Temporal and spatial equivalence in demographic responses of emperor penguins (Aptenodytes forsteri) to environmental change.

Population ecology and biogeography applications often necessitate the transfer of models across spatial and/or temporal dimensions to make predictions outside the bounds of the data used for model fitting. However, ecological data are often spatiotemporally unbalanced such that the spatial or the temporal dimension tends to contain more data than the other. This unbalance frequently leads model transfers to become substitutions, which are predictions to a different dimension than the predictive model was built on.

Effectiveness and Safety of Tralokinumab in Atopic Dermatitis: 1-year Results From a Real-world Multicentre Study.

Tralokinumab is a monoclonal antibody selectively targeting IL-13, approved for moderate-to-severe atopic dermatitis (AD), for which real-world data are scarce. This prospective, observational, multicentric study aimed to assess the long-term effectiveness and safety of tralokinumab in patients with AD in a real-world setting. Primary outcomes included 50%, 75%, and 90% improvement in Eczema Area and Severity Index score (EASI50, EASI75, EASI90, respectively) and improvements in Dermatology Life Quality Index (DLQI) at 1 year.

Escherichia coli α-hemolysin induces red blood cell retention in a microfluidic spleen-like device.

α-hemolysin (HlyA) is a major exotoxin secreted by uropathogenic Escherichia coli (UPEC), known for its ability to lyse red blood cells (RBCs). While its lytic effects are well characterized, the non-lytic alterations on RBCs, such as increased permeability to Ca, osmotic imbalance, and morphological alterations, remain less understood and may be critical in UPEC pathogenesis. This study investigates the impact of these non-lytic alterations on the rheology and mechanics of RBCs using two biomimetic microfluidic devices that model key aspects of RBCs' circulation.

Illustrator-anatomist-clinician triad based pedagogical model in anatomy education: An auxiliary resource amidst lack of hands-on human dissection.

Adherence to the highest ethical standards is mandatory while handling precious human tissues received through the altruistic act of body donation. In 2019, misconduct at the Body Donation Center in Paris led to its closure. This adversely affected the hands-on human dissection sessions within the anatomy education program at Université Paris-Saclay.

Chemical Durability of Uranium Oxide Microspheres for Use as QC Materials for Nuclear Safeguards.

This study investigates the chemical durability of uranium oxide microparticles (UO and UO), as potential reference materials for nuclear safeguards. To optimize long-term preservation, the particles were exposed to three different storage media: dilute nitric acid (10 mol L HNO), deionized water, and ethanol. Dissolution rates in nitric acid (∼5 × 10 g.

Foot Malalignment and Proximal Fifth Metatarsal Fractures.

Background: Proximal fifth metatarsal fractures are common injuries that are classified into 3 zones according to their anatomical localization. While zone 1 and 2 fractures typically are traumatic, zone 3 fractures may be linked to foot alignment abnormalities, such as hindfoot varus and metatarsus adductus. The aim of the study was to explore the association between hindfoot alignment and different fracture zones, as well as the relationship between traumatic and atraumatic fracture origin and foot alignment.

Year-Round Quantification, Structure and Dynamics of Epibacterial Communities From Diverse Macroalgae Reveal a Persistent Core Microbiota and Strong Host Specificities.

Macroalgae-bacteria interactions play pivotal ecological roles in coastal ecosystems. Previous characterisation of surface microbiota from various macroalgae evidenced fluctuations based on host tissues, physicochemical and environmental parameters. However, the dynamics and degree of similarity of epibacterial communities colonising phylogenetically distant algae from the same habitat are still elusive.

Benefits of Dietary Supplementation with Specific Silicon-Enriched Spirulina on Arterial Function in Healthy Elderly Individuals: A Randomized, Placebo-Controlled Trial.

: Vascular aging is associated with increased arterial stiffness and changes in the wall structure, leading to a loss of elasticity. Silicon is abundant in arteries and plays a key role in the synthesis and stabilization of elastin fibers. In animal models of accelerated cardiovascular aging, a specific nutritional supplement based on silicon-enriched spirulina (SpSi) has been shown to have beneficial effects on vascular function.

Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.

: Post-menopausal women are at an increased risk of developing cardiovascular disease. Menaquinone-7 (MK-7) is a fat-soluble vitamin involved in coagulation and maintaining vascular health. The aim of the post hoc analysis of this one-year study is to investigate the effects of MK-7 supplementation on the vascular parameters in pre-, peri-, and post-menopausal women.

Microencapsulation and Probiotic Characterization of LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis.

Background: Microencapsulation improves the storage, handling, and administration of probiotics by protecting them from environmental factors and adverse conditions in the gastrointestinal tract. This process facilitates their controlled delivery in the body, which can simplify their use in therapies without compromising their therapeutic efficacy.

Objectives: This study investigates the microencapsulation of LM-20, its probiotic properties, and its effects in a murine model of ulcerative colitis.

Unravelling Cocoa Drying Technology: A Comprehensive Review of the Influence on Flavor Formation and Quality.

Cocoa quality serves as a differentiating factor that provides monetary and non-monetary benefits to farmers, defined by the genotype, agroecological conditions of cultivation, and the post-harvest processes involved in transforming seeds into cocoa beans, including harvesting, pre-conditioning, fermentation, and drying. Drying plays a crucial role in ensuring the sensory, chemical, and microbiological quality of the beans, as simultaneous mass and heat transfer phenomena occur during this process, along with chemical reactions (both enzymatic and non-enzymatic) that influence the concentration and dynamics of phenolic compounds, organic acids, methylxanthines, and the formation of volatiles, directly impacting flavor development in cocoa beans. This paper comprehensively reviews cocoa drying methods, variables, and equipment and analyzes their impact on these flavor-determining compounds.

Enhanced Cement Foam Composite with Biochar for Eriochrome Black T Dye Removal.

Cement-based foam composites have gained attention as innovative and high-performing adsorbents for wastewater treatment due to their lightweight, porous, and structurally robust properties. This study investigates the adsorption of Eriochrome Black T dye onto biochar-modified cement foam, providing a cost-effective solution for industrial wastewater management. The integration of biochar into cement foam enhances its surface area and adsorption capabilities while maintaining structural stability and tunable porosity.

Feelings of Patients Admitted to the Emergency Department.

: Very few studies describe the various feelings experienced in the emergency department (ED). Our study describes the pain, stress, and negative and positive emotions experienced by patients admitted to the ED in relation to age, gender, and reason for ED admission. : Patients admitted to the ED of seven French hospitals were surveyed as part of the randomised multicentre study SOFTER IV (n = 2846).

A SEIPS-Based Analysis to Understand Safety Culture During Postpartum Hemorrhage.

Maternal mortality occurs at alarming rates in the United States. In 2018, there were 17 maternal deaths for every 100,000 births-double that of other high-income countries, including France and Canada. Postpartum hemorrhage (i.

Updated Views on Vestibular Physical Therapy for Patients with Vestibular Disorders.

Vestibular Physical Therapy (VPT) plays a crucial role in the rehabilitation of patients with vestibular disorders by promoting vestibular compensation through adaptation, habituation, and substitution mechanisms. While traditional VPT approaches have demonstrated effectiveness in restoring balance and gaze stability, some patients with chronic vestibular dysfunction continue to experience persistent deficits. review of recent advancements in neuroplasticity research suggest the need for updated rehabilitation strategies that integrate sensorimotor substitution, saccadic training, optokinetic stimulation, and cognitive-motor dual-task training to optimize vestibular compensation.

Use of Natural Biomolecules in Animal Feed to Enhance Livestock Reproduction.

Feed additives are crucial in livestock production, enhancing performance, health, and reproductive efficiency. Recently, there has been a shift toward natural biomolecules as feed additives, specifically targeting improved reproductive outcomes and sperm quality. This transition arises from concerns about antibiotic misuse, antimicrobial resistance, and consumer preferences for eco-friendly products, along with the superior bioavailability, lower toxicity, and reduced environmental impact of natural biomolecules compared to synthetic alternatives.

Widespread and Heterologous Effects of L-DOPA on Monoaminergic Tissue Metabolism in Newborn Rats Expressing Air-Stepping.

L-DOPA triggers a dose-dependent increase in locomotor activity in newborn rats suspended in the air (air-stepping). Here, we report the effects of L-DOPA injection on the tissue level of monoamines and metabolites in different regions of the central nervous system (CNS) of postnatal day 5 pups. We also established correlations between some of our neurochemical measurements and basic locomotor parameters.

Xanthohumol Sensitizes Melanoma Cells to Vemurafenib by Lowering Membrane Cholesterol and Increasing Membrane Fluidity.

Chemoresistance remains one of the major obstacles to cancer treatment. The search for specific molecules that could improve cancer treatment has become one of the objectives of biomedical research. Identifying new natural molecules to enhance chemotherapy treatment or improve sensitization to conventional therapies has become a key objective.

1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines.

Getting through the cell membrane is challenging, and transporting a therapeutic agent while entering the cell is even more complicated. Cell-penetrating peptides (CPPs) are valuable tools for solving this problem, although they have drawbacks. In this work, the synthesis and investigation of efficient CPPs are described.

Cranberry Oil: A Potent Natural Intimate Care Ingredient Displaying Antioxidant and Anti-Inflammatory Effects and Promoting Beneficial Vaginal .

Cranberry oil is known for nutritional benefits, and this work is aimed at studying its soothing properties and potential as an intimate care ingredient. The antioxidant, anti-inflammatory, and anti-irritation properties of cranberry oil were evaluated on epithelial cells and tissues, including the vaginal epithelium. The impact of the oil on vaginal microbiota was assessed in vitro.

Synthesis of the Titanium Oxides Using a New Microwave Discharge Method.

This research highlights the different behaviors of titanium (Ti) wires under the action of 500 W and 800 W microwave power levels. Following the interaction between microwaves and a titanium wire placed in the node of the (TM-transverse magnetic mode) waveguide in air at atmospheric pressure, plasma was generated. Using optical emission spectroscopy technique it was observed that during plasma generation at 500 W and 800 W microwaves powers, metallic ions, and gas ions were created, and the plasmas fulfilled the local thermodynamic equilibrium (LTE) conditions.

Cellular Phenotypic Transformation During Atherosclerosis: The Potential Role of miRNAs as Biomarkers.

Cellular phenotypic transformation is a key process that occurs during the development and progression of atherosclerosis. Within the arterial wall, endothelial cells, vascular smooth muscle cells, and macrophages undergo phenotypic changes that contribute to the pathogenesis of atherosclerosis. miRNAs have emerged as potential biomarkers for cellular phenotypic changes during atherosclerosis.

Synthesis, Physicochemical Properties and Anti-Fungal Activities of New -Arylporphyrins.

In this work, we describe the synthesis of three new -arylporphyrins, named -tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (), -tetrakis [4-(picolinoyloxy)phenyl] porphyrin (), and -tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (). These new synthesized -arylporphyrins are characterized using spectroscopic analysis: Fourier Transform Infrared Spectroscopy (FTIR) and One-dimensional Nuclear Magnetic Resonance (1D NMR), and mass spectrometry (MS). The photophysical studies (UV-visible absorption, singlet oxygen (O) luminescence, and fluorescence emissions) demonstrate their potential uses as photosensitizers (PSs) in photodynamic therapy (PDT) applications.

Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of "Psychobiotics".

Psychobiotics, live microorganisms that provide mental health by interacting with the gut microbiota, are emerging as a promising therapeutic option for psychiatric and neurodevelopmental disorders. Their effectiveness in addressing conditions such as depression, anxiety, insomnia, stress, autism spectrum disorder (ASD), and eating disorders were examined through a comprehensive analysis of existing studies up to the first half of 2024, based on data from reliable electronic databases. We found that psychobiotics can significantly reduce symptoms of various psychiatric disorders by influencing neurotransmitter levels, regulating the hypothalamic-pituitary-adrenal (HPA) axis, and improving gut barrier function through short-chain fatty acids (SCFAs) and other metabolites.