91 results match your criteria: "Friedrich Wilhelm University[Affiliation]"

Engineered as a Phototrophic Platform Organism for the Synthesis of Plant Sesquiterpenoids.

Front Microbiol

September 2019

Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, Forschungszentrum Jülich GmbH, Jülich, Germany.

Sesquiterpenoids are a large class of natural compounds offering manifold properties valuable for food, cosmetics, agriculture, and pharma industry. Production in microorganisms is a sustainable approach to provide sesquiterpenoids for research and industrial use independent of their natural sources. This requires the functional transfer of the respective biocatalytic pathways in an adequate host microorganism offering a sufficient supply of precursors that is ideally adjusted to the individual demand of the recombinant biosynthesis route.

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Aims: Despite increasing interest in the recently established immunoglobulin 4-related disease (IgG4-RD), its pathogenesis and aetiology remain largely unclear. Characteristic histopathological features are one of the key elements of diagnosis, including 'storiform' fibrosis, obliterative phlebitis, increased lymphoplasmacytic infiltration and increased levels of IgG4 in serum and tissue. Histopathological features of IgG4-RD are striking but not specific, and can pose a pitfall for surgical pathologists.

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DAMPening sterile inflammation of the kidney.

Kidney Int

March 2019

Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany. Electronic address:

Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al.

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Analysis of heat-induced protein aggregation in human mitochondria.

J Biol Chem

July 2018

Institute for Biochemistry and Molecular Biology, Friedrich Wilhelm University, 53115 Bonn, Germany. Electronic address:

Proteins in mammalian cells exhibit optimal stability at physiological temperatures, and even small temperature variations may cause unfolding and nonspecific aggregation. Because this process leads to a loss of function of the affected polypeptides and to cytotoxic stress, formation of protein aggregates has been recognized as a major pathogenic factor in human diseases. In this study, we determined the impact of physiological heat stress on mitochondria isolated from HeLa cells.

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Orexin plays a key role in mediating stress-induced drug relapse. However, the role of different types of orexinergic receptors that modulate stress-induced drug seeking remains unknown. The nucleus accumbens (NAc) has an important role in the reward system and receives orexinergic projections of the lateral hypothalamus.

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Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each (A/B/C) to 3 experimental groups (7 rats, 1/2/3): (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C) reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR)/cotinine serology-(1) control; (2) orthodontic tooth movement (OTM) of the first and second upper left molar (NiTi closed coil spring, 0.

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Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide.

Anticancer Res

February 2017

Center for Integrated Oncology (CIO), Department of Internal Medicine III, University Hospital Bonn, Rheinische Friedrich Wilhelm University Bonn, Bonn, Germany

Background/aim: Prostate cancer is the most common cancer in the Western world. A bi-functional peptide was combined with wingless-related integration site (WNT) inhibitors to determine if there is an additive therapeutic effect when they are used against prostate cancer, since their efficacy has already been proven when used alone.

Materials And Methods: A bi-functional peptide (TP-LYT) was designed with a target domain (LTVSPWY) and a lytic domain (KLAKLAK), and a second peptide with the same lytic domain but a random sequence instead of the target domain was used as a negative control.

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Article Synopsis
  • Adult orthodontic patients often experience chronic periodontitis, which complicates orthodontic treatment and increases the risk of dental root resorption (DRR) and periodontal bone loss.
  • A study using Fischer344 rats showed that orthodontic tooth movement (OTM) combined with induced periodontitis led to increased DRR, osteoclast activity, and accelerated tooth movement velocity despite the risks.
  • The findings suggest that orthodontic treatments should ideally occur only after effective periodontal therapy to avoid complications related to active inflammation.
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Longitudinal analysis of head and somatic growth in fetuses with congenital heart defects.

J Clin Ultrasound

February 2017

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, 6th Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.

Purpose: Fetal head and somatic growth dynamics differs in fetuses with congenital heart defects (CHD). We longitudinally characterized fetal head and somatic growth in relation to the type of CHD.

Methods: Four hundred eleven exams from isolated CHD were compared with 1,219 controls.

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Background: The reasons for, and the extent of, misuse of prescribed substitution medication as well as parallel consumption of other drugs during substitution-based therapy have still not been adequately researched in Germany.

Methods: This study examines the use of substitution medication in German substitution clinics utilizing a nationwide survey with anonymised questionnaires.

Results: The analysis of the 605 questionnaires showed a 30-day consumption prevalence of 8.

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Cellular and molecular immunologic mechanisms in patients with atopic dermatitis.

J Allergy Clin Immunol

August 2016

Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland; Swiss Institute for Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of the atopic diathesis. Recent evidence supports the concept that AD can also recognize other comorbidities, such as chronic inflammatory bowel or cardiovascular diseases. These comorbidities might result from chronic cutaneous inflammation or from a common, yet-to-be-defined immunologic background leading to immune deviations.

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Inflammation, vitamin D and dendritic cell precursors in chronic kidney disease.

Clin Exp Immunol

October 2016

Department of Internal Medicine III, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.

Decreased blood dendritic cell precursors (DCP) count is linked with atherosclerotic disease, while reduction of circulating DCP is also seen in patients with chronic kidney disease (CKD). As poor vitamin D status could be linked to a compromised innate immune response, we hypothesized that vitamin D status might be involved in the decrease in circulating DCP in CKD. Moreover, the potential role of inflammation was considered.

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Objectives: To obtain valid results in relative gene/mRNA-expression analyses by RT-qPCR, a careful selection of stable reference genes is required for normalization. Currently there is little information on reference gene stability in dental, periodontal and alveolar bone tissues of the rat, especially regarding orthodontic tooth movement and periodontitis. We therefore aimed to identify the best selection and number of reference genes under these experimental as well as physiological conditions.

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Landscape genomics reveal signatures of local adaptation in barley (Hordeum vulgare L.).

Front Plant Sci

October 2015

Department of Crop Genetics and Biotechnology, Institute of Crop Science and Resource Conservation, Rhenish Friedrich-Wilhelm University of Bonn Bonn, Germany.

Land plants are sessile organisms that cannot escape the adverse climatic conditions of a given environment. Hence, adaptation is one of the solutions to surviving in a challenging environment. This study was aimed at detecting adaptive loci in barley landraces that are affected by selection.

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Chronic testicular inflammation and infection have been regarded as important factors in the pathogenesis of azoospermia. As key effector cells in innate and adaptive immune system, mast cells (MCs) were observed in inflammation and autoimmune disease. Furthermore, increased expression of tryptase-positive MCs has been reported in testicular disorders associated with male infertility/subfertility.

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Media influence on risk competence in self-medication and self-treatment.

Ger Med Sci

April 2016

Committee of Research into Natural Medicines, Munich, Germany.

Media play an important role in the reception of health risks; thus, media competence is important for enhancing the risk competence of patients and consumers. In addition to life-long health education, risk competence particularly requires careful handling of health information because, at present, the key problem is not the lack of sufficient information on health topics but the quality of such information. Patients and consumers of health procedures and health products also require information which relates to their daily life and matches their life style.

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Conservation and monitoring of tropical forests requires accurate information on their extent and change dynamics. Cloud cover, sensor errors and technical barriers associated with satellite remote sensing data continue to prevent many national and sub-national REDD+ initiatives from developing their reference deforestation and forest degradation emission levels. Here we present a framework for large-scale historical forest cover change analysis using free multispectral satellite imagery in an extremely cloudy tropical forest region.

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Background: Chronic recurrent multifocal osteomyelitis is a form of non-bacterial osteomyelitis which occurs primarily in childhood. In some cases painful bone swelling occurs. After a malignancy has been ruled out, antibiotic therapy is often started to treat the osteomyelitis.

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Objectives: Self-ligating brackets are widely believed to be more effective in clinical use and to involve less friction and force. Thus, the goal of this in vitro investigation was to experimentally assess the effectiveness of different bracket-archwire combinations and the force levels exerted in two-dimensional direction during correction of tooth malalignment. An important aspect of this objective was to determine whether the behaviors of conventional bracket systems with an elastic or steel ligature differ from that of self-ligating brackets.

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We analyzed clinical outcomes of partial lateral patellar facetectomy and medial reefing in patients with lateral patellar facet syndrome with painful patellar-retaining total knee arthroplasty. 34 patients were followed for a mean of 40 months. All 34 patients were matched with those having secondary patellar resurfacing without facetectomy.

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Objective: The purpose of this study was to evaluate the surveillance characteristics that precede stillbirth in growth-restricted fetuses that receive integrated Doppler and biophysical profile scoring (BPS).

Study Design: Nine hundred eighty-seven singleton pregnancies that were complicated by fetal growth restriction had multivessel Doppler scans (umbilical and middle cerebral arteries [MCA], ductus venosus, and umbilical vein) and BPS. Surveillance findings were compared between live births and stillbirths.

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Aim: Neck pain is a common problem that may result from abnormalities in the soft tissues, bones and joints of the spine. However, upper neck and occipital pain syndrome due to unilateral idiopathic arthrosis of a C1-2 lateral articulation is a very rare condition.

Material And Methods: We describe two patients with unilateral arthrosis of a C1-2 lateral articulation who were successfully treated with C1-2 fusion.

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