Radiotherapy for oligoprogressive disease in non-small cell lung cancer treated with pembrolizumab in first-line setting: a retrospective study.

Background: Oligoprogression (OP) is common in patients with metastatic non-small cell lung cancer (mNSCLC) treated with immune checkpoint inhibitors (ICIs). This study aims to assess the benefit and the safety profile of ablative radiotherapy (RT) for OP in mNSCLC treated with pembrolizumab in first-line setting.

Methods: We retrospectively analyzed records of all consecutive mNSCLC patients who underwent treatment with pembrolizumab (+/- chemotherapy) in first-line setting and developed an OP treated with ablative RT while continuing pembrolizumab, in a French Hospital from 2019 to 2022.

Population Dynamics of the Exotic Flatworm in an Invaded Garden.

Population dynamics and the way abundance fluctuates over time may be key determinants of the invasion success of an introduced species. Fine-scale temporal monitoring of invasive species is rarely carried out due to the difficulties in collecting data regularly and over a long period. Thanks to the collaboration of an amateur naturalist, a unique dataset on the abundance of the invasive land flatworm was obtained during a 4-year survey of a French private garden, where up to 1585 were recorded in 1 month.

An instruction dataset for extracting quantum cascade laser properties from scientific text.

Quantum Cascade Lasers (QCL) are promising semiconductor lasers, compact and powerful, but of complex design. Availability of structured data of the QCL properties can support data mining activities that seek to understand the relationship between these properties, for instance between the design and performance features. The main open source of QCL data is in scientific text which in most cases is usually unstructured.

A dataset of annotated free comments on the sensory perception of madeleines for benchmarking text mining techniques.

This dataset was created to investigate the impact of data collection modes and pre-processing techniques on the quality of free comment data related to consumers' sensory perceptions. A total of 200 consumers were recruited and divided into two groups of 100. Each group evaluated six madeleine samples (five distinct samples and one replicate) in a sensory analysis laboratory, using different free comment data collection modes.

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice.

Background: Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested.

Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis.

Automatic tool for the reconciliation of serious adverse events for pharmacovigilance: design and implementation of Reconciliaid.

Background: Reporting serious adverse events (SAEs) is crucial to reduce or avoid toxicities that can lead to major consequences for patient's health due to treatments tested in clinical trials. Its exhaustiveness is often inadequate, and we observe discrepancies between data published by pharmacovigilance organizations and clinical databases.

Objectives: While the process of reconciliation aims at reducing these differences, it remains a very time-consuming and imprecise task.

Automated tight Lyapunov analysis for first-order methods.

We present a methodology for establishing the existence of quadratic Lyapunov inequalities for a wide range of first-order methods used to solve convex optimization problems. In particular, we consider (i) classes of optimization problems of finite-sum form with (possibly strongly) convex and possibly smooth functional components, (ii) first-order methods that can be written as a linear system on state-space form in feedback interconnection with the subdifferentials of the functional components of the objective function, and (iii) quadratic Lyapunov inequalities that can be used to draw convergence conclusions. We present a necessary and sufficient condition for the existence of a quadratic Lyapunov inequality within a predefined class of Lyapunov inequalities, which amounts to solving a small-sized semidefinite program.

Whole blood ratio of mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study.

Background: Transcriptomics biomarkers have been widely used to predict mortality in patients with sepsis. However, the association between mRNA levels and outcomes shows substantial variability over the course of sepsis, limiting their predictive performance. We aimed to: (a) identify and validate an mRNA biomarker signature whose association with all-cause intensive care unit (ICU) mortality is consistent at several timepoints; and (b) evaluate how this mRNA signature could be used in association with lactate levels for predictive and prognostic enrichment in sepsis.

Introducing subgen. a new and very small lineage sharing with () an identical, largely circum-Pacific distribution pattern.

The application of DNA data on a worldwide sampling has revolutionized the infrageneric classification of the highly diverse ectomycorrhizal genus . Based on collections made in New Zealand, East Asia and North America, this study describes a new subgenus , the ninth subgenus of . Even though BLASTn of the ITS sequences suggested affinities with species of subgenera and the phylogenetic analysis based on a five-locus DNA dataset placed the target samples in an independent major clade that is taxonomically equivalent to subgenus.

Role of Fe Impurity Reactions in the Electrochemical Properties of MgFeBO.

We investigate magnesium-iron pyroborate MgFeBO as a potential cathode material for rechargeable magnesium-ion batteries. Synchrotron powder X-ray diffraction and Mössbauer spectroscopy confirm its successful synthesis and iron stabilization in the high-spin Fe(II) state. Initial electrochemical testing against a lithium metal anode yields a first charge capacity near the theoretical value (147.

Electrically Modulated Multilevel Optical Chirality in GdFeCo Thin Films.

This study introduces a simple approach to dynamically control multilevel optical ellipticity in ferrimagnetic GdFeCo alloys by switching the spin orientation through Joule heating induced by electrical current, with the assistance of a low magnetic field of 3.5 mT. It is demonstrated that selecting specific compositions of Gd (FeCo) alloys, with magnetic compensation temperatures near or above room temperature, allows for significant manipulation of the circular dichroism (CD) effect.

Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer's disease stages.

Introduction: Recent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression of glutamatergic genes, mediating early neuronal damage.

Methods: In this study, we discovered that changes in Tau availability are linked to global alterations in gene expression that affect multiple neuronal pathways.

Racial-Ethnic Stratification in Work-Family Arrangements among Black, Hispanic, and White Couples.

Objective: This article builds on work-family scholarship to document racial-ethnic variation in couples' work-family arrangements, i.e., how couples respond to their work and family demands.

Effect of chest compressions in addition to extracorporeal life support on carotid flow in an experimental model of refractory cardiac arrest in pigs.

Background: Extracorporeal life support (ECLS) provides organ perfusion in refractory cardiac arrest but during the initiation of ECLS mean arterial pressure (MAP) and carotid flow may be suboptimal due to hypotension and/or insufficient flow. We hypothesized that cardiopulmonary resuscitation (CPR) in addition to ECLS may increase carotid flow and MAP compared to ECLS alone.

Methods: Observational pilot study comparing hemodynamic parameters before and after CPR cessation in pigs supported by ECLS for experimental refractory cardiac arrest.

Phylogenetic and Sequence Analyses of the Variable Region in the Glycoprotein Gene of the Respiratory Syncytial Virus Isolated from Iraqi Patients.

Background: Respiratory syncytial virus (RSV) is a common aetiological agent that causes respiratory infections, especially among infants. Identifying circulating RSV genotypes is an essential strategy for understanding the spread of the virus in a certain area. Sequencing the variable regions of the attachment glycoprotein (G) gene of RSV is a quick and direct approach for identifying the genotypes.

Tidal Deformation and Dissipation Processes in Icy Worlds.

Tidal interactions play a key role in the dynamics and evolution of icy worlds. The intense tectonic activity of Europa and the eruption activity on Enceladus are clear examples of the manifestation of tidal deformation and associated dissipation. While tidal heating has long been recognized as a major driver in the activity of these icy worlds, the mechanism controlling how tidal forces deform the different internal layers and produce heat by tidal friction still remains poorly constrained.

Is provisioning rate of parents and helpers influenced by the simulated presence of novel individuals?

Abstract: Cooperative behaviour is widespread in animals and is likely to be the result of multiple selective pressures. A contentious hypothesis is that helping enhances the probability of obtaining a sexual partner (i.e.

Income rank and life satisfaction: Examining the relationship with wealth inequality among middle-aged and older indian adults.

The relationship between income and subjective well-being (SWB) has intrigued scholars for decades. Richard Easterlin's groundbreaking research in the 1970s revealed a paradox: while higher individual incomes within countries are associated with greater happiness, this trend does not hold across countries. This paradox highlights the significance of relative income over absolute income.

Deep Learning for Biomarker Discovery in Cancer Genomes.

Background: Genomic data is essential for clinical decision-making in precision oncology. Bioinformatic algorithms are widely used to analyze next-generation sequencing (NGS) data, but they face two major challenges. First, these pipelines are highly complex, involving multiple steps and the integration of various tools.

Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis.

Background & Aims: Biliary abnormalities in autoimmune hepatitis (AIH) and interface hepatitis in primary biliary cholangitis (PBC) occur frequently, and misinterpretation may lead to therapeutic mistakes with a negative impact on patients. This study investigates the use of a deep learning (DL)-based pipeline for the diagnosis of AIH and PBC to aid differential diagnosis.

Methods: We conducted a multicenter study across six European referral centers, and built a library of digitized liver biopsy slides dating from 1997 to 2023.

Dynamics of Persistent Submicroscopic and Microscopic in Pregnant Women Under Intermittent Preventive Treatment: A Study Cohort in Benin.

Background: Malaria infections in pregnancy are a major cause of maternal morbidity and neonatal mortality in sub-Saharan Africa. A high proportion of these infections are submicroscopic, which are usually asymptomatic and therefore untreated during pregnancy. Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) aims to prevent and treat all potential infections whether submicroscopic or not.