1,079,962 results match your criteria: "France; University of Pierre and Marie Curie Paris VI[Affiliation]"

Long-term immune related adverse events.

Curr Opin Oncol

December 2024

Université Paris Saclay, AP-HP, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, CEA, INSERM UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre France, France.

Purpose Of Review: Long-term immune related adverse events (irAEs) are an increasing reality in cancer patients treated with immune checkpoint inhibitors (ICIs) but remain under-reported. With the number of ICI treated patients increasing, we here aimed to expose the current evidence on their clinical presentations and diagnosis criteria.

Recent Findings: First described in ICI validation trials, long term irAEs were further characterized through retrospective studies, providing clues on their frequency, clinical spectrum, risk factors and impact on patient's quality of life.

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Cancer-associated thrombosis: what is new?

Curr Opin Oncol

January 2025

Paris Cité University, Assistance-Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Interne, Hôpital Louis-Mourier, Inserm, Paris Cardiovascular Research Center, Team « Endotheliopathy and Hemostasis Disorders », Paris, France.

Purpose Of Review: The life expectancy of patients suffering from thrombosis associated with cancer has improved significantly, making them a chronic disease. Patients with thrombosis and cancer are fragile. Treated with anticoagulants, they remain at risk of complications.

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Alba domain-containing proteins are ubiquitously found in archaea and eukaryotes. By binding to either DNA, RNA, or DNA:RNA hybrids, these proteins function in genome stabilization, chromatin organization, gene regulation, and/or translational modulation. In the malaria parasite , six Alba domain proteins PfAlba1-6 have been described, of which PfAlba1 has emerged as a "master regulator" of translation during parasite intra-erythrocytic development (IED).

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Effects of Elexacaftor-Tezacaftor-Ivacaftor on Nasal and Sinus Symptoms in Children With Cystic Fibrosis.

Pediatr Pulmonol

January 2025

Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, Lyon, France.

Background: New CFTR Modulator triple therapy Elexacaftor-Ivacaftor-Tezacaftor (ETI) prove efficacy in pulmonary outcomes. However, its impact on nasal sinus symptoms in children has not been specifically studied. The aim of this study is to evaluate the impact of this therapy on nasal sinus symptomatology in children aged 6-12 years.

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Despite viral suppression with antiretroviral therapy, immune nonresponders (INR) among people living with HIV (PLWH) still have a higher risk of developing AIDS-related and non-AIDS-related complications. Our study aimed to investigate the phenotype and functions of Natural Killer (NK) cells in INR, to better understand underlying mechanisms of immune nonresponse. Our cross-sectional study included PLWH aged over 45 with an undetectable HIV viral load sustained for at least 2 years.

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Immune-Mediated Liver Injury From Checkpoint Inhibitor: An Evolving Frontier With Emerging Challenges.

Liver Int

February 2025

APHP, Hôpital Paul-Brousse, Centre Hépato-Biliaire, Inserm, Unité 1193, Université Paris-Saclay, FHU Hepatinov, Villejuif, France.

Over the past decade, immune checkpoint inhibitors (ICIs) have transformed the treatment of cancer, though they come with the risk of immune-related adverse (irAEs) events such as hepatotoxicity or Immune-mediated Liver Injury from Checkpoint Inhibitors (ILICI). ILICI is a serious irAE that, when severe, requires cessation of ICI and initiation of immunosuppression. Cytotoxic T Lymphocytes (CTLs) play a central role in ILICI; however, they are just part of the picture as immunotherapy broadly impacts all aspects of the immune microenvironment and can directly and indirectly activate innate and adaptive immune cells.

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Hepatocellular carcinoma (HCC) ranks among the most prevalent types of cancer globally. Zinc finger protein 169 (ZNF169) holds significant importance as a transcription factor, yet its precise function in HCC remains to be elucidated. This study aims to examine the clinical importance, biological functions, and molecular pathways associated with ZNF169 in the development of HCC.

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Introduction: Freedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF). This sub-analysis from the Cryo Global Registry sought to investigate predictors of ablation success after PVI using cryoballoon ablation (CBA) for PsAF.

Methods And Results: ATA recurrence was defined as ≥ 30 s recurrence of atrial fibrillation, atrial flutter or atrial tachycardia after a 90-day blanking period and through 12-months.

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Massive Sampling Strategy for Antibody-Antigen Targets in CAPRI Round 55 With MassiveFold.

Proteins

January 2025

Univ. Lille, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.

Massive sampling with AlphaFold2 improves protein-protein complex predictions. This has been shown during the last CASP15-CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody-antigen binding remain challenging.

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Introduction: Graft optimization is a necessity in order to develop uterus transplantation from brain-dead donors, as a complement to living donors, as these grafts are rare and the last organs retrieved in multiple organ donation. The aim of this study was to assess the feasibility and interest of hypothermic machine perfusion (HMP) in uterus transplantation using a porcine model; secondary outcomes were the evaluation of the graft's tolerance to a prolonged cold ischaemia time and to find new biomarkers of uterus viability.

Material And Methods: Fifteen uterus allotransplantations were performed in a porcine model, after 18 h of cold ischaemia, divided in three groups: Static cold storage in a HTK solution, HMP (with the VitaSmart (™) machine Bridge to Life Ltd.

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Acute Nonsustained Mitral Isthmus Block Obtained With Sphere-9 Lattice-Tip Catheter Completed With Vein of Marshall Ethanol Infusion.

J Cardiovasc Electrophysiol

January 2025

Hôpital Cardiologique du Haut Léveque, CHU de Bordeaux, L'Institut de RYthmologie et modelisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France.

Background: Achieving a durable mitral line block using radiofrequency as a part of an anatomical approach for ablation in patients with persistent atrial fibrillation or for treating peri-mitral flutter has always been challenging due to the complex anatomy of the mitral isthmus. Epicardial ablation via the coronary sinus and the vein of Marshall has been proposed to help create durable lesions. Recently, a novel lattice-tip catheter using pulsed field ablation has shown promising results for creating mitral lines, despite limited data.

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Background: Five fulfilled hemophagocytic lymphohistiocytosis (HLH)-2004 criteria, and the HScore are widely used and recommended by international expert consensus to diagnose secondary HLH. Both diagnostic scores have never been validated in heterogeneous patient cohorts of secondary HLH patients. We aimed to systematically optimize and validate diagnostic criteria of secondary HLH using a multicenter approach.

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This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia-T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau.

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Diet quality indicators and organic food consumption in mothers of young children.

J Sci Food Agric

January 2025

Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Warsaw, Poland.

Background: The health benefits of organic food provide one reason for consuming it. Various studies have shown that regular organic food consumers (REG eco-con) follow a healthier diet. However, this topic has not been explored in Poland.

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Mediation of modifiable risk factors in two multidomain dementia prevention trials.

Alzheimers Dement

January 2025

Department of Public and Occupational Health, Amsterdam UMC Location VUMC, Amsterdam, the Netherlands.

Introduction: We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence.

Methods: We pooled data from the multidomain MAPT (Multidomain Alzheimer Preventive Trial; n = 1679, up to 5-year follow-up) and preDIVA trials (Prevention of Dementia by Intensive Vascular Care; n = 3526, up to 12-year follow-up) in adults aged 70+. We used multiple mediation analysis to quantify the role of 2-year changes in body mass index, systolic blood pressure, total cholesterol, and physical activity in the intervention effects on dementia incidence.

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Retroviruses carry a genomic intron-containing RNA with a long structured 5'-untranslated region, which acts either as a genome encapsidated in the viral progeny or as an mRNA encoding the key structural protein, Gag. We developed a single-molecule microscopy approach to simultaneously visualize the viral mRNA and the nascent Gag protein during translation directly in the cell. We found that a minority of the RNA molecules serve as mRNA and that they are translated in a fast and efficient process.

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In 2020, we isolated a strain, Marseille-Q4381, from healthy skin. We describe herein its genome sequence and annotation characteristics.

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[microRNAs: regulators of metamorphosis in insects].

Biol Aujourdhui

January 2025

Sorbonne Université, Université Paris-Est Créteil, INRAE, CNRS, IRD, Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), 4 place Jussieu, F-75005 Paris, France.

In the animal kingdom, metamorphosis is a well-known developmental transition within various taxa (Cnidarians, Echinoderms, Molluscs, Arthropods, Vertebrates, etc.), which is characterized by the switching from a larval stage to an adult form through the induction of morpho-anatomical, physiological, behavioral, and/or ecological changes. Over the last decades, numerous studies have focused on the hormonal control of cellular processes underlying metamorphosis.

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[Allelopathy: chemical communication between plants].

Biol Aujourdhui

January 2025

Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin for Plant Sciences (IJPB), 78000 Versailles, France.

Today, weed control in agricultural systems is largely based on the use of synthetic pesticides. However, the use of these compounds is increasingly controversial among farmers and consumers, who point to their harmful properties for human health and the environment. In this context, the development of eco-friendly agricultural approaches and practices is becoming essential, and allelopathy represents a promising solution.

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[The role of volatile organic compounds in plant-insect communication].

Biol Aujourdhui

January 2025

Sorbonne Université, Institut d'Écologie et des Sciences de l'Environnement de Paris, 4 place Jussieu, 75005 Paris, France - Institut Universitaire de France, Paris, France.

Insects and flowering plants are the most abundant and diverse multicellular organisms on Earth, accounting for 75% of known species. Their evolution has been largely interdependent since the so-called Angiosperm Terrestrial Revolution (100-50 Mya), when the explosion of plant diversity stimulated the evolution of pollinating and herbivorous insects. Plant-insect interactions rely heavily on chemical communication via volatile organic compounds (VOCs).

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[The many ways flowers send signals to pollinators].

Biol Aujourdhui

January 2025

Institut d'Écologie et des Sciences de l'Environnement de Paris (iEES Paris), Paris, France - Sorbonne Université, 4 place Jussieu, 75005 Paris, France.

The evolutionary success of angiosperms, which make up more than 95 percent of the world's terrestrial flora, is largely based on their interactions with animal pollinators. Indeed, it is estimated that, on average, 87.5 percent of flowering plants are pollinated by animals.

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[Thousands of years of human-dog relationship].

Biol Aujourdhui

January 2025

Univ. Rennes, CNRS, ECOBIO (Ecosystèmes, biodiversité, évolution) - UMR 6553, Campus de Beaulieu, Avenue du Général Leclerc, 35042 Rennes Cedex, France.

During recent years, much progress has been made in understanding the origin and evolution of the dog. Thanks to the collaboration between zooarchaeology, genomics and paleogenetics, researchers were able to hypothesize scenarios regarding the origins of the canine lineages present in Europe at the end of the Pleistocene and the beginning of the Holocene. Research has also shown a correlation between human and canine migration across time and space, highlighting a strong relationship between man and his best friend.

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The disruption of proteostasis provides a favourable context for the emergence of therapeutic innovations, in particular by exploiting technologies such as the PROTAC (Proteolysis Targeting Chimera) approach. These technologies aim to selectively target proteins involved in various diseases, including cancer and neurodegenerative diseases, by inducing their specific degradation via the ubiquitin-proteasome system. The PROTAC approach opens new opportunities for restoring altered protein homeostasis and modulating the pathological consequences of proteostasis deregulation.

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[Marine trophic and socio-ecological networks under pressure: study of the cumulative impact of climate change and offshore wind farm development].

Biol Aujourdhui

January 2025

UMR CNRS-UniCaen-MNHN-SU-UA-IRD BOREA, Biologie des Organismes et des Écosystèmes Aquatiques, Université de Caen-Normandie, CS 14032, 14000 Caen, France - France Énergies Marines, 53 rue de Prony, 76600 Le Havre, France.

In the anthropocene era, one of the greatest challenges facing trophic modeling applied to the marine environment is its ability to couple the multiple effects of both climate change and local anthropogenic activities, notably the development of offshore wind farms. The major challenge is to create scenarios to characterize their cumulative effects on the functioning of the entire socio-ecological system, in order to propose appropriate management plans. Although modeling cumulative impact on socio-ecological networks is not yet widely used, data reported in the present review article show that the relevance of this approach could be established in the context of offshore wind power.

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[Gene coexpression networks: concepts and applications].

Biol Aujourdhui

January 2025

Sorbonne Université, CNRS, Inserm U1156, Institut de Biologie Paris Seine, Laboratoire de Biologie du Développement/UMR7622, 9 Quai St-Bernard, 75005 Paris, France.

The advent of high-throughput omics data and the generation of new algorithms provide the biologists with the opportunity to explore living processes in the context of systems biology aiming at revealing the gene interactions, the networks underlying complex cellular functions. In this article, we discuss two methods for gene network reconstruction, WGCNA (Weighted Gene Correlation Network Analysis) developed by Steve Horvath and collaborators in 2008, and MIIC (Multivariate Information-based Inductive Causation) developed by Hervé Isambert and his team in 2017 and 2024. These two methods are complementary, WGCNA generating undirected networks in which most gene-to-gene interactions are indirect, while MIIC reveals direct interactions and some causal links.

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