Pembrolizumab in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) and non-MSI-H/non-dMMR advanced endometrial cancer: Phase 2 KEYNOTE-158 study results.

Objective: We report updated results with longer follow-up in patients with MSI-H/dMMR endometrial cancer (EC) in cohort D (advanced EC of any MSI/dMMR status) and cohort K (any MSI-H/dMMR advanced solid tumor, except colorectal) of the phase 2 KEYNOTE-158 study (NCT02628067) and the first results from patients with non-MSI-H/non-dMMR advanced EC (cohort D).

Methods: Patients received pembrolizumab 200 mg Q3W for ≥35 cycles. The primary endpoint was objective response rate (ORR) per RECIST v1.

Iodine intakes of pregnant females from Québec, Canada.

Background: Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 -2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.

Objectives: To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.

Loneliness is positively associated with populist radical right support.

Objectives: The mental and physical health consequences of loneliness are well documented. However, loneliness's socio-political ramifications have been largely unexplored. We theorize that loneliness, due to its physiologically dysregulating impact on the nervous system, facilitates greater susceptibility towards populist radical right parties.

A multimodal deep learning model for cervical pre-cancers and cancers prediction: Development and internal validation study.

Background: The current cervical cancer screening and diagnosis have limitations due to their subjectivity and lack of reproducibility. We describe the development of a deep learning (DL)-based diagnostic risk prediction model and evaluate its potential for clinical impact.

Method: We developed and internally validated a DL model which accommodates both clinical data and colposcopy images in predicting the patients CIN2+ status using a retrospective cohort of 6356 cases of LEEP-conization/cone-biopsy (gold-standard diagnosis) following an abnormal screening result.

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: Insights from a brain-inspired perspective.

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in terms of functional connectivity (i.

Simulated breathing in virtual reality does not affect perceived effort during the physical rehabilitation of people with long COVID.

Objective: To assess the effectiveness of simulated breathing in virtual reality (VR) for manipulating the level of perceived effort of people with long COVID during sessions of physical rehabilitation.

Methods: We conducted a within-participants randomized prospective study during a cycling exercise in immersive VR with three counterbalanced conditions of simulated breathing: slower breathing, neutral breathing, and faster breathing compared to theirs. 37 participants with long COVID and deconditioning were included in the study, 36 of which could finish the experiment.

New modern and Pleistocene fossil micromammal assemblages from Swartkrans, South Africa: Paleobiodiversity, taphonomic, and environmental context.

The oldest deposit at the hominin-bearing cave of Swartkrans, South Africa, is the Lower Bank of Member 1, dated to ca. 2.2 million years ago.

Resilience of hierarchical actuators highlighted by a myosin-to-muscle mock-up.

Skeletal muscle is the main actuator of various families of vertebrates (mammals, fish, reptiles). It displays remarkable robustness to micro-damage, that supposedly originates both from its redundant hierarchical structure and its nervous command. A bioinspired mock-up was designed and manufactured mimicking sarcomeres (micro-scale) and its series and parallel structure from fibre to muscle.

Effect of siponimod on retinal thickness, a marker of neurodegeneration, in participants with SPMS: Findings from the EXPAND OCT substudy.

Background: People with MS show abnormal thinning of the retinal layers, which is associated with clinical disability and brain atrophy, and is a potential surrogate marker of neurodegeneration and treatment effects.

Objective: To evaluate the utility of retinal thickness as a surrogate marker of neurodegeneration and treatment effect in participants with secondary progressive MS (SPMS) from the optical coherence tomography (OCT) substudy of the EXPAND Phase 3 clinical trial (siponimod versus placebo).

Methods: In the OCT substudy population (n = 159), treatment effects on change in the average thickness of the retinal layer, peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (GCIPL) were analyzed by high-definition spectral domain OCT at months 3, 12, and 24.

Differential effect of three types of exoskeletons and handling height on muscular activity, postural control and perceived effort during simulated bedside mobilization task.

Home care workers are affected by musculoskeletal disorders caused by biomechanical factors. This study investigated the effect of three exoskeletons devices (HAPO, HAPO FRONT and Japet.W) during load mobilization tasks at three bed heights in order to reduce physical risk factor.

Analysis of aliphatic and phenolic compounds present in industrial black liquors using HPLC-DAD and IC-MS/MS methods.

Carboxylic acids and aromatic compounds are essential building blocks and starting materials for the production of a wide range of fine chemicals and materials. Their recovery from kraft black liquor, an industrial effluent from pulp and paper mills, is a promising way to produce alternative bio-based chemicals. Reliable methods are needed to identify and quantify the molecules of interest in complex mixtures such as black liquors.

Correction: Factors Associated With Digital Intervention Engagement and Adherence in Patients With Cancer: Systematic Review.

[This corrects the article DOI: 10.2196/52542.].

Modulation of the modulated magnetic structure of an Ho i-MAX phase described by a magnetic (3+2)-dimensional superspace group.

The magnetic structures of the Ho-based i-MAX phase (MoHo)GaC were studied with neutron powder diffraction at low temperature. (MoHo)GaC crystallizes in the orthorhombic space group Cmcm. The material undergoes two successive antiferromagnetic transitions at T = 10 K and T = 7.

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 () deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes.

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.

The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality-deserving equal attention. Three potentially life-threatening endemic bacterial diseases (leptospirosis, melioidosis, and rickettsioses) are a huge public health concern especially in low- and middle-income countries.

zIncubascope: Long-term quantitative imaging of multi-cellular assemblies inside an incubator.

Recent advances in bioengineering have made it possible to develop increasingly complex biological systems to recapitulate organ functions as closely as possible in vitro. Monitoring the assembly and growth of multi-cellular aggregates, micro-tissues or organoids and extracting quantitative information is a crucial but challenging task required to decipher the underlying morphogenetic mechanisms. We present here an imaging platform designed to be accommodated inside an incubator which provides high-throughput monitoring of cell assemblies over days and weeks.

Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study.

Objectives: Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneous manifestations. First-line treatment is based on colchicine, hydroxychloroquine, dapsone or low-dose glucocorticoids. In refractory forms, the use of biologics has been anecdotally described as potentially effective.

A cortico-subcortical loop for motor control via the pontine reticular formation.

Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear.

Pharmacology of Intestinal Inflammation and Repair.

Chronic inflammation is a common trait in the pathogenesis of several diseases of the gut, including inflammatory bowel disease and celiac disease. Control of the inflammatory response is crucial in these pathologies to avoid tissue destruction and loss of intestinal function. Over the last 50 years, the identification of the mechanisms and mediators involved in the acute phase of the inflammatory response, which is characterized by massive leukocyte recruitment, has led to a number of therapeutic options.

A systematic review suggests extension and redefinition of a food-deception pollination syndrome involving anautogenous flies.

Background And Aims: The currently recognized diversity of pollination strategies requires pollination syndromes to be updated. Described a decade ago, kleptomyiophily is a deceptive pollination system in which plants exploit the nutrient-seeking behavior of females of kleptoparasitic flies (Chloropidae and Milichiidae) by olfactorily mimicking their insect host. Such a pollination system was already hypothesized for pollination by biting midges (Ceratopogonidae) but has never been formalized.

Ageing and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19.

CD8+ T cells are critical for immune protection against severe COVID-19 during acute infection with SARS-CoV-2. However, the induction of antiviral CD8+ T cell responses varies substantially among infected people, and a better understanding of the mechanisms that underlie such immune heterogeneity is required for pandemic preparedness and risk stratification. In this study, we analyzed SARS-CoV-2-specific CD4+ and CD8+ T cell responses in relation to age, clinical status, and inflammation among patients infected primarily during the initial wave of the pandemic in France or Japan.

Human Oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome.

Oncostatin M (OSM) is a cytokine with the unique ability to interact with both the OSM receptor (OSMR) and the leukemia inhibitory factor receptor (LIFR). On the other hand, OSMR interacts with IL31RA to form the interleukin-31 receptor. This intricate network of cytokines and receptors makes it difficult to understand the specific function of OSM.

Two Cases of ROSAH-Like Syndrome Restricted to the Ophthalmologic Presentation.

Purpose: To report the clinical presentation and follow-up, including the optical coherence tomography, angiography and electrophysiology of two individuals from the same family presenting with an isolated retinal dystrophy and optic nerve edema who were diagnosed with ROSAH-like syndrome.

Method: Observational case report of a 55-year-old woman and her 36-year-old son with a genetic analysis of ROSAH, after a long-term follow-up.

Results: Both the mother and her son displayed severe optic nerve infiltration and retinal pigment atrophy with intraocular inflammation, which were not improved by immunosuppressive treatment.