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Breast cancer risk, nightwork, and circadian clock gene polymorphisms.

Endocr Relat Cancer

August 2014

InsermCESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, FranceUniversité Paris-SudUMRS 1018, Villejuif, FranceBiostatistical UnitMRC, Cambridge, UKSchool of Mathematics and PhysicsThe University of Queensland, St Lucia, Queensland, AustraliaInsermCESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, FranceUniversité Paris DescartesINSERM UMR-S775 EPIGENETEC, Paris, FranceDépartement d'informatique médicaleCenter Georges-François Leclerc, Dijon, FranceCenter Eugène MarquisRennes, FranceInsermCESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, FranceUniversité Paris-SudUMRS 1018, Villejuif, FranceBiostatistical UnitMRC, Cambridge, UKSchool of Mathematics and PhysicsThe University of Queensland, St Lucia, Queensland, AustraliaInsermCESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, FranceUniversité Paris DescartesINSERM UMR-S775 EPIGENETEC, Paris, FranceDépartement d'informatique médicaleCenter Georges-François Leclerc, Dijon, FranceCenter Eugène MarquisRennes, France

Night shift work has been associated with an increased risk of breast cancer pointing to a role of circadian disruption. We investigated the role of circadian clock gene polymorphisms and their interaction with nightwork in breast cancer risk in a population-based case-control study in France including 1126 breast cancer cases and 1174 controls. We estimated breast cancer risk associated with each of the 577 single nucleotide polymorphisms (SNPs) in 23 circadian clock genes.

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