Cost of Carbon in the Total Cost of a Healthcare Procedure: Example of Micro-Costing Study in a French Setting.

Background: Economic evaluation aims to compare the costs and results of health strategies to inform public decision making. Although sometimes suggested, until now no national evaluation agency has recommended formally incorporating the cost of greenhouse gas (GHG) emissions generated by health interventions into the estimation of healthcare costs.

Objective: The objective of this study was to test and discuss the feasibility of estimating and including the contribution of GHG emissions cost to the total cost of a surgical intervention, with the example of robot-assisted total knee arthroplasty (RTA), using a micro-costing approach.

A Systematic Review of the Prevalence of Overactive Bladder in Women with Non-Urinary Tract Endometriosis and the Effect of Endometriosis Surgery on Symptoms of Overactive Bladder.

Introduction And Hypothesis: Overactive bladder (OAB) is characterised by urinary urgency, with or without incontinence, often accompanied by daytime frequency and nocturia, in the absence of urinary tract infection or other identifiable causes. Population studies estimate the prevalence of OAB at 12.8% (EPIC study), increasing with age, reaching up to 43% after age 40.

Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study.

Gaucher disease (GD), an autosomal recessive lysosomal disorder, primarily affects the lysosomal enzyme β-glucocerebrosidase (GCase), leading to glucosylceramide accumulation in lysosomes. GD presents a wide spectrum of clinical manifestations. This study deploys immune-based proteomics and mass spectrometry-based metabolomics technologies to comprehensively investigate the biochemical landscape in 43 deeply phenotyped type 1 GD patients compared to 59 controls.

Extraction of 3D trajectories of mandibular condyles from 2D real-time MRI.

Objective: Computing the trajectories of mandibular condyles directly from MRI could provide a comprehensive examination, providing both anatomical and kinematic details. This study aimed to investigate the feasibility of extracting 3D condylar trajectories from 2D real-time MRI.

Materials And Methods: Twenty healthy subjects underwent real-time MRI while performing jaw opening and closing movements.

RICTOR variants are associated with neurodevelopmental disorders.

RICTOR is a key component of the mTORC2 signaling complex which is involved in the regulation of cell growth, proliferation and survival. RICTOR is highly expressed in neurons and is necessary for brain development. Here, we report eight unrelated patients presenting with intellectual disability and/or development delay and carrying variants in the RICTOR gene.

Optimized chelator and nanoparticle strategies for high-activity Pd-loaded biodegradable brachytherapy seeds.

Background: Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort.

Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes.

Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. Post-kidney transplantation management of T2D remains challenging, leading to inferior long-term outcomes compared to non-diabetic recipients. This study aimed to assess the association between Homeostatic Model Assessment 2 (HOMA2) derived insulin resistance and beta-cell function on kidney graft outcomes in T2D kidney transplant recipients.

Multitarget Peptides Released by In Vitro Static Gastrointestinal Digestion of an Amaranth Protein Beverage.

Beverages formulated from alternative proteins, such as amaranth, are gaining attraction due to changes in human dietary patterns and environmental concerns like resource use and biodiversity loss. This study focuses on assessing the bioactive peptide release from an amaranth protein beverage. This beverage was subjected to a static simulated gastrointestinal digestion (SGD) protocol to evaluate its bioaccessibility and functional potential.

Symmetry breaking organizes the brain's resting state manifold.

Spontaneously fluctuating brain activity patterns that emerge at rest have been linked to the brain's health and cognition. Despite detailed descriptions of the spatio-temporal brain patterns, our understanding of their generative mechanism is still incomplete. Using a combination of computational modeling and dynamical systems analysis we provide a mechanistic description of the formation of a resting state manifold via the network connectivity.

Development of novel microsatellite marker sets for 5 common tropical hydrozoan species (Cnidaria: Hydrozoa) from the Southwestern Indian Ocean.

Background: In the context of global change, coral reefs and their associated biodiversity are under threat. Several conservation strategies using population genetics have been explored to protect them. However, some components of this ecosystem are understudied, such as hydrozoans, an important class of benthic organisms worldwide.

Increase maximum economic yield in a patchy environment.

In this work, we study the model of a fish species growing logistically exploited by a fishing fleet in a heterogeneous environment. The environment is made up of a network of fishing patches connected by fish migrations taking place on a fast time scale. We are interested in the maximum economic yield (MEY) which corresponds to the maximum profit made by the fishing fleet.

Would you publish unrealistic models?

The theoretical neurosciences research community produces many models, of different natures, to capture activities or functions of the brain. Some of these models are presented as «realistic » models, often because variables and parameters have biophysical units, but not always. In this opinion article, I explain why this term can be misleading and I propose some elements that can be useful to characterize a model.

Initial and recurrent management of parastomal hernia after cystectomy and ileal conduit urinary diversion: a 10 year single-center experience.

Purpose: The management of parastomal hernia following cystectomy and ileal conduit diversion is challenging due to its specific nature and a high recurrence rate, yet is poorly described.

Methods: We retrospectively searched the clinical data warehouse of our center for patients who had primary parastomal hernia repair following cystectomy and ileal conduit diversion. The primary endpoint was recurrence of parastomal hernia; secondary endpoints were postoperative complications and surgical management of recurrences.

Automatic ovarian follicle detection using object detection models.

Ovaries are of paramount importance in reproduction as they produce female gametes through a complex developmental process known as folliculogenesis. In the prospect of better understanding the mechanisms of folliculogenesis and of developing novel pharmacological approaches to control it, it is important to accurately and quantitatively assess the later stages of ovarian folliculogenesis (i.e.

Post mortem cadaveric and imaging mapping analysis of the influence of cochlear implants on cMRI assessment regarding implant positioning and artifact formation.

Objectives: In times of an aging society and considering the escalating health economic costs, the indications for imaging, particularly magnetic resonance imaging (MRI), must be carefully considered and strictly adhered to. This cadaver study aims to examine the influence of cochlear implant (CI) on the assessment of intracranial structures, artifact formation, and size in cranial MRI (cMRI). Furthermore, it seeks to evaluate the potential limitations in the interpretability and diagnostic value of cMRI in CI patients.

Lack of fibro-inflammatory response in human mammary adipose tissue in obesity.

Background: Understanding how obesity impacts human mammary adipose tissue (MAT) biology is crucial for deciphering its role in mammary epithelium during both physiological and pathophysiological processes, including breast cancer. Hypertrophic mammary adipocytes and Crown-Like Structures are present in MAT of patients with obesity but whether these changes initiate a fibro-inflammatory response at the tissue level remains insufficiently explored.

Objective: We investigated the markers of adipose tissue dysfunction (immune cell infiltration, secretion pattern and fibrosis) in tumor-free MAT of patients with obesity versus patients who are lean.

The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.

The parasitic wasp, Cotesia congregata, manipulates the behaviour of its host, the caterpillar Manduca sexta. The female wasp injects her eggs and a symbiotic virus (i.e.

A machine learning-based clinical predictive tool to identify patients at high risk of medication errors.

A medication error is an inadvertent failure in the drug therapy process that can cause serious harm to patients by increasing morbidity and mortality and are associated with significant economic costs to the healthcare system. Medication reconciliation is the most cost-effective intervention and can result in a 66% reduction in medication errors. To improve patient safety, we developed a machine learning-based tool that prioritizes patients at risk of medication errors upon admission to the hospital to ensure that they undergo medication reconciliation by clinical pharmacists.

Balancing economic growth and environmental conservation through the optimization of rail transit routes for sustainable development.

Drawing from the United Nations Sustainable Development Goals (SDGs), this study offers a framework for optimizing rail transit routes, balancing economic benefits with environmental preservation. Using the Bivariate Choropleth-Multi-Criteria Decision Analysis (BC-MCDA) model, we categorize global regions into economic benefit, environmental conservation, high-conflict, and low-conflict zones. Specifically, 7.

Reaction kinetics and molecular characterization of the compounds formed by photosensitized degradation of the plastic additive bisphenol A in the atmospheric aqueous phase.

Bisphenol A (BPA, 4,4'-(propane-2,2-diyl)diphenol) is a common plasticizer that is very widespread in the environment and is also found at significant concentrations in the global oceans, due to contamination by plastics. Here we show that triplet sensitization is an important degradation pathway for BPA in natural surface waters, which could prevail if the water dissolved organic carbon is above 2-3 mg L. Bromide levels as per seawater conditions have the potential to slow down BPA photodegradation, a phenomenon that could not be offset by reaction of BPA with Br (second-order reaction rate constant of (2.

Marked spatial heterogeneity of macro-benthic communities along a shallow-mesophotic depth gradient in Reunion Island.

Mesophotic coral ecosystems (MCEs) have gained considerable attention this last decade but the paucity of knowledge on these ecosystems is pronounced, particularly in the Southwestern Indian Ocean region. We explore the spatial variation in macro-benthic and scleractinian communities along a wide depth gradient (15-95 m) and among contrasted sites around Reunion Island. Values for percent cover of macro-benthic and scleractinian communities varied significantly along depth, resulting in a vertical zonation of communities.

Tumor hypoxia evidences the differential regulation of Mdm2-p53 axis by PTEN in tumor derived vs. normal endothelial cells.

Hypoxia, a condition of oxygen tension lower than physiological level, plays a crucial role in shaping the tumor microenvironment and modulates distinct cell populations activity. The tumor suppressor PTEN regulates angiogenesis, a process involving endothelial cells (ECs). Pathological in tumors, it is crucial for growth.