Research note: In vitro anticoccidial activity of protein and lipid extracts from the black soldier fly larvae (Hermetia illucens).

Avian coccidiosis, caused by Eimeria spp., is the main parasitic disease in the poultry industry, responsible for high economic costs worldwide. Faced with anticoccidial resistance and societal pressure to reduce inputs in livestock sector, insects could provide a relevant alternative to anticoccidial molecules.

Value of tacrolimus 0.1% in the treatment of vitiligo in the era of targeted therapy.

Background: Vitiligo, a prevalent depigmenting condition, affects both adults and children, significantly impacting their quality of life. The standard treatment approach involves the application of topical corticosteroids in conjunction with narrow-band ultraviolet B (UVB) phototherapy. A novel topical treatment, ruxolitinib (a Janus kinase inhibitor), has recently received approval.

Comprehensive review of emerging analytical methods for pea protein structure analysis: Advances and implications for food science over the last five years.

This review explores recent advancements in analytical techniques for characterizing pea protein structure. With growing interest in sustainable protein sources, understanding the relationship between pea protein's structure and its functionality has become essential. This review covers a range of methods used to assess the structural properties of pea protein, focusing on the impact of environmental and processing conditions, as well as interactions with other materials, including mid-infrared spectroscopy, fluorescence spectroscopy, nuclear magnetic resonance spectroscopy, scanning electron microscopy, X-ray methods and calorimetric methods.

Methods to assess on-farm biosecurity in Europe and beyond.

The aim of this study was to identify which biosecurity assessment methods (BAMs) are currently used in practice in animal farms. To address this, a structured questionnaire was developed to gather information such as the animal species, main objectives, type of enforcement, output generated and feedback of the result. In the context of the BETTER Cost Action project, country representatives identified in each of their countries which BAMs were used and completed an online survey.

Scalable interlinked hierarchical porous biochar-nanosheets for efficient removal of thallium from aquatic environment.

The scalable development of engineeredcarbonaceous materials for commercialization at industrial scale is a formidable issue. Herein, a scalable and innovative chemical exfoliation approach was introduced to develop interlinkedhierarchical biocharnanosheets (BCNs) framework form agricultural wastes. The developed BCNs exhibited higher surface area (1048.

Degradative removal of diclofenac from wastewater - Statistical and analytical approaches to understand degradation pathways.

In environmental management area, quality of water is a major growing concern with the emerging contaminants such as pesticides and pharmaceuticals likely to be present at low concentrations in water bodies, thereby potentially harming the ecosystem and human health. Diclofenac (DCF), a commonly used drug, has been found in wastewater, surface water, and drinking water sources, whose elimination can be a challenge issue. This study investigates the elimination of DCF by the photochemical method from aqueous media using short-wavelength radiation and hydrogen peroxide.

Assessing the value of environmental DNA into conservation planning: A case study of freshwater bivalves in France.

Environmental DNA (eDNA) is emerging as a valuable tool for generating standardised biodiversity data. Whether used alone or alongside conventional surveys, it is expected that eDNA data can improve conservation planning, but this remains largely untested. Here, we assessed the value of eDNA data for making more robust conservation prioritisation decisions, by comparing errors made when identifying priority areas based on conventional data, eDNA or a combination of both.

The NERVE-ML (Neural Engineering Reproducibility and Validity Essentials for Machine Learning) Checklist: Ensuring Machine Learning Advances Neural Engineering.

Machine learning's ability to capture intricate patterns makes it vital in neural engineering research. With its increasing use, ensuring the validity and reproducibility of machine learning methods is critical. Unfortunately, this has not always been the case in practice, as there have been recent retractions across various scientific fields due to the misuse of machine learning methods and validation procedures.

Exploring the Anion Site Disorder Kinetics in Lithium Argyrodites.

Lithium argyrodites LiPS ( = Cl, Br, I) are a promising class of solid-state electrolytes with the potential to achieve high conductivities (>10 mS·cm) necessary for use in solid-state batteries. Previous research has shown that structural factors, in particular, site disorder between the sulfide and halide anions, can impact the ionic conductivity of lithium argyrodites. One current hypothesis for this correlation between anion site disorder and ionic transport is a connection to the lithium-ion substructure.

Low-input breeding potential in stone pine, a multipurpose forest tree with low genome diversity.

Stone pine (Pinus pinea L.) is an emblematic tree species within the Mediterranean basin, with high ecological and economic relevance due to the production of edible nuts. Breeding programmes to improve pine nut production started decades ago in Southern Europe but have been hindered by the near absence of polymorphisms in the species genome and the lack of suitable genomic tools.

Clinical phenotypes and outcomes associated with respiratory syncytial virus infection in critically ill patients: a retrospective multicentre cohort study in Great Paris area hospitals, 2017-2023.

Background: Respiratory syncytial virus (RSV) is one of the deadliest respiratory viruses. There is a need to better identify prognostic factors in RSV-infected patients, particularly those requiring intensive care unit (ICU) admission, with a focus on immunosuppressed patients.

Methods: Multicenter, retrospective cohort study of RSV-infected adults hospitalized in 17 ICUs in the Great Paris area between 08/01/2017 and 05/01/2023.

Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q.

The development of targeted therapy for patients with multiple myeloma (MM) is hampered by the low frequency of actionable genetic abnormalities. Gain or amplification of chromosome 1q (1q+) is the most frequent arm-level copy number gain in patients with MM and is associated with higher risk of progression and death despite recent therapeutic advances. Thus, developing targeted therapy for MM patients with 1q+ stands to benefit a large portion of patients in need of more effective management.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority randomized controlled trial.

Aim(s): To investigate the impact of the absence of specific advice for oral fluid intake, compared to supplementation water intake on the occurrence of post-dural puncture headache.

Design: A prospective, open-label, non-inferiority, multicenter trial including hospitalized patients requiring a diagnostic lumbar puncture in seven hospitals in France.

Methods: Patients were randomly allocated (1:1) either to receive no specific advice on oral fluid intake (FREE-FLUID), or to be encouraged to drink 2 liters of water (CONTROL) within the 2 hours after lumbar puncture.

A methodological framework for deriving the German food-based dietary guidelines 2024: Food groups, nutrient goals, and objective functions.

Background: For a growing number of food-based dietary guidelines (FBDGs), diet optimization is the tool of choice to account for the complex demands of healthy and sustainable diets. However, decisions about such optimization models' parameters are rarely reported nor systematically studied.

Objectives: The objectives were to develop a framework for (i) the formulation of decision variables based on a hierarchical food classification system; (ii) the mathematical form of the objective function; and (iii) approaches to incorporate nutrient goals.

Characterization and comparison of immunity against MPXV for individuals infected with MPXV or vaccinated with modified vaccinia Ankara vaccines.

The 2022 Mpox virus (MPXV) outbreak revitalized questions about immunity against MPXV and vaccinia-based vaccines (VAC-V), but studies are limited. We analyzed immunity against MPXV in individuals infected with MPXV or vaccinated with the licensed modified vaccinia Ankara (MVA) Bavarian Nordic or an experimental MVA-HIVB vaccine. The frequency of neutralizing antibody responders was higher among MPXV-infected individuals than MVA vaccinees.

Active restoration of a long-lived octocoral drives rapid functional recovery in a temperate reef.

Whether restoration actions achieve full ecological recovery is still debated. This is particularly controversial in the marine realm, where the success of restoration is mostly evaluated in terms of the short-term survival of transplanted organisms. In view of this, we combined population and trait-based approaches to explore the long-term effectiveness of active restoration of a key Mediterranean octocoral.

Enhanced activity and self-regeneration in dynameric cross-linked enzyme nanoaggregates.

Directed evolution, enzyme design, and effective immobilization have been used to improve the catalytic activity. Dynamic polymers offer a promising platform to improve enzyme activity in aqueous solutions. Here, amphiphilic dynamers and lipase self-assemble into nanoparticles of 150- to 600-nanometer diameter, showing remarkable threefold enhancement in catalytic activity.

Aging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity.

Microglia, the major population of brain resident macrophages, differentiate from yolk sac progenitors in the embryo and play multiple nonimmune roles in brain organization throughout development and life. Various microglia subtypes have been described by transcriptomic and proteomic signatures, involved metabolic pathways, morphology, intracellular complexity, time of residency, and ontogeny, both in development and in disease settings. Such macrophage heterogeneity increases with aging or neurodegeneration.

SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.

Natural killer (NK) cells express activating receptors that signal through ITAM (immunoreceptor tyrosine-based activation motif)-bearing adapter proteins. The phosphorylation of each ITAM creates binding sites for SYK and ZAP70 protein tyrosine kinases to propagate downstream signaling including the induction of Ca2+ influx. While all immature and mature human NK cells coexpress SYK and ZAP70, clonally driven memory or adaptive NK cells can methylate SYK genes, and signaling is mediated exclusively using ZAP70.

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop to promote robust activity during walking and cycling assisted by robotic devices.

Revealed Preferential Short-Range Anion Ordering in Disordered RbMOF (M = Nb, Ta) Pyrochlore-Type Oxyfluorides.

Describing the crystal structure of disordered materials with mixed-occupancy crystallographic sites is essential for understanding their physicochemical properties and designing new materials tuned to their targeted functionalities. Here, we investigate the structure of RbMOF (M = Nb, Ta) pyrochlore-type oxyfluorides using a multimodal approach that combines experimental and computational techniques. Rietveld structural refinement of powder X-ray powder diffraction (PXRD) data confirmed that these oxyfluorides are isostructural, and their average crystal structure is disordered.

FcrX coordinates cell cycle and division during free-living growth and symbiosis by a ClpXP-dependent mechanism.

is a soil bacterium that establishes a nitrogen-fixing symbiosis within root nodules of legumes. In this symbiosis, undergoes a drastic cellular change leading to a terminally differentiated form, called bacteroid, characterized by genome endoreduplication, increased cell size, and high membrane permeability. Bacterial cell cycle (mis)regulation is at the heart of this differentiation process.