1 results match your criteria: "France. juliana.silva_bernardes@sorbonne-universite.fr.[Affiliation]"
Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances.
BMC Bioinformatics
February 2023
UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative, Sorbonne University, Paris, France.
Article Synopsis
- B cell receptor genes undergo somatic hypermutations and natural selection, leading to a diverse and specific B cell lineage that enhances antibody affinity through a process called affinity maturation.
- Phylogenetic tree inference is crucial for reconstructing these B cell lineages; however, existing methods often struggle with balancing accuracy and computational efficiency, particularly when analyzing large datasets.
- The newly proposed method, ClonalTree, offers a faster and more efficient way to build B-cell lineage trees by incorporating cellular abundances and outperforms traditional algorithms while maintaining accuracy and reducing computation time significantly.