4 results match your criteria: "France. Electronic address: Guy.Gorochov@sorbonne-universite.fr.[Affiliation]"
Intestinal Candida albicans overgrowth in IgA deficiency.
J Allergy Clin Immunol
September 2023
Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France. Electronic address:
Background: Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown.
Objectives: Our goal was to study the impact of IgA on gut mycobiota ecology.
Phenotypic Heterogeneity of Fulminant COVID-19--Related Myocarditis in Adults.
J Am Coll Cardiol
July 2022
Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital La Pitié-Salpêtrière, Service de Médecine Intensive Réanimation, Paris, France. Electronic address:
Article Synopsis
- - The study examines adults suffering from fulminant myocarditis related to COVID-19, identifying two distinct groups: those meeting multisystem inflammatory syndrome criteria (MIS-A) and those who do not.
- - Out of 38 patients analyzed, 66% met the MIS-A criteria, with significant differences in clinical outcomes; those with MIS-A exhibited higher in-hospital mortality (31% vs. 4%) and more severe organ failure.
- - Biological markers also varied between the groups, suggesting differing underlying inflammatory processes, which could impact treatment approaches in future cases of COVID-19-related myocarditis.
Distinct cytokine profiles associated with COVID-19 severity and mortality.
J Allergy Clin Immunol
June 2021
Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département d'Immunologie, Paris, France. Electronic address:
Background: Markedly elevated levels of proinflammatory cytokines and defective type-I interferon responses were reported in patients with coronavirus disease 2019 (COVID-19).
Objective: We sought to determine whether particular cytokine profiles are associated with COVID-19 severity and mortality.
Methods: Cytokine concentrations and severe acute respiratory syndrome coronavirus 2 antigen were measured at hospital admission in serum of symptomatic patients with COVID-19 (N = 115), classified at hospitalization into 3 respiratory severity groups: no need for mechanical ventilatory support (No-MVS), intermediate severity requiring mechanical ventilatory support (MVS), and critical severity requiring extracorporeal membrane oxygenation (ECMO).
Synergistic convergence of microbiota-specific systemic IgG and secretory IgA.
J Allergy Clin Immunol
April 2019
Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Département d'Immunologie, Paris, France. Electronic address:
Background: Commensals induce local IgA responses essential to the induction of tolerance to gut microbiota, but it remains unclear whether antimicrobiota responses remain confined to the gut.
Objective: The aim of this study was to investigate systemic and intestinal responses against the whole microbiota under homeostatic conditions and in the absence of IgA.
Methods: We analyzed blood and feces from healthy donors, patients with selective IgA deficiency (SIgAd), and patients with common variable immunodeficiency (CVID).