Pharmacokinetics and absorption, distribution, metabolism and excretion profiling of tanimilast following an intravenous C-microtracer coadministered with an inhaled dose in healthy male individuals.

Tanimilast is an inhaled phosphodiesterase-4 inhibitor currently in phase III clinical development for treating chronic obstructive pulmonary disease and asthma. This trial aimed to characterize the pharmacokinetics, mass balance, and metabolite profiling of tanimilast. Eight healthy male volunteers received a single dose of nonradiolabeled tanimilast via powder inhaler (Chiesi NEXThaler [3200 μg]), followed by a concomitant intravenous infusion of a microtracer ([C]-tanimilast: 18.

[Management of women with abnormal cervical cytology: Update of INCa recommendations after the implementation of HPV screening].

Objective: To update the recommendations issued by the National Cancer Institute (INCa) on the management of women with abnormal cervical cytology.

Methods: INCa recommendations on the management of women with abnormal cervical cytology were published in 2016. In 2019, the High Authority of Health (HAS) recommends HPV test for cervical cancer screening in women over 30.

Side-by-Side Comparison of the In Vivo Performance of [Pb]Pb-DOTAMTATE and Other SSTR2-Targeting Compounds.

There are numerous versions of octreotide and octreotate, including DOTAMTATE, DOTATATE, JR11, and lead-specific chelator (PSC)-PEG2-TOC. These peptides, which can be either analogs or antagonists, are used in nuclear medicine for diagnostic imaging or targeted radionuclide therapy of neuroendocrine tumors that are positive for somatostatin receptors (SSTRs). Despite their structural and targeting similarities, they have distinct properties and clinical uses.

Initial therapy in patients with pulmonary arterial hypertension and cardiovascular comorbidities.

Background: European guidelines recommend initial monotherapy in PAH patients with cardiovascular (CV) comorbidities based on the limited of evidence for combination therapy in this growing population.

Methods: A retrospective analysis was conducted on incident PAH patients enrolled in the French Pulmonary Hypertension Registry between 2009 and 2020. Propensity score matching was used to investigate initial dual oral combination therapy oral monotherapy in patients with at least one CV comorbidity (, hypertension, obesity, diabetes and coronary artery disease).

Efficacy and safety of the activin signalling inhibitor, sotatercept, in a pooled analysis of PULSAR and STELLAR studies.

Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Sotatercept is a first-in-class activin signalling inhibitor that acts to restore the balance between the growth-promoting and growth-inhibiting signalling pathways.

Methods: This post-hoc, exploratory, pooled analysis combines data from the double-blind placebo periods of the phase 2 PULSAR (NCT03496207) and phase 3 STELLAR (NCT04576988) studies.

A proof-of-mechanism trial in asthma with lunsekimig, a bispecific nanobody® molecule.

Background: Monovalent biologics blocking thymic stromal lymphopoietin or interleukin-13 have been shown to elicit pharmacodynamic responses in asthma following a single dose. Therefore, dual blockade of these cytokines may result in an enhanced response compared to single targeting and has the potential to break efficacy ceilings in asthma. This study assessed the safety and tolerability of lunsekimig, a bispecific NANOBODY molecule that blocks thymic stromal lymphopoietin and interleukin-13, and its effect on Type 2 inflammatory biomarkers and lung function in asthma.

Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states- A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project.

Objectives: The Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) has developed a calcium pyrophosphate deposition (CPPD) nomenclature project. This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of the last 20 years.

Methods: A systematic literature search was undertaken in the , and databases between 2000 and 2022, restricted to studies on humans and in the English language.

Earliest evidence for heavy metal pollution on wildlife in Middle Age Europe.

Effects of past anthropogenic metal pollution on the wildlife are understudied. We investigate trace element incorporation in the dentition of a 1000 BP-year-old brown bear from the Romanian Carpathians, an area known historically for strong metallurgical activities. Background values as well as unnatural high lead (Pb), lithium (Li) and zinc (Zn) levels in a circa 5‒6-year-old brown bear male were detected using trace element maps across its functional dentition.

Transcriptomic and Biochemical analysis of Procambarus clarkii upon exposure to Pesticides: Population-Specific responses as a sign of pollutant resistance?

The effects that anthropogenic stressors may have on modulating species' plasticity has been relatively unexplored; however, it represents a scientific frontier that may offer insights into their ability to colonize new habitats. To explore the advantage that inhabiting polluted environments may offer to invasive species, we selected the crayfish Procambarus clarkii, a species that can colonize and thrive in a wide range of aquatic environments, including heavily polluted ones. Here, we studied the molecular and physiological responses of crayfish when experimentally exposed to a pesticide mix of azoxystrobin and oxadiazon at sublethal concentrations.

Historical biogeography of the Mugil cephalus species complex and its rapid global colonization.

Our understanding of speciation processes in marine environments remains very limited and the role of different reproductive barriers are still debated. While physical barriers were considered important drivers causing reproductive isolation, recent studies highlight the importance of climatic and hydrological changes creating unsuitable habitat conditions as factors promoting population isolation. Although speciation in marine fish has been investigated from different perspectives, these studies often have a limited geographical extant.

PREDICTIVE MODELS OF CLINICAL OUTCOME OF ENDOVASCULAR TREATMENT FOR ANTERIOR CIRCULATION STROKE USING MACHINE LEARNING.

Background And Purpose: Mechanical Thrombectomy (MT) has recently become the standard of care for anterior circulation stroke with large vessel occlusion, but predictive factors of successful MT are still not clearly defined. To tailor treatment individually for each patient, the aim of this study was to evaluate the performances of Machine Learning to predict clinical outcome (mRS) at 3 months after MT.

Material And Methods: From the ETIS French prospective multicenter registry, data from patients who underwent MT for anterior circulation stroke with large vessel occlusion between January 2018 and December 2020 were extracted.

[Impact of the European Medical Device Regulation on the availability of medical devices: Scoping review and two-year analysis on the risk for patients in the cardiovascular field].

The implementation of the Medical Devices Regulation (MDR) 2017/745/EU leaves manufacturers facing new requirements to certify their medical devices (MDs). Our objective is to accurately assess the impact of regulation on the availability of cardiovascular MDs in healthcare facilities. High-risk cardiovascular MDs appear to be heavily impacted by the regulation, with reclassification leading to mandatory clinical investigations.

Sibling similarity in telomere length in Adélie penguin chicks.

Early life telomere length is thought to influence and predict an individual's fitness. It has been shown to vary significantly in early life compared to adulthood. Investigating the factors influencing telomere length in young individuals is therefore of particular interest, especially as the relative importance of heredity compared to post-natal conditions remains largely uncertain.

Bifunctional chimeras of myeloperoxidase and glucose oxidase. Antimicrobial, topological and enzymatic properties.

Enhancing the local substrate concentration is a crucial strategy in nature for facilitating the proximity of two enzymes. The substrate of the first enzyme is transformed into a by-product that travels to the active site of the second enzyme without external diffusion, then transformed into a product and eventually expelled from the complex. In an effort to optimize the antimicrobial properties of myeloperoxidase from Rhodopirellula baltica (RbMPO), we created a library of fused chimeras between a glucose oxidase (GOx) and RbMPO so that HO could be continuously perfused in the vicinity RbMPO, enabling the production of HOCl or HOSCN, well-known antimicrobial agents.

Reconstruction of large thermal burn areas by hair transplantation.

Introduction: Alopecia resulting from burns represents a surgical challenge, with significant functional, physical, psychological and social consequences. Current management is based on various techniques. However, the results are most often very disappointing.

Cold and longevity: Can cold exposure counteract aging?

Aging is a multifaceted biological process characterized by a progressive decline in physiological functions and heightened vulnerability to diseases, shaped by genetic, environmental, and lifestyle factors. Among these, cold exposure has garnered interest for its potential anti-aging benefits. This review examines the impact of cold exposure on aging, focusing on key physiological processes such as inflammation, oxidative stress, metabolic regulation, and cardiovascular health.

Epidemiology and outcomes associated with MBL-producing Enterobacterales: A systematic literature review.

The increasing prevalence of infections due to metallo-β-lactamase (MBL)-producing Enterobacterales poses a serious concern given the limited treatment options available. This systematic literature review (SLR) describes the molecular epidemiology, geographical distribution, and clinical outcomes of such infections. Systematic searches of literature published between January 2013 and May 2023 were performed, and 39 studies with an MBL sample size of ≥25 isolates and ≥2 well-defined outcomes were eligible.

P2 purinergic receptors at the heart of pathological left ventricular remodeling following acute myocardial infarction.

Pathological left ventricular remodeling is a complex process following an acute myocardial infarction, leading to architectural disorganization of the cardiac tissue. This phenomenon is characterized by sterile inflammation and the exaggerated development of fibrotic tissue, which is non-contractile and poorly conductive, responsible for organ dysfunction and heart failure. At present, specific therapies are lacking for both prevention and treatment of this condition, and no biomarkers are currently validated to identify at-risk patients.

Floating photovoltaics strongly reduce water temperature: A whole-lake experiment.

Floating photovoltaics (FPVs), solar panels installed on floating structures in freshwater ecosystems such as lakes, represent a growing renewable technology aimed at decarbonizing the energy sector. However, robust empirical assessments of its environmental effects are still lacking. We used a Before-After-Control-Impact design replicated at the ecosystem level (n = 6 lakes: three lakes with FPV compared to three non-FPV lakes) to determine the global effects of FPV on water temperature over three years and allowing to isolate FPV effects from natural variability.

Rhythmic EEG patterns: The oldest idea in the EEG world, but without an obvious definition.

The word "rhythmic" was quickly introduced in the vocabulary of the electroencephalographers with the discovery of the alpha rhythm and typical discharges of spike-and-waves at 3 Hz in childhood absence epilepsy, but without any definition until recently. In its last revision (2017), the International Federation of Clinical Neurophysiology proposed a specific definition. The word "rhythmic" is "applied to regular waves occurring at a constant period and of relatively uniform morphology.

Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts.

Neglecting proper skin care and repeated exposure to ultraviolet (UV) radiation can have serious consequences, including skin burns, photoaging and even the development of skin cancer. UV radiation-induced damage is mediated by highly unstable and reactive molecules, named reactive oxygen species (ROS). To counteract ROS, the skin has an endogenous antioxidant system.

Dyadic adjustment of persons with albinism and their significant other: A Bayesian mediation model of the Actor-Partner Interdependence (APIMeM).

Background: Limited standardized empirical research exists in France on the psychosocial implications of albinism, prompting an investigation into how affected persons adapt to their disabilities. Recent advancements in health psychology have led researchers to adopt a systemic approach, considering disabilities and involving close relatives in the adaptation process. The aim of this study was to explore the mediating role of dyadic coping within family dyads, where one is a person with albinism (PWA) and the other is a close relative.