1,079,846 results match your criteria: "France; Federation Hospitalo-Universitaire INCREASE[Affiliation]"
Microbiol Res
January 2025
Instituto de Ciencias de la Vid y del Vino (ICVV), CSIC - Gobierno de la Rioja - Universidad de La Rioja, Logroño 26007, Spain. Electronic address:
The microbiota, a component of the plant holobiont, plays an active role in the response to biotic and abiotic stresses. Nowadays, with recurrent drought and global warming, a growing challenge in viticulture is being addressed by different practices, including the use of adapted rootstocks. However, the relationships between these practices, abiotic stress and the composition and functions of the rhizosphere microbiota remain to be deciphered.
View Article and Find Full Text PDFPlant Physiol Biochem
January 2025
Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, IRD, Université G. Eiffel, ISTerre, Grenoble, France. Electronic address:
Understanding cadmium (Cd) pathways in cacao trees is critical for developing Cd mitigation strategies. This study investigates whether Cd uptake and translocation mechanisms differ between a low and a high Cd-accumulating cacao cultivar. We sampled three replicate trees of each cultivar, and a grafted cultivar that shared the same scion as the low Cd accumulator but had a different rootstock.
View Article and Find Full Text PDFSci Total Environ
January 2025
Université de Lorraine, CNRS, LIEC, F-54000, Nancy, France. Electronic address:
The use of lithium (Li) in decarbonization strategies has positioned it as a central component of modern technological advances, particularly in battery applications. However, the increasing demand for Li has raised concerns about its environmental consequences, which are poorly documented. This study aimed to fill this knowledge gap by examining the impact of Li on soil bacterial/fungal communities.
View Article and Find Full Text PDFDev Cogn Neurosci
January 2025
Normandie Univ, UNICAEN, INSERM, COMETE, GIP CYCERON, Caen 14000, France. Electronic address:
Sensory prediction and repetition suppression are closely related cognitive mechanisms that allow the brain to form predictions about the environment, and guide perception in synergy with attention. Predictive coding is a theory of the fundamental role of predictive mechanisms in brain functions. Authors have proposed a central role of predictive impairments in autism and possibly other neurodevelopmental disorders.
View Article and Find Full Text PDFChemosphere
January 2025
Utrecht University, Utrecht, the Netherlands.
Carbohydr Res
January 2025
Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address:
Farnesol (FAR) belongs to terpenes group and is a sesquiterpene alcohol and a hydrophobic compound, which can be extracted from natural sources or obtained by organic chemical or biological synthesis. Recent advances in the field of nanotechnology allow the drawbacks of low drug solubility, which can improve the drug therapeutic index. Therefore, this study aimed to prepare the FAR inclusion complexes with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) through freeze-drying method, proposing their physicochemical characterization, comparing their toxicity, and evaluating their in vitro antibacterial activity.
View Article and Find Full Text PDFKnee
January 2025
IULS-University Institute for Locomotion and Sports, Pasteur 2 Hospital, University Côte d'Azur, Nice, France; ICARE Team, Côte d'Azur University, Inserm, CNRS, Valrose Institute of Biology, Nice, France. Electronic address:
Background: Several studies have demonstrated the interest in patient-specific custom cutting guides in total knee arthroplasty (TKA), but clinical improvement remains debated. The purpose of this study was to evaluate the functional outcomes (Forgotten Joint Score, FJS) of patients undergoing individualized TKA compared with those receiving off-the-shelf (OTS) implants, both using patient-specific cutting guides with personalized alignment over a minimum follow up period of 12 months. We hypothesized that individualized TKA demonstrates significantly better functional outcomes than OTS TKA (FJS and percentage of patients reaching the minimum clinically important difference).
View Article and Find Full Text PDFJ Exp Bot
January 2025
National Institute of Science and Technology on Plant Physiology under Stress Conditions, Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Viçosa 36570-900, Minas Gerais, Brazil.
The transport of metabolites across the inner mitochondrial membrane (IMM) is crucial for maintaining energy balance and efficient distribution of metabolic intermediates between cellular compartments. Under abiotic stress, mitochondrial function becomes particularly critical, activating complex signaling pathways essential for plant stress responses. These pathways modulate stress-responsive gene expression, influencing key physiological processes such as cell respiration and senescence, helping plants adapt to stress.
View Article and Find Full Text PDFJ Math Biol
January 2025
Institut universitaire de France (IUF), Paris, France.
We build and study an individual based model of the telomere length's evolution in a population across multiple generations. This model is a continuous time typed branching process, where the type of an individual includes its gamete mean telomere length and its age. We study its Malthusian's behaviour and provide numerical simulations to understand the influence of biologically relevant parameters.
View Article and Find Full Text PDFCytotherapy
January 2025
Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Division of Hematology, University of Toronto, Toronto, Ontario, Canada. Electronic address:
The December 2024 US Food and Drug Administration (FDA) approval of Mesoblast's Ryoncil (remestemcel-L-rknd)-allogeneic bone marrow mesenchymal stromal cell (MSC(M)) therapy-in pediatric acute steroid-refractory graft-versus-host-disease finally ended a long-lasting drought on approved MSC clinical products in the United States. While other jurisdictions-including Europe, Japan, India, and South Korea-have marketed autologous or allogeneic MSC products, the United States has lagged in its approval. The sponsor's significant efforts and investments, working closely with the FDA addressing concerns regarding clinical efficacy and consistent MSC potency through an iterative process that spanned several years, was rewarded with this landmark approval.
View Article and Find Full Text PDFActa Derm Venereol
January 2025
Department of Dermatology, Saint-André Hospital, Bordeaux University Hospital, Bordeaux, France.
The objective of this retrospective observational study was to estimate the prevalence of actinic keratosis (AK) in individuals aged ≥ 40 years in France, to describe the characteristics of affected patients, and to describe treatments. A representative panel of 20,000 households with ≥ 1 member aged ≥ 40 years were invited to participate. Participants who reported AK lesions diagnosed by a physician were eligible.
View Article and Find Full Text PDFDis Esophagus
January 2025
Department of Digestive and Oncological Surgery, Claude Huriez Hospital, Chu Lille, Lille, France.
Background: Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and reduces postoperative morbidity and toxicities during neoadjuvant treatment.
Methods: A multicenter double-blind randomized controlled trial (RCT) was undertaken.
BMC Med Ethics
January 2025
Ethics and Work Research Unit, Institute of Advanced Studies (EPHE), Paris, France.
Aim: To carry out a detailed study of existing positions in the French public of the acceptability of refusing treatment because of alleged futility, and to try to link these to people's age, gender, and religious practice.
Method: 248 lay participants living in southern France were presented with 16 brief vignettes depicting a cancer patient at the end of life who asks his doctor to administer a new cancer treatment he has heard about. Considering that this treatment is futile in the patient's case, the doctor refuses to prescribe it.
Eur Arch Otorhinolaryngol
January 2025
Guilloz Imaging Department, Central Hospital, University Hospital Center of Nancy, Nancy, 54000, France.
Background And Purpose: To evaluate various anatomical parameters and their relationship to chorda tympani nerve (CTN) injury and round window (RW) access during cochlear implantation.
Materials And Methods: Ultra-high-resolution CT images of 66 patients were retrospectively reviewed and compared with operative reports. The facial recess and the round window were analyzed, mainly using the chorda-facial angle (CFA), the width of the facial recess, the CTN-tympanic annulus distance, the RW-mastoid portion of the facial nerve angle, and the type of RW.
Ann Surg Oncol
January 2025
Department of Hepatobiliary and Digestive Surgery, Pontchaillou University Hospital, Rennes, France.
Background: Hepatocellular carcinoma (HCC) associated with major vasculature tumor extension is considered an advanced stage of disease to which palliative radiotherapy or chemotherapy is proposed. Surgical resection associated with chemotherapy or chemoembolization could be an opportunity to improve overall survival and recurrence-free survival in selected cases in a high-volume hepatobiliary center. Moreover, it has been 25 years since Couinaud described the entity of a posterior liver located behind an axial plane crossing the portal bifurcation.
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Commun Biol
January 2025
Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392, Giessen, Germany.
In vertebrates and plants, dsRNA plays crucial roles as PAMP and as a mediator of RNAi. How higher fungi respond to dsRNA is not known. We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad size range of 21 to about 3000 bp.
View Article and Find Full Text PDFBone Marrow Transplant
January 2025
Université de Franche-Comté, EFS, INSERM, UMR RIGHT, F-, 25000, Besançon, France.
The accessibility of CAR-T cells in centralized production models faces significant challenges, primarily stemming from logistical complexities and prohibitive costs. However, European Regulation EC No. 1394/2007 introduced a pivotal provision known as the hospital exemption.
View Article and Find Full Text PDFSci Rep
January 2025
College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing, 210098, China.
Internal instability of embankment soils under seepage can occur in two distinct ways: suffusion and suffosion. Suffusion involves the removal of fine particles from the matrix without causing significant disturbance to the soil skeleton, while suffosion is characterized by the movement of fine particles accompanied by skeleton collapse or deformation. In terms of dam safety, suffosion poses a greater threat than suffusion.
View Article and Find Full Text PDFNat Commun
January 2025
Sorbonne Université, CNRS, Laboratory of Computational and Quantitative Biology, LCQB, Paris, France.
Telomere shortening ultimately causes replicative senescence. However, identifying the mechanisms driving replicative senescence in cell populations is challenging due to the heterogeneity of telomere lengths and the asynchrony of senescence onset. Here, we present a mathematical model of telomere shortening and replicative senescence in Saccharomyces cerevisiae which is quantitatively calibrated and validated using data of telomerase-deficient single cells.
View Article and Find Full Text PDFNat Commun
January 2025
Université de Lorraine, CNRS, Inria, LORIA, F-54000, Nancy, France.
The main obstacle to large scale quantum computing are the errors present in every physical qubit realization. Correcting these errors requires a large number of additional qubits. Two main avenues to reduce this overhead are (i) low-density parity check (LDPC) codes requiring very few additional qubits to correct errors (ii) cat qubits where bit-flip errors are exponentially suppressed by design.
View Article and Find Full Text PDFFoot Ankle Surg
January 2025
Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh EH16 4SA, United Kingdom.
Introduction: It is unclear how pre-operative anxiety/depression affects patient reported outcome measures (PROMs) following total ankle replacements (TAR). We investigated the effects of anxiety/depression on PROMs using the Manchester-Oxford Foot Questionnaire (MOXFQ) following TAR.
Methods: PROMs data for primary TAR patients between 2011 and 2022 were extracted from a single-centre regional registry.
Trends Microbiol
January 2025
Climate Change Cluster (C3), University of Technology Sydney, Sydney, New South Wales 2007, Australia; UAR 3278 CRIOBE, PSL Université Paris: EPHE-UPVD-CNRS, Université de Perpignan, 52 Avenue Paul Alduy, 66860, Perpignan, France. Electronic address:
Inter-microbial interactions fundamentally govern ocean ecology and biogeochemistry. Recently, Henshaw and colleagues revealed that important inter-bacterial associations in the ocean can be shaped by viral infections, whereby infected cyanobacteria release specific chemicals that attract heterotrophic bacteria, uncovering a new tripartite microbial interaction that influences carbon transfer in the surface ocean.
View Article and Find Full Text PDFTrends Microbiol
January 2025
Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker-Enfants Malades, Paris, France. Electronic address:
Bull Cancer
January 2025
Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France; Inserm U1296 rayonnements : défense, santé, environnement, centre Léon-Bérard, 69008 Lyon, France.
Context: The aim of this practice evaluation was to assess weight trends during and after a nutritional intervention in cancer patients and survivors.
Methods: This retrospective study was conducted between January 2014 and October 2020 in adults with different cancer types managed at the Léon-Bérard Cancer Center, undergoing treatment or during post-treatment follow-up, with a BMI≥25kg/m and who had at least 3 consultations with a nutrition physician. Nutritional management focused on behavioral, metabolic and nutritional aspects.