7,956 results match your criteria: "Friedrich-Alexander University Erlangen[Affiliation]"

Article Synopsis
  • The study explores the challenge of treating head and neck tumors due to their low radiosensitivity and investigates whether small molecule kinase inhibitors (smKIs) can enhance the effectiveness of radiotherapy by altering immune-related factors in tumor cells.
  • The researchers combined ATM and ATR inhibitors with a specific radiotherapy regimen and examined various effects, including tumor cell death, immune checkpoint marker expression, and cytokine release using cell lines with different HPV statuses.
  • Results showed that while the combination therapy effectively induced cell death, particularly with ATR inhibitors, it also altered the immune profile of surviving cancer cells, suggesting a complex interaction between treatment types and immune responses.
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Thirty years ago, the Global Solar UV Index (UVI) has been introduced as a health promotion instrument to improve sun protection. We assessed systematically global levels of awareness and use of the UVI as a prerequisite for the preventive effectiveness of this public health tool. We conducted a comprehensive literature search across 10 databases, including PubMed, Scopus and Web of Science Core Collection, as well as clinical trial registries and gray literature databases.

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The development of effective recycling technologies is essential for the recovery and reuse of the raw materials required for lithium-ion batteries (LIBs). Future recycling processes depend on accessible information, necessitating the implementation of a digital battery passport. The European battery regulation mandates the use of a machine-readable identifier physically attached to the batteries for accessing digital information.

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  • The study investigates the morphomolecular features of high-grade metastasized G3 neuroendocrine tumors (G3NETs) undergoing prolonged systemic treatments, revealing associations with rapid progression and transformation into NEC-like histology.
  • Out of 40 patients, 22% exhibited NEC-like characteristics such as high-grade atypia and a significant increase in Ki67, indicating aggressive tumor behavior compared to non-NEC-like G3NETs.
  • The presence of TP53 mutations was found in all NEC-like tumors, while they still retained some typical NET mutations, suggesting partial histological and genetic features despite their progression and transformation.
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Design of PtSn Nanocatalysts for Fuel Cell Applications.

Chempluschem

December 2024

Friedrich-Alexander University Erlangen-Nürnberg, Interdisciplinary Center for Functional Particle Systems, Haberstraße 9a, 91058, Erlangen, Germany.

Article Synopsis
  • * Alloying, particularly with transition metals, has been explored to improve these catalysts, but stability remains an issue, and many transition metals are either expensive or rare.
  • * Tin (Sn) shows promise as a cost-effective and abundant alloying option that enhances catalytic performance, especially against CO poisoning and in oxygen reduction reactions, making it a key candidate for developing more efficient fuel cell electrodes.
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  • The study explores the real-world treatment patterns for inflammatory bowel diseases (IBD) at a large referral center, highlighting the challenges in decision-making due to the variety of therapies available.
  • A total of 502 patients with Crohn's disease and ulcerative colitis were analyzed, showing that infliximab remains the most commonly used first-line therapy, while newer options like ustekinumab and vedolizumab are gaining traction.
  • The findings indicate that remission rates decline with subsequent lines of therapy, pointing to the need for better biomarkers to guide treatment choices in IBD.
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Validation of the German version of the .

Int J Occup Med Environ Health

November 2024

Friedrich-Alexander-University Erlangen-Nuremberg (FAU), University Hospital, Erlangen, Germany (Department of Psychosomatic Medicine and Psychotherapy).

Objectives: Team or group cohesion is a multifaceted construct with a variety of definitions and measurement instruments. However, most of these measures are context and group-specific and/or time-consuming. There is no adaptable and economic measure of group cohesion in Germany.

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Article Synopsis
  • Imlunestrant is a new pill for treating a type of breast cancer, and researchers looked at how well it works and its safety.
  • In a study, women with a specific type of breast cancer took either 400mg or 800mg of the pill for two weeks before surgery, and more tests were done with a 200mg dose.
  • The results showed that the 400mg dose worked well and had fewer side effects, making it the best choice for treating patients in this study.
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Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation.

JAMA Neurol

September 2024

Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands.

Article Synopsis
  • Patients with a heart condition called atrial fibrillation (AF) who have strokes can still be at very high risk of having more strokes, even when taking medication to prevent them.
  • Left atrial appendage occlusion (LAAO) is a special procedure aimed at helping these patients avoid future strokes.
  • A study compared two groups – one that had LAAO and one that only continued their usual medication – and found that there was still a risk of strokes in both groups over a two-year period.
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  • Hyperglycemia and diabetic ketoacidosis are critical emergencies in diabetes that require quick recognition and management.
  • Effective treatment includes rehydration, insulin therapy, electrolyte replacement, and addressing the underlying causes.
  • The case study presents an 83-year-old male who experienced severe blood gas abnormalities after hand surgery and successfully received intensive care treatment.
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Background: Preventing worsening osteoarthritis (OA) in persons with early OA is a major treatment goal. We evaluated if different early OA definitions yielded enough cases of worsening OA within 2-5 years to make trial testing treatments feasible.

Methods: We assessed different definitions of early OA using data from Multicenter Osteoarthritis (MOST) Study participants who were followed up longitudinally.

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Introduction: As healthcare is shifting from a paternalistic to a patient-centred approach, medical decision making becomes more collaborative involving patients, their support persons (SPs) and physicians. Implementing shared decision-making (SDM) into clinical practice can be challenging and becomes even more complex with the introduction of artificial intelligence (AI) as a potential actant in the communicative network. Although there is more empirical research on patients' and physicians' perceptions of AI, little is known about the impact of AI on SDM.

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Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.

Circulation

November 2024

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.).

Article Synopsis
  • A meta-analysis of randomized, sham-controlled trials was conducted to evaluate the effectiveness and safety of catheter-based renal denervation (RDN) in treating hypertension, involving 10 trials with a total of 2,478 patients.
  • The study found that RDN significantly lowered both 24-hour and office systolic and diastolic blood pressure compared to sham procedures, without a notable difference in complications or changes in renal function.
  • Overall, RDN appears to be a safe and effective method for reducing blood pressure in patients with hypertension, although significant variability was noted among the studies analyzed.
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Background/aim: Tubular adenomas of the colon (TA) are neoplastic polyps composed of dysplastic tube-like crypts. Nondysplastic crypts, mostly in asymmetric branching have been previously reported, both beneath and bordering TA. In the present article, intercalated nondysplastic crypts (INDC) amidst dysplastic crypts in TA are showcased.

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The interplay of personality pathology and treatment outcome in psychosomatic psychotherapy: A longitudinal analysis using latent change score modelling.

Compr Psychiatry

November 2024

Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307 Dresden, Germany; Department of Clinical Psychology, Institute of Psychology, Friedrich-Schiller University Jena, Am Steiger 3-1, 07743 Jena, Germany; German Center for Mental Health (DZPG), Site Halle-Jena-Marburg, Germany.

Introduction: While ample data demonstrate the effectiveness of inpatient psychosomatic treatment, clinical observation and empirical evidence demonstrate that not all patients benefit equally from established therapeutic methods. Especially patients with a comorbid personality disorder often show reduced therapeutic success compared to other patient groups. Due to the heterogeneous and categorical personality assessment, previous studies indicated no uniform direction of this influence.

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Antibodies provide an essential layer of protection from infection and reinfection with microbial pathogens. An impaired ability to produce antibodies results in immunodeficiency and necessitates the constant substitution with pooled serum antibodies from healthy donors. Among the five antibody isotypes in humans and mice, immunoglobulin G (IgG) antibodies are the most potent anti-microbial antibody isotype due to their long half-life, their ability to penetrate almost all tissues and due to their ability to trigger a wide variety of effector functions.

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Article Synopsis
  • Polyethylene terephthalate (PET) is a widely used plastic, but its microplastics (MPs/NPs) pose increasing environmental threats that lack effective study methods.
  • This study introduces a new approach using functionalized superparamagnetic iron oxide nanoparticles (PET-fSPIONs) and magnetic resonance microimaging (µMRI) to track PET NP distribution in germinating wheat seeds.
  • Findings indicate significant accumulation of PET-fSPIONs in key seed areas and show effects on MRI relaxation times and lipid content, highlighting the method's ability to non-invasively monitor PET NP interactions in plant biology.
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The Effect of Ionizing Irradiation on the Autotaxin-Lysophasphatidic Acid Axis and Interleukin-6/8 Secretion in Different Breast Cancer Cell Lines.

J Pers Med

September 2024

Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Background: The Autotaxin (ATX)-lysophosphatidic acid (LPA) axis is involved in decreasing radiation sensitivity of breast tumor cells. This study aims to further elucidate the effect of irradiation on the ATX-LPA axis and cytokine secretion in different breast cancer cell lines to identify suitable breast cancer subtypes for targeted therapies.

Methods: Different breast cancer cell lines (MCF-7 (luminal A), BT-474 (luminal B), SKBR-3 (HER2-positive), MDA-MB-231 and MDA-MB-468 (triple-negative)) and the breast epithelial cell line MCF-10A were irradiated.

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Article Synopsis
  • Tumors of salivary glands vary widely and can overlap, making them challenging to diagnose, despite advances in molecular testing.
  • A study examined 363 cases of 20 different salivary gland tumors and found distinct DNA methylation patterns that help classify these tumors, achieving high accuracy with a machine learning algorithm.
  • The research identified specific epigenetic signatures, distinguishing certain tumor types, and suggested that DNA methylation could aid in diagnosing and potentially uncovering new tumor classes in the future.
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The aim of this study was to evaluate prediction equations to estimate 1RM in different exercises in older men and women with osteopenia/osteoporosis. Forty well-trained older women and men (73 ± 8 years) with osteopenia/osteoporosis performed 1RM dynamic and isometric maximum strength tests on resistance devices. In addition, each participant performed repetitions-to-fatigue (RTF) in the 5-8RM, 9-12RM, and 13-16RM zones.

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Objectives: The purpose of this study was to explore currently utilized readiness to Return to Sport (RTS) criteria after Hip Arthroscopy (HA) used in elite athletes to gain novel insights into the RTS decision-making process of professional team physicians. The authors hypothesized that even among this group of highly specialized physicians, there exists variability of measures and criteria used to determine RTS after HA.

Methods: A total of 15 qualitative semi-structured interviews with professional team physicians were conducted by a single trained interviewer.

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Article Synopsis
  • Current methods to predict sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy (HCM) are insufficient, although late gadolinium enhancement (LGE) in CMR imaging has shown a link to SCD in adults.
  • This study aimed to assess the significance of LGE in HCM patients under 21 years, utilizing data from various international centers between 2015 and 2022.
  • Results indicated that 32.9% of the 700 patients had LGE, and those with LGE were more likely to experience SCD or related events, emphasizing the potential role of LGE in clinical assessments for younger patients with HCM.
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  • The study focuses on the histological findings and AS-OCT results in patients suffering from severe keratomalacia and corneal perforation due to vitamin A deficiency (VAD).
  • Four patients were examined, with most showing severe VAD and evidence of corneal damage, including perforation in three cases.
  • The findings highlight a correlation between AS-OCT imaging and histological results, demonstrating that keratomalacia, while rare, can still occur in well-nourished populations, showcasing symptoms such as Bitot's spots in one patient.
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  • * These nutrient-starved cancer cells showed increased amounts and sizes of lysosomes, which were primarily located near the nucleus, due to a boost in the protein Rab7a responsible for lysosomal trafficking.
  • * The acidic environment of lysosomes in these cells can trap certain drugs like doxorubicin, contributing to drug resistance, but this resistance can be mitigated by using a lysosomal inhibitor, bafilomycin A1, which, along with 5-Fluorouracil, significantly reduced microtumor volume in tests.
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Background: To date there is no causal treatment for post-COVID syndrome, leaving symptomatic treatments as the primary recourse. However, the practical implementation and effectiveness of these interventions remain underexplored. This study aimed to investigate the utilization frequency of symptomatic therapies and patient-reported effectiveness across various treatment modalities at a German post-COVID center.

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