1,080,419 results match your criteria: "France; Interuniversity Consortium of Marine Sciences CoNISMa[Affiliation]"
Biomolecules
January 2025
ENDOLIFE, 28 Rue de Courcelles, 75008 Paris, France.
Endometriosis is a chronic, estrogen-dependent disorder associated with the presence of endometrial cells mainly in the pelvic cavity, causing systemic immune inflammation, infertility, epigenetic dysregulation of differential DNA methylation, coelomic metaplasia, and pain. It affects approximately 10-12% of women. Despite decades of research, full pathophysiology, a diagnostic roadmap, and clinical management strategies for endometriosis are not yet fully elucidated.
View Article and Find Full Text PDFBiomolecules
January 2025
Área de Genética, Facultad de Ciencias del Mar y Ambientales, INMAR, Universidad de Cádiz, 11510 Cádiz, Spain.
Fish exhibit diverse mechanisms of sex differentiation and determination, shaped by both external and internal influences, often regulated by distinct DNA methylation patterns responding to environmental changes. In aquaculture, reproductive issues in captivity pose significant challenges, particularly the lack of fertilization capabilities in captive-bred males, hindering genetic improvement measures. This study analyzed the methylation patterns and transcriptomic profiles in gonadal tissue DNA from groups differing in rearing conditions and sexual maturity stages.
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December 2024
Drug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy.
essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. Although these properties are recognized as playing a key role in the mechanism of action of this substance, many unresolved issues still exist, and fundamental studies focused on such aspects are scarce.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Departamento de Química, Faculdade de Ciências Exatas, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Campus JK, Diamantina 39100-000, MG, Brazil.
This study investigates the structural and biophysical properties of the wild-type antimicrobial peptide LyeTx I, isolated from the venom of the spider , and its analog LyeTx I-b, designed to enhance antibacterial activity, selectivity, and membrane interactions by the acetylation and increased amphipathicty. : To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. Both peptides were isotopically labeled with H-Ala and N-Leu to facilitate structural studies via NMR spectroscopy.
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December 2024
Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, 08036 Barcelona, Spain.
The rise of multidrug-resistant (MDR) infections demands personalized antibiotic strategies for febrile neutropenia (FN) in hematological malignancies. This study investigates machine learning (ML) for identifying patient profiles with increased susceptibility to bloodstream infections (BSI) during FN onset, aiming to tailor treatment approaches. From January 2020 to June 2022, we used the unsupervised ML algorithm KAMILA to analyze data from hospitalized hematological malignancy patients.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
Laboratoire de BioMécanique et BioIngénierie (UMR CNRS 7338), Centre of Excellence for Human and Animal Movement Biomechanics (CoEMoB), Université de Technologie de Compiègne (UTC), Alliance Sorbonne Université, 60200 Compiègne, France.
Aquatic training has been integrated into equine rehabilitation and training programs for several decades. While the cardiovascular effects of this training have been explored in previous studies, limited research exists on the locomotor patterns exhibited during the swimming cycle. This study aimed to analyze three distinct swimming strategies, identified by veterinarians, based on the propulsion phases of each limb: (S1) two-beat cycle with lateral overlap, (S2) two-beat cycle with diagonal overlap, and (S3) four-beat cycle.
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January 2025
ICBAS-School of Medicine and Biomedical Sciences, Porto University, 4050-313 Porto, Portugal.
This study is the first to report sp. in dairy cattle from Terceira Island, part of the Azores Archipelago. sp.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
Equestrian Performance Research Centre, Hartpury University, Gloucester GL19 3BE, UK.
This paper highlights and summarizes the experiences and perceptions of European equestrian educational experts from a workshop held at the French National Riding School in Saumur. The workshop, which brought together fifty leading experts, aimed to address challenges in equestrian education, identify common ground, and share best practices. Using 'The World Café' method, the participants were divided into groups to discuss four key topics: the relationship between horses and humans, diversity of perspectives versus common ground, training philosophy, and social acceptability.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
Clinique Vétérinaire des Mazets, 15400 Riom es Montagnes, France.
()-caused calf diarrhoea (scours) is widespread and leads to calf mortality in cattle industries worldwide. A recent discovery of a glycopeptide epitope on the parasite recognized by a monoclonal antibody has led to the development of a new vaccine. It was designed for cows to pass on passive immunity to their neonatal calves.
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January 2025
Joint Lab ANR FeedInTech (FIT: SONAS/Nor-Feed), 49070 Beaucouzé, France.
This study aimed to investigate the effects of a Standardized Natural Citrus Extract (SNCE) on broiler chickens' growth performance, gut health, carcass quality, and welfare. A total of 756 one-day-old Ross 308 males were randomly assigned to two groups: a control group (CTL) fed with a standard diet, and a citrus group (SNCE) fed with the same standard diet supplemented with 250 g/ton of feed of SNCE. Growth performance was recorded weekly until d 35, while mortality was recorded daily.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Department of Neurosurgery, Río Hortega University Hospital, 47014 Valladolid, Spain.
Intraoperative ultrasound (ioUS) provides real-time imaging during neurosurgical procedures, with advantages such as portability and cost-effectiveness. Accurate tumor segmentation has the potential to substantially enhance the interpretability of ioUS images; however, its implementation is limited by persistent challenges, including noise, artifacts, and anatomical variability. This study aims to develop a convolutional neural network (CNN) model for glioma segmentation in ioUS images via a multicenter dataset.
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January 2025
Anaesthesiology and Pain Department, Institut de Cancérologie de l'Ouest, 49055 Angers, France.
CAPTRANE evaluated the efficacy and tolerability of high-concentration capsaicin patch (HCCP) vs. oral pregabalin for the treatment of postsurgical neuropathic pain (PSNP) following breast cancer surgery. The study was designed with the aim of demonstrating noninferiority of one HCCP against daily pregabalin.
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January 2025
Department of Neurosurgery, Río Hortega University Hospital, 47014 Valladolid, Spain.
Background: Accurate prognostic models are essential for optimizing treatment strategies for glioblastoma, the most aggressive primary brain tumor. While other neuroimaging modalities have demonstrated utility in predicting overall survival (OS), intraoperative ultrasound (iUS) remains underexplored for this purpose. This study aimed to evaluate the prognostic potential of iUS radiomics in glioblastoma patients in a multi-institutional cohort.
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January 2025
Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
: Since 2011, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) has emerged as a promising treatment option for patients with peritoneal surface malignancies (PSM) who are not eligible for cytoreductive surgery (CRS). Repeated minimal-invasive treatment is one of the key features and the current empirical standard treatment (ST) consists of at least three administrations over about three months. However, many patients are unable to complete the full course, limiting the potential benefits of PIPAC.
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January 2025
Regenerative NanoMedicine, Centre de Recherche en Biomédecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), UMR_S U1260 INSERM and University of Strasbourg, 67085 Strasbourg, France.
Prostate cancer is one of the most common diseases among men worldwide and continues to pose a serious threat to health. This review shows the history and the new developments in the management of prostate cancer, with an emphasis on a range of therapeutic approaches, such as hormone therapy, radiation therapy, surgery, and innovative targeted therapeutics. The evolution of these treatments is examined in light of clinical outcomes, patient quality of life, and emerging resistance mechanisms, such as the recently shown vitamin D-based strategies.
View Article and Find Full Text PDFChildren (Basel)
December 2024
Lenval University Children's Hospital, SUPEA (University Department of Child and Adolescent Psychiatry), Competence Center for Rare Diseases with Psychiatric Expression (CC MREP), Expert Center for Pediatric Psychotrauma (CE2P), 06200 Nice, France.
Background: The first year of life is the period of greatest brain plasticity. Postpartum depression can adversely affect the first interactions with the child and, consequently, their emotional, social, and cognitive development.
Objectives: First, to describe the developmental profile of six-month-old infants of mothers suffering from severe postpartum depression, and, second, to compare the development of infants whose mothers suffer from depression with or without bipolar disorder.
Biomedicines
January 2025
CIRI-Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, 42023 Saint Etienne, France.
Avolition is a symptom responsible for a high burden in patients suffering from psychiatric diseases. It refers to a motivation loss for initiating and maintaining goal-directed activities, often called fatigue by patients. Fatigue is a widespread complaint of patients suffering from inflammatory bowel disease (IBD), significantly impacting patients' well-being, even during the quiescent stage of the disease.
View Article and Find Full Text PDFBiomedicines
January 2025
Department of Radiological, Oncological and Anatomo-Pathological Sciences, University Sapienza of Rome, 00161 Rome, Italy.
Background/objectives: Astroblastoma is a rare glial neoplasm more frequent in young female patients, with unclear clinical behaviors and outcomes. The diagnostic molecular alteration is a rearrangement of the Meningioma 1 () gene. MicroRNAs (miRNAs) are important gene expression regulators with strong implications in biological processes.
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December 2024
Jean Lamour Institute, Department of Micro and Nanomechanics for Life, University of Lorraine, UMR 7198, 54011 Nancy, France.
Oral implantology faces a multitude of technical challenges in light of current clinical experience, underlining the need for innovation in implantable medical devices in both mechanical and biological terms. This study explores the influence of the thickness factor of calcium-doped zirconia (Ca-SZ) coatings deposited by PVD on their intrinsic mechanical properties and the determinism of the latter on adhesion to the TA6V alloy substrate after mechanical loading for applications in dental implantology. Three separate thicknesses of 250 nm, 450 nm and 850 nm were evaluated in terms of mechanical strength, modulus of elasticity and adhesion to the substrate, in accordance with ISO 20502:2005.
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December 2024
EuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, Romania.
Background/objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation.
Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated cardiomyopathy patients with a compensated phase of heart failure before discharge.
Antioxidants (Basel)
January 2025
Université de Lorraine, INRAE, IAM, F-54000 Nancy, France.
The oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (HS) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching mechanism as other reversible redox post-translational modifications. Considering their reductase activity but also their connections with proteins that generate HS and its related molecules, the glutaredoxin (GRX) and thioredoxin (TRX)-reducing systems have potential dual roles in both protein persulfidation and depersulfidation.
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January 2025
Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, F-75006 Paris, France.
Medulloblastoma (MB) is the most common malignant brain tumor in children, typically arising during infancy and childhood. Despite multimodal therapies achieving a response rate of 70% in children older than 3 years, treatment remains challenging. Ferroptosis, a form of regulated cell death, can be induced in medulloblastoma cells in vitro using erastin or RSL3.
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January 2025
Reproductive Medicine, Reproductive Biology and Genetics, Peritox Laboratory, University Hospital and School of Medicine, Picardie University Jules Verne, 80054 Amiens, France.
Sperm cryopreservation provides patients undergoing oncological, surgical, or infertility treatments the opportunity to conceive their own children, using assisted reproductive technologies. However, the freezing-thawing process can negatively influence both the quantity and the quality of spermatozoa, mainly due to an excessive production of reactive oxygen species and/or an impaired antioxidant defense system in sperm. Aromatic and medicinal plants synthesize essential oils with antioxidant proprieties as a part of their ecological adaptation to environmental stress, thanks to their rich bioactive phytochemical components.
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December 2024
IHAP, Université de Toulouse, INRAE, ENVT, 31076 Toulouse, France.
This study aimed to assess the effects of a diet containing 20.8 mg FB1 + FB2/kg over four and nine days on oxylipin (OL) profiles in the liver and brain of chickens. A total of 96 OLs, derived from seven polyunsaturated fatty acids (PUFAs) via the cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (P450), and non-enzymatic pathways, were measured using HPLC-MS/MS.
View Article and Find Full Text PDFBiology (Basel)
December 2024
Andean Geothermal Center of Excellence, University of Chile, Santiago 8370446, Chile.
We used otolith chemistry to test and complement current hypotheses regarding habitat use and connectivity between sub-populations in Area 48 of the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). Sagittal otoliths from 45 fish sampled near the South Orkney Islands were analysed. Their elemental (Li, Na, Mg, Cr, Mn, Sr, Sn, and Ba relative to Ca) and isotopic (δO and δC) signatures were examined in both the nuclear and marginal regions, representing juvenile and adult stages.
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