Pharmaceutical services to the mentally ill.

This paper provides an overview of the pharmaceutical services to the mentally ill within the community, the District General Hospital, Psychiatric Hospital, Regional Secure Unit, Special Hospital and Prison. With an overall picture of underfunding and underprovision a number of models of service are proposed for the future.

Down's syndrome and fragile-X syndrome in a single patient.

A profoundly mentally handicapped patient is described with the karyotype 47,X, fra (X) (q27), + 21. Her phenotype demonstrates features of both Down's Syndrome and fragile-X syndrome. The authors believe only one other similar case has been described.

Atlanto-occipital instability in Down's syndrome.

A patient with Down's syndrome and asymptomatic atlanto-occipital instability is described. The relationship between atlanto-occipital instability, atlanto-axial instability and generalized ligamentous laxity, is discussed.

Autoscopy, mental handicap and epilepsy. A case report.

A case of autoscopy in a 43-year-old epileptic and mentally handicapped woman is described. The possible significance of this phenomenon to the patient is discussed.

A case of mosaicism with fragile-X and XXY components.

The case of a 63-year-old severely mentally handicapped man is reported with chromosomal mosaicism. His karyotype was established as mosaic 46XY/47XXY with the fragile site present in a proportion of cells of both cell-lines. He showed phenotypic features which could be related both to the fragile-X and Klinefelter's syndromes.