Anesthetic Management of a Patient With Arnold Chiari Malformation and Syringomyelia During Laparoscopic Surgery With Neurologic Monitoring: A Case Report.

We describe a patient with severe Arnold Chiari Malformation and syringomyelia who underwent gynecological laparoscopy in an emergency context; no brain imaging was available. We here report the successful use of optic nerve sheath diameter (ONSD) and middle cerebral artery (MCA) velocity measurements as surrogate monitoring for cerebral blood flow and intracranial pressure, respectively. MCA velocity was low when assessed after peritoneal insufflation and ONSD increased to 6.

Predictive Factors of a Dominant Superficial Venous Drainage System in DIEP Flap Surgery With Preoperative Computed Tomography Angiography.

Background: Venous congestion due to superficial venous system dominance (SVD) in deep inferior epigastric perforator (DIEP) flap surgery occurs in approximately 2% of cases, with attendant sequelae and increased cost to healthcare systems. This study aimed to describe the predictive factors for SVD in DIEP flap breast reconstruction based on preoperative computed tomography angiography (CTA) findings.

Methods: All women who required takebacks for additional venous anastomosis to the cephalic vein because of SVD after DIEP flap breast reconstruction between 2015 and 2022 were included.

Feasibility and Acceptability of a Virtual "Dementia Awareness for Caregivers" Course in Brazil and India.

Objective: To establish whether a virtual dementia awareness course is feasible for caregivers of people with dementia in Brazil and India.

Methods: A pre/posttest single group, multisite feasibility study, mixed methods exploratory design was applied. Primary caregivers of people with dementia in Brazil and India took a 3 to 4-hour course adapted for online delivery, with 10 to 15 caregivers.

Interest of hair tests to discriminate a tail end of a doping regimen from a possible unpredictable source of a prohibited substance in case of challenging an anti-doping rule violation.

The presence of letrozole, an aromatase inhibitor, in an athlete's sample constitutes one of the more frequent anti-doping rules violation. It is possible to challenge this violation but it is the athletes who have to demonstrate their innocence. The conditions to evidence/establish the absence of fault or negligence hinge on two points: 1.

Pushing the limits of electron donation for -chelating ligands an alliance of phosphonium ylide and anionic abnormal NHC.

The grafting of a -(CH)PR moiety on an NHC ligand backbone in the Mn(I) complex [Cp(CO)Mn(IMes)] followed by double deprotonation opens a route to bidentate ligands with extreme electron-donating character. Such remarkable electronic properties can even allow intramolecular sp C-H functionalization in typically inert square-planar Rh(I) dicarbonyl complexes.

Ground and excited state aromaticity in azulene-based helicenes.

Electron delocalization is studied in the ground singlet and first excited triplet states of azulene-containing helicenes. After showing that the compounds we study can be synthesized, we show that they exhibit a charge separation in the ground state, which does not appear in their triplet excited state. Then, magnetically induced properties (IMS3D and ACID) and electron density decomposition methods (EDDB) are used to rationalize aromaticity in these systems.

Effect of Nitrogen and Phosphorus Doping of Reduced Graphene Oxide in the Hydrogen Evolution Catalytic Activity of Supported Ru Nanoparticles.

Three different cathodic materials for the hydrogen evolution reaction (HER) consisting of Ru nanoparticles (NPs) supported onto a bare and two doped reduced graphene oxides (r-GO) have been studied. Ru NPs have been synthesized in situ by means of the organometallic approach in the presence of each reduced graphene support (bare (rGO), N-doped (NH-rGO) and P-doped (P-rGO)). (HR)TEM, EDX, EA, ICP-OES, XPS, Raman and NMR techniques have been used to fully characterize the obtained rGO-supported Ru materials.

Covariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI.

A growing number of covariate modeling methods have been proposed in the field of popPK modeling, but limited information exists on how they all compare. The objective of this study was to perform a systematic review of all popPK covariate modeling methods, focusing on assessing the existing knowledge on their performances. For each method of each article included in this review, evaluation setting, performance metrics along with their associated values, and relative computational times were reported when available.

Lipophilic molecular rotor to assess the viscosity of oil core in nano-emulsion droplets.

Characterization of nanoscale formulations is a continuous challenge. Size, morphology and surface properties are the most common characterizations. However, physicochemical properties inside the nanoparticles, like viscosity, cannot be directly measured.

The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2.

The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect the viral genome. In numerous viruses, this inhibition is achieved through direct or indirect interference with the RNA helicase UPF1, thereby promoting viral replication and enhancing pathogenesis.

Genomic selection for resistance to one pathogenic strain of in blue mussel .

Introduction: The blue mussel is one of the major aquaculture species worldwide. In France, this species faces a significant threat from infectious disease outbreaks in both mussel farms and the natural environment over the past decade. Diseases caused by various pathogens, particularly spp.

Epidemiological and genomic analysis of strains from retailed raw meat.

causes hospital-acquired infections in human patients with compromised immune system. Strains associated to nosocomial infections are often resistant to carbapenems and belong to few international clones (IC1-11). .

Surfacic networks.

Surfacic networks are structures built upon a 2D manifold. Many systems, including transportation networks and various urban networks, fall into this category. The fluctuations of node elevations imply significant deviations from typical plane networks and require specific tools to understand their impact.

3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography.

The human placenta exhibits a complex three-dimensional (3D) structure with a interpenetrating vascular tree and large internal interfacial area. In a unique and yet insufficiently explored way, this parenchymal structure enables its multiple functions as a respiratory, renal, and gastrointestinal multiorgan. The histopathological states are highly correlated with complications and health issues of mother, and fetus or newborn.

First Observation of a Nuclear Recoil Peak at (100eV) with Crab: A Potential New Calibration Standard for Cryogenic Detectors.

Any experiment aiming to measure rare events, like Coherent Elastic neutrino-Nucleus Scattering (CE NS) or hypothetical Dark Matter scattering, via nuclear recoils in cryogenic detectors relies crucially on a precise detector calibration at sub-keV energies. The Crab collaboration developed a new calibration technique based on the capture of thermal neutrons inside the target crystal. Together with the Nucleus experiment, first measurements with a moderated Cf neutron source and a cryogenic detector were taken.

Subpial hemorrhage: A rare and underrecognized site of intracranial hemorrhage in neonates.

Subpial hemorrhage (SPH) is a rare but significant cause of neonatal seizures and respiratory distress, primarily affecting full-term infants without apparent risk factors. We report the case of a full-term newborn who presented with recurrent episodes of apnea, desaturation, and seizures shortly after birth. MRI revealed an acute hemorrhagic collection in the left temporal region, accompanied by cortical cytotoxic edema.

Percolation for 2D Classical Heisenberg Model and Exit Sets of Vector Valued GFF.

Our motivation in this paper is twofold. First, we study the geometry of a class of exploration sets, called , which are naturally associated with a 2D vector-valued Gaussian Free Field : . We prove that, somewhat surprisingly, these sets are a.

Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France.

Background: The COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling with compromised immune systems. This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.

Examining the prevention approach in National Dementia Plans from European and North American countries.

Objectives: This paper aims to provide a comprehensive review of National Dementia Plans (NDPs) from selected European and North American countries, focusing on the distinct prevention strategies outlined and the approaches employed for reducing dementia risk.

Method: The sample consisted of 16 NDPs from Austria, Canada, Finland, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Malta, the Netherlands, Spain, Switzerland, the UK, and the USA. These NDPs were retrieved from the Alzheimer's Disease International (ADI) database, with regular updates checked on official governmental websites.

Improvement of Iron and β-Carotene Bioaccessibility in Complementary Foods: Biofortification of Local Crops With Organic Residual Products and Microorganisms.

Micronutrient deficiencies remain a great public health challenge worldwide with iron, zinc, and vitamin A being the most problematic. It has been shown that biofortification through agronomic strategies can increase their micronutrient content, but data on the bioavailability remain limited. In Senegal, consumption of cereals and legumes is high, and orange-fleshed sweet potato (OFSP), rich in β-carotene, has been introduced a decade ago.

A transdisciplinary, comparative analysis reveals key risks from Arctic permafrost thaw.

Permafrost thaw poses diverse risks to Arctic environments and livelihoods. Understanding the effects of permafrost thaw is vital for informed policymaking and adaptation efforts. Here, we present the consolidated findings of a risk analysis spanning four study regions: Longyearbyen (Svalbard, Norway), the Avannaata municipality (Greenland), the Beaufort Sea region and the Mackenzie River Delta (Canada) and the Bulunskiy District of the Sakha Republic (Russia).

Workaholism, work engagement, and affective commitment: relationships to self-concept levels and work outcomes.

As a result of the significant changes in businesses around the globe such as the generalization of remote working and digital transformation, the boundaries between work and private life tend to vanish, causing concerns about whether individuals' investment in their work could have detrimental effects on their life and health. In such context, the notion of heavy work investment, an umbrella construct that subsumes different forms of investment of the self into the work domain, warrants scholarly attention as it may have both a bright and dark side for individuals. The present study focuses on three forms of heavy work investment, i.

Radiotherapy for oligoprogressive disease in non-small cell lung cancer treated with pembrolizumab in first-line setting: a retrospective study.

Background: Oligoprogression (OP) is common in patients with metastatic non-small cell lung cancer (mNSCLC) treated with immune checkpoint inhibitors (ICIs). This study aims to assess the benefit and the safety profile of ablative radiotherapy (RT) for OP in mNSCLC treated with pembrolizumab in first-line setting.

Methods: We retrospectively analyzed records of all consecutive mNSCLC patients who underwent treatment with pembrolizumab (+/- chemotherapy) in first-line setting and developed an OP treated with ablative RT while continuing pembrolizumab, in a French Hospital from 2019 to 2022.