Modulation of the Oxygenation State and Intracellular pH of Erythrocytes by Inositol-Trispyrophosphate Investigated by P NMR Study of 2,3-DPG.

The hypoxic microenvironment is crucial for tumour cell growth and invasiveness. Tumour tissue results from adaptation to reduced oxygen availability. Hypoxia first activates pro-angiogenic signals for alleviation.

Loneliness-associated factors among older adults: Focus on friendship type and number of friends.

Aim: Loneliness among older people is prevalent. Few studies have examined the association of loneliness with the type of friendship and number of friends. This study aimed to clarify the loneliness-related factors among older adults by gender focusing on the type of friendship and number of friends.

Delamination of chick cephalic neural crest cells requires an MMP14-dependent downregulation of Cadherin-6B.

Matrix Metalloproteinases (MMPs) are known for their role in matrix remodeling via their catalytic activities in the extracellular space. Interestingly, these enzymes can also play less expected roles in cell survival, polarity and motility via other substrates (e.g.

Diagnostic-constrained fault-tolerant control of bi-directional AGV transport systems with fault-prone sensors.

This paper explores a novel challenge regarding bidirectional Automated Guided Vehicles (AGVs): supervisory control amidst potential sensor faults. The proposed approach uses an event-based control architecture, guided by Supervisory Control Theory (SCT), to achieve non-blocking routing of AGVs. Unlike most routing approaches assuming full event observability, this paper investigates scenarios where events might become unobservable due to sensor faults or disturbances, which may affect the supervisor efficiency.

Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial.

Background: Activating mutations in the epidermal growth factor receptor (EGFR) gene occur in 7% to 23% of patients with non-small-cell lung cancer (NSCLC). A small proportion of these (3-5%) are exon 18 mutations. Neratinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), had activity in the phase II SUMMIT basket study.

Beyond COVID-19, the case for collecting, analysing and using sex-disaggregated data and gendered data to inform outbreak response: a scoping review.

Introduction: Understanding sex and gender differences during outbreaks is critical to delivering an effective response. Although recommendations and minimum requirements exist, the incorporation of sex-disaggregated data and gender analysis into outbreak analytics and response for informed decision-making remains infrequent. A scoping review was conducted to provide an overview of the extent of sex-disaggregated data and gender analysis in outbreak response within low- and middle-income countries (LMICs).

The Role and Future of Artificial Intelligence in Robotic Image-Guided Interventions.

Artificial intelligence and robotics are transforming interventional radiology, driven by advancements in computer vision, robotics and procedural automation. Historically focused on diagnostics, AI now also enhances procedural capabilities in IR, enabling future robotic systems to handle complex tasks such as catheter manipulation or needle placement with increasing precision and reliability. Early robotic systems in IR demonstrated improved accuracy in both vascular and percutaneous interventions, though none were equipped with automatic decision-making.

Fusion Technologies for Image-Guided Robotic Interventions.

An image guided robot only becomes fully useful with integrated software leveraging image fusion. Image fusion is the process of registering and superimposing imaging data in the same coordinate space and can be helpful to image-guided robotic interventions. Effective percutaneous robotic procedures can utilize real-time image guidance and navigation which are powered by fusion technologies.

A benchmarking study of individual somatic variant callers and voting-based ensembles for whole-exome sequencing.

By identifying somatic mutations, whole-exome sequencing (WES) has become a technology of choice for the diagnosis and guiding treatment decisions in many cancers. Despite advances in the field of somatic variant detection and the emergence of sophisticated tools incorporating machine learning, accurately identifying somatic variants remains challenging. Each new somatic variant caller is often accompanied by claims of superior performance compared to predecessors.

Regulation of UCP1 expression by PPARα and pemafibrate in human beige adipocytes.

Aims: Thermogenic adipocytes are able to dissipate energy as heat from lipids and carbohydrates through enhanced uncoupled respiration, due to UCP1 activity. PPAR family of transcription factors plays an important role in adipocyte biology. The purpose of this work was to characterize the role of PPARα and pemafibrate in the control of thermogenic adipocyte formation and function.

Perivascular enhancement pattern: Identification, Diagnostic spectrum and Practical approach - A pictorial review.

Perivascular spaces (PVS) are fluid-filled structures that form the immediate peripheral environment of small cerebral vessels. They are a central component of the glymphatic system, which plays a crucial role in maintaining cerebral homeostasis. Their involvement in central nervous system diseases is currently a major focus of research, particularly in neuroimaging.

Emergence and establishment of Staphylococcus haemolyticus ST29 in two Western France neonatal intensive care units.

Purpose: Since 2021, several reports of Staphylococcus haemolyticus outbreaks in neonatal intensive care units (NICUs) have been reported in France. The aim of this study was to understand how it became established in the NICUs of two facilities, which share the care of newborns.

Methods: All positive S.

Hydrological and hydraulic drivers of microplastics in a rural river sourced from the UK's largest opencast coal mine.

Microplastics (MPs) are ubiquitous in river and freshwater ecosystems. However, the hydraulic and hydrological mechanisms that regulate the activation and emissions of MPs from both the land surface and subsurface into rivers are not well understood. This study aims to quantify the instream MP concentration and MP load in a remote headwater catchment river (Taff Bargoed, Wales UK), which drains the UK's largest opencast coal mine (Ffos-y-fran), over a two-year period.

Toscana virus: a comprehensive review of 1,381 cases showing an emerging threat in the Mediterranean regions.

Background: Toscana virus (TOSV) is a sand fly-borne phlebovirus causing central nervous system (CNS) infection in Mediterranean countries, during summer season. However, clinical aspects of the disease caused by this virus are poorly known by clinicians, so that its prevalence is probably underestimated due to a lack of diagnosis.

Study Design: The data was gathered from all available case series and retrospective studies identifying TOSV as the causative viral agent.

Signs of in-vivo aging of zirconia from explanted dental implants with porous coating after several years in function.

The present study investigated the in vivo aging of yttria-stabilized zirconia (YSZ) oral implants (ZiUnite®) removed after 37 to 181 months. These implants featured a porous zirconia surface to enhance osseointegration. They were placed in prospective clinical investigations and had to be explanted due to peri-implant bone breakdown.

Anterior Tibial Tubercle Internal Torsion Osteotomy (ATTITO) in Patient with Patellar Instability.

Anterior tibial tuberosity osteotomy is a well-described therapeutic option for the treatment of patellar instability. External torsion of the anterior tibial tuberosity can be one of several factors that adversely affect the patellofemoral joint and its stability. The Anterior Tibial Tubercle Internal Torsion Osteotomy (ATTITO) allows the correction of excessive external torsion of the tibial tuberosity in a safe and reproducible manner.

Primary total knee arthroplasty in patients under 55 years of age: is the mid-term revision rate worrying?

Introduction: The indications for total knee arthroplasty (TKA) are expanding to include younger and more active patients. Several recent studies have warned of a higher revision rate and lower patient satisfaction in younger patients. The aim of this study was to assess the survival of TKAs in patients under the age of 55 and to determine the risk factors for revision and complications.

Change in spinopelvic mobility 3 months after THA using a direct anterior approach.

Introduction: Spinopelvic kinematics, reflected by the change in spinopelvic tilt (ΔSPT) from a standing position to a flexed seated position, has been associated with the risk of prosthetic impingement and hip dislocation. Some studies have suggested changes in spinopelvic mobility after total hip arthroplasty (THA), but none have explored changes in mobility in the first three months following THA using a direct anterior approach.

Hypothesis: Our hypothesis was that changes in spinopelvic mobility occur in the first 3 months postoperatively, leading to increased hip mobility and increased spinopelvic kinematic abnormalities.

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow.

The traditional model of protein structure determined by the amino acid sequence is today seriously challenged by the fact that approximately half of the human proteome is made up of proteins that do not have a stable 3D structure, either partially or in totality. These proteins, called intrinsically disordered proteins (IDPs), are involved in numerous physiological functions and are associated with severe pathologies, e.g.

Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry.

Despite tremendous advancements in neuroscience, there has been limited impact on patient care. Current psychiatric treatments are largely non-specific, and drug development is hindered by outdated, overinclusive diagnostic categories and a "one-size-fits-all" approach. Additionally, mechanisms underlying psychiatric illnesses and their treatments with conventional medications remain poorly understood.