3 results match your criteria: "Franz Volhard Clinic and HELIOS Klinikum[Affiliation]"
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension.
PLoS One
December 2008
Medical Faculty of the Charité, Franz-Volhard Clinic and HELIOS Klinikum-Berlin, Experimental and Clinical Research Center, Berlin, Germany.
Background: Agonistic autoantibodies directed at the alpha(1)-adrenergic receptor (alpha(1)-AAB) have been described in patients with hypertension. We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target.
Methodology/principal Findings: To pursue the issue, we performed clinical and basic studies.
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide.
Hypertension
March 2008
Medical Faculty of the Charité, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum, Berlin-Buch, Germany.
Article Synopsis
- Researchers studied a special receptor called (P)RR that helps some proteins called renin and prorenin activate certain signals in cells.
- They found that these proteins can make a signal pathway (ERK 1/2) work on its own without needing another molecule named angiotensin II.
- They also discovered that two blockers, called aliskiren and HRP, didn’t stop renin and prorenin from activating this signal pathway.
Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension.
Hypertension
February 2008
Medical Faculty of the Charité, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin-Buch, Berlin, Germany.
We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition on electrophysiological remodeling in angiotensin II-induced cardiac injury. We treated double-transgenic rats expressing the human renin and angiotensinogen genes (dTGRs) from week 4 to 7 with n-3 PUFA ethyl-esters (Omacor; 25-g/kg diet) or a direct renin inhibitor (aliskiren; 3 mg/kg per day). Sprague-Dawley rats were controls.
View Article and Find Full Text PDF