The Rate of Torque Development as a Determinant of the Torque-Velocity Relationship.

We investigate the contribution of isometric rate of torque development (RTD) and maximal voluntary torque (MVT) to the dynamic force production capacities of knee extensors obtained from the torque-velocity (TV) relationship, that is, the theoretical maximal velocity (V), torque (T), and maximal power (P). Single-leg knee extensors were tested in 64 young adults (31 females). RTD and root mean square (RMS) of electromyographic signals from the knee extensors were recorded during isometric and incremental load dynamic (nonisokinetic) contractions.

[Hearing loss leading to the diagnosis of granulomatosis with polyangiitis: An unusual case in the Afro-Caribbean population].

Granulomatosis with polyangiitis (GPA) was diagnosed in a 65-year-old Afro-Caribbean patient presenting initially with hearing loss and a pseudo-tumoral 6cm lung mass. Lung biopsy findings favored the diagnosis of vasculitis. Rapid disease progression was noted with near-complete deafness and lack of speech, severe renal failure necessitating dialysis, and persisting disturbance of consciousness following tonic-clonic seizures due to posterior reversible encephalopathy syndrome (PRES).

Antidiabetic Drugs Consumption in France Over a Decade: An Observational Study.

Aims: The prevalence of type 2 diabetes has increased in France over the past decade, with changes in available pharmacologic treatments. This study aimed to assess trends in the sales of antidiabetic drugs in France over the last decade.

Methods: This retrospective cohort study used data from French national health insurance databases.

Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial.

Background: Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia.

Methods: Women aged ≥18 yr with fibromyalgia refractory to best available treatment were enrolled in Brazil, France, and Japan, and randomised to 10 Hz motor cortex (M1) rTMS, 3000 pulses day, or sham stimulation.

Acute intestinal obstruction due to duodenal metastasis of laryngeal squamous cell carcinoma: A CARE case report.

Objective: To report a case of duodenal metastasis of laryngeal squamous cell carcinoma revealed by acute intestinal obstruction.

Case Report: A 55-year-old male was initially treated for cT4N1M0 laryngeal squamous cell carcinoma, with total laryngectomy, bilateral neck dissection, total thyroidectomy and pectoralis major flap. Subsequently, he received radiotherapy and chemotherapy.

[Cancer of the cervix management in Reunion Island from 2016 to 2020].

Introduction: In Réunion Island, the standardized mortality rate for cervical cancer is 4.8/100,000 women, while it is 2.2/100,000 in France.

Health-Related Quality of Life in Patients With Relapsed/Refractory Multiple Myeloma Treated With Carfilzomib, Dexamethasone, and Daratumumab Versus Carfilzomib and Dexamethasone: An Analysis of Patient-Reported Outcomes From the Phase 3 CANDOR Trial.

Background: In the phase 3 CANDOR trial (NCT03158688), daratumumab added to carfilzomib and dexamethasone (KdD) significantly prolonged progression-free survival relative to carfilzomib and dexamethasone (Kd) alone in previously treated patients with relapsed/refractory multiple myeloma (RRMM).

Materials And Methods: We present a post hoc analysis of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-item module (EORTC QLQ-C30) and EORTC QLQ Myeloma 20-item module (EORTC QLQ-MY20) patient-reported outcome (PRO) measures from the CANDOR trial.

Results: Median (range) duration of observation for PROs was 18.

Metagenomic driven isolation of poorly culturable species in food.

Although isolating microorganisms from food microbiota may appear less challenging than from the gut or environmental sources, recovering all representative species from food remains a difficult task. Here, we showed by metagenomic analysis that several abundant species had escaped isolation in a previous study of ten cheeses, including several previously uncharacterized species. This highlights the ongoing challenge of achieving a comprehensive recovery of microbes from food.

From fat to fear: how lipid powers cancer spread.

Metastasis and therapy resistance drive cancer-related deaths, with melanoma cells exhibiting phenotypic plasticity that allows them to switch between proliferative and invasive states. In this issue of , Chocarro-Calvo and colleagues (doi:10.1101/gad.

Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers.

The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its antitumor properties in preclinical models of the rare and aggressive skin cancer Merkel cell carcinoma (MCC).The present study aims to further optimize Adcitmer to overcome the therapeutic limitations observed with previously evaluated CD56-targeting ADCs, which were partially related to toxic effects on leukocytes.

Controlling Aedes mosquitoes using densovirus-based biolarvicides: Current status and prospects.

Aedes albopictus and Aedes aegypti are the main vectors of emerging arboviruses, such as dengue, chikungunya and Zika viruses. Entomopathogenic viruses, such as densoviruses, might represent more environmentally friendly control methods. Densoviruses are single-stranded DNA viruses belonging to the Parvoviridae family and three species are known to infect mosquitoes: Protoambidensovirus dipteran, Brevihamaparvovirus dipteran 1, and Brevihamaparvovirus dipteran 2.

Tracing acid mine drainage from an accidental spill on the Estuary of Huelva (SW Spain).

The Estuary of Huelva in southwestern Spain is severely impacted by acid mine drainage (AMD), primarily due to extensive mining activities in the Iberian Pyrite Belt (IPB), and to a lesser extent by industrial sources. The AMD has led to significant contamination of the Odiel and Tinto rivers, which carry high loads of metals into the estuary. In May 2017, an accidental spill occurred at La Zarza mine, releasing approximately 270,000 m of acidic water contained in a pit lake.

Disulfiram-loaded electrospun fibers with antimicrobial and antitumoral properties for glioblastoma treatment.

Glioblastoma (GB) is a malignant brain tumor with low survival rates and a high recurrence ratio due to limited therapeutic arsenal. The repurposed drug disulfiram (DSF), approved for alcoholism treatment, shows promising anticancer and antimicrobial activity, but its poor biopharmaceutical profile hinders its clinical use. This work aimed to develop DSF-loaded silk fibroin (SF) electrospun fibers for controlled release in the postsurgical resection cavity.

Patient and healthcare providers' perspectives on participation in a postpartum pilot trial of venous thromboembolism prophylaxis: A qualitative study.

Background: There is a need to better understand barriers to recruitment and participation in randomized controlled trials (RCTs) evaluating postpartum thromboprophylaxis, as previous trials had low recruitment and were not feasible. In a qualitative interview study of the pilot PARTUM trial (a feasibility trial of low-dose aspirin versus placebo for six weeks postpartum), we explored the facilitators and barriers to trial involvement.

Methods: Patients eligible for the pilot PARTUM trial, including those who declined joining the trial, were invited to participate in a qualitative study.

Gender imbalance in critical care medicine journals.

Introduction: The present study aimed at assessing gender balance in the Editorial roles of Critical Care Medicine (CCM) journals.

Methods: A cross-sectional survey was performed for assessing the gender distribution in Editorial Board (EB) roles of journals indexed under Clarivate Journal Citation Reports and Scimago Journal & Country Rank. The influences of editorial roles and of journal rank (separated in quartiles) on gender balance were also assessed.

Use of norepinephrine for intraoperative hypotension in pediatric anesthesia: a French survey.

Introduction: Intraoperative hypotension (IOH) is a common complication in the operating room. Vasopressors are crucial in managing IOH but data on their use in children, particularly norepinephrine (NE), are limited. This study aimed to explore NE use in IOH management among French pediatric anesthesiologists.

Lung resistance - but not compliance - impairs P0.1 and maximal inspiratory pressure measurements.

Introduction: Bedside tools have been developed to assess inspiratory muscle function and inspiratory drive for patients under invasive mechanical ventilation. Occlusion maneuvers are currently considered but their pitfalls remain underexplored. We aimed to assess the impact of respiratory system compliance and resistance on P0.

Post-induction hypotension during rapid sequence intubation in the operating room: a post hoc analysis of the randomized controlled REMICRUSH trial.

Background: We explored the risk factors of post-induction hypotension during rapid sequence intubation.

Methods: We performed an ancillary analysis of a multicenter randomized clinical trial comparing remifentanil versus neuromuscular blockers associated with hypnotic in patients at risk for aspiration who underwent tracheal intubation in the operating room. The primary outcome was post-induction hypotension, defined as an episode of hypotension (MBP ≤ 55 mmHg and/or SBP ≤ 80 mmHg) within 10 minutes after anesthetic induction.

Serum Intestinal Permeability Biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort.

Objective: To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).

Methods: Serum concentrations of four intestinal permeability biomarkers (LPS binding protein (LBP), FABP2, sCD14, Zonulin-related proteins (ZRP) along with calprotectin, and high-sensitivity C-Reactive Protein (hs-CRP) were assessed in 410 patients of the DIGICOD cohort. The study compared patients with EHOA (≥ 2 erosion in Verbruggen score N=140) to those without EHOA (N=270) using the Mann-Whitney U test.

Neural representation of allegedly sex-specific human body odor compounds.

Body odors play an important role in nonverbal communication, and particularly in one's attractiveness. However, their central processing remains underexplored, especially as a function of gender. This study aims at identifying the neural networks involved in the processing of two allegedly sex-specific human body odor compounds (3-hydroxy-3-methylhexanoic acid, HMHA, and 3-methyl-3-sulfanylhexan-1-ol, MSH).

Slow/Fast Atrioventricular Nodal Reentrant Tachycardia Catheter Ablation Guided by Atrial Resetting: The New Insight.

Background: Atrial resetting can be used for discerning the anterograde pathway in slow/fast atrioventricular nodal reentrant tachycardia (AVNRT).

Objectives: Assess the prevalence of right inferior extension (RIE) and left extension (LE) and the potential impact on the ablation approach.

Methods: During the electrophysiological study of patients with slow/fast AVNRT, a decremental supraventricular extrastimulus was delivered within the vulnerability window of the tachycardia cycle at two distinct sites: the infero-paraseptal area of the Koch triangle (near the RIE) and the proximal few centimeters of the coronary sinus (near the LE).