6 results match your criteria: "France [2] Imagine Institute[Affiliation]"
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
J Exp Med
July 2016
Immunology Division, Garvan Institute of Medical Research, Darlinghurst 2010, Australia St Vincent's Clinical School, Darlinghurst 2010, Australia.
Naive CD4(+) T cells differentiate into specific effector subsets-Th1, Th2, Th17, and T follicular helper (Tfh)-that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human primary immunodeficiencies on these processes, and how they compromise specific immune responses, remain unresolved.
View Article and Find Full Text PDFMutation in MMP2 gene may result in scleroderma-like skin thickening.
Ann Rheum Dis
January 2016
Hopital Necker Assistance Publique-Hôpitaux de Paris, France et Imagine Institute, INSERM U1163, Paris, France Imagine Institute, INSERM U1163, Paris, France.
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.
Eur Respir J
August 2015
Université Paris Diderot, Sorbonne Paris Cité, Paris, France APHP, Hôpital Bichat, Service de Pneumologie A, DHU FIRE Centre de compétence des maladies pulmonaires rares, Paris, France.
Pulmonary fibrosis is a fatal disease with progressive loss of respiratory function. Defective telomere maintenance leading to telomere shortening is a cause of pulmonary fibrosis, as mutations in the telomerase component genes TERT (reverse transcriptase) and TERC (RNA component) are found in 15% of familial pulmonary fibrosis (FPF) cases. However, so far, about 85% of FPF remain genetically uncharacterised.
View Article and Find Full Text PDFSTAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
J Exp Med
June 2015
Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia
Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their development and function in humans are unknown. Primary immunodeficiencies caused by single gene mutations provide a unique opportunity to investigate the role of specific molecules in regulating human lymphocyte development and function. We found that individuals with loss-of-function mutations in STAT3 had reduced numbers of peripheral blood MAIT and NKT but not γδ T cells.
View Article and Find Full Text PDFInherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
J Exp Med
May 2015
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections of the skin, nail, oral, and genital mucosae with Candida species, mainly C. albicans. Autosomal-recessive (AR) IL-17RA and ACT1 deficiencies and autosomal-dominant IL-17F deficiency, each reported in a single kindred, underlie CMC in otherwise healthy patients.
View Article and Find Full Text PDFCausal analysis of H1N1pdm09 influenza infection risk in a household cohort.
J Epidemiol Community Health
March 2015
INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Sorbonne Universités, Paris, France Public Health Unit, Saint-Antoine Hospital, Paris, France.
Article Synopsis
- A study was conducted to identify critical factors influencing H1N1pdm09 influenza infection during the 2010-2011 season, using data from 601 households and 1450 participants.
- The research utilized structural equations to examine relationships between infection risk, behaviors, social factors, and individual susceptibility, finding that host susceptibility and compliance with preventive measures were key factors directly linked to infection risk.
- The study concludes that prioritizing vaccination and effective public health campaigns promoting personal preventive behaviors could significantly help in controlling influenza outbreaks.