An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of .

Insertion sequences (IS) represent mobile genetic elements that have been shown to be associated with bacterial evolution and adaptation due to their effects on genome plasticity. In , the causative agent of whooping cough, the numerous IS elements induce genomic rearrangements and contribute to the diversity of the global population. Previously, we have shown that the majority of IS-specific endogenous promoters induce the synthesis of alternative transcripts and thereby affect the transcriptional landscape of .

Taylor's swimming sheet near a soft boundary.

In 1951, G. I. Taylor modeled swimming microorganisms by hypothesizing an infinite sheet in 2D moving in a viscous medium due to a wave passing through it.

Small-angle neutron scattering differentiates molecular-level structural models of nanoparticle interfaces.

The highly anisotropic and nonadditive nature of nanoparticle surfaces restricts their characterization by limited types of techniques that can reach atomic or molecular resolution. While small-angle neutron scattering (SANS) is a unique tool for analyzing complex systems, it has been traditionally considered a low-resolution method due to its limited scattering vector range and wide wavelength spread. In this article, we present a novel perspective on SANS by showcasing its exceptional capability to provide molecular-level insights into nanoparticle interfaces.

Draft genomes and assemblies of the ectomycorrhizal basidiomycetes hr and jo associated with chestnut trees.

The earthball , an ectomycorrhizal basidiomycete belonging to the Sclerodermataceae family, serves as a significant mutualistic tree symbiont globally. Originally, two genetically sequenced strains of this genus were obtained from fruiting bodies collected under chestnut trees (). These strains were utilized to establish ectomycorrhizal roots of chestnut seedlings.

The effect of sevelamer on serum calcification propensity in patients with chronic kidney disease: the results of a multicentre, double-blind, placebo-controlled, randomized clinical trial.

Background: The serum calcification propensity test (or T50 test) might become a standard tool for the assessment of vascular calcification risk and T50 might be a valuable biomarker in clinical trials of treatments intended to slow the progression of vascular calcification. Literature data suggest that non-calcium-containing phosphate binders can influence T50 in chronic dialysed patients. However, it is not clear whether similar interventions are effective in patients at earlier stages of chronic kidney disease (CKD).

Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease.

Background: We sought to comprehensively describe drug-related components associated with acute kidney injury (AKI) in patients with chronic kidney disease (CKD), describing the incidence of drug-related AKI, the proportion of preventable AKI, identified the various drugs potentially associated with it, explored the risk factors, and assessed the 1-year incidences of the recurrence of drug-related AKI, kidney failure, and death.

Methods: CKD-REIN is a French national prospective cohort of 3033 nephrology outpatients with a confirmed diagnosis of CKD (eGFR <60 ml/min/1.73 m²).

Clinical and magnetic resonance imaging findings of presumed limber tail syndrome in a cat.

A 4-year-old neutered female domestic shorthair indoor cat was presented with sudden onset of abnormal and painful tail-carriage. The tail was held horizontally for the first centimeters from the base and a flaccid paralysis was evident more distally. Magnetic resonance imaging of the lumbosacral spine and tail revealed a lesion located in the right and muscles along the 1st coccygeal vertebrae.

Bibliometric Analysis of the Composition of Landmark Cerebral Venous Sinus Thrombosis Research.

Background: Cerebral Venous Sinus Thrombosis (CVST) is a relatively rare type of stroke, accounting for less than 3% of all stroke cases, and is associated with significant morbidity and mortality in young females. However, when promptly diagnosed and treated, it can have favorable outcomes. Several knowledge gaps remain regarding pathophysiology, diagnosis, and management of CVST, so critical assessment of past and present research could help close these gaps or establish targeted future research goals.

How Can Overlooking Social Interactions, Space Familiarity or Other "Invisible Landscapes" Shaping Animal Movement Bias Habitat Selection Estimations and Species Distribution Predictions?

Species' future distributions are commonly predicted using models that link the likelihood of occurrence of individuals to the environment. Although animals' movements are influenced by physical and non-physical landscapes, for example related to individual experiences such as space familiarity or previous encounters with conspecifics, species distribution models developed from observations of unknown individuals cannot integrate these latter variables, turning them into 'invisible landscapes'. In this theoretical study, we address how overlooking 'invisible landscapes' impacts the estimation of habitat selection and thereby the projection of future distributions.

A Riemannian multimodal representation to classify parkinsonism-related patterns from noninvasive observations of gait and eye movements.

Parkinson's disease is a neurodegenerative disorder principally manifested as motor disabilities. In clinical practice, diagnostic rating scales are available for broadly measuring, classifying, and characterizing the disease progression. Nonetheless, these scales depend on the specialist's expertise, introducing a high degree of subjectivity.

Cranial osteology and neuroanatomy of the late Permian reptile and implications for early reptile evolution.

Millerettidae are a group of superficially lizard-like Permian stem reptiles originally hypothesized as relevant to the ancestry of the reptile crown group, and particularly to lepidosaurs and archosaurs. Since the advent of cladistics, millerettids have typically been considered to be more distant relatives of crown reptiles as the earliest-diverging parareptiles and therefore outside of 'Eureptilia'. Despite this cladistic consensus, some conspicuous features of millerettid anatomy invite reconsideration of their relationships.

Unexpected stability of the iron(II) complex by an asymmetrical Schiff base from Fe(III): structure, magnetic and Mössbauer investigations.

The asymmetric Schiff base prepared from ethylenediamine and pyridine-2-carboxaldehyde reacts with Fe(ClO)·6HO to form the Fe(II) complex [FeL](ClO) with L = ,-diethyl-'-(pyridin-2-yl)methylene)ethane-1,2-diamine, where the Fe(III) starting material has been unexpectedly reduced to Fe(II). This complex was characterized by elemental analysis, infrared spectra, single crystal and powder X-ray diffraction measurements, variable temperature DC magnetic measurement and room temperature Mössbauer spectroscopy. The asymmetric ligand L coordinates in a tridentate fashion through its pyridyl, azomethine and amino nitrogen atoms, generating a distorted octahedral geometry around the central metal ion.

The Mason-Loop for Single-Row Full-Thickness Rotator Cuff Repair.

Rotator cuff injuries are common and can lead to pain and functional limitation of the shoulder, sometimes requiring surgical procedure. We describe a surgical approach combining the modified Mason-Allen and lasso-loop techniques for the repair of rotator cuff injuries. This hybrid approach brings the 2 advantages of each suture: the compression provided by the loop and the large quantity of tendons caught by the Mason-Allen in a single repair row.

Surgical management of atrioesophageal fistula after catheter ablation of atrial fibrillation: A French nationwide study.

Objective: The study objective was to assess the efficacity of different surgical strategies for atrioesophageal fistula after catheter ablation of atrial fibrillation.

Methods: Between January 2010 and April 2023, all patients with a diagnosis of atrioesophageal fistula or pericardo-esophageal fistula after catheter ablation of atrial fibrillation were analyzed retrospectively from the French database EPITHOR. Patients without surgical management were excluded.

Fifteen-year experience of direct bridge with venoarterial extracorporeal membrane oxygenation to heart transplantation.

Objective: The study objective was to evaluate outcomes of patients directly bridged with venoarterial extracorporeal membrane oxygenation to heart transplantation.

Methods: A single-center retrospective study was performed on 1152 adult patients undergoing isolated cardiac transplantation between January 2007 and December 2021. Among these, patients bridged with an extracorporeal membrane oxygenation to transplantation (extracorporeal membrane oxygenation group, n = 317) were compared with standard cohorts of patients (no extracorporeal membrane oxygenation group, n = 835).

Multimodal analgesia with parasternal plane block protocol within an enhanced recovery after cardiac surgery program decreases opioid use.

Objective: This study investigated the efficacy of a multimodal analgesia (MMA) with an opioid-sparing strategy, incorporating a parasternal plane block (PPB) within a systematic standardized Enhanced Recovery After Surgery (ERAS) program for patients undergoing elective cardiac surgery.

Methods: From 2015 to 2021, 3153 patients underwent elective coronary artery bypass grafting and/or valve procedures. Patients were dichotomized by the presence or absence of an ERAS program including a perioperative MMA with an opioid-sparing approach and PPB protocols.

Too Far From Relatives? Impact of the Genetic Distance on the Success of Exon Capture in Phylogenomics.

The exon capture approach allows for sequencing a large number of loci to reconstruct phylogenetic relationships at varying taxonomic levels. In order to efficiently recover the targeted loci, the probes designed to capture the exons need to be genetically sufficiently similar to bind to the DNA, with a proposed limit of 10% of divergence. However, this threshold has never been tested with a specific protocol.

Breaking the deep-red light absorption barrier of iridium(III)-based photosensitizers.

Activating photosensitizers with long-wavelength excitation is an important parameter for effective photodynamic therapy due to the minimal toxicity of this light, its superior tissue penetration, and excellent spatial resolution. Unfortunately, most Ir(III) complexes suffer from limited absorption within the phototherapeutic window, rendering them ineffective against deep-seated and/or large tumors, which poses a significant barrier to their clinical application. To address this issue, several efforts have been recently made to shift the absorption of Ir(III) photosensitizers to the deep-red/near-infrared region by using different strategies: functionalization with organic fluorophores, including porphyrinoid compounds, and ligand design π-extension and donor-acceptor interactions.

Insights into the structural complexity and local disorder of crystalline AsTe from semi-automated first-principles modelling.

A semi-automated workflow relying on atomic-scale modelling is introduced to explore and understand the yet-unsolved structure of the crystalline AsTe material, recently obtained from crystallization of the parent AsTe glass, which shows promising properties for thermoelectric applications. The seemingly complex crystal structure of AsTe is investigated with density functional theory, from the stand point of As/Te disorder, in a structural template derived from elemental-Te (Te), following experimental findings from combined X-ray total scattering and diffraction. Our workflow includes a combinatorial structure generation step followed by successive structure selection and relaxation steps with progressively-increasing accuracy levels and a multi-criterion evaluation procedure.

Virtual reality in clinical evaluation of Unilateral Spatial Neglect, anatomy of current trends: A scoping review.

Background: Virtual technologies (VR) could respond to several challenges in Unilateral Spatial Neglect (USN) assessment, particularly the lack of sensitivity and ecological validity of traditional paper-and-pencil tests. A scoping review was conducted to explore current trends in this area.

Methods: PubMed, EMBASE, PsycINFO, Web of Science, IEEE, ACM, and the Cochrane Library were systematically searched for VR USN assessment.

An Alternative Hypothesis on Enhanced Deep Supercooling of Water: Nucleator Inhibition via Bicarbonate Adsorption.

Supercooling allows for retarding water crystallization toward negative Celsius temperatures. Previous findings of CO molecules shifting into bicarbonate species upon freezing, the latter which naturally adsorb on hydrophobic interfaces, are put in perspective here to interpret earlier published data. Since it has been shown that ice nucleation is unlikely on negatively charged surfaces, I propose that bicarbonates adsorb on most solid particles present in water that act as nucleators, thus retarding freezing and enhancing supercooling.

Graph-Based Deep Learning Models for Thermodynamic Property Prediction: The Interplay between Target Definition, Data Distribution, Featurization, and Model Architecture.

In this contribution, we examine the interplay between target definition, data distribution, featurization approaches, and model architectures on graph-based deep learning models for thermodynamic property prediction. Through consideration of five curated data sets, exhibiting diversity in elemental composition, multiplicity, charge state, and size, we examine the impact of each of these factors on model accuracy. We observe that target definition, i.

Measuring trends in extinction risk: a review of two decades of development and application of the Red List Index.

The Red List Index (RLI) is an indicator of the average extinction risk of groups of species and reflects trends in this through time. It is calculated from the number of species in each category on the IUCN Red List of Threatened Species, with trends influenced by the number moving between categories when reassessed owing to genuine improvement or deterioration in status. The global RLI is aggregated across multiple taxonomic groups and can be disaggregated to show trends for subsets of species (e.