4 results match your criteria: "Friedrich Schiller University of Jena Medical School[Affiliation]"
NF-κB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS.
J Cell Sci
July 2014
Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany.
Article Synopsis
- NF-κB plays a dual role in neurogenesis and brain-related disorders, particularly through its subunits RelA and p50, which affect axon regeneration in adult neurons.
- Activation of RelA was found in various cell types following optic nerve injury, and specific deletions of RelA in neurons and glial cells enhanced axonal regeneration.
- In contrast, deletion of the p50 subunit hindered regeneration by promoting degeneration, indicating a complex interaction between NF-κB and cell-cycle regulators like Cdh1 that could lead to new treatments for central nervous system injuries.
Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1.
Mol Immunol
April 2006
Institute of Biochemistry I, Friedrich Schiller University of Jena Medical School, Nonnenplan 2, D-07743 Jena, Germany.
Interleukin-13 (IL-13) is a cytokine with a crucial role in the development of allergic asthma. The IL-13 receptor shares the IL-4Ralpha subunit with the IL-4R system, but contains as a specific component the IL-13Ralpha1 chain. Blocking signal release by IL-13 without affecting IL-4 function is a potentially interesting therapeutical option for the treatment of asthma.
View Article and Find Full Text PDFThe potential role of antileukotriene drugs in atherosclerosis.
Drug News Perspect
October 2003
Institute of Vascular Medicine, Friedrich-Schiller University of Jena Medical School, Erfurt, Germany.
Developing drugs to treat atherosclerosis is a daunting task. However, recent studies of advanced human atherosclerotic lesions have yielded new information on potential mechanisms of inflammation and immune responses in late-stage human atherosclerosis. As leukotrienes (LTs) are among the most powerful inflammatory mediators known and because the 5-lipoxygenase pathway is expressed in diseased arteries, the roles of LTs in atherogenesis merit consideration.
View Article and Find Full Text PDFDecreased trigeminal sensitivity in anosmia.
ORL J Otorhinolaryngol Relat Spec
July 2001
Department of Otorhinolaryngology, Friedrich Schiller University of Jena Medical School, Jena, Germany.
The present study aimed to investigate intranasal trigeminal sensitivity in a large sample of patients with anosmia due to different etiologies. We investigated the trigeminal detection threshold for formic acid in healthy controls (n = 96) and patients with anosmia due to head trauma (n = 18) or sinonasal disease (n = 54). Anosmics exhibited higher thresholds compared with normosmics (p < 0.
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