Incidence and comparison of postoperative explained and unexplained fever in open aortic repair.

Objective: Fever is a classic symptom in postoperative period, but to our knowledge no study shows exclusively the occurrence of fever after open aortic repair (OAR) and explores the difference between explained and unexplained fever.

Methods: Patients who underwent an OAR between March 2018 to April 2023 in Reims University Hospital were enrolled retrospectively. The primary endpoint was the rate of fever after OAR, which was classed in explained fever group (eFG) or unexplained fever group (uFG).

Pulsed Field Ablation in the Elderly via a Pentaspline Multielectrode Catheter: Safety, Efficacy, and Comparison with Cryoballoon and Radiofrequency Devices.

Background: Catheter ablation is an effective treatment for atrial fibrillation (AF). Pulsed field ablation (PFA) has emerged as a novel energy modality, which relies on high-voltage electric fields to achieve cardiac tissue ablation. Data on its efficacy in the elderly are scarce.

Real-World Safety and Effectiveness of Vosoritide in Children with Achondroplasia: French Early Access Program.

Introduction: Vosoritide is the first approved treatment for achondroplasia, a rare genetic disorder that results in disproportionate short stature. In clinical trials, vosoritide has shown a positive safety profile and increased height in children with achondroplasia. This paper shares the organizational structure, initiation, follow-up protocol, and findings of a vosoritide early access program (EAP) conducted in France.

Nivolumab and hypofractionated radiotherapy in patients with advanced melanoma: A phase 2 trial.

Background: Radiotherapy is thought to enhance anti-tumor immunity, particularly when delivered in a hypofractionated and multisite manner. Therefore, we investigated the effects of combining radiotherapy with nivolumab in patients with advanced melanoma.

Methods: This was a multicenter, non-randomized, phase 2 trial that enrolled patients with treatment-naïve metastatic melanoma.

Survival outcomes for patients with invasive lobular cancer by MammaPrint: Results from the MINDACT phase III trial.

Background: Evaluation of the prognostic performance and clinical utility of the MammaPrint 70-gene signature in early-stage invasive lobular carcinoma (ILC) for whom such analyses in a randomized trial is awaited.

Patients And Methods: Exploratory subgroup analysis of MINDACT trial patients with centrally assessed histology (n = 5929) with invasive breast cancer of no-special-type (NST), or pure ILC. In the trial patients were categorized based on the 70-gene signature for genomic risk and modified Adjuvant!Online for clinical risk.

Unsupervised segmentation of heart sounds from abrupt changes detection.

Background And Objective: Heart auscultation enables early diagnosis of cardiovascular diseases. Automated segmentation of cardiograms into fundamental heart states can guide physicians to analyze the patient's condition more effectively. In this work, we propose an unsupervised method of segmentation into heart sounds and silences based on the detection of abrupt changes in the signal.

Influence of two strength training modalities (hypertrophy vs. contrast training) on muscular strength, bone health parameters and quality of life in a group of older adults with low skeletal muscle mass index.

The main aim of the current study was to compare the effects of two strength training modalities (hypertrophy vs. contrast training) on bone health parameters, physical performance and quality of life in a group of subjects aged 60 and above with low skeletal muscle mass index (SMI). 45 older adults voluntarily participated in this study, but only 41 (22 women and 19 men) completed it.

Bees as environmental and toxicological bioindicators in the light of pesticide non-targeted exposure.

Pesticides have a significant impact on the environment, harming valuable non-target organisms like bees. Honeybees, in particular, are ideal bioindicators of pesticide exposure due to extensive research on how pesticides affect their behavior, immunity, development, biomolecules, and detoxification. However, wild pollinators are less studied in terms of pesticide exposure, and their inclusion is essential for a comprehensive risk assessment.

The New HLA-B*44:384 Allele Characterised by Two Different Sequencing-Based Typing Techniques.

The new allele HLA-B*44:384 differs from HLA-B*44:02:01:01 by one non-synonymous nucleotide substitution in exon 2.

Synchrotron XRF spectroscopy for reading salt-encrusted cuneiform tablets.

Cuneiform tablets were a primary writing medium in the ancient Near East from the late fourth millennium BCE to the first century CE. Although these clay tablets were durable for daily use, prolonged burial over millennia has made them vulnerable to salt damage. Fluctuations in temperature and humidity cause the migration of salts to the surface of the tablets, damaging them and covering the inscriptions, making the text unreadable.

A 15 month-monitoring of biofouling in relationship with hydrological parameters and contaminants in three French harbours of the English Channel.

Three French harbours connected to different water masses of the English Channel were chosen to investigate the hydrological parameters, chemical contaminants, and biofouling characteristics for 15 months. The biofouling development on two kinds of coatings, an anticorrosion coating (Epoxy) and a foul-release coating (FRC), was studied to compare micro- and macro- biofouling in harbour environments. Biofouling was investigated by considering wet biofouling biomass and composition, microalgae concentration, and bacterial abundance.

Additive-free 3D-printed nanostructured carboxymethyl cellulose aerogels.

3D printing of polysaccharide solutions is widely recognized as a highly promising method in the biomedical field for achieving complex customized shapes. One of the main challenges is in selecting conditions, in particular, the rheological properties of the system, to retain the printed shape. For the first time, the direct ink writing (DIW) is successfully applied to neat carboxymethyl cellulose (CMC) solutions without any additives or crosslinking, only by adjusting solutions' rheological properties.

Unveiling results and insights from multinational, multicenter Study of Prescribing patterns and Effectiveness of Ceftolozane/Tazobactam Real-world Analysis (SPECTRA).

Objectives: Antibacterial-resistant gram-negative hospital-acquired infections result in significant morbidity and mortality. In clinical trials, ceftolozane/tazobactam (C/T) has been effective against these infections; however, real-world findings are limited.

Methods: SPECTRA was a global, retrospective, observational inpatient study of adults treated with C/T for ≥48 hours, conducted between 2016 and 2020.

Two Recombinant Cytomegalovirus Antigens Formulated with the SPA14 Adjuvant System: Impact of Temperature, pH and Excipients on the Stability of each Antigen and Adjuvant Component.

By evaluating the stability profiles of each component of a vaccine candidate (antigens, adjuvants), formulation conditions to mitigate vaccine instability can be identified. In this work, two recombinant Cytomegalovirus (CMV) glycoprotein antigens (gB, Pentamer) were formulated with SPA14, a novel liposome-based adjuvant system containing a synthetic TLR4 agonist (E6020) and a saponin (QS21). Analytical characterization and accelerated stability studies were performed with the two CMV antigens, formulated with and without SPA14, under various conditions (temperature, pH, excipients).

Brief Report: Preventing Infusion-related Reactions With Intravenous Amivantamab: Results From SKIPPirr, a Phase 2 Study.

Introduction: Amivantamab, an EGFR-MET bispecific antibody, is approved for multiple indications in EGFR-mutated advanced non-small cell lung cancer (NSCLC) as monotherapy or combined with other agents. Intravenous amivantamab is associated with a 67% infusion-related reactions (IRR) rate.

Methods: The phase 2 SKIPPirr study (NCT05663866) enrolled patients with EGFR-mutated (Ex19del/L858R) advanced NSCLC after progression on osimertinib and platinum-based chemotherapy who received intravenous amivantamab plus oral lazertinib (amivantamab-lazertinib), a third-generation tyrosine kinase inhibitor.

Dual role of Xenopus Odf2 in multiciliated cell patterning and differentiation.

In developing tissues, the number, position, and differentiation of cells must be coordinately controlled to ensure the emergence of physiological function. The epidermis of the Xenopus embryo contains thousands of uniformly distributed multiciliated cells (MCCs), which grow hundreds of coordinately polarized cilia that beat vigorously to generate superficial water flow. Using this model, we uncovered a dual role for the conserved centriolar component Odf2, in MCC apical organization at the cell level, and in MCC spatial distribution at the tissue level.

Life expectancy losses in the Gaza Strip during the period October, 2023, to September, 2024.

Background: In the context of the ongoing war in the Gaza Strip, the Gaza Health Ministry (GHM) has reported 45 936 fatalities and more than 10 000 individuals missing or under the rubble for the period Oct 7, 2023, to Jan 8, 2025. The scope of this death count is difficult to fully interpret because it does not account for the size and age distribution of the Gaza Strip population. Moreover, the quality of this death count has been questioned.

Impact of circulating lymphocyte kinetics following radiotherapy on patient survival: A model-based meta-analysis.

Introduction: Radiation-induced lymphopenia (RIL) has been shown to adversely affect the prognosis of cancer patients undergoing radiotherapy (RT). This model-based meta-analysis investigated the prognostic significance of lymphocyte counts both early and late after RT and examined the dose‒response relationship between post-RT lymphocyte levels and patient survival.

Methods: A literature search of published articles on the effect of RIL on cancer prognosis was conducted using the PubMed and Cochrane databases.