13,885 results match your criteria: "Friedrich Schiller University[Affiliation]"

Gallium phosphide (GaP) offers unique opportunities for nonlinear and quantum nanophotonics due to its wide optical transparency range, high second-order nonlinear susceptibility, and the possibility to tailor the nonlinear response by a suitable choice of crystal orientation. However, the availability of single crystalline thin films of GaP on low index substrates, as typically required for nonlinear dielectric metasurfaces, is limited. Here we designed and experimentally realized monolithic GaP metasurfaces for enhanced and tailored second harmonic generation (SHG).

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Ultrafast Q-boosting in semiconductor metasurfaces.

Nanophotonics

May 2024

ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS), Department of Electronics Materials Engineering, Research School of Physics, Australian National University, Canberra, ACT 2600, Australia.

All-optical tunability of semiconductor metasurfaces offers unique opportunities for novel time-varying effects, including frequency conversion and light trapping. However, the all-optical processes often induce optical absorption that fundamentally limits the possible dynamic increase of their quality factor (Q-boosting). Here, we propose and numerically demonstrate the concept of large Q-boosting in a single-material metasurface by dynamically reducing its structural anisotropy on a femtosecond timescale.

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Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome.

Front Endocrinol (Lausanne)

December 2024

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

Article Synopsis
  • Aromatase excess syndrome (AEXS) is a rare genetic disorder that leads to excessive conversion of androgens to estrogens, causing issues like gynecomastia and delayed puberty in males, and fewer cases reported in females.
  • A family study revealed that all four members with AEXS shared a specific genetic deletion, and the long-term use of aromatase inhibitors like letrozole improved symptoms such as accelerated growth and gynecomastia.
  • Treatment outcomes varied among family members: significant gains in adult height and reduction of gynecomastia were noted in the male patients, while the female sibling experienced normal puberty development and growth with a combination of therapies.*
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This research elucidates the intricate nature of electronic coupling in the redox-active (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), commonly utilized in organic radical batteries. This study employs a combination of classical molecular dynamics and various electronic coupling calculation schemes. Within the context of the generalized Mulliken-Hush method, the electronic couplings are investigated via the complete active space self-consistent field approach, in combination with n-electron valence state perturbation theory, to provide an accurate description of both static and dynamic electron correlation as well as using (time-dependent) density functional theory simulations.

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Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier.

J Nanobiotechnology

December 2024

CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Parque Tecnológico de Cantanhede, Coimbra, Portugal.

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We developed and tested an automated measurement platform which can fit multiple samples for their investigation in transmission mode using terahertz time-domain spectroscopy. The temperature inside the platform can be varied to simulate different storage conditions of the samples, in our case, pharmaceuticals. As a proof-of-concept, the setup was successfully tested to monitor the crystallization process of amorphous nifedipine, as a model drug, at 24 °C, 30 °C and 35 °C for over 144 h.

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  • mPGES-1 is highlighted as a key target for developing treatments for inflammation and pain, with the study introducing new benzimidazole compounds that effectively inhibit this enzyme.
  • One of the compounds, AGU654, showed exceptional selectivity for mPGES-1 over other related enzymes, with a low inhibition concentration (IC = 2.9 nM) and promising bioavailability.
  • AGU654 was able to reduce PGE production from activated immune cells without affecting other prostaglandins, and it also demonstrated success in alleviating fever and pain in guinea pig models, indicating its potential for managing inflammatory diseases.
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  • * In this randomized controlled trial involving 446 patients, the SurVeil PCB showed a primary safety rate of 91.8% and a primary efficacy rate of 82.2%, while the IN.PACT Admiral had rates of 89.8% and 85.9%, respectively.
  • * The results indicate that the SurVeil PCB is a safe and effective treatment option, demonstrating non-inferiority to the IN.PACT Admiral PCB over a 24-month period.
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Background:  Rapid and accurate diagnosis of infective endocarditis (IE) allows timely management of this life-threatening disease and improves outcome. The Duke criteria have traditionally been the clinical method for diagnosing IE. These criteria were reformulated at different timepoints.

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To understand biodiversity change and support conservation decision-making, estimates of species' long-term population trends at regional and national scales are essential. However, such estimates are missing for many freshwater taxa, despite the diverse range of threats that they face. For this study, we mobilised monitoring data on riverine freshwater fish abundance collected across different regions of Germany.

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Cyclooctyne End-Functionalized Poly(morpholine-2,5-dione)s.

Macromol Rapid Commun

November 2024

Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.

The cyclooctyne-functionalized alcohol (1R,8S,9S)-bicyclo-[6.1.0]non-4-yn-9-ylmethanol (BCN-OH) is applied as initiator for the organo-catalyzed ring-opening polymerization (ROP) of morpholine-2,5-diones based on the l-amino acids valine, isoleucine, and phenylalanine.

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RNA-protein interaction prediction without high-throughput data: An overview and benchmark of tools.

Comput Struct Biotechnol J

December 2024

RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, Leutragraben 1, 07743 Jena, Germany.

Article Synopsis
  • * Effective computational prediction of RPIs faces challenges due to limited data and specific research, hence current methods need to adapt to new findings across all life kingdoms.
  • * The text reviews various RPI prediction tools that rely on non-high-throughput data, assessing their input requirements, usability, and output value, while providing guidance for selecting the appropriate tool based on user needs.
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  • Effective conservation of migratory species requires protecting their habitats throughout the entire year, but assessments of current protected areas (PAs) have been limited.
  • A study on 418 migratory butterfly species found that 84% lacked adequate PA coverage in at least one season, with only 17% being adequately protected in one season and 45% inadequately protected year-round.
  • Geographic differences highlight that while 77% of species met conservation goals in Sri Lanka, only 32% did so in Italy, indicating a need for coordinated international efforts to create comprehensive PA networks for migratory insects.
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Electrospun nanofibrous membranes made of chiral selectors (CSs) have shown their potential for efficient chiral resolutions via filtrations. It is thus of great importance to expand the number of electrospun membranes made of various CSs for the resolution of a wide range of chiral compounds. Here, the electrospinning of two benzyl carbamate derivatives of cellulose, namely cellulose benzyl carbamate (CBzC) and cellulose 4-chlorobenzyl carbamate (CCBzC), to form a new type of enantioselective membranes for chiral resolutions of racemic compounds, is reported.

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Background: For individuals living alone, having a diverse personal network is considered crucial for mitigating the risk of social isolation and enhancing well-being. Although a reciprocal dynamic between network diversity and well-being is likely, longitudinal evidence supporting reciprocal effects is limited. This study investigates dynamic transactions between network diversity and well-being (life satisfaction, loneliness, and depressiveness) in a community-based sample of middle-aged adults from Germany.

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Metagenomic Analyses of Water Samples of Two Urban Freshwaters in Berlin, Germany, Reveal New Highly Diverse Invertebrate Viruses.

Microorganisms

November 2024

Section II 1.4 Microbiological Risks, Department of Environmental Hygiene, German Environment Agency, 14195 Berlin, Germany.

In an attempt to explore the RNA viromes of two German rivers, we searched the virus particle contents of one 50 L water sample each from the Teltow Canal and the Havel River for viruses assumed to infect invertebrates. More than 330 complete and partial virus genomes up to a length of 37 kb were identified, with noda-like and reo-like viruses being most abundant, followed by bunya-like and birna-like viruses. Viruses related to the , , , as well as the unclassified Jῑngmén virus and Negev virus groups were also present.

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Direct Effects of the Janus Kinase Inhibitor Baricitinib on Sensory Neurons.

Int J Mol Sci

November 2024

Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, D-07740 Jena, Germany.

Article Synopsis
  • Baricitinib, a Janus kinase inhibitor, helps alleviate rheumatoid arthritis symptoms and pain by affecting joint nociceptors.
  • In studies with rats, baricitinib did not impact normal joint responses but reduced pain signals from inflamed joints, particularly in C-fibers.
  • The drug works by blocking the activation of Stat3, a signaling pathway involved in pain sensitivity, suggesting that it directly influences pain mechanisms in inflamed conditions.
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Werner Nachtigall (1934-2024).

J Comp Physiol A Neuroethol Sens Neural Behav Physiol

November 2024

Science of Motion, Friedrich-Schiller-University, 07749, Jena, Germany.

On September 5th, 2024, Werner Nachtigall (born July 6, 1934) passed away. Nachtigall is a pioneer in biomechanics, a founder of biomimetics (bionics), and a relentless advocate for his field in Germany. He conducted broad-ranging and innovative work on biomechanics in insects, birds, and fishes.

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