Return to work after primary total knee replacement in patients under 55 years of age: a retrospective study of 129 cases.

Introduction: Primary total knee arthroplasty (TKA) has shown excellent results in the treatment of osteoarthritis, and its indications have now been extended to younger patients of working age. Few articles in the literature have studied the return to work of young subjects, and no specific studies have been conducted in France. Therefore, we carried out a retrospective study to 1) investigate the rate and delay of return to work after primary TKA in a population under 55 years of age and 2) identify factors influencing early return to work before 3 months, the period usually used as the duration of initial work stoppage (TS).

Biomechanical assessment of ligament maturation after arthroscopic ligament reconstruction of the anterior talofibular ligament.

Background: Many techniques have been described for lateral ankle ligament reconstruction. Although the biomechanical properties of gracilis tendons are different from those of ligaments, the use of a gracilis tendon autograft is a popular option for anatomical reconstruction. Graft maturation and the biomechanical processes over time remain unclear.

Low-level primary clarithromycin resistance of Helicobacter pylori in Reunion Island.

Introduction: The increasing resistance of Helicobacter pylori to clarithromycin leads to an ongoing adaptation of empirical first-line treatment for H. pylori infections.

Patients And Methods: Prospective study (2022-2023) of 364 patients with no previous treatment for H.

Exploring the influence of perineal biometrics and stiffness measured by elastography during pregnancy on perineal tears : a pilot study.

Objectives: This study aimed to describe the biometrics and elasticity of the perineal body and the anal sphincter in the ninth month of pregnancy and explore their association with the risk of perineal tears during childbirth.

Methods: In this prospective observational study, pregnant women at 36-40 weeks of gestation were included. Using transperineal 2D-mode ultrasound and shear wave elastography (SWE), we measured the biometrics and stiffness of the perineal body (PB), external anal sphincter (EAS), internal anal sphincter (IAS), and anal mucosa (AM) at rest and during Valsalva maneuvers.

Hospital outbreak of NDM-producing Klebsiella pneumoniae in a surgical intensive care unit: sink traps as the causing source of epidemic strain resurgence.

We report the management of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae outbreak in a surgical intensive care unit over 1 year. NDM-producing Enterobacterales were isolated from sink traps. The installation of new sink traps closed the outbreak.

Results from a phase 1b study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein-overexpressing, EGFR-mutated locally advanced/metastatic non-small cell lung cancer (NSCLC) after progression on prior osimertinib.

Background: Osimertinib is the standard first-line treatment for advanced epidermal growth factor receptor (EGFR)-mutated NSCLC. However, treatment resistance is inevitable and increased c-Met protein expression correlates with resistance. Telisotuzumab vedotin (Teliso-V) is an antibody-drug conjugate that targets c-Met protein overexpression.

Medication Use in People Aged 90 Years and Older: A Nationwide Study.

Objective: We aimed to describe the medications prescribed to people aged ≥90 years.

Design: A cohort study was performed using data from the year 2022.

Setting And Participants: Using data from the French National Health Data System, people aged ≥90 years affiliated with the general insurance scheme were included.

Design and Ex Vivo Evaluation of a PCLA Degradable Device To Improve Annulus Fibrosus Repair.

With a prevalence of over 90% in people over 50, intervertebral disc degeneration (IVDD) is a major health concern. This weakening of the intervertebral discs can lead to herniation, where the nucleus pulpus (NP) leaks through the surrounding Annulus Fibrosus (AF). Considering the limited self-healing capacity of AF tissue, an implant is needed to restore its architecture and function.

Assessment of the effects of cadmium, samarium and gadolinium on the blue mussel (Mytilus edulis): A biochemical, transcriptomic and metabolomic approach.

Improving the understanding of how chemicals affect on organisms and assessing the associated environmental risks is of major interest in environmental studies. This can be achieved by using complementary approaches based on the study of the molecular responses of organisms. Because of the known chemical pressures on the environment, regulations on the content of some chemicals, such as cadmium, have been mostly completed.

Subgroups varying in risk and density highlight the potential for stratified breast cancer screening.

Most breast cancer screening programs rely only on demographic data without considering individual risk factors of the population, which might limit their effectiveness by over- and underscreening specific subgroups. Therefore, the aim of this study is to highlight health and economic disparities in outcomes from such a uniform screening strategy. With the microsimulation model MISCAN, we simulated outcomes of the Dutch screening program considering 16 subgroups varying by their 5-year breast cancer risk and breast density.

Interatomic Coulombic decay in lithium-doped large helium nanodroplets induced by photoelectron impact excitation.

Irradiation of condensed matter with ionizing radiation generally causes direct photoionization as well as secondary processes that often dominate the ionization dynamics. Here, large helium (He) nanodroplets with radius ≳ 40 nm doped with lithium (Li) atoms are irradiated with extreme ultraviolet (XUV) photons of energy hν ≥ 44.4 eV and indirect ionization of the Li dopants is observed in addition to direct photoionization of the He droplets.

Single-molecule resolution of the conformation of polymers and dendrimers with solid-state nanopores.

Polymers and dendrimers are macromolecules, possessing unique and intriguing characteristics, that are widely applied in self-assembled functional materials, green catalysis, drug delivery and sensing devices. Traditional approaches for the structural characterization of polymers and dendrimers involve DLS, GPC, NMR, IR and TG, which provide their physiochemical features and ensemble information, whereas their unimolecular conformation and dispersion also are key features allowing to understand their transporting profile in confined ionic nanochannels. This work demonstrates the nanopore approach for the determination of charged homopolymers, neutral block copolymer and dendrimers under distinct bias potentials and pH conditions.

Microplastics in freshwaters: Comparing effects of particle properties and an invertebrate consumer on microbial communities and ecosystem functions.

The effects of microplastic (MP) accumulation in freshwaters on organisms and ecosystem functions are poorly understood, as are the roles of MP particle properties in regulating these effects. In freshwater microcosms, we quantified variation in microbial communities and ecosystem functions and compared effects of MP concentration (0, 1000, 50000 particles/kg), shape (sphere, fragment, fibre), and polymer (polyethylene, polyethylene terephthalate, polypropylene, polystyrene) with those of a model invertebrate consumer (Chironomus riparius). We detected multiple effects of specific MP properties, especially associated with MP fragments and fibres, and the polymer polypropylene.

The pan-PPAR agonist lanifibranor reduces portal pressure independent of fibrosis reduction through the splanchnic vasculature.

Portal hypertension (PH) can cause severe complications in patients with advanced chronic liver disease (aCLD). The pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist lanifibranor reduces portal pressure in preclinical models of aCLD. Since the effect on PH might be secondary to fibrosis improvement, we investigated the effect of lanifibranor on PH, hepatic and splanchnic angiogenesis in mouse models of fibrotic and prehepatic non-fibrotic PH.

Wild bees show local spatial and temporal dynamics in southeastern US blueberry farmscapes.

Wild bee communities are the target of various conservation and ecological restoration programs. Strategic conservation can influence bee communities visiting fields and help mitigate pollinator limitations in fruit production. However, planning compatible conservation strategies and gauging their effectiveness requires understanding how local communities vary across space and time in crops and adjacent semi-natural areas.

Coupling of single nanodiamonds hosting SiV color centers to plasmonic double bowtie microantennas.

Color centers are promising single-photon emitters owing to their operation at room temperature and high photostability. In particular, using nanodiamonds as a host material is of interest for sensing and metrology. Furthermore, being a solid-state system allows for incorporation to photonic systems to tune both the emission intensity and photoluminescence spectrum and therefore adapt the individual color center to desired properties.

Prospective associations between organisational changes and health outcomes among French employees who remained in employment.

Objectives: To explore the prospective associations of organisational changes with health outcomes among employees who remained in employment.

Methods: The study relied on the prospective data of the national French working conditions survey collected from employees and their employers in 2013, 2016 and 2019. The study sample included 4480 private sector employees.

"Knife cut technique". A new way for intra ocular lens (IOL) explantation.

Purpose: We report a novel technique which enables to cut any kind of foldable lens and extract it using capsulorhexis forceps and a 1.2 mm single-use slit angled knife.

Methods: The technique consists in using the capsulorhexis forceps to mantain and stabilize the IOL in the anterior chamber, and while one hand holds the IOL in that way, the second hand introduces a 1.

Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy.

Despite the development of various controlled release systems for antitumor therapies, off-target side effects remain a persistent challenge. In situ therapeutic synthesis from biocompatible substances offers a safer and more precise alternative. This study presents a hypoxia-initiated supramolecular free radical system capable of inducing intracellular polymerization, thereby disrupting the cytoskeleton and organelles within 4T1 cells.

Floodplain forests drive fruit-eating fish diversity at the Amazon Basin-scale.

Unlike most rivers globally, nearly all lowland Amazonian rivers have unregulated flow, supporting seasonally flooded floodplain forests. Floodplain forests harbor a unique tree species assemblage adapted to flooding and specialized fauna, including fruit-eating fish that migrate seasonally into floodplains, favoring expansive floodplain areas. Frugivorous fish are forest-dependent fauna critical to forest regeneration via seed dispersal and support commercial and artisanal fisheries.