Transcriptomic and Biochemical analysis of Procambarus clarkii upon exposure to Pesticides: Population-Specific responses as a sign of pollutant resistance?

The effects that anthropogenic stressors may have on modulating species' plasticity has been relatively unexplored; however, it represents a scientific frontier that may offer insights into their ability to colonize new habitats. To explore the advantage that inhabiting polluted environments may offer to invasive species, we selected the crayfish Procambarus clarkii, a species that can colonize and thrive in a wide range of aquatic environments, including heavily polluted ones. Here, we studied the molecular and physiological responses of crayfish when experimentally exposed to a pesticide mix of azoxystrobin and oxadiazon at sublethal concentrations.

Historical biogeography of the Mugil cephalus species complex and its rapid global colonization.

Our understanding of speciation processes in marine environments remains very limited and the role of different reproductive barriers are still debated. While physical barriers were considered important drivers causing reproductive isolation, recent studies highlight the importance of climatic and hydrological changes creating unsuitable habitat conditions as factors promoting population isolation. Although speciation in marine fish has been investigated from different perspectives, these studies often have a limited geographical extant.

PREDICTIVE MODELS OF CLINICAL OUTCOME OF ENDOVASCULAR TREATMENT FOR ANTERIOR CIRCULATION STROKE USING MACHINE LEARNING.

Background And Purpose: Mechanical Thrombectomy (MT) has recently become the standard of care for anterior circulation stroke with large vessel occlusion, but predictive factors of successful MT are still not clearly defined. To tailor treatment individually for each patient, the aim of this study was to evaluate the performances of Machine Learning to predict clinical outcome (mRS) at 3 months after MT.

Material And Methods: From the ETIS French prospective multicenter registry, data from patients who underwent MT for anterior circulation stroke with large vessel occlusion between January 2018 and December 2020 were extracted.

[Impact of the European Medical Device Regulation on the availability of medical devices: Scoping review and two-year analysis on the risk for patients in the cardiovascular field].

The implementation of the Medical Devices Regulation (MDR) 2017/745/EU leaves manufacturers facing new requirements to certify their medical devices (MDs). Our objective is to accurately assess the impact of regulation on the availability of cardiovascular MDs in healthcare facilities. High-risk cardiovascular MDs appear to be heavily impacted by the regulation, with reclassification leading to mandatory clinical investigations.

Sibling similarity in telomere length in Adélie penguin chicks.

Early life telomere length is thought to influence and predict an individual's fitness. It has been shown to vary significantly in early life compared to adulthood. Investigating the factors influencing telomere length in young individuals is therefore of particular interest, especially as the relative importance of heredity compared to post-natal conditions remains largely uncertain.

Bifunctional chimeras of myeloperoxidase and glucose oxidase. Antimicrobial, topological and enzymatic properties.

Enhancing the local substrate concentration is a crucial strategy in nature for facilitating the proximity of two enzymes. The substrate of the first enzyme is transformed into a by-product that travels to the active site of the second enzyme without external diffusion, then transformed into a product and eventually expelled from the complex. In an effort to optimize the antimicrobial properties of myeloperoxidase from Rhodopirellula baltica (RbMPO), we created a library of fused chimeras between a glucose oxidase (GOx) and RbMPO so that HO could be continuously perfused in the vicinity RbMPO, enabling the production of HOCl or HOSCN, well-known antimicrobial agents.

Reconstruction of large thermal burn areas by hair transplantation.

Introduction: Alopecia resulting from burns represents a surgical challenge, with significant functional, physical, psychological and social consequences. Current management is based on various techniques. However, the results are most often very disappointing.

Cold and longevity: Can cold exposure counteract aging?

Aging is a multifaceted biological process characterized by a progressive decline in physiological functions and heightened vulnerability to diseases, shaped by genetic, environmental, and lifestyle factors. Among these, cold exposure has garnered interest for its potential anti-aging benefits. This review examines the impact of cold exposure on aging, focusing on key physiological processes such as inflammation, oxidative stress, metabolic regulation, and cardiovascular health.

Epidemiology and outcomes associated with MBL-producing Enterobacterales: A systematic literature review.

The increasing prevalence of infections due to metallo-β-lactamase (MBL)-producing Enterobacterales poses a serious concern given the limited treatment options available. This systematic literature review (SLR) describes the molecular epidemiology, geographical distribution, and clinical outcomes of such infections. Systematic searches of literature published between January 2013 and May 2023 were performed, and 39 studies with an MBL sample size of ≥25 isolates and ≥2 well-defined outcomes were eligible.

P2 purinergic receptors at the heart of pathological left ventricular remodeling following acute myocardial infarction.

Pathological left ventricular remodeling is a complex process following an acute myocardial infarction, leading to architectural disorganization of the cardiac tissue. This phenomenon is characterized by sterile inflammation and the exaggerated development of fibrotic tissue, which is non-contractile and poorly conductive, responsible for organ dysfunction and heart failure. At present, specific therapies are lacking for both prevention and treatment of this condition, and no biomarkers are currently validated to identify at-risk patients.

Floating photovoltaics strongly reduce water temperature: A whole-lake experiment.

Floating photovoltaics (FPVs), solar panels installed on floating structures in freshwater ecosystems such as lakes, represent a growing renewable technology aimed at decarbonizing the energy sector. However, robust empirical assessments of its environmental effects are still lacking. We used a Before-After-Control-Impact design replicated at the ecosystem level (n = 6 lakes: three lakes with FPV compared to three non-FPV lakes) to determine the global effects of FPV on water temperature over three years and allowing to isolate FPV effects from natural variability.

Rhythmic EEG patterns: The oldest idea in the EEG world, but without an obvious definition.

The word "rhythmic" was quickly introduced in the vocabulary of the electroencephalographers with the discovery of the alpha rhythm and typical discharges of spike-and-waves at 3 Hz in childhood absence epilepsy, but without any definition until recently. In its last revision (2017), the International Federation of Clinical Neurophysiology proposed a specific definition. The word "rhythmic" is "applied to regular waves occurring at a constant period and of relatively uniform morphology.

Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts.

Neglecting proper skin care and repeated exposure to ultraviolet (UV) radiation can have serious consequences, including skin burns, photoaging and even the development of skin cancer. UV radiation-induced damage is mediated by highly unstable and reactive molecules, named reactive oxygen species (ROS). To counteract ROS, the skin has an endogenous antioxidant system.

Dyadic adjustment of persons with albinism and their significant other: A Bayesian mediation model of the Actor-Partner Interdependence (APIMeM).

Background: Limited standardized empirical research exists in France on the psychosocial implications of albinism, prompting an investigation into how affected persons adapt to their disabilities. Recent advancements in health psychology have led researchers to adopt a systemic approach, considering disabilities and involving close relatives in the adaptation process. The aim of this study was to explore the mediating role of dyadic coping within family dyads, where one is a person with albinism (PWA) and the other is a close relative.

Crisis management in the operating room: A systematic review of simulation training to develop non-technical skills.

Aims: Crises in the operating room, often resulting from human factors, endangers patient safety. Simulation-based training to develop non-technical skills shows promise in managing these crises. This review examines the simulation techniques, targeted healthcare professionals, non-technical skills, crisis scenarios, and evaluation metrics used in operating room crisis management training.

Ferrous iron oxidation in the presence of antimonate at neutral pH: Mutual effects on iron mineral products and antimony sequestration.

Antimony is a priority pollutant, whose mobility in redox-dynamic environments may be controlled by interactions with Fe(III) hydroxide minerals that form via Fe(II) oxidation. In this study, we examined the Fe(III) hydroxide precipitates and associated mechanisms of Sb(V) sequestration that result from Fe(II) oxidation in the presence of Sb(V) under neutral pH conditions. To achieve this aim, oxidation experiments were carried out in O-saturated, Fe(II)-bearing solutions (buffered at pH 7) over a range of environmentally relevant Sb(V) concentrations (equivalent to Sb(V):Fe(II) molar ratios of 0, 0.

Long-term, continuous, subcutaneous levodopa/carbidopa infusion with ND0612 in Parkinson's disease: 3-year outcomes from the open-label BeyoND study.

Introduction: ND0612 is being investigated as a continuous, subcutaneous levodopa/carbidopa infusion, in combination with oral levodopa/carbidopa, for motor fluctuations in Parkinson's disease (PD). One-year data from the ongoing BeyoND study (NCT02726386) showed that the ND0612 regimen was safe and well tolerated and provided a sustained ≥2-h improvement in daily Good ON-time through 12 months of treatment.

Methods: We describe 3-year safety and efficacy outcomes for participants who completed 12 months of ND0612 treatment in the core study period and entered the extension phase.

Evaluating the efficacy of transcranial direct current stimulation (tDCS) in managing neuropathic pain-induced emotional consequences: Insights from animal models.

Neuropathic pain is a global health concern due to its severity and its detrimental impact on patients' quality of life. It is primarily characterized by sensory alterations, most commonly hyperalgesia and allodynia. As the disease progresses, patients with neuropathic pain develop co-occurring emotional disorders, such as anxiety and depression, which further complicate therapeutic management.

To what extent does status epilepticus contribute to brain damage in the developmental and epileptic Encephalopathies.

This paper is based on a presentation made at the 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures in April 2024. Status Epilepticus (SE) is a neurological emergency involving prolonged seizures that disrupt brain function and may cause severe, long-term neurological damage. Developmental and Epileptic Encephalopathies (DEEs), a group of severe genetic disorders with early-onset epilepsy, often exhibit SE episodes that compound their inherent cognitive and developmental challenges.

Prediction of marbling score in ribeye quartered at the 5th- 6th rib of French beef using the Q-FOM™ beef assessment camera.

In the Meat Standards Australia (MSA) and Guaranteed Global Grading (3G) grading schemes, beef marbling is scored visually in the chiller by accredited graders from 100 to 1190 marble score points in increments of 10. This study aimed to evaluate a hand-held camera (Q-FOM™ Beef) for determining MSA marbling scores of carcasses quartered between the 5th and 6th rib. The carcasses were scored by two accredited graders, including an expert grader (i.

Detection and correction of translational motion in SPECT with exponential data consistency conditions.

Rigid patient motion can cause artifacts in single photon emission computed tomography (SPECT) images, compromising the diagnosis and treatment planning. Exponential data consistency conditions (eDCCs) are mathematical equations describing the redundancy of exponential SPECT measurements. It has been recently shown that eDCCs can be used to detect patient motion in SPECT projections.

Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS: Nine-Year Data From the OPERA Studies Open-Label Extension.

Background And Objectives: Patients with multiple sclerosis (MS) may demonstrate better disease control when treatment is initiated on high-efficacy disease-modifying therapies (DMTs) from onset. This subgroup analysis assessed the long-term efficacy and safety profile of the high-efficacy DMT ocrelizumab (OCR) as first-line therapy for early-stage relapsing MS (RMS).

Methods: Post hoc exploratory analyses of efficacy and safety were performed in a subgroup of treatment-naive patients with RMS who received ≥1 dose of OCR in the multicenter OPERA I/II (NCT01247324/NCT01412333) studies.