Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation.

Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB, or less commonly MYBL1::NFIB. Sinonasal AdCC is an aggressive salivary gland malignancy with no effective systemic therapy. Therefore, it is urgent to search for potentially targetable genetic alterations associated with AdCC.

Rapidly spreading with OXA-48-like carbapenemases.

(mostly , ) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy.

Subchronic Exposure to Regulated Trihalomethanes and Haloacetic Acids: Do We Need to Refine Our Exposure Assessment? A Full-Scale Case Study in a Canadian Municipality.

Regulated disinfection byproducts (e.g., trihalomethanes and haloacetic acids) in drinking water networks fluctuate spatially and temporally, depending on water sources and treatment practices with higher concentrations during the summer.

Adolescents and young adults with social withdrawal in France: Sociodemographic characteristics and validation of the French version of the Hikikomori Questionnaire-25 (HQ-25).

Background: Clinical situations marked by severe social withdrawal in youths are increasingly recognized as an important public health issue in European countries, while the relation with the hikikomori syndrome initially described in Japan remains poorly investigated.

Aims: This study aims to describe the sociodemographic features of adolescents and young adults with social withdrawal in French and to validate a French version of the Hikikomori Questiuonnaire-25 (HQ-25).

Method: An online questionnaire was completed by 450 participants aged 13 to 25 years.

Can democracy save children's lives? Addressing the constitutional problem of expertise.

This comment critically examines Collins, Evans, and Reyes-Galindo's (CE&RG) concept of 'virtual diversity', proposed as a norm to safeguard scientific expertise in policy-making. CE&RG argue that scientists should acquire 'interactional expertise' in relevant 'non-scientific domains', enabling informed policy advice while preserving scientific integrity. This comment describes CE&RG's dualist approach, which separates epistemic and political concerns, and discusses its implications.

Real-world assessment of the patient profile, clinical characteristics, treatment patterns, and outcomes associated with erythropoietic and X-linked protoporphyria.

Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are rare genetic disorders. There are limited data regarding how these disorders are managed in real-world settings. The aim of this study was to document the characteristics and treatment patterns among patients diagnosed with EPP or XLP in general real-world settings in the United States.

Insights into proliferative glomerulonephritis with monoclonal immunoglobulin deposits - is it really monoclonal or not?

Purpose Of Review: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), is a disease defined by the presence of glomerulonephritis with nonorganized mono-isotypic immunoglobulin (Ig) deposits. This review will discuss the pathogenesis of PGNMID and address novel techniques for detection of monoclonal Ig and pathologic B-cell clones and for distinguishing monoclonal from oligoclonal Ig deposits.

Recent Findings: Because of low detection rate of circulating monoclonal Ig and nephritogenic B-cell clones and emerging reports of PGNMID-IgG in children, it has been recently argued that many PGNMID-IgG3 cases may not be monoclonal lesions.

Data from extensive monitoring of agricultural practices, soil health, and wheat grain production in 44 farms in Northwestern France from 2021 to 2023.

This article presents data measured in 44 farms covering a range of cropping practices, soil, and production parameters under contrasted types of crop management: conventional and conservation agriculture. Eighty-six winter wheat fields in Northwestern France were monitored for two growing seasons (2021-2023). The dataset encompasses data about cropping practices (tillage, soil cover, rotation, pesticide use, nutrition), soils (chemical, biological, and physical parameters, including texture), and grain production (nutritional, technological, and sanitary indicators).

Kinematic limitations during stair ascent and descent in patients with adult spinal deformity.

Background: Adults with spinal deformity (ASD) are known to have spinal malalignment, which can impact their quality of life and their autonomy in daily life activities. Among these tasks, ascending and descending stairs is a common activity of daily life that might be affected.

Research Question: What are the main kinematic alterations in ASD during stair ascent and descent?

Methods: 112 primary ASD patients and 34 controls filled HRQoL questionnaires and underwent biplanar X-from which spino-pelvic radiographic parameters were calculated.

Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?

Background: There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatric nephrology services within Europe.

Methods: In 2020, the European society for Paediatric Nephrology (ESPN) conducted a cross-sectional survey to identify the existing pediatric nephrology healthcare systems in 48 European countries covering a population of more than 200 million children.

A Comparative Study of Laparoscopic Skills Between Novices and Experts: How to Steepen the Learning Curve.

Introduction and aim Laparoscopic surgery has revolutionized the field of surgery over the past few decades. The learning curve in laparoscopy is known to be slow, flat, and complex. This study aims to conduct a comparative analysis of laparoscopic skills, specifically focusing on suturing, knot tying, and needle handling, between novices and experts.

Assessing immunotherapy response: going beyond RECIST by integrating early tumor growth kinetics.

Objective: Assess the contribution of early tumor growth dynamics modeling to predict clinical outcomes in non-small cell lung cancer patients receiving immunotherapy, alongside standard RECIST 1.1 criteria.

Methods: Our retrospective studies used data from 861 patients with advanced NSCLC enrolled in three randomized Phase III trials evaluating immunotherapy plus chemotherapy were analyzed.

Heat and Drought Events Alter Biogenic Capacity to Balance CO Budget in South-Western Europe.

Heat and drought events are increasing in frequency and intensity, posing significant risks to natural and agricultural ecosystems with uncertain effects on the net ecosystem CO exchange (NEE). The current Vegetation Photosynthesis and Respiration Model (VPRM) was adjusted to include soil moisture impacts on the gross ecosystem exchange (GEE) and respiration ( ) fluxes to assess the temporal variability of NEE over south-western Europe for 2001-2022. Warming temperatures lengthen growing seasons, causing an increase in GEE, which is mostly compensated by a similar increment in .

A graph neural architecture search approach for identifying bots in social media.

Social media platforms, including X, Facebook, and Instagram, host millions of daily users, giving rise to bots automated programs disseminating misinformation and ideologies with tangible real-world consequences. While bot detection in platform X has been the area of many deep learning models with adequate results, most approaches neglect the graph structure of social media relationships and often rely on hand-engineered architectures. Our work introduces the implementation of a Neural Architecture Search (NAS) technique, namely Deep and Flexible Graph Neural Architecture Search (DFG-NAS), tailored to Relational Graph Convolutional Neural Networks (RGCNs) in the task of bot detection in platform X.

Ticks as vectors of Trypanosomatidae with medical or veterinary interest: Insights and implications from a comprehensive systematic review and meta-analysis.

Since the 20th century, numerous studies have detected or isolated parasites from the Trypanosomatidae family in various tick species. However, the status of ticks as vectors for medically or veterinary significant and remains unclear. We conducted a systematic review and meta-analysis to provide new insights into the potential vector status of these pathogens, which have significant medical and veterinary implications.

Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy.

Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions. When deciphering metabolic adaptations, traditional experiments face challenges due to numerous enzymatic activities, needing modelling to anticipate pathway behaviours and orientate research. This paper aims to implement a constraint-based modelling method of muscular energy metabolism, adaptable to individual situations, energy demands, and complex disease-specific metabolic alterations like muscular dystrophy calpainopathy.

Multi-center evaluation of the first, low-cost, open source and totally 3D-printed pediatric laparoscopic trainer.

Objective: This study created and evaluated the face validity of a novel, low-cost, three-dimensional printed pediatric laparoscopic trainer and compared it to a standard laparoscopic trainer (LT).

Design: We developed the Space Child Laparoscopic Trainer (SCLT) using fused deposition modeling technology with a Bambulab P1S 3D printer.The cost per unit was five euros and the assembly time was 10 min.