73 results match your criteria: "From Columbia University[Affiliation]"
Coronary Artery Bypass Graft Versus Percutaneous Coronary Intervention: Meds Matter: Impact of Adherence to Medical Therapy on Comparative Outcomes.
Circulation
October 2016
From Columbia University, New York, NY (P.K.); Medical City Dallas Hospital, Dallas, TX (M.H., S.P.); and Baylor Health Care System, Plano, TX (M.M.).
Background: Multiple studies have compared coronary artery bypass graft (CABG) with percutaneous coronary interventions (PCI) for coronary revascularization. There is considerable evidence that adherence to medical therapy can affect the outcomes of therapeutic interventions. However, the long-term influence of compliance with recommended medical therapy on the comparative outcomes of CABG versus PCI remains to be defined.
View Article and Find Full Text PDFPatient Expectancy as a Mediator of Placebo Effects in Antidepressant Clinical Trials.
Am J Psychiatry
February 2017
From Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York; the Department of Psychology and Neuroscience and the Institute of Cognitive Science, University of Colorado at Boulder, Boulder, Colo.; the Institute for the Developing Mind, Children's Hospital Los Angeles; the Keck School of Medicine at the University of Southern California, Los Angeles; Harvard Medical School, Boston; and Beth Israel Deaconess Medical Center, Boston.
Objective: Causes of placebo effects in antidepressant trials have been inferred from observational studies and meta-analyses, but their mechanisms have not been directly established. The goal of this study was to examine in a prospective, randomized controlled trial whether patient expectancy mediates placebo effects in antidepressant studies.
Method: Adult outpatients with major depressive disorder were randomly assigned to open or placebo-controlled citalopram treatment.
Health and Big Data: An Ethical Framework for Health Information Collection by Corporate Wellness Programs.
J Law Med Ethics
September 2016
Ifeoma Ajunwa, J.D., Ph.D., is an Assistant Professor of Law at the University of the District of Columbia School of Law. She holds a J.D. from the University of San Francisco School of Law (San Francisco, CA) and a Ph.D. in Sociology from Columbia University in the City of New York. Kate Crawford, Ph.D., is a Principal Researcher at Microsoft Research (Social Media Collective), a Visiting Professor at the MIT Center for Civic Media, a Senior Fellow at the Information Law Institute at NYU, and an Associate Professor in the Journalism and Media Research Centre at the University of New South Wales. She holds a Ph.D. from the University of Sydney (Sydney, Australia). Joel S. Ford, M.D., is an internal medicine resident at Inova Fairfax Hospital in Falls Church, VA. He holds an M.S. in Mechanical Engineering from Stanford University (Palo Alto, CA) and an M.D. from Case Western Reserve University (Cleveland, Ohio).
This essay details the resurgence of wellness program as employed by large corporations with the aim of reducing healthcare costs. The essay narrows in on a discussion of how Big Data collection practices are being utilized in wellness programs and the potential negative impact on the worker in regards to privacy and employment discrimination. The essay offers an ethical framework to be adopted by wellness program vendors in order to conduct wellness programs that would achieve cost-saving goals without undue burdens on the worker.
View Article and Find Full Text PDFMother-Daughter-Granddaughter Double GuideLiner Technique for Delivering Stents Past Multiple Extreme Angulations.
Circ Cardiovasc Interv
August 2016
From Columbia University, New York (M.T.F., P.G., S.K., D.K.); Piedmont Heart Institute, Atlanta, GA (D.E.K., N.L.); Wellspan York Hospital, York, PA (W.N.); and Boston Scientific, Natick, MA (C.A.T.).
Binge-Eating Disorder Comes of Age.
Ann Intern Med
September 2016
From Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
Transcatheter Valve-in-Valve Implantation for Failing Bioprosthetic Triscupid Valves: Completing the Quest.
Circulation
April 2016
From Columbia University Medical Center, New York Presbyterian Hospital, New York, NY.
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.
N Engl J Med
April 2016
From Columbia University, New York (C.G.-B.); the George Washington University Biostatistics Center, Washington, DC (E.A.T.); the University of Texas Health Science Center at Children's Memorial Hermann Hospital, Houston (S.C.B.), the University of Texas Medical Branch, Galveston (G.R.S.), and the University of Texas Southwestern Medical Center, Dallas (B.M.C.) - all in Texas; the University of Alabama at Birmingham, Birmingham (A.T.N.T.); the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (U.M.R.); Brown University, Providence, RI (D.J.R.); Ohio State University, Columbus (D.S.M.), and the MetroHealth Medical Center, Case Western Reserve University, Cleveland (E.K.C.) - both in Ohio; the University of Utah Health Sciences Center, Salt Lake City (E.A.S.C.); the University of North Carolina at Chapel Hill, Chapel Hill (J.M.T.), and Duke University, Durham (G.K.S.) - both in North Carolina; Northwestern University, Chicago (A.M.P.); the University of Colorado School of Medicine, Anschutz Medical Campus, Aurora (R.S.G.); Stanford University, Stanford, CA (M.E.N.); University of Pittsburgh, Pittsburgh (S.N.C.); Oregon Health and Science University, Portland (J.E.T.); Wayne State University, Detroit (Y.S.); the Medical University of South Carolina, Charleston (J.P.V.); and Emory University, Atlanta (L.J.).
Background: Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities.
Methods: We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days).
Biobanks, Data Sharing, and the Drive for a Global Privacy Governance Framework.
J Law Med Ethics
February 2017
Ph.D. candidate in the School of Law at the University of Edinburgh. Previously, he was an Academic Associate at the Centre of Genomics and Policy at McGill University in Montreal. He received his LL.M. degree from Columbia University.
Biobanks are a key emerging biomedical research infrastructure. They manifest the turn towards greater global sharing of genomic and health-related data, which is considered by many to be an ethical and scientific imperative. Our collective interests lie in improving the health and welfare of individuals, communities, and populations; improving health and welfare requires access to, and use of, widely dispersed quality data.
View Article and Find Full Text PDFPreferences Regarding Return of Genomic Results to Relatives of Research Participants, Including after Participant Death: Empirical Results from a Cancer Biobank.
J Law Med Ethics
January 2017
Professor of Bioethics and Medical Anthropology based at the Institute for Health & Aging, University of California, San Francisco. Currently, she co-directs a Center of Excellence in ELSI Research that focuses on translational genomics, co-leads an NCI/NHGRI R01 on return of results in genomic biobanks, and directs the ELSI component of a U19 award focused on newborn screening in an era of whole genome analysis.
Data are lacking with regard to participants' perspectives on return of genetic research results to relatives, including after the participant's death. This paper reports descriptive results from 3,630 survey respondents: 464 participants in a pancreatic cancer biobank, 1,439 family registry participants, and 1,727 healthy individuals. Our findings indicate that most participants would feel obligated to share their results with blood relatives while alive and would want results to be shared with relatives after their death.
View Article and Find Full Text PDFNeurology Resident & Fellow Section: The second decade begins.
Neurology
October 2015
From Columbia University (M.S.V.E.), New York, NY; Ann & Robert H. Lurie Children's Hospital of Chicago (J.J.M.), Northwestern University Feinberg School of Medicine, IL; and Johns Hopkins Medicine (R.E.S.), Baltimore, MD.
Institutional Oversight of Faculty-Industry Consulting Relationships in U.S. Medical Schools: A Delphi Study.
J Law Med Ethics
December 2016
Professor of Law at Stanford Law School and a Professor of Health Research and Policy at Stanford School of Medicine. She received her J.D. from Yale Law School in New Haven, CT, a Ph.D. in Health Policy and Administration from the University of North Carolina at Chapel Hill, and an M.Phil. in Comparative Social Research from Oxford University in Oxford, UK. At the time of this research, she was a Professor of Law and Public Health in the Department of Health Policy and Management at the Harvard School of Public Health.
The conflicts of interest that may arise in relationships between academic researchers and industry continue to prompt controversy. The bulk of attention has focused on financial aspects of these relationships, but conflicts may also arise in the legal obligations that faculty acquire through consulting contracts. However, oversight of faculty members' consulting agreements is far less vigorous than for financial conflicts, creating the potential for faculty to knowingly or unwittingly contract away important rights and freedoms.
View Article and Find Full Text PDFBreaking Up Is Hard to Do.
N Engl J Med
July 2015
From Columbia University Medical Center, New York.
Cardiology Patient Page. Chelation therapy: a new look at an old treatment for heart disease, particularly in diabetics.
Circulation
May 2015
From Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, FL.
Therapeutic hypothermia in children after cardiac arrest: a systematic review and meta-analysis.
Pediatr Emerg Care
April 2015
From Columbia University School of Nursing, New York, NY.
Background: Therapeutic hypothermia (TH) has been shown to be effective in resuscitation of some adults following cardiac arrest and infants with hypoxic ischemic encephalopathy, but has not been well studied in children.
Objectives: The purpose of this systematic review/meta-analysis was to examine mortality, neurologic outcomes, and adverse events in children following use of TH.
Results: A search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and the Institute for Scientific Information's Web of Knowledge from 1946 to 2014 yielded 6 studies (3 retrospective and 3 prospective cohort studies) that met our inclusion criteria.
Racial differences and racial disparities: the distinction matters.
Circulation
March 2015
From Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
Connectivity at a crossroads: what white matter integrity can tell us about cognitive impairment.
Neurology
July 2014
From Columbia University Medical Center (R.S.M.), New York; and Massachusetts General Hospital Stroke Center (Y.D.R.), Boston.
STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension.
Circulation
May 2014
From Columbia University, New York, NY (R.J.B.); Department of the Child and Adolescent, University of Geneva, Geneva, Switzerland (M.B.); National Heart Institute, Mexico City, Mexico (T.P.); Pfizer Ltd, Sandwich, UK (during study conduct) (G.L., I.K.); Pfizer Inc, La Jolla, CA (M.Z.); and Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora (D.D.I.).
Background: The double-blind, placebo-controlled Sildenafil in Treatment-Naive Children, Aged 1 to 17 Years, With Pulmonary Arterial Hypertension (STARTS-1) study assessed sildenafil in pediatric patients with pulmonary arterial hypertension; improved hemodynamics and exercise capacity occurred in medium- and high-dose groups. STARTS-2 was the extension study.
Methods And Results: In STARTS-1, 234 children ≥8 kg were randomly assigned to low-, medium-, or high-dose sildenafil or placebo orally thrice daily; within-group dose depended on weight.
Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: main results.
Neurology
March 2014
From Columbia University Medical Center (R.S.M., Y.-K.C., M.A.P., K.S., R.M.L.), New York; St. Luke's Roosevelt Medical Center New York (J.R.F.), New York; NINDS (Y.-K.C.), Bethesda, MD; Washington University (C.P.D., T.O.V., R.L.G.), St. Louis, MO; University of Iowa (W.R.C.), Iowa City; and the University of North Carolina at Chapel Hill (W.J.P.).
Objective: To determine whether extracranial-intracranial (EC-IC) bypass can improve cognition over 2 years compared to best medical therapy alone in patients with symptomatic internal carotid artery (ICA) occlusion and increased oxygen extraction fraction (OEF) on PET.
Methods: Patients underwent (15)O PET and were randomized if OEF ratio was >1.13 on the occluded side.
Strategies to predict, measure, and improve psychosocial treatment adherence.
Harv Rev Psychiatry
September 2014
Nonadherence to psychosocial and behavioral treatment is a significant public health problem that presents a barrier to recovery and effective treatment. An estimated 20% to 70% of individuals who initiate psychosocial mental health services discontinue treatment prior to clinicians' recommendations. Empirically supported, evidence-based, stand-alone or adjunctive psychosocial interventions treat an increasingly wide range of mental health conditions.
View Article and Find Full Text PDFAcamprosate: safety and tolerability in the treatment of alcohol dependence.
J Addict Med
March 2008
From Columbia University College of Physicians & Surgeons and St. Luke's Roosevelt Hospital Center (RNR), New York, NY; Forest Laboratories, Inc. (AG, JLP), New York, NY; Lipha Pharmaceuticals, Inc. (AMG), New York, NY.
Acamprosate, in conjunction with psychosocial treatment, has demonstrated efficacy in maintaining abstinence in alcohol-dependent patients in multiple clinical trials. Data from 13 short-term (≤26 weeks) and long-term (≥48 weeks) clinical trials were analyzed to assess the safety and tolerability of acamprosate: 4234 patients were randomized to placebo (N = 1962), acamprosate 1332 mg/d (N = 440), 1998 mg/d (N = 1749), or 3000 mg/d (N = 83). Overall incidence of treatment-emergent adverse events (AEs) was 61% for acamprosate and 56% for placebo (P < 0.
View Article and Find Full Text PDFRamelteon: a novel hypnotic indicated for the treatment of insomnia.
Psychiatry (Edgmont)
September 2007
Dr. Zammit is from Columbia University College of Physicians and Surgeons, and Clinilabs, Inc., New York, New York.
Ramelteon is a hypnotic with a novel mechanism of action and is the only melatonin agonist currently indicated for the treatment of insomnia. This drug acts at the MT1 and MT2 receptors to promote sleep and exert an effect on circadian rhythms. Unlike traditional hypnotics, ramelteon demonstrates no affinity for any CNS receptors commonly associated with sedation (GABA, dopamine, opiate, serotonin).
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