13,940 results match your criteria: "Friedrich Schiller University.[Affiliation]"

Article Synopsis
  • The study examines how valley degrees of freedom in two-dimensional transition metal dichalcogenides, like molybdenum disulfide, could influence future electronic devices.
  • Researchers investigate the interaction between valley-specific light emission and a resonant plasmonic nanosphere to understand its effects on circular polarization.
  • The findings show unexpected depolarization of light, providing essential insights into light-matter interactions and paving the way for advanced valleytronic device development.
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Polymer-based batteries represent a promising candidate for next-generation batteries due to their high power densities, decent cyclability, and environmentally friendly synthesis. However, their performance essentially depends on the complex multiscale morphology of their electrodes, which can significantly affect the transport of ions and electrons within the electrode structure. In this paper, we present a comprehensive investigation of the complex relationship between the three-dimensional (3D) morphology of polymer-based battery electrodes and their effective transport properties.

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Acidic dimethyl sulfoxide: A solvent system for the fast dissolution of pectin derivatives suitable for subsequent modification.

Carbohydr Polym

January 2025

Friedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Center of Excellence for Polysaccharide Research, Humboldtstraße 10, 07743 Jena, Germany. Electronic address:

This study investigates the use of dimethyl sulfoxide (DMSO) as a solvent for the dissolution and subsequent chemical modification of various pectin derivatives. DMSO was found to effectively dissolve low-methoxy pectin, high-methoxy pectin, polygalacturonic acid hydrazide, pectin amide, and polygalacturonic hydroxamic acid when the negative charges on the polysaccharide backbone were neutralized with organic acids. The dissolution process was further enhanced by increasing the temperature, although higher temperatures also promoted chain cleavage.

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Antinociceptive interactions between excitatory interferon-γ and interleukin-17 in sensory neurons.

Brain Behav Immun

November 2024

Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany. Electronic address:

Interferon-γ (IFNγ) and interleukin-17 (IL-17) are master regulators of innate and adaptive immunity. Here we asked whether these cytokines also regulate pain. Both cytokines increased the excitability of isolated small- to medium-sized sensory neurons, suggesting a pronociceptive effect.

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Ecdysteroid-dependent molting in tardigrades.

Curr Biol

December 2024

Institute of Zoology and Evolutionary Research, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany; Department of Biological Sciences, University of Bergen, 5006 Bergen, Norway. Electronic address:

Although molting is a defining feature of the most species-rich animal taxa-the Ecdysozoa, including arthropods, tardigrades, nematodes, and others-its evolutionary background remains enigmatic. In pancrustaceans, such as insects and decapods, molting is regulated by the ecdysteroid (Ecd) hormone and its downstream cascade (Figure 1A, see also the text). However, whether Ecd-dependent molting predates the emergence of the arthropods and represents an ancestral machinery in ecdysozoans remains unclear.

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Due to their ultra-high sensitivity, solution-gated graphene-based field-effect transistors (SG-GFET) have been proposed for applications in bio-sensing. However, challenges regarding the functionalization of GFETs have prevented their applications in clinical diagnostics so far. Here GFET sensors based on van der Waals (vdW) heterostructures of single-layer graphene layered with a molecular ≈1 nm thick carbon nanomembrane (CNM) are presented.

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Article Synopsis
  • Antimicrobial resistance (AMR) in Enterobacterales, particularly in Escherichia coli, poses serious health and economic issues for humans and animals, highlighting the "One Health" approach to understanding this problem.
  • The study aimed to find extended-spectrum cephalosporin-resistant Enterobacterales in ruminants across Rwanda's provinces and to characterize the isolates.
  • From 454 rectal swabs collected from cattle, goats, and sheep, 64 resistant isolates were found, predominantly E. coli, with many showing multidrug-resistance and various resistance phenotypes linked to specific genes.
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  • The study examined how serum levels of minerals and phosphate relate to overall and cardiovascular death rates, especially in patients with varying kidney functions.
  • Low levels of sodium and iron were linked to worse kidney performance and higher death risks, while higher zinc levels correlated with lower risks.
  • Those with kidney functions below 60 mL/min faced a fourfold increase in mortality risk, emphasizing the need for regular monitoring of serum minerals and kidney health in cardiovascular patients.
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Biodiversity experiments revealed that plant diversity loss can decrease ecosystem functions across trophic levels. To address why such biodiversity-function relationships strengthen over time, we established experimental mesocosms replicating a gradient in plant species richness across treatments of shared versus non-shared history of (1) the plant community and (2) the soil fauna community. After 4 months, we assessed the multitrophic functioning of soil fauna via biomass stocks and energy fluxes across the food webs.

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Article Synopsis
  • Coronary artery disease (CAD) reduces life expectancy, especially in older adults, with myocardial infarctions being a leading cause of death in people over 70.
  • A study analyzed data from 4,045 elderly patients (>70 years) who underwent coronary artery bypass grafting (CABG) to assess its impact on long-term survival compared to the general age-matched population.
  • Results showed that CABG significantly lowers the risk of death in elderly patients, suggesting that the surgery effectively prolongs life by mitigating the risks associated with CAD, particularly after the first year post-surgery.
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Enhancing prediction stability and performance in LIBS analysis using custom CNN architectures.

Talanta

March 2025

Leibniz Institute of Photonics Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research (LPI), Albert-Einstein-Strasse 9, 07745, Jena, Germany; Institute of Physical Chemistry (IPC) and Abbe Centre of Photonics (ACP), Friedrich Schiller University Jena, Member of the Leibniz Centre for Photonics (LPI), Helmholtzweg4, 07743, Jena, Germany; Former Institution: Institute of Computer Science, Faculty of Mathematics, Physics & Computer Science, University of Bayreuth Universitaetsstraße 30, 95447, Bayreuth, Germany. Electronic address:

Article Synopsis
  • * Two predictive modeling methods, Partial Least Squares (PLS) and Convolutional Neural Networks (CNNs), are utilized to estimate concentrations of 24 elements in LIBS spectra, with CNNs demonstrating superior predictive accuracy and stability compared to PLS.
  • * The study progresses through three phases, ultimately fine-tuning CNN models to focus on specific elements and yielding notable predictions for Aluminum, Silicon, Iron, and others, while exploring the effects of changing model training parameters.
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Rare primary dedifferentiated liposarcoma of the thoracic spine: A case report and literature review.

Brain Spine

October 2024

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.

Introduction: Primary dedifferentiated liposarcomas of the spine mark a rare tumor entity.

Research Question And Case Description: We present a rare case of a primary dedifferentiated liposarcoma of the thoracic spine. A 36-year-old previously completely healthy woman presented with a sudden ascending paresthesia of both legs, persistently increasing over the course of two days before initial presentation.

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Article Synopsis
  • - Psoriasis is a common skin condition that currently has no cure, and more research is needed to understand its underlying processes and develop new treatments; however, there are challenges due to the lack of effective preclinical models.
  • - Recent advancements include creating 3D skin models that mimic psoriasis features, allowing researchers to study treatment responses using these replicas, which exhibit characteristics like inflammation and hyperproliferation when treated with cytokines.
  • - Treatments such as dexamethasone (DEX), celastrol (CEL), and biologics like adalimumab (ADM) and bimekizumab (BMM) demonstrated varying degrees of effectiveness in reducing inflammation and promoting skin differentiation, suggesting that this new in vitro
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Article Synopsis
  • Humans excel at recognizing familiar faces, but past research using EEG/ERP methods hasn't fully captured the neural mechanisms involved in this ability.
  • The article highlights key aspects of familiar face recognition, including image-independence, varying levels of familiarity, automatic recognition, and how selective this process is.
  • A new theoretical framework is proposed, breaking down familiar face recognition into distinct phases and integrating current concepts, marking significant progress in understanding the brain's role in this skill.
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Article Synopsis
  • Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
  • A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
  • The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
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Investigation of Astyanax mexicanus (Characiformes, Characidae) chromosome 1 structure reveals unmapped sequences and suggests conserved evolution.

PLoS One

November 2024

Departamento de Biologia Estrutural, Molecular e Genética, Programa de Pós-Graduação em Biologia Evolutiva, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brazil.

Article Synopsis
  • - The Mexican tetra, Astyanax mexicanus, has evolved unique traits like pigment loss due to natural selection in cave habitats and serves as an important species for studying evolution, with a chromosome count of 2n = 50.
  • - Researchers utilized advanced techniques including whole chromosome isolation and sequencing to analyze the structure of a specific chromosome (chromosome 1) in A. mexicanus, contributing to the understanding of its genetic makeup.
  • - Findings showed strong conservation of chromosome features across related species, suggesting a shared evolutionary origin, and the gathered data can be useful for comparative studies in other fish species of the same family.
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Orthogonal Functionalization of Oxo-Graphene Nanoribbons.

Chemistry

November 2024

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Altensteinstraße 23a, 14195, Berlin, Germany.

Article Synopsis
  • Oxo-graphene nanoribbons (oxo-GNRs) are created by cutting single-walled carbon nanotubes through an oxidative process.
  • An orthogonal functionalization method is introduced that allows for modifications on both the edges and the flat surface of oxo-GNRs due to their unique structure.
  • This functionalization technique, which was tracked using X-ray photoelectron spectroscopy, can also be adapted for other oxo-functionalized carbon materials like graphene quantum dots and reduced graphene oxide.
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Scope: The α-tocopherol long-chain metabolite α-tocopherol-13'-hydroxy-chromanol (α-T-13'-COOH) is a proposed regulatory intermediate of endogenous vitamin E metabolism. Effects of α-T-13'-COOH on cell viability and adaptive stress response are not well understood. The present study aims to investigate the concentration-dependent effects of α-T-13'-COOH on cellular redox homeostasis, genotoxicity, and cytotoxicity in murine RAW264.

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Climate change and land-use intensification are threatening soil communities and ecosystem functions. Understanding the combined effects of climate change and land use is crucial for predicting future impacts on soil biodiversity and ecosystem functioning in agroecosystems. Here, we used a field experiment to quantify the combined effects of climate change (warming and altered precipitation patterns) and land use (agricultural type and management intensity) on soil food webs across nematodes, micro-, and macroarthropods.

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Purpose: Complex chromosomal rearrangements (CCRs) often remain unidentified as they are rarely observed in the general population. Females with CCRs are generally recognized on the identification of an affected child with multiple congenital anomalies (MCA) or having a history of repeated pregnancy loss/bad obstetric history (RPL/BOH). In contrast, males with CCRs are diagnosed primarily due to infertility.

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Polar angle asymmetries (PAAs), the differences in perceptual experiences and performance across different regions of the visual field are present in various paradigms and tasks of visual perception. Currently, research in this area is sparse, particularly regarding the influence of PAAs during perceptual illusions, highlighting a gap in visual cognition studies. We aim to fill this gap by measuring PAAs across the visual field during an illusion applied to test conscious vision widely.

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Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, and their extent and fundamental principles across cell types remain controversial. We develop a supervised and unsupervised learning algorithm, termed Signature, to call NHCCs in Hi-C datasets to advance our understanding of genome topology.

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Article Synopsis
  • TAVI (Transcatheter Aortic Valve Implantation) generally results in lower rates of postoperative delirium compared to SAVR (Surgical Aortic Valve Replacement), as shown in a study of 12,015 patients.
  • No significant differences in secondary outcomes like 30-day mortality, stroke, or hospital stay were found between the two procedures.
  • More research is needed to evaluate the long-term effects of postoperative delirium on patient outcomes.
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  • Emerging research indicates that repetitive negative thinking (RNT), such as worry and rumination, is linked to biomarkers of Alzheimer's disease, highlighting a potential concern for brain health.
  • The study focused on 134 cognitively healthy older adults, examining whether worry and brooding are associated with neurodegeneration and if these effects differ between men and women.
  • Results showed that higher levels of brooding correlated with increased neurofilament light chain (NfL) levels, a marker of neurodegeneration, particularly in women, suggesting that RNT may negatively impact brain health, especially in females.
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