Hinged Carboxylate in the Artificial Distal Pocket of an Iron Porphyrin Enhances CO Electroreduction at Low Overpotential.

To efficiently capture, activate, and transform small molecules, metalloenzymes have evolved to integrate a well-organized pocket around the active metal center. Within this cavity, second coordination sphere functionalities are precisely positioned to optimize the rate, selectivity, and energy cost of catalytic reactions. Inspired by this strategy, an artificial distal pocket defined by a preorganized 3D strap is introduced on an iron-porphyrin catalyst (sc-Fe) for the CO-to-CO electrocatalytic reduction.

Hypotensive Episodes Identified on 24-Hour Ambulatory Blood Pressure and Impaired Cognitive Function: Insights From the SPRINT Study.

Background: Hypotensive episodes detected by 24-hour ambulatory blood pressure (BP) monitoring capture daily cumulative hypotensive stress and could be clinically relevant to cognitive impairment, but this relationship remains unclear.

Methods: We included participants from the Systolic Blood Pressure Intervention Trial (receiving intensive or standard BP treatment) who had 24-hour ambulatory BP monitoring measured near the 27-month visit and subsequent biannual cognitive assessments. We evaluated the associations of hypotensive episodes (defined as systolic BP drops of ≥20 mm Hg between 2 consecutive measurements that reached <100 mm Hg) and hypotensive duration (cumulative time of systolic BP <100 mm Hg) with subsequent cognitive function using adjusted linear mixed models.

Clinical significance of stratifying prostate cancer patients through specific circulating genes.

Patient stratification remains a challenge for optimal treatment of prostate cancer (PCa). This clinical heterogeneity implies intra-tumoural heterogeneity, with different prostate epithelial cell subtypes not all targeted by current treatments. We reported that such cell subtypes are traceable in liquid biopsies through representative transcripts.

[Overview of the French Memory Centres healthcare pathway for patients with early Alzheimer disease].

The growing prevalence of the Alzheimer's disease (AD) is an increasing public health concern that led to French recommendations for timely AD diagnosis and patient management as well as a territorial coverage of specialized structures [Memory Centers including Resources and Memory Research Centers (RMRC) and Memory Consultations (MC)]. In view of the potential availability of Disease Modifying Therapies (DMTs), this French observatory aimed to describe the current organization of the Memory Centers, and the care pathway of patients suffering from early AD. Overall, 12 of the 28 RMRC and 44 of the 250 MC solicited by the Federation of Memory Centers participated in this study.

Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of on improving HFD-induced diabetic nephropathy rats.

Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lacking curative therapy. Sporoderm-broken spores of (GLP), an herbal medicine, has been used for the treatment of metabolic disorders. In this study, DN was induced in Sprague-Dawley rats using streptozotocin (STZ) and a high-fat diet (HFD), and the protective mechanisms of GLP were investigated through transcriptomic, metabolomic, and network pharmacology (NP) analyses.

Photon antibunching in single-molecule vibrational sum-frequency generation.

Sum-frequency generation (SFG) enables the coherent upconversion of electromagnetic signals and plays a significant role in mid-infrared vibrational spectroscopy for molecular analysis. Recent research indicates that plasmonic nanocavities, which confine light to extremely small volumes, can facilitate the detection of vibrational SFG signals from individual molecules by leveraging surface-enhanced Raman scattering combined with mid-infrared laser excitation. In this article, we compute the degree of second order coherence ( (0)) of the upconverted mid-infrared field under realistic parameters and accounting for the anharmonic potential that characterizes vibrational modes of individual molecules.

Coupled acoustoplasmonic resonators: the role of geometrical symmetries.

Acoustoplasmonic resonators, such as nanobars and crosses, are efficient acousto-optical transducers. The excitation of mechanical modes in these structures strongly depends on the spatial profile of the eigenmodes of the resonator. Using a system of two identical gold elongated bars placed on a silicon dioxide substrate, we examine how breaking mirror symmetries affects the optical and acoustic properties to provide insights in the design of acoustoplasmonic metasurfaces for nonsymmetric acousto-optical transducers.

Detection of clinically relevant variants in the gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL.

In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different laboratories using their NGS method of choice. The sensitivity was 85.

Comprehensive comparative metabolome study of a large collection of Corsican bryophytes.

Introduction: Bryophytes are non-vascular plants that appeared on Earth before vascular plants. More than 24,000 species are reported worldwide, and only a small proportion have been studied. However, part of their biosynthetic potential has been unveiled and more than 1,600 terpenoids have been detected and identified.

Competing pathways to aromaticity governed by amine dehydrogenation and metal-organic complexation in on-surface synthesis.

We investigated the reactivity of a -dichlorovinyl-carbazole precursor in the on-surface synthesis approach. Our findings reveal that, on the Au(111) surface, the thermally-induced dehalogenation reaction led to the formation of cumulene dimers. Contrastingly, the more reactive Cu(111) surface promoted the formation of a polyheterocyclic compound exhibiting extended aromaticity.

Laboratory performance assessment of low-cost water level sensor for field monitoring in the tropics.

As Water Sensitive Urban Design (WSUD) is a key strategy in integrated urban water management worldwide, there is a need for robust monitoring of WSUD systems. Being economical and flexible for operation and communication, low-cost sensor systems show great potential to mainstream digital water management. Yet, such systems are insufficiently tested, casting doubt on the reliability of their measurements.

Hemorrhoidal disease: what role can rectal artery embolization play?

Introduction: Hemorrhoidal artery embolization, also known as Emborrhoid, has emerged in recent years as a minimally invasive treatment option for patients with recurrent and unresponsive to medical therapies hemorrhoidal bleeding symptoms. We present here an overview of the profile of rectal artery embolization based on the most relevant and recent literature.

Methods: A comprehensive review of literature on Hemorrhoidal artery embolization, was conducted on PubMed-Medline.

Molecular dynamics simulation dataset for SiO-BO-(1--)NaO glasses.

Silicate glasses are commonly used for many important industrial applications. As such, the literature provides a wealth of different structural, physical, thermodynamic and mechanical properties for many different chemical compositions of oxide glasses. However, a frequent limitation to existing datasets is that only one or two material properties can be evaluated for a given sample.

Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach.

Human rhinovirus C (HRV-C) is a significant contributor to respiratory tract infections in children and is implicated in asthma exacerbations across all age groups. Despite its impact, there is currently no licensed vaccine available for HRV-C. Here, we present a novel approach to address this gap by employing immunoinformatics techniques for the design of a multi-epitope-based vaccine against HRV-C.

Clinical Outcomes of Isolated ACL Reconstruction Versus Combined ACL and ALL Reconstruction With Indication Guided by Intraoperative Ultrasound: A Propensity Score-Matched Study of 260 Patients With a Minimum 2-Year Follow-up.

Background: Additional anterolateral ligament (ALL) reconstruction has been associated with improved clinical outcomes and reduced failure rates in anterior cruciate ligament (ACL) reconstruction. Despite the excellent clinical results reported, there is still a heated debate about its indications. Currently, the indications are mainly based on the patient's clinical criteria and not the imaging diagnosis of the injury of this ligament.

Anticipation training for expert tennis players when facing a specific player.

Introduction: In fast ball sports, such as tennis, when spatiotemporal constraints are high, players have to anticipate the opponent action. Not much is known about how players acquire and improve this ability. The aim of this study was to use an implicit training protocol (no information was given to participants) based on the knowledge of one particular opponent to analyse how experts could improve their anticipation ability.

Task-irrelevant emotional expressions are not mimicked, but may modulate the mimicry of task-relevant emotional expressions.

Emotional mimicry-the imitation of others' emotions-is an empathic response that helps to navigate social interactions. Mimicry is absent when participants' task does not involve engaging with the expressers' emotions. This may be because task-irrelevant faces (i.

Honey bees rely on associative stimulus strength after training on an olfactory transitive inference task.

Transitive inference, the ability to establish hierarchical relationships between stimuli, is typically tested by training with premise pairs (e.g., A + B-, B + C-, C + D-, D + E-), which establishes a stimulus hierarchy (A > B > C > D > E).

analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells.

Background: Hepatocellular carcinoma (HCC) is the most common subtype of primary liver cancer with varied incidence and epidemiology worldwide. Sorafenib is still a recommended treatment for a large proportion of patients with advanced HCC. Different patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 cells.

Sexual reproduction during diatom bloom.

Phytoplankton supports food webs in all aquatic ecosystems. Ecological studies highlighted the links between environmental variables and species successions . However, the role of life cycle characteristics on phytoplankton community dynamics remains poorly characterized.

Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.

Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk.