1,087,203 results match your criteria: "France; Paris-Saclay université 16[Affiliation]"
Scand J Med Sci Sports
March 2025
Univ Savoie Mont Blanc, Interuniversity Laboratory of Human Movement Sciences, Chambéry, EA, France.
We investigate the contribution of isometric rate of torque development (RTD) and maximal voluntary torque (MVT) to the dynamic force production capacities of knee extensors obtained from the torque-velocity (TV) relationship, that is, the theoretical maximal velocity (V), torque (T), and maximal power (P). Single-leg knee extensors were tested in 64 young adults (31 females). RTD and root mean square (RMS) of electromyographic signals from the knee extensors were recorded during isometric and incremental load dynamic (nonisokinetic) contractions.
View Article and Find Full Text PDFRev Mal Respir
March 2025
Service de pneumologie, CHU de la Guadeloupe, 97110 Pointe-à-Pitre, France.
Granulomatosis with polyangiitis (GPA) was diagnosed in a 65-year-old Afro-Caribbean patient presenting initially with hearing loss and a pseudo-tumoral 6cm lung mass. Lung biopsy findings favored the diagnosis of vasculitis. Rapid disease progression was noted with near-complete deafness and lack of speech, severe renal failure necessitating dialysis, and persisting disturbance of consciousness following tonic-clonic seizures due to posterior reversible encephalopathy syndrome (PRES).
View Article and Find Full Text PDFAnn Phys Rehabil Med
March 2025
Service de Médecine Physique et de Réadaptation, Clermont-Ferrand, INRAE, Université Clermont Auvergne, France.
Clin Ther
March 2025
Nutrition Department, Hopital Européen Georges Pompidou, AP-HP, Paris Cité University, Paris, France; CIC1418, Hopital Européen Georges Pompidou, AP-HP, Paris Cité University, Paris, France.
Aims: The prevalence of type 2 diabetes has increased in France over the past decade, with changes in available pharmacologic treatments. This study aimed to assess trends in the sales of antidiabetic drugs in France over the last decade.
Methods: This retrospective cohort study used data from French national health insurance databases.
Br J Anaesth
March 2025
LIM 62 - Pain Center, Department of Neurology, São Paulo, Brazil; Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, University of Aalborg, Gistrup, Denmark. Electronic address:
Background: Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia.
Methods: Women aged ≥18 yr with fibromyalgia refractory to best available treatment were enrolled in Brazil, France, and Japan, and randomised to 10 Hz motor cortex (M1) rTMS, 3000 pulses day, or sham stimulation.
Eur Ann Otorhinolaryngol Head Neck Dis
March 2025
Service de chirurgie digestive, CHU Saint-Etienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
Objective: To report a case of duodenal metastasis of laryngeal squamous cell carcinoma revealed by acute intestinal obstruction.
Case Report: A 55-year-old male was initially treated for cT4N1M0 laryngeal squamous cell carcinoma, with total laryngectomy, bilateral neck dissection, total thyroidectomy and pectoralis major flap. Subsequently, he received radiotherapy and chemotherapy.
Bull Cancer
March 2025
Unité U9192, université de Montpellier, 34960 Montpellier, France; CHU de Montpellier, 34090 Montpellier, France.
Bull Cancer
March 2025
Service de gynécologie-obstétrique, centre hospitalier universitaire Sud-Réunion, BP350, 97448 Saint-Pierre cedex, France; Centre d'études périnatales Océan Indien, centre hospitalier universitaire Sud-Réunion, BP350, 97448 Saint-Pierre cedex, France; Unité de formation et de recherche santé de La Réunion, faculté de médecine, 97490 Saint Denis, France.
Introduction: In Réunion Island, the standardized mortality rate for cervical cancer is 4.8/100,000 women, while it is 2.2/100,000 in France.
View Article and Find Full Text PDFClin Lymphoma Myeloma Leuk
February 2025
Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
Background: In the phase 3 CANDOR trial (NCT03158688), daratumumab added to carfilzomib and dexamethasone (KdD) significantly prolonged progression-free survival relative to carfilzomib and dexamethasone (Kd) alone in previously treated patients with relapsed/refractory multiple myeloma (RRMM).
Materials And Methods: We present a post hoc analysis of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-item module (EORTC QLQ-C30) and EORTC QLQ Myeloma 20-item module (EORTC QLQ-MY20) patient-reported outcome (PRO) measures from the CANDOR trial.
Results: Median (range) duration of observation for PROs was 18.
Food Microbiol
August 2025
Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France. Electronic address:
Although isolating microorganisms from food microbiota may appear less challenging than from the gut or environmental sources, recovering all representative species from food remains a difficult task. Here, we showed by metagenomic analysis that several abundant species had escaped isolation in a previous study of ten cheeses, including several previously uncharacterized species. This highlights the ongoing challenge of achieving a comprehensive recovery of microbes from food.
View Article and Find Full Text PDFGenes Dev
March 2025
Normal and Pathological Development of Melanocytes, U1021, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Sciences and Letters (PSL) Research University, Institut Curie, 91405 Orsay Cedex, France; UMR 3347, Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, 91405 Orsay Cedex, France
Metastasis and therapy resistance drive cancer-related deaths, with melanoma cells exhibiting phenotypic plasticity that allows them to switch between proliferative and invasive states. In this issue of , Chocarro-Calvo and colleagues (doi:10.1101/gad.
View Article and Find Full Text PDFJ Immunother Cancer
March 2025
Team "Biologie des Infections à Polyomavirus", UMR1282, Tours, France.
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its antitumor properties in preclinical models of the rare and aggressive skin cancer Merkel cell carcinoma (MCC).The present study aims to further optimize Adcitmer to overcome the therapeutic limitations observed with previously evaluated CD56-targeting ADCs, which were partially related to toxic effects on leukocytes.
View Article and Find Full Text PDFJ Invertebr Pathol
March 2025
Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Montpellier University, IRD, CNRS, Montpellier, France. Electronic address:
Aedes albopictus and Aedes aegypti are the main vectors of emerging arboviruses, such as dengue, chikungunya and Zika viruses. Entomopathogenic viruses, such as densoviruses, might represent more environmentally friendly control methods. Densoviruses are single-stranded DNA viruses belonging to the Parvoviridae family and three species are known to infect mosquitoes: Protoambidensovirus dipteran, Brevihamaparvovirus dipteran 1, and Brevihamaparvovirus dipteran 2.
View Article and Find Full Text PDFEnviron Pollut
March 2025
Department of Earth Sciences & Research Center on Natural Resources, Health and the Environment. University of Huelva, Campus "El Carmen", E-21071, Huelva, Spain.
The Estuary of Huelva in southwestern Spain is severely impacted by acid mine drainage (AMD), primarily due to extensive mining activities in the Iberian Pyrite Belt (IPB), and to a lesser extent by industrial sources. The AMD has led to significant contamination of the Odiel and Tinto rivers, which carry high loads of metals into the estuary. In May 2017, an accidental spill occurred at La Zarza mine, releasing approximately 270,000 m of acidic water contained in a pit lake.
View Article and Find Full Text PDFJ Control Release
March 2025
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Spain. Electronic address:
Glioblastoma (GB) is a malignant brain tumor with low survival rates and a high recurrence ratio due to limited therapeutic arsenal. The repurposed drug disulfiram (DSF), approved for alcoholism treatment, shows promising anticancer and antimicrobial activity, but its poor biopharmaceutical profile hinders its clinical use. This work aimed to develop DSF-loaded silk fibroin (SF) electrospun fibers for controlled release in the postsurgical resection cavity.
View Article and Find Full Text PDFJ Thromb Haemost
March 2025
Department of Medicine, University of Calgary, AB, Canada. Electronic address:
Background: There is a need to better understand barriers to recruitment and participation in randomized controlled trials (RCTs) evaluating postpartum thromboprophylaxis, as previous trials had low recruitment and were not feasible. In a qualitative interview study of the pilot PARTUM trial (a feasibility trial of low-dose aspirin versus placebo for six weeks postpartum), we explored the facilitators and barriers to trial involvement.
Methods: Patients eligible for the pilot PARTUM trial, including those who declined joining the trial, were invited to participate in a qualitative study.
Anaesth Crit Care Pain Med
March 2025
UR-UM103 IMAGINE, University of Montpellier, Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nimes University Hospital, Montpellier, France; Clinical Research and Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain; Centro de Investigacion Biomedica en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Medicine Department, Universitat Internacional de Catalunya, Barcelona, Spain. Electronic address:
Introduction: The present study aimed at assessing gender balance in the Editorial roles of Critical Care Medicine (CCM) journals.
Methods: A cross-sectional survey was performed for assessing the gender distribution in Editorial Board (EB) roles of journals indexed under Clarivate Journal Citation Reports and Scimago Journal & Country Rank. The influences of editorial roles and of journal rank (separated in quartiles) on gender balance were also assessed.
Anaesth Crit Care Pain Med
March 2025
Service d'Anesthésie-Réanimation Pédiatrique, Hôpital Timone 2, APHM, Aix Marseille Univ, France; Service d'Anesthésie-Réanimation Pédiatrique, Hôpital Timone 2, APHM, Espace Ethique Méditerranéen, UMR ADES 7268. Aix Marseille Univ. France. Electronic address:
Introduction: Intraoperative hypotension (IOH) is a common complication in the operating room. Vasopressors are crucial in managing IOH but data on their use in children, particularly norepinephrine (NE), are limited. This study aimed to explore NE use in IOH management among French pediatric anesthesiologists.
View Article and Find Full Text PDFAnaesth Crit Care Pain Med
March 2025
Service de Médecine Intensive et Réanimation Brabois, CHRU Nancy, Pôle Cardio-Médico-Chirurgical, Université de Lorraine, 54511 Vandœuvre-lès-Nancy, France; INSERM U1116, Faculté de Médecine, Vandœuvre-lès-Nancy, France; Université de Lorraine, Nancy, France.
Introduction: Bedside tools have been developed to assess inspiratory muscle function and inspiratory drive for patients under invasive mechanical ventilation. Occlusion maneuvers are currently considered but their pitfalls remain underexplored. We aimed to assess the impact of respiratory system compliance and resistance on P0.
View Article and Find Full Text PDFAnaesth Crit Care Pain Med
March 2025
Nantes Université, CHU Nantes, Service d'Anesthésie Réanimation Chirurgicale, INSERM CIC 0004 Immunologie et Infectiologie, Nantes, France. Electronic address:
Background: We explored the risk factors of post-induction hypotension during rapid sequence intubation.
Methods: We performed an ancillary analysis of a multicenter randomized clinical trial comparing remifentanil versus neuromuscular blockers associated with hypnotic in patients at risk for aspiration who underwent tracheal intubation in the operating room. The primary outcome was post-induction hypotension, defined as an episode of hypotension (MBP ≤ 55 mmHg and/or SBP ≤ 80 mmHg) within 10 minutes after anesthetic induction.
J Vasc Interv Radiol
March 2025
CardioVascular and Interventional Radiology.
Osteoarthritis Cartilage
March 2025
Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Research Center Saint Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France. Electronic address:
Objective: To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).
Methods: Serum concentrations of four intestinal permeability biomarkers (LPS binding protein (LBP), FABP2, sCD14, Zonulin-related proteins (ZRP) along with calprotectin, and high-sensitivity C-Reactive Protein (hs-CRP) were assessed in 410 patients of the DIGICOD cohort. The study compared patients with EHOA (≥ 2 erosion in Verbruggen score N=140) to those without EHOA (N=270) using the Mann-Whitney U test.
Neuroimage
March 2025
Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL UMR5292, U1028, Bron, France.
Body odors play an important role in nonverbal communication, and particularly in one's attractiveness. However, their central processing remains underexplored, especially as a function of gender. This study aims at identifying the neural networks involved in the processing of two allegedly sex-specific human body odor compounds (3-hydroxy-3-methylhexanoic acid, HMHA, and 3-methyl-3-sulfanylhexan-1-ol, MSH).
View Article and Find Full Text PDFAm J Kidney Dis
March 2025
Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. Electronic address:
Heart Rhythm
March 2025
Cardiology Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France; Université Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut Pascal, F-63000 Clermont-Ferrand, France.
Background: Atrial resetting can be used for discerning the anterograde pathway in slow/fast atrioventricular nodal reentrant tachycardia (AVNRT).
Objectives: Assess the prevalence of right inferior extension (RIE) and left extension (LE) and the potential impact on the ablation approach.
Methods: During the electrophysiological study of patients with slow/fast AVNRT, a decremental supraventricular extrastimulus was delivered within the vulnerability window of the tachycardia cycle at two distinct sites: the infero-paraseptal area of the Koch triangle (near the RIE) and the proximal few centimeters of the coronary sinus (near the LE).