[Management of a fetus suspected of differences of sex development (DSD).].

The management of a fetus suspected of having a variation in genital development is a complex situation. In cases of complete discordance or an unusual appearance of the external genitalia (EG), management always begins with a diagnostic morphological ultrasound. This ultrasound aims to provide detailed imaging of the EG and internal genitalia (IG), focusing on identifying the presence of Müllerian derivatives and detecting any associated malformations.

Relations between psychosis and emotion regulation in daily life: A systematic review and meta-analyses of studies using experience sampling methods.

Research has shown that heightened emotionality often precedes psychotic experiences. Understanding how individuals cope with these emotions is crucial for psychosis. While prior studies on emotion regulation (ER) and psychosis have mainly relied on self-report questionnaires, recent research has increasingly utilised daily life methods.

Neuroretinal and RPE changes and susceptibility to Age-Related Macular Degeneration: insights from the longitudinal Alienor Study.

Purpose: We assessed the associations of macular layer thicknesses, measured using spectral-domain OCT (SD-OCT), with incident age-related macular degeneration (AMD) and AMD polygenic risk scores (PRS).

Design: Population-based cohort study PARTICIPANTS: 653 participants of the Alienor study, with biennial eye imaging from 2009 to 2024.

Methods: Macular layer thicknesses of eight distinct layers and three compound layers were automatically segmented based on SD-OCT imaging of the macula.

Ultrasound-guided trigger finger release with a minimally invasive knife: A retrospective analysis of 297 releases.

Trigger finger, or stenosing tenovaginitis, is a common condition characterized by impaired flexor tendon sliding due to thickening of the A1 pulley. While open surgical release remains the gold standard for the treatment of persistent trigger finger, there is increasing interest in minimally invasive ultrasound-guided techniques to improve precision and outcomes. The purpose of this study is to evaluate the outcomes, safety, and complications associated with ultrasound-guided trigger finger release using a minimally invasive surgical knife.

Predicting the evolution from first-episode psychosis to mood or psychotic disorder: A systematic review of biological markers.

Background And Hypothesis: The development of paraclinical tools to assist clinical assessment is already widespread in nearly all other medical specialties. In psychiatry, many efforts are being made to improve management strategies using these new techniques. The first episode psychosis (FEP) is a clinical entity whose evolution after onset is difficult to predict in the current state of our practices.

Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis.

Background And Aims: Bulevirtide (BLV) 2 mg/day is EMA approved for treatment of compensated chronic hepatitis due to Delta virus (HDV) infection, however real-life data in large cohorts of patients with cirrhosis are lacking.

Methods: Consecutive HDV-infected patients with cirrhosis starting BLV 2 mg/day since September 2019 were included in a European retrospective multicenter real-life study (SAVE-D). Patient characteristics before and during BLV treatment were collected.

Tamuzimod in patients with moderately-to-severely active ulcerative colitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 induction trial.

Background: Tamuzimod (VTX002) is a selective sphingosine 1-phosphate receptor 1 modulator in development for ulcerative colitis. We aimed to assess the safety and efficacy of tamuzimod in patients with moderately-to-severely active ulcerative colitis.

Methods: This double-blind, randomised, placebo-controlled, phase 2 induction trial was conducted at 122 centres across 15 countries in Asia, Europe, and North America.

Functional and oncological outcomes of transoral laser versus robotic surgery in supraglottic squamous cell carcinoma.

Objective: To compare the surgical, functional and oncological outcomes of Transoral Laser Microsurgery (TLM) and Transoral Robotic Surgery (TORS) for the treatment of supraglottic squamous cell carcinoma.

Study Design: Retrospective case series with prospective data.

Settings: Tertiary Academic Medical Center.

Association of MTHFR C677T and A1298C variants with preeclampsia risk and angiogenic imbalance in Tunisian women.

Unlabelled: Preeclampsia (PE) is a pregnancy-specific vascular disorder associated with endothelial dysfunction, hypertension, and proteinuria. The methylenetetrahydrofolate reductase (MTHFR) enzyme regulates essential cellular functions in pregnancy owing to its effects on folate metabolism and DNA methylation. Previous studies implicated the association of rs1801133 (C677T; Ala222Val) and rs1801131 (A1298C; Glu429Ala) in the MTHFR gene with PE in different ethnic groups, but with mixed outcomes.

A first-in-human phase 1/2 dose-escalation study of MAK683 (EED inhibitor) in patients with advanced malignancies.

Purpose: MAK683, a first-in-class and highly selective allosteric inhibitor of the embryonic ectoderm development subunit of polycomb repressive complex 2, has shown sustained antitumor activity in tumor xenograft models. This first-in-human phase 1/2 study evaluated the safety, pharmacokinetics (PK), and clinical activity of single-agent MAK683 in advanced malignancies.

Methods: MAK683 was administered fasted once daily or twice daily continuously in 28-day treatment cycles.

Whole-cell aptamer-based techniques for rapid bacterial detection: Alternatives to traditional methods.

Controlling the spread of bacterial infectious diseases is a major public health issue, particularly in view of the pandemic of bacterial resistance to antibiotics. In this context, the detection and identification of pathogenic bacteria is a prerequisite for the implementation of control measures. Current reference methods are mainly based on culture methods, which generate a delay in obtaining a result and requires equipment.

A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers.

Objectives: Evaluating invasion in non-mucinous adenocarcinoma (NMA) of the lung is crucial for accurate pT-staging. This study compares the World Health Organization (WHO) with a recently modified NMA classification.

Materials And Methods: A retrospective case-control study was conducted on small NMA pT1N0M0 cases with a 5-year follow-up.

Prognostic implications of regional lung impairment evaluation in quantitative computed tomography imaging of COVID-19.

Aim: To enhance the understanding of COVID-19 regional lung damage pattern by analyzing the organ in subregions, beyond the typical lobe segmentation.

Materials And Methods: This study used semiautomatic computed tomography (CT) imaging segmentation and quantification to investigate regional lung impairments in patients with COVID-19. Each lung was divided into 12 regions, and the anatomical impairments obtained from the CT image (emphysema, ground glass opacity, and collapsed tissue) were quantified.

Synthesis of fluorescent dicyanomethylenevinyl-1,3-dicoumarin compounds with donor-acceptor-π-donor (D-A-π-D) system and investigation of their photophysical, NLO, and chemosensor properties: Part 1.

Coumarin compounds have heterocyclic core with different properties such as high quantum yields, broad Stokes shifts, and superior photophysical and biological activity. It is known that fluorescence properties increase with increased intramolecular charge transfer in systems where electron-withdrawing or donor groups are attached to different positions of the coumarin compound. When these compounds interact with analytes in the environment, the analytes in the environment can be detected by quenching or increasing fluorescence.

H-F cross-polarization magic angle spinning dynamic nuclear polarization NMR investigation of advanced pharmaceutical formulations.

A new 3.2 mm H-F-X magic angle spinning dynamic nuclear polarization NMR (MAS DNP-NMR) probe was developed with a unique coil design with separate radiofrequency channels for H excitation and C or F detection to enable acquisition of H-F cross-polarization (CP) MAS experiments, direct-detected F spectra with proton decoupling, and acquisition on C with simultaneous double decoupling on the H and 19F channels as well as H-F-C double-CP experiments under low temperature MAS DNP conditions. We use these sequences to study AZD2811, which is an active pharmaceutical ingredient (API), in its pure dry state as well as in its corresponding drug delivery formulation consisting of drug-loaded polymeric nanoparticles (PNPs).

Influence of phase and dominance on ground reaction forces and upper extremity muscle activity during the modified-Closed Kinetic Chain Upper Extremity Stability Test.

Background: The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) is a physical performance test designed to assess the upper extremity (UE) stability. However, only one outcome measure is provided for both UEs, limiting its application if the UEs are not similarly involved. Moreover, the changes in loads sustained by the support UE throughout the movement may influence the support UE stability.

Machine learning in the prediction of human wellbeing.

Subjective wellbeing data are increasingly used across the social sciences. Yet, despite the widespread use of such data, the predictive power of approaches commonly used to model wellbeing is only limited. In response, we here use tree-based Machine Learning (ML) algorithms to provide a better understanding of respondents' self-reported wellbeing.

Biological and environmental degradation of two-dimensional materials.

As the use of two-dimensional materials continues to grow, so too does the need to understand the environmental and biological impact of such materials. Degradation is a critical step in the life cycle of any material, but the majority of such knowledge is obtained from test tube and in vitro studies. Therefore, there remains a gap in understanding the degradability of two-dimensional materials in complex systems (in vivo) and in different ambient environments.

The human reward system encodes the subjective value of ideas during creative thinking.

Creative thinking involves the evaluation of one's ideas in order to select the best one, but the cognitive and neural mechanisms underlying this evaluation remain unclear. Using a combination of creativity and rating tasks, this study demonstrates that individuals attribute subjective values to their ideas, as a relative balance of their originality and adequacy. This relative balance depends on individual preferences and predicts individuals' creative abilities.

Hypergravity is more challenging than microgravity for the human sensorimotor system.

The importance of gravity for human motor control is well established, but it remains unclear how the central nervous system accounts for gravitational changes to perform complex motor skills. We tested the hypothesis that microgravity and hypergravity have distinct effects on the neuromuscular control of reaching movements compared to normogravity. To test the influence of gravity levels on sensorimotor planning and control, participants (n = 9) had to reach toward visual targets during parabolic flights.

Deep mantle earthquakes linked to CO degassing at the mid-Atlantic ridge.

Volatiles (CO, HO) play a fundamental role in mantle melting beneath ocean spreading centers, but what role they play during the melt migration remains unknown. Using seismological data recorded by ocean-bottom seismometers, here we report the presence of deep earthquakes at 10-20 km depth in the mantle along the Mid-Atlantic Ridge axis, much below the brittle-ductile boundary. Syntheses of regional basaltic rock samples and their geochemical analyses indicate the presence of an abnormally high quantity of CO (~0.

[Psychosocial traits associated with maintenance of physical activity 12months after a pulmonary rehabilitation program - An exploratory study].

Introduction: After a pulmonary rehabilitation (PR) program, 30 to 70% of patients fail to pursue maintenance of physical activity. This study aimed to identify psychosocial markers associated with MPA subsequent to an initial outpatient PR course (≥10 sessions).

Material And Methods: Patients were enrolled in an exploratory quantitative monocentric retrospective study.

Why the belief in meritocracy is so pervasive.

People worldwide tend to believe that their societies are more meritocratic than they actually are. We propose the belief in meritocracy is widespread because it is rooted in simple, seemingly obvious causal-explanatory intuitions. Our proposal suggests solutions for debunking the myth of meritocracy and increasing support for equity-oriented policies.