Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors.

Plants face many abiotic stresses that significantly impact their growth and survival, requiring intricate mechanisms in order to adapt and thrive [...

Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin.

Hair follicle stem cells, located in the bulge region of the outer root sheath, are multipotent epithelial stem cells capable of differentiating into epidermal, sebaceous gland, and hair shaft cells. Efficient culturing of these cells is crucial for advancements in dermatology, regenerative medicine, and skin model development. This investigation aimed to develop a protocol for isolating enriched bulge-derived epithelial cells from scalp specimens to produce tissue-engineered substitutes.

Synbiotic Microencapsulation of Strains from Mexican Fermented Beverages for Enhanced Probiotic Functionality.

Synbiotics, which combine probiotics and prebiotics, represent an innovative approach to developing functional foods with enhanced health benefits compared to their individual components. This study focuses on the production of synbiotics through the microencapsulation of strains isolated from traditional Mexican fermented beverages, contributing to the advancement of technologies for functional food development. Three strains ( LM07, LM19, and LBH1070) were microencapsulated by spray-drying using a mixture of maltodextrin and gum arabic as wall materials and inulin as a prebiotic.

Extraction of Curcuminoids and Carvacrol with Biobased Ionic Liquids-Evaluation of Anti-Cancer Properties of Curcuminoid Extracts.

Six biobased ionic liquids were prepared from saturated fatty acids (octanoic, decanoic and dodecanoic acids) and choline with yields up to 90% following procedures respecting green chemistry principles. These ionic liquids were fully characterized (NMR, IR, elemental analysis, viscosimetry and TGA) and used as extraction solvents for bioactive compounds (curcuminoids and carvacrol) using classical conditions, and the ionic liquids were able to be recovered after five runs without loss of activity. The ionic liquid containing a C12 carbon chain was the best extracting solvent, extracting 95% of the total curcuminoids contained in turmeric and 69% of the total carvacrol contained in oregano, which are higher yields compared to the extraction procedures described in the literature.

Benefit of an Ultrasonic Irradiation on the Depollution by Washing of Nickel- or Zinc-Contaminated Vermiculite.

Pollution of soil by heavy metals has become a critical environmental issue. This study investigated an innovative approach to heavy metals removal, focusing on the desorption of nickel and zinc from vermiculite using a combination of leaching and ultrasonic (US) irradiation at 20 or 362 kHz. When 0.

Electron Scattering Cross Sections from Thiazole for Impact Energies Ranging from 1 to 1000 eV.

Total electron scattering cross sections (TCSs), in the energy range of 1-100 eV, have been measured with a high-resolution magnetically confined electron transmission apparatus, with total uncertainty limits estimated to be within ±5%. No previous experimental TCS data have been found for comparison. Electron attachment resonances, corresponding to transient negative ion formation, have been identified for energies below 20 eV by analyzing their contribution to the measured local maxima of the TCSs.

Chemical Looping CH Reforming Through Isothermal Two-Step Redox Cycling of SrFeO Oxygen Carrier in a Tubular Solar Reactor.

The chemical looping reforming of methane using an SrFeO oxygen carrier to produce synthesis gas from solar energy was experimentally investigated and validated. High-temperature solar heat was used to provide the reaction enthalpy, and therefore the methane feedstock was entirely dedicated to producing syngas. The two-step isothermal process encompassed partial perovskite reduction with methane (partial oxidation of CH) and exothermic oxidation of SrFeO with CO or HO splitting under the same operating temperature.

Ligand-Induced Biased Activation of GPCRs: Recent Advances and New Directions from In Silico Approaches.

G-protein coupled receptors (GPCRs) are the largest family of membrane proteins engaged in transducing signals from the extracellular environment into the cell. GPCR-biased signaling occurs when two different ligands, sharing the same binding site, induce distinct signaling pathways. This selective signaling offers significant potential for the design of safer and more effective drugs.

The Effectiveness of Liquid-Phase Microextraction of Beta-Blockers from Aqueous Matrices for Their Analysis by Chromatographic Techniques.

Beta-blockers are pharmaceuticals used to treat cardiovascular diseases such as hypertension, angina pectoris, and arrhythmia. Due to high consumption, they are continuously released into the environment, being detected in many aqueous matrices. The aim of this research is to test the effectiveness of two green liquid-phase microextraction procedures, such as dispersive liquid-liquid microextraction (DLLME) and solidification of floating organic droplet microextraction (SFOME) for the selective extraction of eight beta-blockers (atenolol, nadolol, pindolol, acebutolol, metoprolol, bisoprolol, propranolol, and betaxolol) from aqueous matrices for their analysis by gas chromatography (GC) or liquid chromatography (LC).

Magnetic Ionic Liquid: A Multifunctional Platform for the Design of Hybrid Graphene/Carbon Nanotube Networks as Electromagnetic Wave-Absorbing Materials.

Magnetic ionic liquid (MIL) based on alkyl phosphonium cation was used as a curing agent for developing epoxy nanocomposites (ENCs) modified with a graphene nanoplatelet (GNP)/carbon nanotube (CNT) hybrid filler. The materials were prepared by a solvent-free procedure involving ball-milling technology. ENCs containing as low as 3 phr of filler (GNP/CNT = 2.

Functionalization of Phenolic Aldehydes for the Preparation of Sustainable Polyesters and Polyurethanes.

Biobased organic diols derived from the phenolic aldehyde by-products in the depolymerization of lignin (4-hydroxybenzaldehyde, vanillin, and syringaldehyde) for the synthesis of polyesters and polyurethanes is described. Methods to prepare lignin-based diols involved a two-step synthetic route using either a hydroxy alkylation and aldehyde reduction or an aldehyde reduction and Williamson-Ether substitution. The preparation of five polyesters (PEs) and ten polyurethanes (PUs) from lignin-based diols was also performed and their physical and thermal properties were analyzed.

Numerical Prediction and Experimental Validation of Deposited Filaments in Direct Ink Writing: Deposition Status and Profile Dimension.

The deposition status and profile dimension of deposited filaments have an impact on the quality of the printed parts fabricated by direct ink writing (DIW). Previous works often failed to realize the full quantitative characterizations of the detailed influence of the process parameters on the deposition status and profile dimension. Herein, we predict and analyze the deposition status and profile dimension by proposing an improved three-dimensional (3D) numerical model.

Proposal of a Modular Classification System for Direct Dental Resin Composites Based on Clinical Applications.

The adhesive-resin composite pair has been the cornerstone of direct restorations in dentistry for many years. Resin composites are traditionally classified in three ways based on their inorganic structure, their organic composition and their viscosity. While these classifications have long been associated with the optical, mechanical, and clinical properties of resin composites, recent studies indicate that this classification is not always valid.

Verification of the Utility of the Standardized Extract to Control Gut Contractility in Sheep-Ex Vivo Study.

Background: Modern societies and policymakers increasingly emphasize the advancement of organic farming practices and the preservation of rural culture. Sheep farming faces several challenges, including environmental impacts, antibiotic usage, and public concerns regarding animal welfare. The purpose of this study was to investigate the effects of extract and its principal phenolic acids on the motility of the sheep jejunum and colon, with the goal of assessing their potential as health-promoting feed additives, particularly in animals with dysmotilities.

An Investigation into the Effect of Body Condition and Other Gilt Characteristics on Estrus Responses Post Altrenogest Treatment and on Reproductive Performance.

This study was conducted to investigate the effect of body condition (BC) and other characteristics on estrus responses post altrenogest treatment and on reproductive performance in 161 gilts, bred artificially, treated with 20 mg altrenogest orally for 18 consecutive days. Parameters recorded at the beginning of altrenogest treatment included age and body weight. Backfat (BFT) and muscle thickness (MT), both defining BC, puberty status and uterine size (UtS, based on cross-sectional areas of the uterine horns) were recorded by real-time-ultrasound (RTU), and BFT, along with MT together with ovary status, were recorded again at the end of altrenogest treatment.

CT Features of Mallory-Weiss Syndrome.

We report in this clinical case Mallory-Weiss syndrome suspected on computed tomography (CT) and confirmed on endoscopy. Mallory-Weiss syndrome is a rare cause of upper gastrointestinal bleeding from vomiting-induced mucosal laceration(s) at the gastroesophageal junction. The description of Mallory-Weiss Syndrome is rare on imaging and this observation provides CT semiological elements useful in detecting signs of Mallory-Weiss syndrome.

Development and Assessment of a Multiple-Analysis System for Diagnosing Malaria and Other Blood Parasite Infections in Humans and Non-Human Primates.

: Many tropical diseases such as malaria, Chagas, human African Trypanosomiasis, and Lymphatic filariasis coexist in endemic countries, affecting more than 1 billion people worldwide, and are recognised as major global vector-borne diseases. Tackling this disease requires an accurate diagnosis that is sensitive, specific, and rapid. This study aimed to describe and validate a new highly sensitive and specific multiple-analysis system that can effectively detect numerous etiological agents in a single test.

Correction: Kotelevets, L.; Chastre, E. Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications. 2023, , 1107.

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Targeting Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer: Beyond PD-1/PD-L1 Monoclonal Antibodies.

Non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Immunotherapy targeting the PD-1/PD-L1 axis has revolutionized treatment, providing durable responses in a subset of patients. However, with fewer than 50% of patients achieving significant benefits, there is a critical need to expand therapeutic strategies.

Naloxegol for the Treatment of Opioid-Induced Constipation in Patients with Cancer Pain: A Pooled Analysis of Real-World Data.

Objective: The aim of the NALOPOOL project was to assess the efficacy and safety of naloxegol in patients with cancer pain who exhibited opioid-induced constipation (OIC) and were treated under real-world conditions.

Methods: We pooled individual patient data from three multicenter observational studies conducted with naloxegol in patients with cancer who exhibited OIC and were prescribed naloxegol under real-world conditions. Efficacy outcomes were evaluated after 4 weeks of treatment.

The Role of Engagement in Virtual Reality to Enhance Emotional Well-Being in Breast Cancer Patients: A Mediation Analysis.

Introduction: Virtual reality (VR) has garnered increasing attention in oncology due to its potential to enhance patient care by alleviating anxiety and emotional distress. The present work evaluates the hypothesis proposed by a recent theoretical model that engagement and the sense of presence are key mediators that impact the degree of beneficial effects that VR may have on the emotional well-being of breast cancer patients.

Methods: This study draws on data from three previous studies comprising 156 breast cancer patients.

Line-Field Confocal Optical Coherence Tomography: Is One Hour of Training Sufficient for Diagnosing Basal Cell Carcinoma?

Basal cell carcinoma (BCC) is the most common malignancy, characterised by local invasiveness and the potential for tissue destruction. Diagnosing BCC can be challenging, particularly for less experienced dermatologists. Line-field confocal optical coherence tomography (LC-OCT), a new noninvasive optical technique, has become increasingly useful in clinical practice, allowing in vivo imaging at cellular resolution.

Ovarian Cancer in Women with Intellectual Disability: Current Data.

Objective: We evaluate ovarian cancer (OC) in women with intellectual disability (ID).

Methods: We reviewed the literature and added personal observations. The literature search included data from epidemiological studies on cancer incidence and mortality, institutional experiences, and case reports.

Absolute Quantification of Nucleotide Variants in Cell-Free DNA via Quantitative NGS: Clinical Application in Non-Small Cell Lung Cancer Patients.

: Circulating tumor DNA (ctDNA) analysis is a powerful tool for non-invasive monitoring of tumor burden and treatment response. Reliable quantification methods are critical for the effective use of ctDNA as a tumor biomarker. Digital PCR (dPCR) offers high sensitivity and quantification, but requires the prior knowledge of tumor-specific genomic alterations.