3 results match your criteria: "France. Electronic address: marie-helene.verlhac@college-de-france.fr.[Affiliation]"
Aberrant cortex contractions impact mammalian oocyte quality.
Dev Cell
April 2024
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Université PSL, CNRS, INSERM, 75005 Paris, France. Electronic address:
The cortex controls cell shape. In mouse oocytes, the cortex thickens in an Arp2/3-complex-dependent manner, ensuring chromosome positioning and segregation. Surprisingly, we identify that mouse oocytes lacking the Arp2/3 complex undergo cortical actin remodeling upon division, followed by cortical contractions that are unprecedented in mammalian oocytes.
View Article and Find Full Text PDFDyes illuminate live human embryogenesis.
Cell
July 2023
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Université PSL, Paris, France. Electronic address:
Article Synopsis
- Assisted reproduction is becoming more common around the world.
- Current methods for selecting embryos mainly rely on examining cell structure, but there's still a lot we don't know about early embryo development.
- A new study has uncovered important characteristics of human embryos that could improve preimplantation genetic testing.
Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes.
Dev Cell
October 2019
CIRB, Collège de France/CNRS-UMR7241/INSERM-U1050, PSL Research University, Equipe Labellisée FRM, Paris 75005, France. Electronic address:
Article Synopsis
- Nucleus positioning in mammalian oocytes is influenced by an F-actin pressure gradient, which remains unclear in terms of its biological importance.
- Research utilized advanced imaging, biophysical analysis, and experiments on mouse oocyte mutants to investigate how this pressure gradient affects the nucleus.
- Findings revealed that optimal F-actin levels promote proper nuclear shape and chromatin mobility, which are crucial for gene expression and embryo development, indicating a link between cytoplasmic structures and oocyte functionality.