91 results match your criteria: "Friedrich Wilhelm University[Affiliation]"
Front Microbiol
September 2019
Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, Forschungszentrum Jülich GmbH, Jülich, Germany.
Sesquiterpenoids are a large class of natural compounds offering manifold properties valuable for food, cosmetics, agriculture, and pharma industry. Production in microorganisms is a sustainable approach to provide sesquiterpenoids for research and industrial use independent of their natural sources. This requires the functional transfer of the respective biocatalytic pathways in an adequate host microorganism offering a sufficient supply of precursors that is ideally adjusted to the individual demand of the recombinant biosynthesis route.
View Article and Find Full Text PDFHistopathology
January 2020
Institute of Pathology, Rheinisch Friedrich-Wilhelm University, University Hospital Bonn, Bonn, Germany.
Aims: Despite increasing interest in the recently established immunoglobulin 4-related disease (IgG4-RD), its pathogenesis and aetiology remain largely unclear. Characteristic histopathological features are one of the key elements of diagnosis, including 'storiform' fibrosis, obliterative phlebitis, increased lymphoplasmacytic infiltration and increased levels of IgG4 in serum and tissue. Histopathological features of IgG4-RD are striking but not specific, and can pose a pitfall for surgical pathologists.
View Article and Find Full Text PDFKidney Int
March 2019
Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany. Electronic address:
Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al.
View Article and Find Full Text PDFJ Biol Chem
July 2018
Institute for Biochemistry and Molecular Biology, Friedrich Wilhelm University, 53115 Bonn, Germany. Electronic address:
Proteins in mammalian cells exhibit optimal stability at physiological temperatures, and even small temperature variations may cause unfolding and nonspecific aggregation. Because this process leads to a loss of function of the affected polypeptides and to cytotoxic stress, formation of protein aggregates has been recognized as a major pathogenic factor in human diseases. In this study, we determined the impact of physiological heat stress on mitochondria isolated from HeLa cells.
View Article and Find Full Text PDFBrain Res Bull
March 2018
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Orexin plays a key role in mediating stress-induced drug relapse. However, the role of different types of orexinergic receptors that modulate stress-induced drug seeking remains unknown. The nucleus accumbens (NAc) has an important role in the reward system and receives orexinergic projections of the lateral hypothalamus.
View Article and Find Full Text PDFInt J Oral Sci
September 2017
Department of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each (A/B/C) to 3 experimental groups (7 rats, 1/2/3): (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C) reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR)/cotinine serology-(1) control; (2) orthodontic tooth movement (OTM) of the first and second upper left molar (NiTi closed coil spring, 0.
View Article and Find Full Text PDFAnticancer Res
February 2017
Center for Integrated Oncology (CIO), Department of Internal Medicine III, University Hospital Bonn, Rheinische Friedrich Wilhelm University Bonn, Bonn, Germany
Background/aim: Prostate cancer is the most common cancer in the Western world. A bi-functional peptide was combined with wingless-related integration site (WNT) inhibitors to determine if there is an additive therapeutic effect when they are used against prostate cancer, since their efficacy has already been proven when used alone.
Materials And Methods: A bi-functional peptide (TP-LYT) was designed with a target domain (LTVSPWY) and a lytic domain (KLAKLAK), and a second peptide with the same lytic domain but a random sequence instead of the target domain was used as a negative control.
Ann Anat
March 2017
Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauß-Allee 11, D-93053 Regensburg, Germany. Electronic address:
J Clin Ultrasound
February 2017
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, 6th Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
Purpose: Fetal head and somatic growth dynamics differs in fetuses with congenital heart defects (CHD). We longitudinally characterized fetal head and somatic growth in relation to the type of CHD.
Methods: Four hundred eleven exams from isolated CHD were compared with 1,219 controls.
Eur Addict Res
April 2017
Institute of General Practice and Family Medicine, University Medical Center Friedrich-Wilhelm University Bonn, Germany.
Background: The reasons for, and the extent of, misuse of prescribed substitution medication as well as parallel consumption of other drugs during substitution-based therapy have still not been adequately researched in Germany.
Methods: This study examines the use of substitution medication in German substitution clinics utilizing a nationwide survey with anonymised questionnaires.
Results: The analysis of the 605 questionnaires showed a 30-day consumption prevalence of 8.
J Allergy Clin Immunol
August 2016
Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland; Swiss Institute for Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of the atopic diathesis. Recent evidence supports the concept that AD can also recognize other comorbidities, such as chronic inflammatory bowel or cardiovascular diseases. These comorbidities might result from chronic cutaneous inflammation or from a common, yet-to-be-defined immunologic background leading to immune deviations.
View Article and Find Full Text PDFClin Exp Immunol
October 2016
Department of Internal Medicine III, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.
Decreased blood dendritic cell precursors (DCP) count is linked with atherosclerotic disease, while reduction of circulating DCP is also seen in patients with chronic kidney disease (CKD). As poor vitamin D status could be linked to a compromised innate immune response, we hypothesized that vitamin D status might be involved in the decrease in circulating DCP in CKD. Moreover, the potential role of inflammation was considered.
View Article and Find Full Text PDFAnn Anat
March 2016
Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg D-93053, Germany. Electronic address:
Objectives: To obtain valid results in relative gene/mRNA-expression analyses by RT-qPCR, a careful selection of stable reference genes is required for normalization. Currently there is little information on reference gene stability in dental, periodontal and alveolar bone tissues of the rat, especially regarding orthodontic tooth movement and periodontitis. We therefore aimed to identify the best selection and number of reference genes under these experimental as well as physiological conditions.
View Article and Find Full Text PDFJ Am Geriatr Soc
November 2015
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Front Plant Sci
October 2015
Department of Crop Genetics and Biotechnology, Institute of Crop Science and Resource Conservation, Rhenish Friedrich-Wilhelm University of Bonn Bonn, Germany.
Land plants are sessile organisms that cannot escape the adverse climatic conditions of a given environment. Hence, adaptation is one of the solutions to surviving in a challenging environment. This study was aimed at detecting adaptive loci in barley landraces that are affected by selection.
View Article and Find Full Text PDFAndrologia
August 2016
Department of Dermatology/Andrology Unit, Rheinische Friedrich Wilhelm University, Bonn, Germany.
Chronic testicular inflammation and infection have been regarded as important factors in the pathogenesis of azoospermia. As key effector cells in innate and adaptive immune system, mast cells (MCs) were observed in inflammation and autoimmune disease. Furthermore, increased expression of tryptase-positive MCs has been reported in testicular disorders associated with male infertility/subfertility.
View Article and Find Full Text PDFGer Med Sci
April 2016
Drug Regulatory Affairs, Rheinische Friedrich-Wilhelm-University, Bonn, Germany.
Ger Med Sci
April 2016
Committee of Research into Natural Medicines, Munich, Germany.
Media play an important role in the reception of health risks; thus, media competence is important for enhancing the risk competence of patients and consumers. In addition to life-long health education, risk competence particularly requires careful handling of health information because, at present, the key problem is not the lack of sufficient information on health topics but the quality of such information. Patients and consumers of health procedures and health products also require information which relates to their daily life and matches their life style.
View Article and Find Full Text PDFCarbon Balance Manag
December 2015
Forest and Environment Program, Center for International Forestry Research, Jalan CIFOR, Bogor, 16115 Indonesia.
Conservation and monitoring of tropical forests requires accurate information on their extent and change dynamics. Cloud cover, sensor errors and technical barriers associated with satellite remote sensing data continue to prevent many national and sub-national REDD+ initiatives from developing their reference deforestation and forest degradation emission levels. Here we present a framework for large-scale historical forest cover change analysis using free multispectral satellite imagery in an extremely cloudy tropical forest region.
View Article and Find Full Text PDFBMC Res Notes
November 2014
Department of General Practice and Family Medicine, University Medical Center Friedrich-Wilhelm University Bonn, Sigmund-Freud-Str, 25, 53127 Bonn, Germany.
Background: Chronic recurrent multifocal osteomyelitis is a form of non-bacterial osteomyelitis which occurs primarily in childhood. In some cases painful bone swelling occurs. After a malignancy has been ruled out, antibiotic therapy is often started to treat the osteomyelitis.
View Article and Find Full Text PDFJ Orofac Orthop
November 2014
Oral Medical Technology, Friedrich-Wilhelm University of Bonn, Welschnonnenstr. 17, 53111, Bonn, Germany.
Objectives: Self-ligating brackets are widely believed to be more effective in clinical use and to involve less friction and force. Thus, the goal of this in vitro investigation was to experimentally assess the effectiveness of different bracket-archwire combinations and the force levels exerted in two-dimensional direction during correction of tooth malalignment. An important aspect of this objective was to determine whether the behaviors of conventional bracket systems with an elastic or steel ligature differ from that of self-ligating brackets.
View Article and Find Full Text PDFJ Arthroplasty
November 2014
Department of Orthopaedic Surgery, University Hospital of Basel, Basel, Switzerland.
We analyzed clinical outcomes of partial lateral patellar facetectomy and medial reefing in patients with lateral patellar facet syndrome with painful patellar-retaining total knee arthroplasty. 34 patients were followed for a mean of 40 months. All 34 patients were matched with those having secondary patellar resurfacing without facetectomy.
View Article and Find Full Text PDFAm J Obstet Gynecol
December 2014
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD. Electronic address:
Objective: The purpose of this study was to evaluate the surveillance characteristics that precede stillbirth in growth-restricted fetuses that receive integrated Doppler and biophysical profile scoring (BPS).
Study Design: Nine hundred eighty-seven singleton pregnancies that were complicated by fetal growth restriction had multivessel Doppler scans (umbilical and middle cerebral arteries [MCA], ductus venosus, and umbilical vein) and BPS. Surveillance findings were compared between live births and stillbirths.
Turk Neurosurg
February 2015
Rheinische Friedrich Wilhelm University, Medical Faculty, Germany.
Aim: Neck pain is a common problem that may result from abnormalities in the soft tissues, bones and joints of the spine. However, upper neck and occipital pain syndrome due to unilateral idiopathic arthrosis of a C1-2 lateral articulation is a very rare condition.
Material And Methods: We describe two patients with unilateral arthrosis of a C1-2 lateral articulation who were successfully treated with C1-2 fusion.
Adv Biochem Eng Biotechnol
January 2013
Department of Pediatric Hematology and Oncology, Center for Pediatrics, University Hospital, Friedrich-Wilhelm University, Bonn, Germany.