2 results match your criteria: "France. Electronic address: sandrine.lacombe@universite-paris-saclay.fr.[Affiliation]"
Human Serum Albumin in the Presence of Small Platinum Nanoparticles.
J Pharm Sci
June 2024
Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France. Electronic address:
Article Synopsis
- Platinum nanoparticles (Pt NPs) show great promise in nanomedicine due to their high electron density and surface area, with intravenous injection being the preferred delivery method.
- Research using synchrotron radiation circular dichroism (SRCD) explored how these nanoparticles interact with human serum albumin (HSA), a key blood component, showing no strong complexation except for some increased thermal stability at a specific nanoparticle-to-protein ratio.
- The study suggests a quick method to assess the potential toxicity of Pt NPs for clinical use, particularly for intravenous applications.
Pharmacokinetics derived from PET imaging of inspiring radio-enhancer platinum nanoparticles.
Nanomedicine
November 2022
Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address:
Personalized medicine approach in radiotherapy requires the delivery of precise dose to the tumor. The concept is to increase the effectiveness of radiotherapy while sparing the surrounding heathy tissue. This can be achieved by the use of high-Z metal-based nanoparticles (NPs) as radio-enhancers and PET imaging for mapping NPs distribution to guide the irradiation.
View Article and Find Full Text PDF