9 results match your criteria: "Fribourg Hospitals[Affiliation]"

In-vitro activity of the novel β-lactam/β-lactamase inhibitor combinations and cefiderocol against carbapenem-resistant Pseudomonas spp. clinical isolates collected in Switzerland in 2022.

Eur J Clin Microbiol Infect Dis

December 2024

Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 18, Fribourg, CH-1700, Switzerland.

To evaluate the in-vitro activity of the novel commercially-available drugs, including meropenem-vaborbactam (MEV), ceftazidime-avibactam (CZA), ceftolozane-tazobactam (C/T), imipenem-relebactam (IPR) as well as cefiderocol (FDC), against carbapenem-resistant Pseudomonas spp. (CRP) isolates. All CRP isolates collected at the Swiss National Reference Laboratory (NARA) over the year 2022 (n = 170) have been included.

View Article and Find Full Text PDF

Background: Fascia iliaca block (FIB) is an effective technique for analgesia. While FIB using ultrasound is preferred, there is no current standardised training technique or assessment scale. We aimed to create a valid and reliable tool to assess ultrasound-guided FIB.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to create a consensus on the surgical technique for sentinel lymph node dissection in cervical cancer by surveying expert gynecological oncology surgeons.
  • A two-step modified Delphi method was employed, involving initial surveys and follow-up interviews, with a 70% agreement threshold for consensus.
  • Findings indicated that experts reached consensus on 15 recommended practices, including the use of indocyanine green as a tracer and specific injection techniques, while recommending against certain procedures such as injecting directly into tumors.
View Article and Find Full Text PDF
Article Synopsis
  • Current biomarkers for selecting cancer patients for PD-1 inhibitors, like PD-L1 expression, are often unreliable, particularly in malignant pleural mesothelioma, prompting a search for more effective markers.
  • In a study involving 144 patients, researchers analyzed immune cells in tumors to determine their relationship with treatment outcomes and discovered that traditional markers like total CD8+ T cells and macrophage presence did not predict patient survival benefits.
  • The study revealed that the presence of PD-1-expressing CD8+ T cells and PD-1-expressing macrophages is an independent predictor of progression-free survival, indicating their potential as valuable biomarkers for immunotherapy success.
View Article and Find Full Text PDF

Background: Overcrowding in the emergency department (ED) is a global problem and a source of morbidity and mortality and exhaustion for the teams. Despite multiple strategies proposed to overcome overcrowding, the accumulation of patients lying in bed awaiting treatment or hospitalisation is often inevitable and a major obstacle to quality of care. We initiated a quality improvement project with the objective of zero patients lying in bed awaiting care/referral outside a care area.

View Article and Find Full Text PDF