11 results match your criteria: "France Univ. Grenoble Alpes[Affiliation]"

The extension of islet transplantation to a wider number of Type 1 diabetic patients is compromised by the scarcity of donors, the reduced ex vivo survival of pancreatic islets and the use of immunosuppressive treatments. Islets of Langerhans isolated from brain-dead donors are currently the only cell source for transplantation. Thus, it is crucial to find an alternative and an abundant source of functional insulin secreting cells not only for clinical use but also for the development of research dedicated to the screening of drugs and to the development of new therapeutic targets.

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Kinetic study of hydrogen lateral diffusion at high temperature in a directly-bonded InP-SiO/Si substrate.

Nanotechnology

March 2020

III-V Lab, a joint lab of Nokia Bell Labs, Thales Research and Technology and CEA LETI, 91120 Palaiseau, France. Univ. Grenoble Alpes; CNRS, CEA LETI Minatec, LTM, F-38054 Grenoble Cedex, France.

Hybrid integration of III-V materials onto silicon by direct bonding technique is a mature and promising approaches to develop advanced photonic integrated devices into the silicon photonics platform. In this approach, the III-V material stack is grown on an InP wafer in a unique epitaxial step prior to the direct bonding process onto the silicon-on-insulator wafer. Currently, no additional epitaxial regrowth steps are implemented after bonding.

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[Big data and new technologies contributions for healthcare: what about prevention and treatment of online gambling disorder].

Med Sci (Paris)

October 2019

Hôpital Paul Brousse, APHP, 94800 Villejuif, France - Univ. Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Inserm, 94800 Villejuif, France.

Information and communication numeric technologies now have a deep influence on the field of healthcare. New medical practices using these technologies attempt to promote greater equality in the access of healthcare services, particularly in the field of mental health and addictions where the use of care remains low. Online gambling addiction, which we will here refer to problem gambling, seems to represent a relevant model of prevention and care measures based on the use of digital data extracted from Big data and the use of new technologies.

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AlO, Al doped ZnO and SnO encapsulation of randomly oriented ZnO nanowire networks for high performance and stable electrical devices.

Nanotechnology

September 2019

Univ. Grenoble Alpes, CNRS, Grenoble INP*, LMGP, F-38000 Grenoble, France. Univ. Grenoble Alpes, CNRS, Grenoble INP*, IMEP-LaHC, F-38000 Grenoble, France.

Two-dimensional randomly oriented nanowire (NW) networks, also called nanonets (NNs), have remarkable advantages including low-cost integration, good reproducibility and high sensitivity, which make them a promising material for electronic devices. With this work, we focus on the study of ZnO NNs as channel materials in field effect transistors (FETs). In our process, ZnO NWs were assembled in NNs by the liquid filtration method and were integrated in transistors, with the bottom-gate configuration, using simple technological steps.

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Formation mechanisms of ZnO nanowires on polycrystalline Au seed layers for piezoelectric applications.

Nanotechnology

August 2019

Univ. Grenoble Alpes, CNRS, Grenoble INP, LMGP, F-38000 Grenoble, France. Univ. Grenoble Alpes, CNRS, LTM, F-38054 Grenoble Cedex, France. Univ. Grenoble Alpes, CEA, LETI, F-38000 Grenoble, France.

ZnO nanowires are considered as attractive building blocks for piezoelectric devices, including nano-generators and stress/strain sensors. However, their integration requires the use of metallic seed layers, on top of which the formation mechanisms of ZnO nanowires by chemical bath deposition are still largely open. In order to tackle that issue, the nucleation and growth mechanisms of ZnO nanowires on top of Au seed layers with a thickness in the range of 5-100 nm are thoroughly investigated.

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In condensed matter physics, simplified descriptions are obtained by coarse-graining the features of a system at a certain characteristic length, defined as the typical length beyond which some properties are no longer correlated. From a physics standpoint, in vitro DNA has thus a characteristic length of 300 base pairs (bp), the Kuhn length of the molecule beyond which correlations in its orientations are typically lost. From a biology standpoint, in vivo DNA has a characteristic length of 1000 bp, the typical length of genes.

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Blood granulocyte patterns as predictors of asthma phenotypes in adults from the EGEA study.

Eur Respir J

October 2016

INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France Univ Grenoble Alpes, Grenoble, France CHU de Grenoble, Pédiatrie, Grenoble, France.

To what extent blood granulocyte patterns may predict asthma control remains under-studied. Our aim was to study associations between blood neutrophilia and eosinophilia and asthma control outcomes in adults.Analyses were conducted in 474 asthmatics from the first follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA2), including 242 asthmatics who were adults a decade earlier (EGEA1).

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The Immune System in Cancer Prevention, Development and Therapy.

Anticancer Agents Med Chem

August 2016

CEA, iRTSV-LCBM, F-38000 Grenoble, France. CNRS, IRTSV-LCBM, F-38000 Grenoble, France. Univ. Grenoble Alpes, iRTSV-LCBM, F-38000 Grenoble, France.

The immune system plays a pivotal role in the maintenance of the integrity of an organism. Besides the protection against pathogens, it is strongly involved in cancer prevention, development and defense. This review focuses on how the immune system protects against infections and trauma and on its role in cancer development and disease.

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Resolving bundled microtubules using anti-tubulin nanobodies.

Nat Commun

August 2015

Division of Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.

Microtubules are hollow biopolymers of 25-nm diameter and are key constituents of the cytoskeleton. In neurons, microtubules are organized differently between axons and dendrites, but their precise organization in different compartments is not completely understood. Super-resolution microscopy techniques can detect specific structures at an increased resolution, but the narrow spacing between neuronal microtubules poses challenges because most existing labelling strategies increase the effective microtubule diameter by 20-40 nm and will thereby blend neighbouring microtubules into one structure.

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HMA6 and HMA8 are two chloroplast Cu+-ATPases with different enzymatic properties.

Biosci Rep

April 2015

CNRS, Laboratoire de Physiologie Cellulaire et Végétale, UMR 5168, 17 rue des Martyrs, F-38054 Grenoble, France Univ. Grenoble Alpes, F-38054 Grenoble, France CEA, DSV, iRTSV, F-38054 Grenoble, France INRA, LPCV, USC1359, 17 rue des Martyrs, F-38054 Grenoble, France.

Copper (Cu) plays a key role in the photosynthetic process as cofactor of the plastocyanin (PC), an essential component of the chloroplast photosynthetic electron transfer chain. Encoded by the nuclear genome, PC is translocated in its apo-form into the chloroplast and the lumen of thylakoids where it is processed to its mature form and acquires Cu. In Arabidopsis, Cu delivery into the thylakoids involves two transporters of the PIB-1 ATPases family, heavy metal associated protein 6 (HMA6) located at the chloroplast envelope and HMA8 at the thylakoid membrane.

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Objective: To assess whether daily variations in three parameters recorded by non-invasive ventilation (NIV) software (respiratory rate (RR), percentage of respiratory cycles triggered by the patient (%Trigg) and NIV daily use) predict the risk of exacerbation in patients with chronic obstructive pulmonary disease (COPD) treated by home NIV.

Methods: Patients completed the EXACT-Pro questionnaire daily to detect exacerbations. The 25th and 75th percentiles of each 24 h NIV parameter were calculated and updated daily.

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