Unraveling the impact of marine heatwaves on the Eukaryome of the emblematic Mediterranean red coral .

Global warming is intensifying heatwaves worldwide, leading to more frequent and severe temperature extremes. This study investigates the impact of the unprecedented 2022 Mediterranean heatwaves on the coral eukaryome, which has received little attention despite its known importance to coral holobiont functioning. Fifty-six colonies of the iconic red coral from the Mediterranean Sea were collected at different sites, depths, and health states.

Nurse-community health mediator pairs: a promising model for promoting the health of populations in remote areas of the French Amazon.

Multicultural Amazonian populations in remote areas of French Guiana face challenges in accessing healthcare and preventive measures. They are geographically and administratively isolated. Health mediation serves as an interface between vulnerable people and the professionals involved in their care.

Marrow Adiposity Content and Composition Are Not Associated With Incident Fragility Fractures in Postmenopausal Women: The ADIMOS Fracture Study.

Context: Noninvasive measurement of bone marrow adipose tissue using magnetic resonance imaging and proton density fat fraction (PDFF) may enhance clinical fractures prediction in postmenopausal women.

Objective: This study aimed to assess the association between PDFF measurements and clinical fracture incidence.

Methods: A longitudinal study was conducted.

Synthesis and structure of 2-oxo-2-chromen-4-yl 4-bromo-benzoate: work carried out as part of the CNRS AFRAMED project.

In the title compound, CHBrO, the dihedral angle between the chromen-2-one ring system (r.m.s.

Modification of the existing maximum residue level for metalaxyl-M in honey.

In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Ascenza Agro S.A. submitted a request to the competent national authority in France to modify the existing maximum residue level (MRL) for the active substance metalaxyl-M in honey.

Peer review of the pesticide risk assessment of the active substance maltodextrin.

The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Ireland, and co-rapporteur Member State, France, for the pesticide active substance maltodextrin and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2020/103. The conclusions were reached on the basis of the evaluation of the representative uses of maltodextrin as an insecticide and acaricide on all edible and non-edible crops.

Reasons for using electronic cigarettes among young adults aged 18 - 30: a systematic review.

The use of psychoactive products by young adults is usually described as part of their exploratory identity development. This behavior is facilitated by social and structural contexts where these substances are perceived as legal and easily accessible. While the motivations for initiating and continuing the use of tobacco and alcohol are well-documented, the same cannot be said for e-cigarettes.

[Dengue fever vaccination Recommendations from the Société Francophone de Médecine Tropicale et de Santé Internationale for Metropolitan France and Overseas Territories].

Dengue fever is spreading rapidly around the world, affecting nearly half the world's population. Causes include urbanization, human mobility, climate change and the spread of mosquito vectors such as In 2023 and 2024, there was a marked increase in cases and deaths worldwide. In mainland France, the increase in imported cases has generated local transmissions.

[Hepatocellular carcinoma (HCC)].

Primary liver cancers are tumors that develop from different liver cells. Hepatocellular carcinoma (HCC), which develops from hepatocytes, accounts for approximately 75-85% of primary liver cancers.HCC is the 6 leading cause of cancer worldwide and the 3 leading cause of cancer-related death.

[Loincloths and health prevention].

The authors report on activities carried out in the 1990s in Côte d'Ivoire using original AIDS prevention methods. These initiatives were based on the use of loincloths. The loincloth is a printed fabric that is highly valued in Africa.

[Evaluation of snakebite management cost at Saint Jean de Dieu Hospital in Tanguiéta, Benin].

Introduction: Snakebite envenomations are a real public health problem in rural areas of sub-Saharan Africa, especially as the cost of management is often beyond the reach of the victims. The aim of our study was to evaluate the costs of treating snakebite envenomations at the Saint Jean de Dieu hospital in Tanguiéta, northern Benin, in a savannah area.

Methods: This was a descriptive cross-sectional study conducted over a three-month period from May 25 to August 25, 2023.

HIV controllers: hope for a functional cure.

Elite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying HIV suppression in ECs and PTCs. Although ECs maintain viral control without antiretroviral therapy (ART), PTCs achieve suppression following ART discontinuation.

Human pluripotent stem cell-derived hepatic progenitors exhibit a partially hypoimmunogenic phenotype and actively inhibit immune responses.

Introduction: GStemHep cells are human cryopreserved hepatic progenitors derived from pluripotent of stem cells (GStem cells) using a cGMP-compliant protocol. They were highly effective in rescuing mice from acute liver failure.

Methods: The objective of this study was to analyze the immunogenicity and immunoregulatory properties of GStemHep cells.

Levofloxacin to Prevent Bacterial Infection in Patients With Acute Myeloid Leukemia Treated by Venetoclax and Azacitidine: A Toulouse-Bordeaux DATAML Registry Study.

Objectives: Antibiotic prophylaxis for patients with cancer remains a controversial issue and is not broadly recommended for hematological malignancies. The venetoclax (VEN) and azacitidine (AZA) combination allows for high rates of complete remission in acute myeloid leukemia (AML) but enhances the incidence of febrile neutropenia (FN) compared to AZA alone, making primary antibiotic prophylaxis a relevant question.

Patients And Methods: Patients with AML who received VEN-AZA were selected from the DATAML registry to investigate the use of levofloxacin (LEVO) prophylaxis, administered at 500 mg/day from day 10 following the first course of VEN-AZA, until neutrophil recovery (>0.

Jurassic Park approached: a coccid from Kimmeridgian cheirolepidiacean Aintourine Lebanese amber.

With the exception of a fly and a mite from the Triassic of Italy, all Mesozoic amber arthropods are from the Cretaceous. Late Jurassic Lebanese amber from Aintourine revealed a completely preserved adult coccid male (wing length 0.8 mm), gen.

Why participatory plant research now?

In the current polycrisis era, plant science, particularly when applied to agronomy, becomes instrumental: because our main substantial and renewable resource is plant biomass, many future solutions will depend on our ability to grow and transform plant material in a sustainable way. This also questions the way we conduct plant research and thus quantitative plant biology. In response to the increasing polarization between science and society, participatory plant research offers a pertinent framework.

Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model.

Introduction: Flow diverters are specialized stents used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) have been proposed as the next-generation of flow diverter technology. BRFDs aim to occlude and heal the aneurysm before safely dissolving into the body, mitigating complications associated with the permanent presence of conventional flow diverters.

Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.

Objective: Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of the c.911G>A; p.

MRI R2* captures inflammation in disconnected brain structures after stroke: a translational study.

Ischemic strokes disrupt brain networks, leading to remote effects in key regions like the thalamus, a critical hub for brain functions. However, non-invasive methods to quantify these remote consequences still need to be explored. This study aimed to demonstrate that MRI-derived R2* changes can capture iron accumulation linked with inflammation secondary to stroke-induced disconnection.

Quality of life in heart failure. The heart of the matter. A scientific statement of the Heart Failure Association and the European Association of Preventive Cardiology of the European Society of Cardiology.

For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a range of physical and psychological symptoms, including shortness of breath, chest discomfort, fatigue, fluid congestion, trouble with sleeping, and depression. These symptoms reduce patients' capacity for daily social and physical activity.

Quality of life in heart failure. The heart of the matter. A scientific statement of the Heart Failure Association and the European Association of Preventive Cardiology of the European Society of Cardiology.

For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a range of physical and psychological symptoms, including shortness of breath, chest discomfort, fatigue, fluid congestion, trouble with sleeping, and depression. These symptoms reduce patients' capacity for daily social and physical activity.

Hospital cybersecurity: Emergency planning response and preparedness to mitigate the effects of a potential cyberattack on French hospitals in Paris, France.

Over the last few years, numerous hospitals in France have been subject to increasingly frequent and severe cyberattacks that have disrupted healthcare provision to varying degrees. To mitigate this threat, especially in light of the forthcoming 2024 Olympic Games, Assistance Publique-Hôpitaux de Paris in Paris has been developing contingency plans that have been tested in simulated exercises called CRYPTolocker EXercice since May 2021. The latest simulated ransomware cyberattack that involved more than 200 participants took place on July 5, 2023, and lasted for 24 hours.

Microvalve-based gradient generators to control flow-free, time zero and long-term conditions.

Experiments with gradients of soluble bioactive species have significantly advanced with microfluidic developments that enable cell observation and stringent control of environmental conditions. While some methodologies rely on flow to establish gradients, others opt for flow-free conditions, which is particularly beneficial for studying non-adherent and/or shear-sensitive cells. In flow-free devices, bioactive species diffuse either through resistive microchannels in microchannel-based devices, through a porous membrane in membrane-based devices, or through a hydrogel in gel-based devices.

A Demographic Study of Aste-Béon (Ossau Valley, Bearn), a Small Community From French Western Pyrenees in the 19th Century.

Objectives: To decipher the social behaviors and public health status of a 19th-century small Western Pyrenean community using various historical demography data.

Methods: From censuses, civil and parish registers of births, marriages, and deaths/burials, migration archives, and administrative records, we analyzed a series of demographic parameters in the village of Aste-Béon between 1801 and 1900.

Results: Acknowledging the limitations of such a historical demography approach (especially losses of data and underreporting of deaths of very young individuals), this study enabled us to draw a series of conclusions.