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Post-trauma behavioral phenotype predicts the degree of vulnerability to fear relapse after extinction in male rats.

Curr Biol

July 2022

Institut de Psychiatrie et Neurosciences de Paris (IPNP)-INSERM U1266, Institut de Psychiatrie-CNRS GDR3557, GHU Psychiatrie Neurosciences, Université Paris Cité, 102-108 Rue de la Santé, 75014 Paris, France; Centre Interdisciplinaire de Recherche en Biologie (CIRB)-CNRS UMR 7241-INSERM U1050, Collège de France, Université PSL, 11 place Marcelin Berthelot, 75005 Paris, France. Electronic address:

Current treatments for trauma-related disorders remain ineffective for many patients. Fear extinction deficiency is a prominent feature of these diseases, and many behavioral treatments rely on extinction training. However, in many patients, therapy is followed by a relapse of symptoms, and the underpinnings of such interindividual variations in vulnerability to relapse remain unknown.

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