1,090 results match your criteria: "Froedtert Hospital & The Medical College of Wisconsin[Affiliation]"

Objective: To implement an electronic health record best practice advisory (BPA) to promote coprescribing of naloxone to patients at high risk of serious opioid-related adverse events (ORADEs).

Design: This pre-post quasi-experimental study evaluated 9 months of opioid and naloxone prescription data before and after BPA implementation.

Setting: The Froedtert & the Medical College of Wisconsin enterprise is comprised of 45 ambulatory clinics and 10 hospitals, including the only adult Level 1 trauma center in eastern Wisconsin.

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PI3K signaling and lysyl oxidase is critical to corneal stroma fibrosis following mustard gas injury.

Exp Eye Res

December 2024

Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; Departments of Veterinary Medicine & Surgery and Biomedical Sciences, University of Missouri, Columbia, MO, United States; Mason Eye Institute, School of Medicine, University of Missouri, Columbia, MO, United States. Electronic address:

Sulfur mustard gas (SM), an alkylating and vesicating agent, has been used frequently in many wars and conflicts. SM exposure to the eye results in several corneal abnormalities including scar/fibrosis formation. However, molecular mechanism for SM induced corneal fibrosis development is poorly understood.

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A Beacon of Wisdom: Tribute to Dr. Betty Ferrell as a Devoted Mentor.

J Pain Symptom Manage

January 2025

Division of Nursing Research and Education, Department of Population Sciences and Department of Surgery, City of Hope (V.S.), Duarte, California.

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Healthcare providers (HCPs) face high rates of distress, experienced as burnout, moral distress, compassion fatigue, and grief. HCPs are also experiencing a crisis in meaning whereby distress is associated with disconnection from meaning in work and, in turn, a lack of meaning in work can further perpetuate distress for HCPs. Although scalable systems-level solutions are needed to tackle multidimensional HCP distress, it is also necessary to address HCP suffering at individual, team, and institutional levels.

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Characterizing Nodal Gamma-Delta T-Cell Lymphoma: Clinicopathological and Molecular Insights.

Mod Pathol

December 2024

Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address:

Peripheral T-cell lymphomas with gamma-delta phenotype (GDTCL) are rare lymphoid malignancies. Beyond the well-recognized entities of extranodal lymphomas with gamma-delta phenotype as defined by the fifth edition of the World Health Organization Classification of Hematolymphoid Tumors and 2022 International Consensus Classification, there is a group of poorly defined gamma-delta T-cell lymphomas with predominantly nodal presentation, termed as nodal GDTCL (nGDTCL). In this study, we present a series of 12 cases of Epstein-Barr virus-negative nGDTCL, highlighting the clinical, histopathological, and molecular features of this rare entity.

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An Analytical Approach that Combines Knowledge from Germline and Somatic Mutations Enhances Tumor Genomic Reanalyses in Precision Oncology.

J Comput Biol

January 2025

Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Expanded analysis of tumor genomics data enables current and future patients to gain more benefits, such as improving diagnosis, prognosis, and therapeutics. Here, we report tumor genomic data from 1146 cases accompanied by simultaneous expert analysis from patients visiting our oncological clinic. We developed an analytical approach that leverages combined germline and cancer genetics knowledge to evaluate opportunities, challenges, and yield of potentially medically relevant data.

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Aims: Our study examined the association between the Cambridge Risk Score (CRS), new hyperglycemia (NH), and complications in patients undergoing elective surgery.

Methods: In this retrospective cross-sectional study, adult surgical patients, without diabetes, with NH (blood glucose ≥140 mg/dL) were identified, and the CRS was calculated. We used univariate regression models to evaluate the relationship between CRS and NH with 30-day readmission, length of stay (LOS), and complications.

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Causes of Mortality From Acute Carbon Monoxide Exposure: A Step Towards Preventative Long-Term Care?

Crit Care Med

December 2024

Department of Veterans Affairs, Center of Innovation for Complex Chronic Healthcare, Edward Hines, Jr VA Hospital, Hines, IL.

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Background: Accurate case length estimation is a vital part of optimizing operating room use; however, significant inaccuracies exist with current solutions. The purpose of this study was to develop and validate an artificial intelligence system for improved surgical case length prediction by applying natural language processing and machine-learning methods.

Methods: All inpatient elective surgical cases longer than 30 minutes completed between 2017 and 2023 at a single, quaternary care hospital were considered.

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Background: The Abdominal Compartment Society (WSACS) established consensus definitions and recommendations for the management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in 2006, and they were last updated in 2013. The WSACS conducted an international survey between 2022 and 2023 to seek the agreement of healthcare practitioners (HCPs) worldwide on current and new candidate statements that may be used for future guidelines.

Methods: A self-administered, online cross-sectional survey was conducted under the auspices of the WSACS to assess the level of agreement among HCPs over current and new candidate statements.

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Article Synopsis
  • Obstructive sleep apnoea increases risks during sedation in hospitals, prompting the implementation of the STOP-BANG screening to ensure proper respiratory monitoring for patients receiving sedatives, narcotics, or anxiolytics.
  • * The STOP-BANG measure was integrated into the admission process, requiring monitoring via pulse oximetry and capnography for patients scoring ≥3 who were prescribed sedatives or narcotics.
  • * An analysis of over 250,000 patients showed that after implementing the protocol, mortality rates for those on sedatives decreased and monitoring was particularly beneficial for high-risk patients with STOP-BANG scores of 5 or more.
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Background: Benign Paroxysmal Positional Vertigo (BPPV) is a common vestibular disorder significantly impacting older adults, characterized by brief episodes of vertigo triggered by head movements. Accurate and timely diagnosis of BPPV can be challenging due to its overlapping symptoms with other conditions. Machine learning (ML) offers a promising approach to enhance diagnostic accuracy and efficiency.

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Cephalosporins for Outpatient Pyelonephritis in the Emergency Department: COPY-ED Study.

Ann Emerg Med

November 2024

Department of Emergency Medicine and Pharmacy, University of Iowa, Iowa City, IA. Electronic address:

Study Objective: The primary objective of our study was to compare the effectiveness of oral cephalosporins versus fluroquinolones and trimethoprim/sulfamethoxazole (TMP-SMX) for the treatment of pyelonephritis in patients discharged home from the emergency department (ED).

Methods: This was a multicenter, retrospective, observational cohort study of 11 geographically diverse US EDs. Patients aged ≥18 years diagnosed with pyelonephritis and discharged home from the ED between January 1, 2021 and October 31, 2023 were included.

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The LAVA Study: A Prospective, Multicenter, Single-Arm Study of a Liquid Embolic System for Treatment of Peripheral Arterial Hemorrhage.

J Vasc Interv Radiol

November 2024

Department of Radiology and Medical Imaging, Division of Interventional Radiology, University of Virginia, Charlottesville, Virginia.

Purpose: To present the results of the Liquid Embolization of Arterial Hemorrhages in Peripheral Vasculature (LAVA) study evaluating safety and effectiveness of Lava Liquid Embolic System, an ethylene vinyl alcohol (EVOH), for peripheral arterial hemorrhage (PAH).

Materials And Methods: LAVA was a pivotal, prospective, multicenter, single-group, centrally adjudicated study of adults with active PAH. Patients received EVOH at 1 of 2 viscosities, administered by experienced physicians.

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Unlabelled: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues its largely aseasonal spread with millions of cases per year. Highly sensitive, point-of-care testing is critical for rapid detection of coronavirus disease 2019 (COVID-19) cases and initiation of antiviral therapy to avert adverse health outcomes and reduce onward transmission of the virus. While hundreds of COVID-19 diagnostics received emergency use authorization from the FDA during the pandemic, significantly fewer have navigated the course to FDA clearance or approval.

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Background: Structured rehabilitation optimizes outcomes and reduces reinjury risk after anterior cruciate ligament reconstruction (ACLR). The coronavirus 2019 (COVID-19) pandemic interrupted standard rehabilitation, possibly affecting ACLR outcomes.

Purpose: To characterize changes to ACLR functional outcomes related to the COVID-19 pandemic.

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Skin injury: Associations with variables related to perfusion and pressure.

Anaesth Intensive Care

November 2024

Institute for Health and Equity, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Article Synopsis
  • Skin injuries, particularly hospital-acquired pressure injuries (HAPIs), pose a significant challenge in critically ill patients, and the study examined how perfusion-related factors might contribute to these injuries.
  • The study involved 533 adult patients in an intensive care unit, analyzing the relationship between various perfusion factors (like vasopressor use and mechanical circulatory support) and the risk of developing HAPIs compared to immobility factors such as long-term mechanical ventilation.
  • Results indicated that perfusion-related issues are more strongly associated with skin injury risk than immobility, suggesting that understanding these factors could lead to new treatment and prevention strategies for skin injuries in critically ill patients.
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Perioperative Management of Adult Patients with Diabetes Wearing Devices: A Society for Perioperative Assessment and Quality Improvement (SPAQI) Expert Consensus Statement.

J Clin Anesth

December 2024

Diabetes Technology Society, Clinical Professor of Medicine, U.C. San Francisco, CA, United States of America; Journal of Diabetes Science and Technology, Medical Director, Diabetes Research Institute, Mills-Peninsula Medical Center, San Mateo, CA, United States of America.

Article Synopsis
  • The use of advanced diabetes technology, like insulin pumps and continuous glucose monitors, is rapidly increasing among diabetes patients, especially those needing insulin.
  • * As these devices become more common in preoperative and surgical settings, they can complicate diabetes management for healthcare providers unfamiliar with them.
  • * This consensus statement provides guidance and education for perioperative clinicians to help them understand and effectively manage patients using these diabetes technologies.
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A Biobehavioral Perspective on Caring for Allogeneic Hematopoietic Stem Cell Transplant Survivors with Graft-Versus-Host Disease.

Transplant Cell Ther

September 2024

Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address:

Article Synopsis
  • Graft-versus-host disease (GVHD) is a common problem that can happen after certain medical treatments, causing serious physical and emotional issues for patients.
  • Even though there have been improvements in treating GVHD, the treatments can weaken the immune system and lead to more suffering and risks.
  • To help patients better, doctors are encouraged to work as a team and focus on both the physical and emotional challenges they face from GVHD, ensuring they get the best overall care.
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Article Synopsis
  • The SIERRA trial aimed to improve outcomes for older patients with relapsed or refractory acute myeloid leukemia (RR AML) by comparing a new treatment, I-apamistamab, against standard care before bone marrow transplant.
  • The study involved 153 patients, with results showing a significantly higher durable complete remission (dCR) rate of 17.1% for the I-apamistamab group compared to 0% for the conventional care group.
  • Although the overall survival rates were similar between the two groups, the I-apamistamab regimen exhibited more promise for achieving long-lasting remission with similar levels of severe side effects.
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The association of social vulnerability index and trial of labor after cesarean: comment on Tavella et al 2024.

J Clin Epidemiol

November 2024

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Froedtert Hospital, Milwaukee, WI 53226, USA. Electronic address:

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Objective:  Hypertensive disorders of pregnancy, defined as chronic (<20 weeks) or gestational (>20 weeks), are a leading cause of pregnancy-related mortality in the United States. Hypertensive disorders of pregnancy had increased prevalence from 13.3 to 15.

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