Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women.

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times of the day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women.

Methods: Random allocation of sixty-one participants into four groups: early time-restricted eating plus physical activity (ETRE-PA, n = 15, 31.8 ± 10.

Growth, Safety and Tolerance in Infants Fed Rice Protein Hydrolysate Formula: The GRITO Randomised Controlled Trial.

: Hydrolysed rice formula (HRF) is tolerated by >90% of children with cow's milk protein allergy (CMPA). However, concerns have been raised about potential suboptimal growth in infants fed HRF compared to those fed an extensively hydrolysed milk protein formula (eHF). : To compare growth, safety and tolerance acquisition in infants with CMPA when fed HRF versus eHF.

A Risk Score to Identify Low Bone Mineral Density for Age in Young Patients with Anorexia Nervosa.

Objective: Developing a scoring assessment tools for the determination of low bone mass for age at lumbar spine and hip in patients with anorexia nervosa (AN).

Methods: The areal bone mineral density (aBMD) was determined with dual-energy X-ray absorptiometry (DXA). In 331 women with AN and 121 controls, aged from 14.

Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition.

Human milk oligosaccharides (HMOs), the third most abundant solid component in human milk, vary significantly among women due to factors such as secretor status, race, geography, season, maternal nutrition and weight, gestational age, and delivery method. In recent studies, HMOs have been shown to have a variety of functional roles in the development of infants. Because HMOs are not digested by infants, they act as metabolic substrates for certain bacteria, helping to establish the infant's gut microbiota.

Bioactive Phenolics of L. Subsp. Falezlez: A Molecular and Biochemical Approach to Antioxidant and Urease Inhibitory Activities.

This study examines the chemical composition, antioxidant properties, and urease inhibitory effects of L. subsp. falezlez (Coss.

Fucosidosis: A Review of a Rare Disease.

Fucosidosis is a rare lysosomal storage disease caused by α-L-fucosidase deficiency following a mutation in the gene. This enzyme is responsible for breaking down fucose-containing glycoproteins, glycolipids, and oligosaccharides within the lysosome. Mutations in result in either reduced enzyme activity or complete loss of function, leading to the accumulation of fucose-rich substrates in lysosomes.

Small Extracellular Vesicles Derived from Lipopolysaccharide-Treated Stem Cells from the Apical Papilla Modulate Macrophage Phenotypes and Inflammatory Interactions in Pulpal and Periodontal Tissues.

Inflammation significantly influences cellular communication in the oral environment, impacting tissue repair and regeneration. This study explores the role of small extracellular vesicles (sEVs) derived from lipopolysaccharide (LPS)-treated stem cells from the apical papilla (SCAP) in modulating macrophage polarization and osteoblast differentiation. SCAPs were treated with LPS for 24 h, and sEVs from untreated (SCAP-sEVs) and LPS-treated SCAP (LPS-SCAP-sEVs) were isolated via ultracentrifugation and characterized using transmission electron microscopy, Western blot, and Tunable Resistive Pulse Sensing.

Head-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort.

High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan 7k) and antibody-based (Olink Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan assays analyzing the same samples, and between SomaScan and Olink results.

Novel Variants Related to a Variable Phenotypic Spectrum Ranging from Epilepsy with Auditory Features to Severe Developmental and Epileptic Encephalopathies.

Pathogenic variants are associated with neonatal epilepsies, ranging from self-limited neonatal epilepsy to -developmental and epileptic encephalopathy (DEE). In this study, next-generation sequencing was performed, applying a panel of 142 epilepsy genes on three unrelated individuals and affected family members, showing a wide variability in the epileptic spectrum. The genetic analysis revealed two likely pathogenic missense variants (c.

Human miR-1 Stimulates Metabolic and Thermogenic-Related Genes in Adipocytes.

MicroRNAs play a pivotal role in the regulation of adipose tissue function and have emerged as promising therapeutic candidates for the management of obesity and associated comorbidities. Among them, miR-1 could be a potential biomarker for metabolic diseases and contribute to metabolic homeostasis. However, thorough research is required to fully elucidate the impact of miR-1 on human adipocyte thermogenesis and metabolism.

Characterization of Mesenchymal and Neural Stem Cells Response to Bipolar Microsecond Electric Pulses Stimulation.

In the tissue regeneration field, stem cell transplantation represents a promising therapeutic strategy. To favor their implantation, proliferation and differentiation need to be controlled. Several studies have demonstrated that stem cell fate can be controlled by applying continuous electric field stimulation.

Immune Checkpoint Inhibitor-Associated Cutaneous Adverse Events: Mechanisms of Occurrence.

Immunotherapy, particularly that based on blocking checkpoint proteins in many tumors, including melanoma, Merkel cell carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast (TNB cancer), renal cancer, and gastrointestinal and endometrial neoplasms, is a therapeutic alternative to chemotherapy. Immune checkpoint inhibitor (ICI)-based therapies have the potential to target different pathways leading to the destruction of cancer cells. Although ICIs are an effective treatment strategy for patients with highly immune-infiltrated cancers, the development of different adverse effects including cutaneous adverse effects during and after the treatment with ICIs is common.

Effect of Chemical Treatment on the Mechanical and Hygroscopic Properties of an Innovative Clay-Sand Composite Reinforced with Fibers.

The viability of using fibers as reinforcement material for developing lightweight sustainable non-structural construction materials in compliance with the valorization of local by-products has been investigated in this work. This study aims to investigate the effect of the chemical treatment of fibers on the mechanical and hygric properties of bio-sourced clay-sand- fiber composite. This lightweight specimen has been produced from a mixture of 60% natural clay and 40% sand by mass, as a matrix, and reinforced with different amounts of Juncus fibers.

Application of a New Thermal Model for the Determination of London Dispersive Properties of H-β-Zeolite/Rhodium Catalysts Using New 2D Chromatographic Models.

A new methodology based on the Hamieh thermal model was applied for the determination of the surface properties of solid surfaces. The new approach consisted of the accurate quantification of the London dispersive surface energy of materials using the two-dimensional inverse gas chromatography technique at infinite dilution. This technique used the notion of the net retention volume of adsorbed molecules on the solid catalysts, allowing the determination of the free energy of adsorption.

In-Volume Glass Modification Using a Femtosecond Laser: Comparison Between Repetitive Single-Pulse, MHz Burst, and GHz Burst Regimes.

In this study, we report, for the first time, to the best of our knowledge, on in-volume glass modifications produced by GHz bursts of femtosecond pulses. We compare three distinct methods of energy deposition in glass, i.e.

An Electrical Method to Detect Both Crack Creation and Propagation in Solid Electrical Insulators.

Fracto-emission is the ejection of electrons and positive ions from matter undergoing a mechanical fracture. The creation and propagation of fractures in insulating material can generate an electrical signal that can be detected using a sufficiently fast signal recorder. The theoretical equations related to crack creation/propagation that induce an externally electric signal are detailed for two conditions: with and without an external applied electric voltage.

[F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review.

: Cervical cancer is a significant global health concern, with high incidence and mortality rates, especially in less-developed regions. [F]FDG PET/CT is now indicated at various stages of management, but its analysis is essentially based on SUVmax, a measure of [F]FDG uptake. Radiomics, by extracting a multitude of parameters, promises to improve the diagnostic and prognostic performance of the examination.

Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review).

Patients diagnosed with multiple endocrine neoplasia type-1 (MEN1) often initially present with primary hyperparathyroidism (pHPT), and typically undergo surgical intervention. While laboratory tests are fundamental for diagnosis, imaging is crucial for localizing pathological parathyroids to aid in precise surgical planning. In this pictorial review, we will begin by comprehensively examining key imaging techniques and their established protocols, evaluating their effectiveness in detecting abnormal parathyroid glands.

Innovative Blown Multi-Micro-Nano-Layer Coextrusion: Insights into Rheology and Process Stability.

The present study introduces an innovative blown coextrusion die technology designed to address a critical gap in the production of multilayer films. Unlike conventional systems, this novel die allows for the creation of films with a high number of layers, ensuring layer integrity even in the micro-nano scale. A key advancement of this die is its ability to increase the number of layers without extending the residence time since it does not require an additional multiplier element.

The Relative Contribution of Root Morphology and Arbuscular Mycorrhizal Fungal Colonization on Phosphorus Uptake in Rice/Soybean Intercropping Under Dry Cultivation.

Intercropping has the potential to improve phosphorus (P) uptake and crop growth, but the potential benefits and relative contributions of root morphology and arbuscular mycorrhizal fungi (AMF) colonization are largely unknown for the intercropping of rice and soybean under dry cultivation. Both field and pot experiments were conducted with dry-cultivated rice ( L.) and soybean ( L.

Combined Effects of Microgravity and Chronic Low-Dose Gamma Radiation on Microgreens.

Plants in space face unique challenges, including chronic ionizing radiation and reduced gravity, which affect their growth and functionality. Understanding these impacts is essential to determine the cultivation conditions and protective shielding needs in future space greenhouses. While certain doses of ionizing radiation may enhance crop yield and quality, providing "functional food" rich in bioactive compounds, to support astronaut health, the combined effects of radiation and reduced gravity are still unclear, with potential additive, synergistic, or antagonistic interactions.

Synthesis and Antiviral Evaluation of 5-(4-Aryl-1,3-butadiyn-1-yl)-uridines and Their Phosphoramidate Pronucleotides.

The emergence of RNA viruses driven by global population growth and international trade highlights the urgent need for effective antiviral agents that can inhibit viral replication. Nucleoside analogs, which mimic natural nucleotides, have shown promise in targeting RNA-dependent RNA polymerases (RdRps). Starting from protected 5-iodouridine, we report the synthesis of -substituted-(1,3-diyne)-uridines nucleosides and their phosphoramidate prodrugs.

Antimicrobial Activity and Mode of Action of N-Heterocyclic Carbene Silver(I) Complexes.

Silver drugs have played a vital role in human healthcare for the treatment of infections for many centuries. Currently, due to antibiotic resistance, a potential scenario or the application of silver complexes may arise as substitutes for conventional antibiotics. In this perspective, N-heterocyclic carbene (NHC) ligands have been selected as carrier molecules for silver ions.

Weakly-Activated Phenol Derivatives as New Green Electrophilic Partners in Suzuki-Miyaura and Related C-C Couplings.

In recent years, there has been growing interest in the development of greener alternatives to traditional reagents used in carbon-carbon coupling reactions, particularly in response to environmental concerns. The commonly used aryl halides, despite being highly reactive in the Suzuki-Miyaura coupling (SMC), pose significant environmental risks. As a result, research has shifted towards exploring the use of phenols, which are widely accessible and environmentally benign.

Exploring the Photocatalytic Efficiency of Gold Nanoparticles Deposited on Ni-Al-Zr-Layered Double Hydroxides for Selective Glucose Oxidation.

Confronting escalating challenges in energy security and environmental sustainability has intensified interest in renewable sources for fuels and chemicals. Among the most promising alternatives, sugars derived from biomass are emerging as a cornerstone in advancing an environmentally sustainable economy. Within this framework, the development of sunlight-driven carbohydrate oxidation is of significant interest, as it enables the production of a broad spectrum of high-value, bio-sourced chemicals through eco-friendly processes.