Prevalence of recreational drug use in myocardial infarction patients without standard modifiable risk factors: Insights from a multicenter prospective cohort study.

Background: The prevalence of recreational drug use in myocardial infarction (MI) patients without standard modifiable cardiovascular risk factors (SMuRF) namely hypercholesterolemia, hypertension, diabetes and smoking, remains unknown.

Methods: All patients enrolled in The Addiction in Intensive Cardiac Care Units (ADDICT-ICCU) study, a French multicenter prospective observational study which systematically assessed the use of recreational drug within 2 h of admission, and presenting with MI but without known coronary artery disease were included. We compared patients with and without SMuRF.

Survival and parenteral nutrition dependence in patients aged 65 and older with short bowel syndrome: a retrospective observational cohort study.

Background: Home parenteral support (PS) is the standard treatment for chronic intestinal failure (CIF) with short bowel syndrome (SBS) as the leading cause. However, outcomes of PS in older patients remain poorly studied.

Methods: This retrospective observational study evaluated patients newly diagnosed with SBS-CIF initiating PS between 2015 and 2020 at a national French CIF referral center.

[Is previable rupture of membranes an independent neonatal prognostic factor from the gestational age at birth?].

Objective: Compare, at the same gestational age at birth, survival without severe neonatal morbidity among live-born infants after previable premature rupture of membranes (PROM) occurring before 22 weeks of gestation (WG) versus at or after 22 weeks.

Methods: Retrospective study conducted in a tertiary care referral center between 2016 and 2021, including live births between 23 and 36 weeks + 6 days after PROM. Only live-born infants with neonatal resuscitation care were included.

Reconstruction of the trapezium with structural bone graft in trapeziometacarpal joint arthroplasty with cup instability.

Periprosthetic complications after trapeziometacarpal arthroplasty mostly require revision surgery to restore function. An unstable cup in the trapezium is typically surgically managed by trapeziectomy. This report highlights a possible alternative to maintain the implant by reconstruction of the trapezium with corticocancellous autograft.

Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Next generation of porphysomes for improved photodynamic therapy applications.

Porphysomes are a class of liposome-like nanoparticles that have demonstrated efficacy in photothermal therapy (PTT) and photodynamic therapy (PDT) against cancer. These nanoparticles results from the self-assembly of amphiphilic phospholipid-porphyrin (PL-Por) conjugates. Despite their potential, porphysomes exhibit a high photothermal effect and a weak photodynamic activity as long as they remain intact within the body.

CHARACTERIZATION OF THE ASSOCIATION BETWEEN BIRTHWEIGHT AND SEVERE POSTPARTUM HEMORRHAGE IN WOMEN WITH DELIVERY AT TERM.

Background: Macrosomia, classically defined by an arbitrary birthweight threshold, is associated with an increased risk of postpartum hemorrhage (PPH). However, some preliminary evidence suggests that lower birthweights may also be at increased risk. We hypothesized that birthweight, analyzed as a continuous variable, is significantly associated with the risk of severe postpartum hemorrhage, with the risk increasing not only at higher birthweights traditionally associated with macrosomia but also potentially at lower birthweights.

Randall Foils Versus Big Blades: Comparative Analysis in On-Water Sprint Rowing.

Purpose: We evaluated the technical and energetical impact of using Randall foils versus simple Big blades during a maximum rowing effort in field conditions.

Methods: Fourteen experienced rowers (12 male and 2 female) 26 (9) versus 25 (9) years of age, 179.8 (4.

Detritivore identity modulates effects of nutrient enrichment and a common fungicide presence on leaf litter decomposition and fungal community.

Understanding the interaction of biotic and abiotic factors on ecosystem function is crucial for freshwater ecosystem management, However, the influence of nutrient enrichment, fungicide presence, and detritivore identity on leaf litter decomposition and associated fungal communities remains poorly understood. We conducted a microcosm experiment to examine: 1) the individual and combined effects of nutrient enrichment and a common fungicide on leaf litter decomposition and fungal communities; and 2) how two types of detritivore invertebrates (scrapers vs. shredders) influence these effects.

People are not becoming "AIholic": Questioning the "ChatGPT addiction" construct.

Generative artificial intelligence (AI) chatbots such as ChatGPT have rapidly gained popularity in many daily life spheres, even sparking scholarly debate about a potential "ChatGPT addiction." Throughout history, new technologies have repeatedly been associated with widespread concerns and "moral panics," especially when their adoption is sudden and involves significant changes in daily functioning. It is thus no surprise that researchers have examined whether intensive use of ChatGPT can be considered an addictive behavior.

The role of emotions reported in the emergency department in four-month chronic pain development: Effects of sadness and anger.

Objective: This study aims to assess whether the emotions experienced during an urgent health problem represent risk factors for developing chronic pain.

Method: A pain study was carried out as part of a randomized multicentre study on the prevention of post-concussion syndrome and post-traumatic stress syndrome (SOFTER) following emergency hospitalisation. Nine hundred and fourteen patients not suffering from chronic pain at admission provided information on the presence and intensity of eight emotions (anger, fear, regret, sadness, relief, contentment, joy, and interest) during their stay at the emergency department.

Research note: In vitro anticoccidial activity of protein and lipid extracts from the black soldier fly larvae (Hermetia illucens).

Avian coccidiosis, caused by Eimeria spp., is the main parasitic disease in the poultry industry, responsible for high economic costs worldwide. Faced with anticoccidial resistance and societal pressure to reduce inputs in livestock sector, insects could provide a relevant alternative to anticoccidial molecules.

Value of tacrolimus 0.1% in the treatment of vitiligo in the era of targeted therapy.

Background: Vitiligo, a prevalent depigmenting condition, affects both adults and children, significantly impacting their quality of life. The standard treatment approach involves the application of topical corticosteroids in conjunction with narrow-band ultraviolet B (UVB) phototherapy. A novel topical treatment, ruxolitinib (a Janus kinase inhibitor), has recently received approval.

Comprehensive review of emerging analytical methods for pea protein structure analysis: Advances and implications for food science over the last five years.

This review explores recent advancements in analytical techniques for characterizing pea protein structure. With growing interest in sustainable protein sources, understanding the relationship between pea protein's structure and its functionality has become essential. This review covers a range of methods used to assess the structural properties of pea protein, focusing on the impact of environmental and processing conditions, as well as interactions with other materials, including mid-infrared spectroscopy, fluorescence spectroscopy, nuclear magnetic resonance spectroscopy, scanning electron microscopy, X-ray methods and calorimetric methods.

Methods to assess on-farm biosecurity in Europe and beyond.

The aim of this study was to identify which biosecurity assessment methods (BAMs) are currently used in practice in animal farms. To address this, a structured questionnaire was developed to gather information such as the animal species, main objectives, type of enforcement, output generated and feedback of the result. In the context of the BETTER Cost Action project, country representatives identified in each of their countries which BAMs were used and completed an online survey.

Scalable interlinked hierarchical porous biochar-nanosheets for efficient removal of thallium from aquatic environment.

The scalable development of engineeredcarbonaceous materials for commercialization at industrial scale is a formidable issue. Herein, a scalable and innovative chemical exfoliation approach was introduced to develop interlinkedhierarchical biocharnanosheets (BCNs) framework form agricultural wastes. The developed BCNs exhibited higher surface area (1048.

Degradative removal of diclofenac from wastewater - Statistical and analytical approaches to understand degradation pathways.

In environmental management area, quality of water is a major growing concern with the emerging contaminants such as pesticides and pharmaceuticals likely to be present at low concentrations in water bodies, thereby potentially harming the ecosystem and human health. Diclofenac (DCF), a commonly used drug, has been found in wastewater, surface water, and drinking water sources, whose elimination can be a challenge issue. This study investigates the elimination of DCF by the photochemical method from aqueous media using short-wavelength radiation and hydrogen peroxide.

Assessing the value of environmental DNA into conservation planning: A case study of freshwater bivalves in France.

Environmental DNA (eDNA) is emerging as a valuable tool for generating standardised biodiversity data. Whether used alone or alongside conventional surveys, it is expected that eDNA data can improve conservation planning, but this remains largely untested. Here, we assessed the value of eDNA data for making more robust conservation prioritisation decisions, by comparing errors made when identifying priority areas based on conventional data, eDNA or a combination of both.

The NERVE-ML (Neural Engineering Reproducibility and Validity Essentials for Machine Learning) Checklist: Ensuring Machine Learning Advances Neural Engineering.

Machine learning's ability to capture intricate patterns makes it vital in neural engineering research. With its increasing use, ensuring the validity and reproducibility of machine learning methods is critical. Unfortunately, this has not always been the case in practice, as there have been recent retractions across various scientific fields due to the misuse of machine learning methods and validation procedures.

Exploring the Anion Site Disorder Kinetics in Lithium Argyrodites.

Lithium argyrodites LiPS ( = Cl, Br, I) are a promising class of solid-state electrolytes with the potential to achieve high conductivities (>10 mS·cm) necessary for use in solid-state batteries. Previous research has shown that structural factors, in particular, site disorder between the sulfide and halide anions, can impact the ionic conductivity of lithium argyrodites. One current hypothesis for this correlation between anion site disorder and ionic transport is a connection to the lithium-ion substructure.

Low-input breeding potential in stone pine, a multipurpose forest tree with low genome diversity.

Stone pine (Pinus pinea L.) is an emblematic tree species within the Mediterranean basin, with high ecological and economic relevance due to the production of edible nuts. Breeding programmes to improve pine nut production started decades ago in Southern Europe but have been hindered by the near absence of polymorphisms in the species genome and the lack of suitable genomic tools.

Clinical phenotypes and outcomes associated with respiratory syncytial virus infection in critically ill patients: a retrospective multicentre cohort study in Great Paris area hospitals, 2017-2023.

Background: Respiratory syncytial virus (RSV) is one of the deadliest respiratory viruses. There is a need to better identify prognostic factors in RSV-infected patients, particularly those requiring intensive care unit (ICU) admission, with a focus on immunosuppressed patients.

Methods: Multicenter, retrospective cohort study of RSV-infected adults hospitalized in 17 ICUs in the Great Paris area between 08/01/2017 and 05/01/2023.

Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q.

The development of targeted therapy for patients with multiple myeloma (MM) is hampered by the low frequency of actionable genetic abnormalities. Gain or amplification of chromosome 1q (1q+) is the most frequent arm-level copy number gain in patients with MM and is associated with higher risk of progression and death despite recent therapeutic advances. Thus, developing targeted therapy for MM patients with 1q+ stands to benefit a large portion of patients in need of more effective management.