My turn or yours? Me-you-distinction in feature-based action planning.

Binding accounts propose that action planning involves temporarily binding codes of the action's unique features, such as its location and duration. Such binding becomes evident when another action (B) is initiated while maintaining the Action Plan A. Action B is usually impaired if it partially overlaps with the planned Action A (as opposed to full or no feature overlap).

The interplay of personality pathology and treatment outcome in psychosomatic psychotherapy: A longitudinal analysis using latent change score modelling.

Introduction: While ample data demonstrate the effectiveness of inpatient psychosomatic treatment, clinical observation and empirical evidence demonstrate that not all patients benefit equally from established therapeutic methods. Especially patients with a comorbid personality disorder often show reduced therapeutic success compared to other patient groups. Due to the heterogeneous and categorical personality assessment, previous studies indicated no uniform direction of this influence.

Raman Spectroscopy for Instant Bladder Tumor Diagnosis: System Development and In Vivo Proof-Of-Principle Study in Accordance with the European Medical Device Regulation (MDR2017/745).

This work reports on an in vivo Raman-based endoscopy system, invaScope, enabling Raman measurements of healthy and tumor bladder tissue during an endoscopic procedure in the operating theatre. The presented study outlines the progression from the initial concept (validated through previously performed ex vivo studies) to the approval and implementation of a clinical investigational device according to the requirement within the framework of the European Medical Device Regulation (MDR2017/745). The study's primary objective was to employ the invaScope Raman system within the bladder, capturing in vivo spectroscopic Raman data followed by standard histo- and cytopathological examinations of urological tissue (considered the gold standard).

Molecular characterization, virulence and antimicrobial and biocidal susceptibility of selected bacteria isolated from the cloaca of nestling ospreys (Pandion haliaetus) from Mono Lake, California, USA.

In the present study, the presence of the Enterobacterales, Staphylococcus spp., Mammaliicoccus spp., and Enterococcus spp.

Bacterial aggregation triggered by low-level antibiotic-mediated lysis.

Suspended bacterial aggregates play a central role in ocean biogeochemistry, industrial processes and probably many clinical infections - yet the factors that trigger aggregation remain poorly understood, as does the relationship between suspended aggregates and surface-attached biofilms. Here we show that very low doses of cell-wall targeting antibiotic, far below the minimal inhibitory concentration, can trigger aggregation of Escherichia coli cells. This occurs when a few cells lyse, releasing extracellular DNA - thus, cell-to-cell variability in antibiotic response leads to population-level aggregation.

Widespread occurrence of dissolved oxygen anomalies, aerobic microbes, and oxygen-producing metabolic pathways in apparently anoxic environments.

Nearly all molecular oxygen (O2) on Earth is produced via oxygenic photosynthesis by plants or photosynthetically active microorganisms. Light-independent O2 production, which occurs both abiotically, e.g.

Reorganized subtotal perfusion blockade of a pulmonary artery without hypertension after successfully lysed massive PE - A case report.

We present the case of an 18-year-old woman with a 5-day history of thoracic pain and dyspnea following physical exertion, along with swelling of her right calf. Computertomography (CT) angiography confirmed a massive central pulmonary artery embolism (PE) of the left main branch. The patient underwent catheter-directed thrombolysis.

Combining systems and synthetic biology for in vivo enzymology.

Enzymatic parameters are classically determined in vitro, under conditions that are far from those encountered in cells, casting doubt on their physiological relevance. We developed a generic approach combining tools from synthetic and systems biology to measure enzymatic parameters in vivo. In the context of a synthetic carotenoid pathway in Saccharomyces cerevisiae, we focused on a phytoene synthase and three phytoene desaturases, which are difficult to study in vitro.

EXCRETE workflow enables deep proteomics of the microbial extracellular environment.

Extracellular proteins play a significant role in shaping microbial communities which, in turn, can impact ecosystem function, human health, and biotechnological processes. Yet, for many ubiquitous microbes, there is limited knowledge regarding the identity and function of secreted proteins. Here, we introduce EXCRETE (enhanced exoproteome characterization by mass spectrometry), a workflow that enables comprehensive description of microbial exoproteomes from minimal starting material.

Leaf-whorl inoculation with may overcome field resistance of maize.

Maize yield is threatened by increasing incidences of head smut disease caused by . To help breeders identify -resistant maize lines, the availability of efficient screening systems would be an advantage. Here we assessed maize lines with distinct levels of field resistance against head smut disease in greenhouse experiments using two different inoculation techniques.

Microbial hub signaling compounds: natural products disproportionally shape microbiome composition and structure.

Microbiomes are shaped by abiotic factors like nutrients, oxygen availability, pH, temperature, and so on, but also by biotic factors including low molecular weight organic compounds referred to as natural products (NPs). Based on genome analyses, millions of these compounds are predicted to exist in nature, some of them have found important applications e.g.

Sustainability in radiation oncology: opportunities for enhancing patient care and reducing CO emissions in breast cancer radiotherapy at selected German centers.

Background And Objective: Radiotherapy often entails a substantial travel burden for patients accessing radiation oncology centers. The total travel distance for such treatments is primarily influenced by two factors: fractionation schedules and the distances traveled. Specific data on these aspects are not well documented in Germany.

A longitudinal study on the relation between parenting and Toddler's disruptive behavior: what is the role of Toddler's negative emotionality and physiological stress reactivity?

Harsh and unsupportive parenting is a risk factor for the development of disruptive behavior in children. However, little is known about how children's temperament and stress reactivity influence this relation. In a three-wave longitudinal study, we examined whether the associations between parenting practices (supportive parenting, positive discipline, and harsh discipline) and child disruptive behavior were mediated by child temperament (negative emotionality) and stress reactivity (heart rate reactivity).

Evaluation of utilization and consequences of CRP point-of-care-testing in primary care practices: qualitative interviews with general practitioners from Germany.

Background: The use and advantages of point-of-care tests (POCTs) for C-reactive protein (CRP) in general practice, especially for upper respiratory tract infections (uRTIs), have been studied extensively. However, there is limited knowledge about test indications, prerequisites, and integration of these tests into everyday practice.

Aim: This study aims to investigate the attitudes and experiences of general practitioners (GPs) in Germany regarding the use of semi-quantitative CRP-POCTs.

Functional dependence following intensive care unit-treated sepsis: three-year follow-up results from the prospective Mid-German Sepsis Cohort (MSC).

Background: Surviving sepsis can lead to chronic physical, psychological and cognitive impairments, which affect millions of patients worldwide, including survivors after COVID-19 viral sepsis. We aimed to characterize the magnitude and trajectory of functional dependence and new impairments post-sepsis.

Methods: We conducted a prospective cohort study including sepsis survivors who had been discharged from five German intensive care units (ICUs), until 36 months post-discharge.

Comparative mitogenomic analysis of f. sp. suggests recombination events during its evolutionary history.

Introduction: Modern understanding of the concept of genetic diversity must include the study of both nuclear and organellar DNA, which differ greatly in terms of their structure, organization, gene content and distribution. This study comprises an analysis of the genetic diversity of the smut fungus f. sp.

A Selective Iron(I) Hydrogenation Catalyst.

Iron is the most abundant transition metal of the Earth's crust, and the understanding of its function in key technologies, such as catalysis, is highly important. We report here on an iron(I) hydrogenation catalyst. Our catalyst activates hydrogen via heterolytic bond cleavage, forms a monohydride, and hydrogenates polar double bonds via a bimetallic pathway (potassium-assisted hydride transfer).

RNA:DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?

Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the trafficking of RNA molecules between organisms has gained prominence as an efficient way to manipulate gene expression via RNA interference (RNAi). Here, we posit a new epigenetic control mechanism based on triple helix (triplex) structures comprising nucleic acids from both host and microbe.

Increased Breathiness in Adolescent Kiezdeutsch Speakers: A Marker of Multiethnolectal Group Affiliation?

Kiezdeutsch is a multiethnolectal variety of German spoken by young people from multicultural communities that exhibits lexical, syntactic, and phonetic differences from standard German. A rather salient and pervasive feature of this variety is the fronting of the standard palatal fricative /ç/ (as in "I") to [ɕ] or [ʃ]. Previous perception work shows that this difference is salient and carries social meaning but dependent on the listener group.

Evaluation of Nontargeted Mass Spectral Data Acquisition Strategies for Water Analysis and Toxicity-Based Feature Prioritization by MS2Tox.

The machine-learning tool MS2Tox can prioritize hazardous nontargeted molecular features in environmental waters, by predicting acute fish lethality of unknown molecules based on their MS spectra, prior to structural annotation. It has yet to be investigated how the extent of molecular coverage, MS spectra quality, and toxicity prediction confidence depend on sample complexity and MS data acquisition strategies. We compared two common nontargeted MS acquisition strategies with liquid chromatography high-resolution mass spectrometry for structural annotation accuracy by SIRIUS+CSI:FingerID and MS2Tox toxicity prediction of 191 reference chemicals spiked to LC-MS water, groundwater, surface water, and wastewater.