1,079,091 results match your criteria: "France; Corpuscular Physics Laboratory-Normandy University[Affiliation]"
J R Soc Interface
January 2025
Laboratoire Matière et Systèmes Complexes, CNRS, Université Paris Cité, Paris, France.
Many swimmers, especially small- to medium-sized animals, use intermittent locomotion that differs from continuous swimming of large species. This type of locomotion, called burst and coast, is often associated with an energetic advantage. In this work, we investigate the intermittent locomotion inspired by fish locomotion but applied to a propeller.
View Article and Find Full Text PDFPhysiol Behav
January 2025
Université Clermont Auvergne, AME2P, F-63000 Clermont-Ferrand, France.. Electronic address:
Perceptual-cognitive skills are determinant for sports performance in young athletes. The present study aimed to clarify how maturity status influences perceptual-cognitive skills with consideration of training background and stereopsis. One hundred and sixty-six 10- to 16-year-old male participants were divided into eight groups based on their training background (moderately-trained: 1-2 weekly sessions; well-trained: 4-5 weekly sessions) and maturity status (Pre-Pubertal ≤ -2 years from APHV, Pre-Pubertal = -2 to -0.
View Article and Find Full Text PDFEur J Pharm Biopharm
January 2025
Inserm UMRS_1138, Team 1, Physiopathology of ocular diseases: Therapeutic Innovations at Centre de Recherche des Cordeliers, Paris, France, 75006; Ophthalmopole at Hôpital Cochin, Paris, France; Sorbonne Paris Cité, UMRS_1138, France. Electronic address:
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the formulation or aspects related to patient comfort, safety, and acceptability. Because of the limited toxicity studies provided, and the several allergic and toxic side effects that have been reported throughout the years, it is not trivial for the regulatory agencies to approve inactive ingredients for human use.
View Article and Find Full Text PDFRadiother Oncol
January 2025
GORTEC 4 bis rue Emile Zola 37000 Tours, France; Department of Radiotherapy, Centre François-Baclesse, Corpuscular Physics Laboratory, IN2P3, ENSICAEN, CNRS UMR 6534, Université de Normandie, Caen, France. Electronic address:
Purpose: The randomized phase II GORTEC 2014-04 and French Head and Neck Intergroup study showed deeper deterioration of the quality of life (HRQoL) and dramatically higher severe toxicity rates with similar overall survival rates using chemo-SABR compared to SABR alone in oligometastatic head and neck cancer (HNSCC) patients. We evaluated the costs associated with SABR-alone versus chemo-SABR and their associated costs (transportation, hospitalizations, etc).
Materials And Methods: 69 HNSCC patients with 1-3 oligometastases and a controlled primary were randomized from September 2015 to October 2022.
Toxicol In Vitro
January 2025
Atomic Energy and Alternative Energies Commission (CEA), Laboratory of Radiotoxicology, CEA, Paris-Saclay University, Bruyères-le-Châtel, France.
Internal contamination by inhalation of plutonium poorly soluble compounds leads to their long time retention in alveolar macrophages inducing delayed pathology development. As previous studies highlighted co-localization of retained Pu and inflammatory lesions, this study was designed to assess the combined effect of the reference treatment (DTPA) and anti-inflammatory drugs on Pu-induced early response of macrophages in vitro. Pu colloids, mimicking poorly soluble Pu, were characterized using filtration and solid-state nuclear track detectors CR39.
View Article and Find Full Text PDFCell
January 2025
Institute of Epigenetics and Stem Cells, Helmholtz Munich, Munich, Germany; Faculty of Biology, Ludwig-Maximilians Universität, Munich, Germany. Electronic address:
Transcriptional activation of the embryonic genome (EGA) is a major developmental landmark enabling the embryo to become independent from maternal control. The magnitude and control of transcriptional reprogramming during this event across mammals remains poorly understood. Here, we developed Smart-seq+5' for high sensitivity, full-length transcript coverage and simultaneous capture of 5' transcript information from single cells and single embryos.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
University of Zagreb, Faculty of Science, Department of Chemistry, Zagreb, HR-10000, Croatia.
The phenomenon of solid dissolution into a solution constitutes a fundamental aspect in both natural and industrial contexts. Nevertheless, its intricate nature at the microscale poses a significant challenge for precise quantitative characterization at a foundational level. In this work, the influence across three specific cleavage planes, namely (100), (111), and (110) on the dissolution kinetics of fluorite in aqueous environments was examined from both experimental and theoretical standpoints.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Biological and Environmental Sciences, Faculty of Natural Sciences, University of Stirling, Stirling, FK9 4LA, United Kingdom.
Tree-planting is increasingly presented as a cost-effective strategy to maximise ecosystem carbon (C) storage and thus mitigate climate change. Its success largely depends on the associated response of soil C stocks, where most terrestrial C is stored. Yet, we lack a precise understanding of how soil C stocks develop following tree planting, and particularly how it affects the form in which soil C is stored and its associated stability and resistance to climate change.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
January 2025
Aix Marseille Univ, CNRS, ISM, 13009, Marseille, France; Aix Marseille Univ, APHM, CNRS, ISM, Sainte-Marguerite Hospital, Institute for Locomotion, Department of Orthopaedics and Traumatology, 13009, Marseille, France.
Surgeons frequently use allograft bone due to its osteoconductive, osteoinductive, and osteogenic properties. Preservation processes are employed to clean the allograft, improve its conservation, and ensure its sterilization. Many current processes use the properties of supercritical CO to remove bone marrow.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
Biozentrum, University of Basel, Spitalstrasse 41, Basel, Basel-Stadt, 4056, SWITZERLAND.
Activity and autonomous motion are fundamental aspects of many living and engineering systems. Here, the scale of biological agents covers a wide range, from nanomotors, cytoskeleton, and cells, to insects, fish, birds, and people. Inspired by biological active systems, various types of autonomous synthetic nano- and micromachines have been designed, which provide the basis for multifunctional, highly responsive, intelligent active materials.
View Article and Find Full Text PDFBiofabrication
January 2025
Univ. Bordeaux, INSERM U1026 (BioTis), CHU Bordeaux, Université de Bordeaux Collège Sciences de la Santé, 146 Rue Léo Saignat, Bordeaux, 33000, FRANCE.
Producing oral soft tissues using tissue engineering could compensate for the disadvantages of autologous grafts (limited availability and increased patient morbidity) and currently available substitutes (shrinkage). However, there is a lack of in vitro-engineered oral tissues due to the difficulty of obtaining stable pre-vessels that connect to the host and enable graft success. The main objective was to assess the connection of pre-vascularised 3D-bioprinted gingival substitutes to the host vasculature when subcutaneously implanted in immunodeficient mice.
View Article and Find Full Text PDFUltrasonics
January 2025
Institut Langevin, ESPCI Paris, Université PSL, CNRS, 1 rue Jussieu, Paris, 75005, France.
Detecting surface contamination on thin thermoformed polymer plates is a critical issue for various industrial applications. Lamb waves offer a promising solution, though their effectiveness is challenged by the strong attenuation and anisotropy of the polymer plates. This issue is addressed in the context of a calcium carbonate (CaCO) layer deposited on a polypropylene (PP) plate.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
CEA, DES, ISEC, DPME, SEME, University of Montpellier, Marcoule, Bagnols-sur-Cèze F-30207, France.
Although models have been proposed to explain the mechanisms of bioglass (BG) dissolution and subsequent calcium phosphate (CaP) mineralization, open questions remain. The processes in which phase transition occurs in aqueous solutions and their dynamics remain underexplored partly because traditional instruments/techniques do not allow for direct observations at the adequate time and length scales at which such phase transformations occur. For instance, given the crucial role of the silica gel in CaP formation during BG dissolution, uncertainty exists about how such a silica gel forms on the BG surface.
View Article and Find Full Text PDFJ Clin Oncol
January 2025
Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
Immune checkpoint blockers (ICBs) have revolutionized the treatment of non-small cell lung cancer (NSCLC). Currently, one-dose-fits-all maximalist regimens have been considered the standard of care, with ICBs administered at flat doses regardless of patients' weight. Treatment duration with ICBs is often arbitrary across stages, ranging from a fixed time point to until disease progression or unacceptable toxicity.
View Article and Find Full Text PDFChem Asian J
January 2025
Universite de Rennes 1, Sciences Chimiques de Rennes - UMR 6226, Avenue du General Leclerc, Campus de Beaulieu, 35042, Rennes, FRANCE.
A novel coordination motif comprising [4]helicene fused with pyrazino-phenanthroline (H4PP) has been synthesized and reacted with ReCl(CO)5 to yield its rhenium(I) complex (Re-H4PP). Absorption and emission spectroscopic analysis conducted in dichloromethane and 2-methyltetrahydrofuran reveals that combining pyrazino-phenanthroline with helicene visibly affects the photophysical attributes of both the resulting ligand and its Re(I) complex as compared to their non-helicene analogues, and even more importantly leads to relatively high photoluminescence quantum yield values, especially in the case of H4PP (29%). Chiroptical studies through electronic circular dichroism and circularly polarized luminescence performed on enantiomerically enriched samples of Re-H4PP show the chiral nature of low-energy excited states affording notable glum values that amplify at cryogenic temperatures.
View Article and Find Full Text PDFMed Sci Sports Exerc
January 2025
University of La Réunion, INSERM, U1188 Diabetes Atherothrombosis Therapies Indian Ocean (DéTROI), Saint Pierre de La Réunion, FRANCE.
Purpose: Red blood cells (RBCs) senescence and blood rheology during ultra-endurance running events appear to be impacted differently depending on the race distance. The physiological mechanisms underlying these differences are poorly understood.
Methods: We investigated the effects of three different ultra-trail running races performed in La Reunion Island (Mascareignes, "the 70 km", 70 km/4,000 m D+; Trail Du Bourbon, "the 100 km", 100 km/6,090 m D+; Diagonale des Fous, "the 170 km", 170 km/10,500 m D+) on RBC oxidative stress, RBC senescence and blood rheology in 66 finishers (18 "70 km", 24 "100 km", 24 "170 km").
J Am Chem Soc
January 2025
Max Planck Institute for Medical Research, Jahnstr. 29, Heidelberg 69120, Germany.
Orange carotenoid protein (OCP) is a photoactive protein that mediates photoprotection in cyanobacteria. OCP binds different ketocarotenoid chromophores such as echinenone (ECN), 3'- hydroxyechinenone (hECN), and canthaxanthin (CAN). In the dark, OCP is in an inactive orange form known as OCP; upon illumination, a red active state is formed, referred to as OCP, that can interact with the phycobilisome.
View Article and Find Full Text PDFPLoS Med
January 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: School closures have been a prominent component of the global Coronavirus Disease 2019 (COVID-19) response. However, their effect on viral transmission, COVID-19 mortality and health care system pressure remains incompletely understood, as traditional observational studies fall short in assessing such population-level impacts.
Methods And Findings: We used a mathematical model to simulate the COVID-19 epidemics of 74 countries, incorporating observed data from 2020 to 2022 and historical school closure timelines.
J Psychiatr Pract
January 2025
Mental Health Medical Activity Center, Caen Normandy University Hospital, Caen, France.
Psychodynamic therapy (PDT), a technical adaptation of psychoanalysis, is one of the most widely practiced forms of psychotherapy, making evaluative research on it essential. Although research on PDT has been ongoing for several decades, theoretical and practical challenges initially hindered the adoption of evidence-based medicine standards in such research, a shift that has largely taken place over the past 20 years. This article reviews the evolution of evaluative research on PDT for mental disorders in adults, with a focus on those with complex conditions.
View Article and Find Full Text PDFPLoS Biol
January 2025
Lendület Laboratory of Thalamus Research, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure triggers an immediate increase in the firing activity of calretinin-positive neurons in the paraventricular thalamic nucleus (PVT/CR+) that persists for several days in mice.
View Article and Find Full Text PDFPLoS Biol
January 2025
CIRB, CNRS, INSERM, Collège de France, Université PSL, Paris, France.
Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence in around 10% of women remain largely unknown. Notwithstanding, it is precisely this information that is crucial for improving treatment, screening, and vaccination strategies.
View Article and Find Full Text PDFACS Chem Biol
January 2025
Department of Chemistry, University of Florida, Gainesville Florida 32611, United States.
Small molecules are essential for investigating the pharmacology of membrane proteins and remain the most common approach for therapeutically targeting them. However, most experimental small molecule screening methods require ligands containing radiolabels or fluorescent labels and often involve isolating proteins from their cellular environment. Additionally, most conventional screening methods are suited for identifying compounds with moderate to higher affinities ( < 1 μM) and are less effective at detecting lower affinity compounds, such as weakly binding molecular fragments.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Université de Lorraine, CNRS, Institut Jean Lamour, Nancy, 54000, France.
ℤ-classified higher-order topological insulators (HOTIs) with chiral-symmetric higher-order topological phases protected by multipole chiral numbers (MCNs) have attracted extensive interest recently. However, how to design artificial ℤ-classified HOTIs with multiple topological phases remains an unresolved issue. Here, multiorbital degrees of freedom are introduced to acoustic crystals and the various methods of topological phase transitions are achieved for the orbital ℤ-classified HOTIs.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
January 2025
Comenius University Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava, Slovakia.
Cholinesterase (ChE) inhibitors are under consideration to be used in the treatment of cardiovascular pathologies. A prerequisite to advancing ChE inhibitors into the clinic is their thorough characterization in the heart. The aim here was to provide a detailed analysis of cardiac ChE to understand their molecular composition, localization, and physiological functions.
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