Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care.

Autologous or allogeneic platelet-derived extracellular vesicles (pEVs) show potential in enhancing tissue recovery and healing chronic wounds. pEVs promote neovascularization and cell migration while reducing inflammation, oxidative stress, and scarring. However, their efficacy in clinical settings is challenged by their susceptibility to washout by wound exudate.

Revisiting the place of surgical portal decompression for adults with noncirrhotic portal hypertension due to chronic extrahepatic portal vein obstruction: a scoping review.

Background: Liver cirrhosis accounts for more than 90 % of portal hypertension cases, and the other cases are due to noncirrhotic portal hypertension (NCPH). Variceal bleeding is the most life-threatening complication of portal hypertension and its primary treatment is medical according to the Baveno VII guidelines. This review discusses the evidence on surgical portal decompression for adult patients with NCPH secondary to chronic extrahepatic portal vein obstruction (EHPVO).

On the consequences of childbirth: obstetrics/gynaecology, comparative anatomy and racial theories in 19th century France and Brazil.

The following paper is centred on an analysis of comparative studies of the human pelvis developed over the 19th century by mostly French natural scientists, physical anthropologists, students of the human anatomy and doctors engaged in the initial stages of the emerging fields of gynaecology and obstetrics. As this paper will argue, there was considerable overlap between these specialisations, producing a fundamentally masculine, Eurocentric and racialised knowledge that had an enormous impact in establishing racially informed gynaecological and obstetric practices. This paper argues that comparative pelvic anatomy studies originated from the belief that African and Black women had specifically different pelves and genitalia and served to stratify women of different races and promoted racially oriented obstetric and gynaecological treatments.

LLL 11.1 Organization of nutritional care.

The increasingly complex health care systems, the large and diverse population to whom nutritional therapy is addressed, and the need of specialized health care professionals implies an organizational strategy to be defined. The organization of nutritional care is a fundamental strategy to promote an optimal, quality and safety nutritional therapy. This is why, the organization of nutritional care should be based on 4 principles, including: Nutritional care should be considered as a process, a multidisciplinary approach is essential to a good nutritional care, the economic approach and the patient centered approach are essential to the organization of nutritional care.

Effects of isolation methods on physicochemical properties of defatted starch from the acorn (Quercus brantii).

This study explores the innovative combined effects of alkaline isolation with ultrasound pretreatment on the physicochemical properties of acorn (Quercus brantii) starch. The optimal pH for maximizing the yield of alkaline-isolated acorn starch (AAS) was determined, followed by comparison with alkaline-isolated defatted acorn starch (ADAS), ultrasound-pretreated acorn starch (UAS), and ultrasound-pretreated defatted acorn starch (UDAS). The results demonstrated substantial improvements in yield and purity, with the highest yield (68.

Correspondence. Reply to the article "Cornelis S, Mufty S, Peters S. Isolated distal radioulnar joint septic arthritis, the intact triangular fibrocartilaginous complex serving as an anatomical barrier. Hand Surg Rehabil, January 2025.

Cornelis et al. reported an isolated DRUJ infection treated with open surgery to prevent spread to the radiocarpal joint. We suggest that arthroscopy, proven effective in other joint infections and technically feasible for the DRUJ without damaging the TFCC,could have been a less invasive and effective alternative.

Many strategies enabling us to optimize kidney care may also be planet-friendly.

Kidney replacement therapy (KRT) is one of the most energy-consuming and waste-producing medical treatments. Reducing the need of dialysis is therefore an environmentally friendly choice. However, preferring prevention, lifestyle-related interventions and patient education to drugs is time consuming and most physicians are already overburdened by the many demands of routine clinical practice.

Specific Rosetta-based protein-peptide prediction protocol allows the design of novel cholinesterase inhibitor peptides.

The search for novel cholinesterase inhibitors is essential for advancing treatments for neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we employed the Rosetta pepspec module, originally developed for designing peptides targeting protein-protein interactions, to design de novo peptides targeting the peripheral aromatic site (PAS) of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). A total of nine peptides were designed for human AChE (hAChE), T.

Adsorption efficiency correction for Ra determination on drinking water using Ra-Nucfilm disc.

A specific goal of the French army is to ensure health protection of soldiers consuming water from overseas operations territories. To do so, the French Defence Radiological Protection Service developed a method to quantify the amount of Ra in water using Ra-Nucfilm discs. Ra analysis is achieved within less than two days and the detection limit, function of adsorption efficiency, ranges from 0.

A conceptual mechanistic model of amino acid fluxes in the small intestine, taking the example of pig.

During digestion, almost 50% of absorbed essential amino acids (AAs) are metabolised by intestinal tissue, thus not appearing directly in the portal vein. This value, which is referred to as first-pass metabolism, seems high in relation to the overall efficiency of AA use considered in growth models. Experimental studies of first-pass metabolism are complicated due to the presence of numerous metabolic fluxes in the intestine and to the dynamics of digestion and absorption.

Enhanced mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO, YO, and AlO as sintering aids.

Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.

Electrochemical pH modulator coupled with Ni-based electrode for glucose sensing.

The non-enzymatic electrochemical detection of glucose by direct oxidation using electrodes modified with suitable electrocatalysts is now well-established. However, it most often requires highly alkaline media, limiting dramatically the use of such electrodes at neutral pH. This is notably the case of Ni-based electrodes.

Understanding complex volcanic hydrosystems using a multi-tracer approach.

Climate change affects groundwater availability and residence times, necessitating a thorough understanding of aquifer characteristics to define sustainable yields, particularly in regions where water is heavily exploited. This study focuses on the Volvic volcanic aquifer (Chaîne des Puys, France), where groundwater recharge has decreased due to climate change, raising concerns about water use sustainability. To address these challenges, this work proposes a multi-tracer approach, based on hydrogeological monitoring, including the estimation of groundwater ages, major elements chemistry and water stable isotopes to better characterise this resource decrease and more peculiarly its origin and its impact on the environment that has never been addressed.

Investigating the quality of European silver eels by quantifying contaminants and parasite infestation in a French Mediterranean lagoon complex.

Coastal lagoons are diverse habitats with significant ecological gradients, which provide crucial ecosystem services but face threats from human activities such as invasive species and pollution. Among the species inhabiting the lagoons, the critically endangered European eel (Anguilla anguilla) is an emblematic species strongly impacted by contamination and parasitism. Several indicators were developed to assess the quality of eel at a large geographic scale.

Bimekizumab efficacy and safety through 3 years in patients with moderate to severe plaque psoriasis: Long-term results from the BE RADIANT phase 3b trial open-label extension period.

Background: Overexpression of interleukin (IL)-17A and IL-17F significantly influences psoriasis pathology. Until recently, biologics targeting IL-17A alone, like secukinumab, were used to treat psoriasis. Bimekizumab is a monoclonal IgG1 antibody that targets both IL-17A and IL-17F.

SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors.

Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).

Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci.

Carbohydrate-active enzymes (CAZymes) involved in the degradation of plant cell walls and/or the assimilation of plant carbohydrates for energy uptake are widely distributed in microorganisms. In contrast, they are less frequent in animals, although there are exceptions, including examples of CAZymes acquired by horizontal gene transfer (HGT) from bacteria or fungi in several of phytophagous arthropods and plant-parasitic nematodes. Although the whitefly Bemisia tabaci is a major agricultural pest, knowledge of HGT-acquired CAZymes in this phloem-feeding insect of the Hemiptera order (subfamily Aleyrodinae) is still lacking.