Breda (M.A.), and Medical Center Leeuwarden, Leeuwarden (R.J.F.) - both in the Netherlands; the National Heart and Lung Institute, Imperial College London, London (P.P.P.); and the International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo (Á.A.).
Background: Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons.
Methods: We conducted a multicenter, randomized trial involving participants with atrial fibrillation and a CHADS-VASc score of at least 2 (on a scale from 0 to 9, with higher scores indicating greater risk of stroke) who were scheduled to undergo cardiac surgery for another indication.
Fostering Clinical Research in the Community Hospital: Opportunities and Best Practices.
Healthc Q
July 2020
An industry outreach associate at Clinical Trials Ontario, MaRS Centre in Toronto, ON. Linnea has over 15 years of clinical research and clinical marketing experience in the medical device industry and is the principal consultant at BESPOKE Business Solutions, Inc. Her role at Clinical Trials Ontario is to develop and manage the QuickSTART and Research Ready programs, aimed at reducing clinical trial start-up times and increasing research capacity at institutions across the province.
With potential to improve patient outcomes, quality of care and cost-effectiveness, clinical research activity in community hospitals has recently begun to increase. Recognizing that establishing or strengthening a clinical research program in this setting is an important, complex and challenging undertaking, this article introduces many of the resources, best practices and success stories that community hospitals can draw upon to develop and incentivize clinical researchers, operationalize the clinical research enterprise and make clinical research impactful.
View Article and Find Full Text PDFEffect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results.
J Rheumatol
August 2019
From McMaster University, Hamilton, Ontario; Southlake Regional Health Centre, Newmarket, Ontario; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario; JSS Medical Research; McGill University, Montreal, Quebec; University of Toronto, Department of Medicine and Institute of Health Policy, Management, and Evaluation; Mount Sinai Hospital, Division of Rheumatology, Toronto, Ontario, Canada.
Objective: Prior studies have suggested that concurrent conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy enhances the efficacy of biologic DMARD (bDMARD). Here, we assessed the effect of concomitant csDMARD use and methotrexate (MTX) route of administration on time to bDMARD discontinuation in a large Canadian (Ontario), observational, rheumatoid arthritis (RA) cohort.
Methods: Patients from the Ontario Best Practices Research Initiative (OBRI) who initiated bDMARD therapy and had ≥ 1 followup assessment were included.
Aspiration Pneumonia.
N Engl J Med
February 2019
From McMaster University, Hamilton, ON, Canada (L.A.M.); and Weill Cornell Medical College, New York (M.S.N.).
Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis.
N Engl J Med
November 2018
From McMaster University and St. Joseph's Healthcare, Hamilton, ON, Canada (M.K.); the University of Washington, Seattle (G.R.); the National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, and the National Heart and Lung Institute, Imperial College, London (A.U.W.); Medizinische Klinik und Poliklinik V, University of Munich and Asklepios Klinik München-Gauting, German Center for Lung Research, Munich (J.B.), and Boehringer Ingelheim International, Ingelheim (B.S., M.Q., S.S.) - both in Germany; Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome (L.R.); and Weill Cornell Medicine, New York (F.J.M.).
Background: Nintedanib is an approved treatment for idiopathic pulmonary fibrosis (IPF). A subgroup analysis of a previously published trial suggested that sildenafil may provide benefits regarding oxygenation, gas exchange as measured by the diffusion capacity of the lungs for carbon monoxide (Dl), symptoms, and quality of life in patients with IPF and severely decreased Dl. That idea was tested in this trial.
View Article and Find Full Text PDFCanadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.
Can J Surg
August 2018
From McMaster University, Hamilton, Ont.
Using the BODY-Q to Understand Impact of Weight Loss, Excess Skin, and the Need for Body Contouring following Bariatric Surgery.
Plast Reconstr Surg
July 2018
From McMaster University; the School of Rehabilitation Sciences, Institute of Applied Health Sciences; Modus Outcomes; and Memorial Sloan Kettering Cancer Center.
Background: A consequence of bariatric surgery is redundant skin for most patients. The authors measured health-related quality of life and appearance following bariatric surgery in relation to weight loss, excess skin, and need for body contouring.
Methods: The sample included Canadian participants from the BODY-Q field-test study recruited between November of 2013 and July of 2014.
Web Exclusives. Annals Graphic Medicine - Memento Mori.
Ann Intern Med
February 2018
From McMaster University, Hamilton, Ontario, Canada.
mutations are associated with features of complex hereditary spastic paraparesis.
Neurology
November 2017
From McMaster University (M.A.T., L.B.), Hamilton; and McGill University (M.T.), Montreal, Canada.
MitraClip and Transcatheter Aortic Valve Replacement in a Patient With Recurrent Heart Failure.
Circ Cardiovasc Interv
September 2017
From McMaster University, Hamilton General Hospital, Ontario, Canada.
Guidelines to Limit Added Sugar Intake.
Ann Intern Med
August 2017
From McMaster University, Hamilton, Ontario, Canada; American College of Physicians, Philadelphia, Pennsylvania; McMaster University, Hamilton, Ontario, Canada; University of Antioquia, Medellin, Colombia.
The Scientific Basis of Guideline Recommendations on Sugar Intake.
Ann Intern Med
August 2017
From McMaster University, Hamilton, Ontario, Canada.
Regulating Information or Allowing Deception? Pharmaceutical Sales Visits in Canada, France, and the United States.
J Law Med Ethics
December 2016
Roojin Habibi, M.Sc., is a second-year law student in the French Common Law (J.D.) program at University of Ottawa. She received a bachelor's degree in environmental and health studies from York University, an M.Sc. in Global Health from McMaster University and completed a research fellowship with Pharmaceutical Policy Research Collaboration. Line Guénette, Ph.D., is an Assistant Professor at Laval University, Quebec city, Quebec, Canada and a researcher with the Population Health and Optimal Health Practices Research Unit at the CHU de Québec Research Center. She received a bachelor degree in pharmacy (BPharm), an M.Sc. and a Ph.D. in pharmacoepidemiology also from Laval University. Her research interests revolve around drug utilization, determinants of rational drug utilization and interventions and policies to improve rational use by patients and healthcare professionals. Joel Lexchin, M.Sc., M.D., has been teaching health policy at York University for the past 14 years and working as an emergency physician at the University Health Network since 1988. He holds B.Sc., M.Sc., and M.D. degrees from the University of Toronto. He has authored or co-authored over 150 peer reviewed papers and on all aspects of pharmaceutical policy both in Canada and internationally. Ellen Reynolds, M.P.A., is Research Coordinator at the School of Population and Public Health, Faculty of Medicine, University of British Columbia. She received her Master's in Public Administration from the University of Victoria in 2015. The focus of her research was on physicians' experiences and attitudes towards interactions with pharmaceutical sales representatives. She has worked as a research coordinator with the University of British Columbia since 2008, and has worked extensively with women's health organizations, including the Canadian Women's Health Network and DES (diethylstilbestrol) Action Canada. Mary Wiktorowicz, Ph.D., is a Professor of Health Policy and Management, the Associate Dean Community and Global in the Faculty of Health, and the Interim Director, Dahdaleh Institute for Global Health, York University. She received her Ph.D. in Health Policy from the University of Toronto, Institute of Health Policy, Management and Evaluation. Her research involves developing frameworks to compare national and transnational governance models that guide the development of health policy to enhance our understanding of them. Her research is funded by the Canadian Institutes of Health Research and published in leading journals. Barbara Mintzes, Ph.D., is Senior Lecturer at the Charles Perkins Centre and the Faculty of Pharmacy at the University of Sydney and an Affiliate Associate Professor at the School of Population and Public Health at the University of British Columbia (UBC). She holds a Ph.D. in epidemiology from UBC. Her main area of research is in pharmaceutical policy, including the influence of drug promotion on prescribing and medicine use. She also carries out systematic reviews on the effectiveness and safety of drug treatments.
Diverse legal and regulatory measures are used internationally to control the information provided during pharmaceutical sales visits. Little is known about the comparative effectiveness of these measures however. We analyzed the perceptions of regulators, pharmaceutical industry officials, health professionals, and consumer respondents concerning these approaches in Canada, France, and the United States using an empirical realist interests-based approach.
View Article and Find Full Text PDFBenefits and Risks of Antithrombotic Therapy in Essential Thrombocythemia: A Systematic Review.
Ann Intern Med
August 2017
From McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Background: Patients with essential thrombocythemia (ET) are at high risk for both thrombosis and hemorrhage.
Purpose: To evaluate the risks and benefits of antithrombotic therapy in adults with ET.
Data Sources: Multiple databases, including MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials, through 4 March 2017.
Computer-Aided Systematic Review Screening Comes of Age.
Ann Intern Med
August 2017
From McMaster University, Hamilton, Ontario, Canada.
Robotic-assisted thoracoscopic surgery for lung resection: the first Canadian series.
Can J Surg
August 2017
From McMaster University, Department of Clinical Epidemiology and Biostatistics, Hamilton, Ont. (Fahim, Hanna); the Department of Surgery, McMaster University, Hamilton, Ont. (Hanna, Shargall); and the Department of Surgery, University of Toronto, Toronto, Ont. (Waddell, Yasufuku).
Background: Robotic surgery was introduced as a platform for minimally invasive lung resection in Canada in October 2011. We present the first Canadian series of robotic pulmonary resection for lung cancer.
Methods: Prospective databases at 2 institutions were queried for patients who underwent robotic resection for lung cancer between October 2011 and June 2015.
Response by Jolly et al to Letters Regarding Article, "Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration".
Circulation
May 2017
From McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada (S.S.J.); Department of Medical Science, Uppsala University and Uppsala Clinical Research Centre, Sweden (S.J.); Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada (V.D.); University of British Columbia, Vancouver, Canada (J.A.C.); and Örebro University, Faculty of Health, Department of Cardiology, Södra Grev Rosengatan, Örebro, Sweden (O.F.).